GO:0002224

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Name toll-like receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0002224
Unique Molecular Interactions 1578
Total Molecular Interactions 2231
Total Single Events 12864
Pain Genes Associated 63

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for toll-like receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for toll-like receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
2 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
3 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
4 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
5 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
6 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
7 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
8 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
9 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
10 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
11 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14
12 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
13 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
14 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
15 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
16 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
17 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
18 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
19 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
20 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
21 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
22 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
23 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
24 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
25 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
26 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
27 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
28 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
29 INT265213 Binding of Ctla4 and Cd86 2 0.13 1.93 1.31
30 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
31 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
32 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
33 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
34 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
35 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
36 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
37 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
38 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
39 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
40 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
41 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16
42 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
43 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
44 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
45 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
46 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
47 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
48 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
49 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
50 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
51 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
52 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
53 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
54 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
55 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
56 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05
57 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
58 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
59 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
60 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
61 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
62 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
63 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
64 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
65 INT94206 SP5 Regulation of Gene_expression of FOS 1 0.22 0.7 0.98
66 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
67 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
68 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
69 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
70 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
71 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
72 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
73 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
74 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
75 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
76 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
77 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
78 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
79 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
80 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
81 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
82 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89
83 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
84 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
85 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
86 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
87 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
88 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
89 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
90 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
91 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
92 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
93 INT343829 TLR1 Positive_regulation of TBCE 1 0.03 0.96 0.85
94 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
95 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
96 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
97 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
98 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
99 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
100 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
101 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
102 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
103 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8
104 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
105 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
106 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
107 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
108 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
109 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
110 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
111 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
112 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
113 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
114 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
115 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
116 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
117 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
118 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
119 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
120 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
121 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
122 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
123 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
124 INT186445 Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
125 INT186443 Phosphorylation of Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
126 INT186444 Creb1 Regulation of FOS 1 0.49 0.43 0.72
127 INT186442 Phosphorylation of Creb1 Regulation of FOS 1 0.49 0.43 0.72
128 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
129 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
130 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
131 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
132 INT139069 Binding of CTLA4 and Cd86 3 0.16 0.65 0.7
133 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
134 INT103134 DCSTAMP Positive_regulation of NFKB1 2 0.07 1.43 0.7
135 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
136 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
137 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
138 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
139 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
140 INT66581 Binding of JUN and Rare2 1 0.00 0.07 0.69
141 INT66582 Binding of FOS and Rare2 1 0.00 0.07 0.69
142 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
143 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
144 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
145 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
146 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
147 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
148 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
149 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
150 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
151 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
152 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
153 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
154 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63
155 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
156 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
157 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
158 INT66207 Positive_regulation of TNF Positive_regulation of NFKB1 1 0.42 0.08 0.61
159 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61
160 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
161 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61
162 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
163 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
164 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
165 INT224419 Binding of NFKB2 and TNFRSF11B 1 0.11 1.37 0.6
166 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
167 INT224420 Regulation of Binding of NFKB2 and TNFRSF11B 1 0.13 1.39 0.6
168 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
169 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
170 INT81916 HSF1 Positive_regulation of FOS 1 0.76 0.66 0.59
171 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
172 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
173 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
174 INT81918 HSF1 Negative_regulation of FOS 1 0.64 0.66 0.59
175 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
176 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
177 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
178 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
179 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
180 INT306330 Cd14 Positive_regulation of Gene_expression of Tlr4 1 0.48 0.54 0.57
181 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
182 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
183 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
184 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
185 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
186 INT183695 Binding of Tlr3 and Ducm1 1 0.04 2.75 0.56
187 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
188 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
189 INT113548 NFKB1 Regulation of Localization of PLAU 1 0.26 1.93 0.55
190 INT249624 Negative_regulation of Binding of CD86 and CTLA4 1 0.47 0.57 0.55
191 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
192 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
193 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
194 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
195 INT84861 Rps6ka3 Positive_regulation of Transcription of APRT 1 0.28 0.19 0.55
196 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
197 INT156246 NFKB1 Regulation of Gene_expression of TNF 1 0.17 0.35 0.54
198 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54
199 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
200 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54

