GO:0002238

From wiki-pain
Jump to: navigation, search
Name response to molecule of fungal origin
Categary Process
Go Slim No
Go Link GO:0002238
Unique Molecular Interactions 106
Total Molecular Interactions 184
Total Single Events 729
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to molecule of fungal origin. They are ordered first by their pain relevance and then by number of times they were reported for response to molecule of fungal origin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
2 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
3 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
4 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
5 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66
6 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
7 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
8 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
9 INT348790 Binding of MYD88 and Tlr4 1 0.35 1.84 0.4
10 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39
11 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
12 INT174699 Binding of Tlr2 and Tlr3 3 0.14 0.66 0.35
13 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
14 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
15 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
16 INT203085 Positive_regulation of Binding of Il1a and Myd88 1 0.07 0.65 0.32
17 INT203087 Binding of Il1a and Myd88 1 0.05 0.65 0.31
18 INT324825 Binding of Chuk and Myd88 1 0.03 0.86 0.28
19 INT288205 Binding of Cd14 and Myd88 1 0.10 0.57 0.28
20 INT324806 Positive_regulation of Binding of Chuk and Myd88 1 0.04 0.86 0.28
21 INT276953 Positive_regulation of Tlr2 Positive_regulation of Phosphorylation of Stat3 1 0.38 0.93 0.27
22 INT276979 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Stat3 1 0.38 0.93 0.27
23 INT256063 Myd88 Positive_regulation of Gene_expression of Mcpt1 1 0.13 0.56 0.27
24 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
25 INT276974 Tlr2 Positive_regulation of Gene_expression of Ccr8 1 0.27 0.16 0.24
26 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
27 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
28 INT266380 Binding of Tlr2 and Il1 1 0.01 0.76 0.21
29 INT163096 Tlr2 Positive_regulation of Gene_expression of VEGFA 1 0.07 0.16 0.21
30 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2
31 INT348789 Positive_regulation of Binding of MYD88 and Tlr4 1 0.46 0.93 0.2
32 INT348032 Fndc3b Positive_regulation of Tlr2 1 0.01 1.3 0.2
33 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
34 INT339503 Tlr2 Positive_regulation of Eif2ak2 1 0.12 0.09 0.19
35 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
36 INT179504 Tlr4 Regulation of Myd88 1 0.07 0.29 0.17
37 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
38 INT324820 Hsp90b1 Positive_regulation of Tlr2 1 0.16 0.42 0.17
39 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
40 INT276958 Binding of Tlr2 and Clec7a 1 0.09 0.58 0.15
41 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
42 INT278394 Myd88 Regulation of Phosphorylation of Hps5 1 0.11 0.35 0.15
43 INT228216 Positive_regulation of Mapk14 Regulation of Gene_expression of Tlr2 1 0.09 1.11 0.15
44 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
45 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
46 INT276948 Tlr2 Negative_regulation of Gene_expression of Tlr4 1 0.25 1.06 0.14
47 INT333270 Tlr2 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
48 INT348040 TNF Positive_regulation of Gene_expression of Tlr2 1 0.02 0.98 0.14
49 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13
50 INT346501 MYD88 Positive_regulation of Nfkb1 1 0.01 0.5 0.13
51 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
52 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12
53 INT254201 Myd88 Positive_regulation of Ik 1 0.00 0.14 0.12