Single Events

The table below shows the top 100 pain related interactions that have been reported for toll-like receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in toll-like receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
2 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
3 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
4 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
5 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
6 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
7 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
8 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
9 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
10 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
11 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
12 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
13 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
14 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
15 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
16 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
17 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
18 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
19 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95
20 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
21 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
22 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
23 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
24 INT134651 Binding of TLR4 89 0.48 66.96 23.19
25 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
26 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
27 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
28 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
29 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
30 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
31 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
32 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
33 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
34 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
35 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
36 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13
37 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
38 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
39 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
40 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
41 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
42 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
43 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
44 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
45 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
46 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
47 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
48 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
49 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
50 INT15246 Regulation of FOS 32 0.60 15.34 12.94
51 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
52 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
53 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36
54 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
55 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
56 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65
57 INT150540 Binding of TLR2 50 0.45 35.86 10.43
58 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
59 INT60198 Binding of JUN 54 0.48 11.56 10.27
60 INT19620 Binding of CD86 30 0.47 12.01 9.89
61 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
62 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
63 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14
64 INT66213 Localization of RELA 63 0.78 14.71 8.77
65 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
66 INT17333 Positive_regulation of Positive_regulation of FOS 17 0.67 6.06 8.4
67 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
68 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
69 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
70 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
71 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63
72 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
73 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
74 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
75 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
76 INT75497 Regulation of JUN 28 0.61 11.04 7.09
77 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
78 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
79 INT60196 Binding of FOS 33 0.47 13.11 6.95
80 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
81 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
82 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
83 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56
84 INT5847 Transcription of FOS 31 0.69 11.11 6.41
85 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4
86 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
87 INT97797 Localization of TLR4 18 0.77 13.78 6
88 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
89 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
90 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
91 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79
92 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
93 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
94 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
95 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
96 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39
97 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
98 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31
99 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
100 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
101 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
102 INT145756 Gene_expression of Tlr2 23 0.74 20.77 5.18
103 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
104 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01
105 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73
106 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6
107 INT54911 Localization of FOS 20 0.78 3.27 4.56
108 INT183681 Positive_regulation of Tlr3 20 0.62 16.25 4.54
109 INT135990 Positive_regulation of Gene_expression of Cd86 34 0.69 12.02 4.53
110 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
111 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
112 INT149197 Negative_regulation of NFKB2 14 0.25 10.55 4.46
113 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39
114 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
115 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
116 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
117 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
118 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
119 INT67936 Transcription of JUN 18 0.52 9.52 4.13
120 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
121 INT158595 Gene_expression of Tlr3 25 0.69 12.09 4.07
122 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
123 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
124 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
125 INT56077 Protein_catabolism of NFKB1 16 0.98 8.03 3.94
126 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83
127 INT56075 Transcription of NFKB1 13 0.71 9.03 3.83
128 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
129 INT158596 Binding of Tlr3 24 0.47 11.66 3.69
130 INT264972 Positive_regulation of MAP2K3 4 0.65 6.92 3.68
131 INT79231 Positive_regulation of Gene_expression of NFKB1 18 0.67 9.16 3.66
132 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63
133 INT44015 Binding of Cd86 16 0.31 5.92 3.58
134 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
135 INT119420 Phosphorylation of MAP2K6 8 0.79 4.89 3.52
136 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43
137 INT264970 Positive_regulation of Localization of TLR2 1 0.11 4.21 3.37
138 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27
139 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23
140 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
141 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
142 INT139801 Phosphorylation of NFKB1 9 0.66 5.2 3.13
143 INT66212 Negative_regulation of Localization of RELA 13 0.57 2.48 3.09
144 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
145 INT186805 Transcription of TLR2 12 0.63 9.66 3.04
146 INT68651 Negative_regulation of Positive_regulation of JUN 11 0.58 4.28 3.04
147 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
148 INT12770 Negative_regulation of Positive_regulation of IKBKG 7 0.56 0.34 3.02
149 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
150 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
151 INT103910 Binding of NOD2 19 0.47 12.24 2.93
152 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
153 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
154 INT155486 Positive_regulation of Gene_expression of CD86 16 0.69 14.6 2.86
155 INT102565 Positive_regulation of Phosphorylation of RPS6KA1 1 0.25 2.77 2.85
156 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
157 INT108358 Phosphorylation of FOS 12 0.80 6.33 2.79
158 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73
159 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
160 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71
161 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71
162 INT107968 Positive_regulation of NFKBIA 9 0.46 5.27 2.69
163 INT47974 Negative_regulation of Protein_catabolism of NFKBIA 7 0.49 2.38 2.69
164 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
165 INT75685 Regulation of CD86 12 0.58 3.55 2.66
166 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
167 INT133029 Regulation of TLR2 18 0.56 11.31 2.62
168 INT19621 Positive_regulation of CD86 23 0.69 14 2.58
169 INT186799 Localization of TLR2 5 0.68 2.51 2.58
170 INT122003 Phosphorylation of NFKBIA 9 0.59 5.44 2.51
171 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
172 INT71305 Regulation of Gene_expression of NFKB1 9 0.61 5.41 2.44
173 INT102646 Positive_regulation of MAP2K6 3 0.63 4.37 2.44
174 INT12769 Localization of IKBKG 6 0.15 1.66 2.43
175 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
176 INT123682 Localization of JUN 8 0.50 4.15 2.38
177 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
178 INT96154 Negative_regulation of Gene_expression of Cd86 10 0.48 3.76 2.35
179 INT48980 Positive_regulation of Transcription of FOS 10 0.67 3.07 2.34
180 INT60199 Positive_regulation of Binding of JUN 5 0.49 1.3 2.34
181 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
182 INT117924 Gene_expression of MAP2K3 2 0.72 5.82 2.32
183 INT150547 Phosphorylation of MAP2K3 2 0.79 4.92 2.3
184 INT132893 Binding of CHUK 1 0.00 0.63 2.25
185 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
186 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
187 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13
188 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
189 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02
190 INT148456 Gene_expression of LY96 7 0.19 4.35 2.02
191 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
192 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
193 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
194 INT123530 Phosphorylation of RELA 9 0.80 3.46 1.99
195 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98
196 INT222609 Binding of Tlr4 8 0.43 4.03 1.98
197 INT243689 Regulation of NFKB2 1 0.35 2.72 1.97
198 INT26317 Gene_expression of NFKBIA 5 0.45 2.97 1.96
199 INT326816 Negative_regulation of Positive_regulation of Tlr4 2 0.59 3.96 1.95
200 INT56080 Transcription of NFKBIA 2 0.40 2.16 1.93
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