54 INT324695 Tlr6 Positive_regulation of Tlr2 1 0.14 0 0.12
55 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1
56 INT343855 Binding of MYD88 and PIK3CG 1 0.03 0.26 0.1
57 INT343858 Binding of AKT1 and MYD88 1 0.02 0.26 0.1
58 INT276966 Tlr2 Negative_regulation of Gene_expression of Mcpt1 1 0.09 1.38 0.1
59 INT334266 Binding of Irak1 and Myd88 2 0.35 0.16 0.09
60 INT288210 Regulation of Tlr2 Positive_regulation of Akt1 1 0.03 0.09 0.08
61 INT350073 Binding of co and Myd88 1 0.00 0.17 0.08
62 INT288206 Tlr2 Positive_regulation of Akt1 1 0.04 0.09 0.08
63 INT276987 Tlr2 Negative_regulation of Gene_expression of Il10 1 0.15 0.19 0.08
64 INT254223 Tlr3 Positive_regulation of Myd88 1 0.16 0.23 0.08
65 INT324871 Ros1 Positive_regulation of Gene_expression of Tlr2 1 0.03 1.12 0.07
66 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
67 INT276980 Binding of Tlr2 and Gopc 1 0.14 0.28 0.07
68 INT294638 Bcl2a1a Positive_regulation of Tlr2 1 0.58 0.43 0.07
69 INT350481 Tlr4 Positive_regulation of Gene_expression of Myd88 1 0.26 0.06 0.06
70 INT334260 Negative_regulation of Binding of Myd88 and Il1 1 0.01 0.4 0.06
71 INT334258 Binding of Myd88 and Irak4 2 0.26 0.24 0.05
72 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
73 INT324867 Positive_regulation of Binding of Tlr6 and Tlr2 1 0.10 0.79 0.05
74 INT324864 Positive_regulation of Binding of Tlr1 and Tlr2 1 0.10 0.79 0.05
75 INT276969 Tlr2 Positive_regulation of Il10 1 0.20 0.75 0.04
76 INT276955 Tlr2 Positive_regulation of Negative_regulation of Il13 1 0.14 0.76 0.04
77 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
78 INT276973 Tlr2 Positive_regulation of Il13 1 0.14 0.76 0.04
79 INT350802 Binding of MYD88 and TLR3 1 0.01 0 0.04
80 INT276981 Tlr2 Positive_regulation of Gene_expression of Il13 1 0.13 0.76 0.04
81 INT276990 Tlr2 Positive_regulation of Negative_regulation of Il10 1 0.20 0.75 0.04
82 INT334262 Myd88 Positive_regulation of Tlr7 1 0.05 0.3 0.04
83 INT238008 Myd88 Regulation of Hand1 1 0.03 0.82 0.04
84 INT324805 Tlr2 Positive_regulation of Cd14 1 0.14 0.09 0.03
85 INT290313 Binding of MYD88 and TLR7 1 0.03 0.1 0.03
86 INT276989 Stat3 Regulation of Positive_regulation of Tlr2 1 0.22 0.13 0.03
87 INT269838 Binding of Hsp90b1 and Tlr2 1 0.26 1.75 0.03
88 INT276972 Tlr2 Negative_regulation of Gene_expression of Hand1 1 0.14 0.65 0.03
89 INT299006 Binding of Il18 and Myd88 1 0.21 0.19 0.03
90 INT313077 Cd180 Regulation of Tlr2 1 0.01 0.09 0
91 INT350077 Negative_regulation of Binding of Myd88 and Tlr4 1 0.12 0.16 0
92 INT275842 HPD Positive_regulation of Tlr2 1 0.01 0.76 0
93 INT348039 Binding of Myd88 and Irak2 1 0.22 0 0
94 INT344224 Tlr2 Regulation of Gene_expression of Tlr4 1 0.03 0 0
95 INT313076 Tlr2 Positive_regulation of Gene_expression of Il10 1 0.02 0.14 0
96 INT324696 Binding of Myd88 and Mapk10 1 0.05 0.68 0
97 INT228215 Tlr2 Positive_regulation of Gene_expression of Tlr4 1 0.19 1.47 0
98 INT344220 Itgam Regulation of Transcription of Tlr2 1 0.03 0.06 0
99 INT313080 ST2 Regulation of Tlr2 1 0.02 0.09 0
100 INT313079 SIGIRR Regulation of Tlr2 1 0.18 0.09 0
101 INT275840 Cfp Positive_regulation of Tlr2 1 0.02 0.75 0
102 INT316536 Binding of Tlr2 and Il23a 1 0.11 0.78 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to molecule of fungal origin. They are ordered first by their pain relevance and then by number of times they were reported in response to molecule of fungal origin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
2 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
3 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
4 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
5 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29
6 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
7 INT145756 Gene_expression of Tlr2 23 0.74 20.77 5.18
8 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4
9 INT142754 Binding of Myd88 20 0.36 9.61 3.8
10 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
11 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74
12 INT233975 Positive_regulation of Gene_expression of Myd88 7 0.66 4.17 1.65
13 INT174683 Transcription of Tlr2 12 0.58 5.95 1.4
14 INT246928 Negative_regulation of Myd88 12 0.38 6.16 1.3
15 INT221131 Localization of Tlr2 17 0.80 13.82 1.28
16 INT233970 Regulation of Myd88 7 0.45 5.2 1.28
17 INT190804 Positive_regulation of Tlr2 6 0.66 3.7 1.16
18 INT288493 Positive_regulation of Gene_expression of Tlr2 4 0.66 4.38 0.94
19 INT237858 Positive_regulation of MYD88 5 0.49 2.93 0.9
20 INT145760 Binding of Tlr2 5 0.46 3.59 0.89
21 INT250171 Localization of Myd88 4 0.72 1.95 0.88
22 INT166126 Gene_expression of MYD88 5 0.54 2.67 0.84
23 INT264973 Binding of MYD88 4 0.35 1.2 0.74
24 INT224630 Positive_regulation of Positive_regulation of Tlr2 6 0.46 4.14 0.73
25 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71
26 INT334226 Positive_regulation of Localization of Myd88 1 0.36 0.54 0.67
27 INT233973 Negative_regulation of Gene_expression of Myd88 4 0.38 1.32 0.61
28 INT234597 Negative_regulation of Positive_regulation of Tlr2 2 0.30 2.25 0.52
29 INT264963 Positive_regulation of Binding of MYD88 1 0.17 0.18 0.52
30 INT234587 Positive_regulation of Transcription of Tlr2 3 0.36 1.84 0.51
31 INT246422 Transcription of MYD88 2 0.52 0.77 0.38
32 INT256056 Positive_regulation of Binding of Myd88 2 0.48 0.36 0.36
33 INT145457 Positive_regulation of Clec7a 2 0.04 0.17 0.34
34 INT203076 Positive_regulation of Positive_regulation of Myd88 1 0.19 0.65 0.32
35 INT203072 Positive_regulation of Myd88 1 0.19 0.65 0.32
36 INT288189 Negative_regulation of Negative_regulation of Tlr2 1 0.26 0.43 0.28
37 INT197492 Regulation of Gene_expression of Myd88 2 0.39 1.95 0.27
38 INT288186 Regulation of Binding of Tlr2 2 0.32 1.72 0.26
39 INT224614 Regulation of Positive_regulation of Tlr2 1 0.13 0.56 0.26
40 INT145758 Regulation of Tlr2 3 0.43 0.94 0.23
41 INT145761 Negative_regulation of Tlr2 2 0.41 1.97 0.23
42 INT242901 Regulation of Gene_expression of MYD88 2 0.18 0.19 0.19
43 INT242897 Positive_regulation of Gene_expression of MYD88 2 0.20 0.27 0.19
44 INT233971 Transcription of Myd88 2 0.60 1.01 0.17
45 INT339625 Binding of Clec7a 1 0.03 0.14 0.17
46 INT294633 Positive_regulation of Binding of Tlr2 1 0.44 0.42 0.16
47 INT145759 Regulation of Gene_expression of Tlr2 3 0.43 0.98 0.14
48 INT301958 Positive_regulation of Regulation of Tlr2 1 0.21 0.32 0.13
49 INT334237 Negative_regulation of Binding of Myd88 1 0.30 1.16 0.12
50 INT306310 Positive_regulation of Positive_regulation of Myd88 1 0.38 0.41 0.12
51 INT242898 Regulation of MYD88 2 0.33 0.88 0.11
52 INT329055 Gene_expression of Myd88 1 0.72 1.18 0.11
53 INT329058 Positive_regulation of Transcription of Tlr2 1 0.48 0.62 0.11
54 INT329049 Transcription of Tlr2 1 0.68 0.62 0.11
55 INT255976 Regulation of Transcription of Tlr2 1 0.22 0.89 0.09
56 INT334227 Positive_regulation of Regulation of Myd88 1 0.36 0.63 0.08
57 INT269821 Regulation of Localization of Tlr2 1 0.27 1.04 0.07
58 INT276937 Localization of Clec7a 1 0.14 0.23 0.07
59 INT329054 Negative_regulation of Gene_expression of Myd88 1 0.54 0.13 0.06
60 INT329067 Positive_regulation of Gene_expression of Myd88 1 0.64 0.12 0.05
61 INT246930 Negative_regulation of Transcription of Tlr2 1 0.36 0.92 0.04
62 INT145757 Negative_regulation of Gene_expression of Tlr2 2 0.41 0.68 0.03
63 INT276939 Positive_regulation of Phosphorylation of Tlr2 1 0.46 0.6 0.03
64 INT276931 Phosphorylation of Tlr2 1 0.75 0.6 0.03
65 INT129802 Gene_expression of Clec7a 5 0.13 0.51 0
66 INT246929 Positive_regulation of Localization of Tlr2 2 0.42 0.26 0
67 INT246927 Negative_regulation of Binding of Tlr2 1 0.31 0 0
68 INT276944 Regulation of Clec7a 1 0.05 0 0
69 INT129801 Positive_regulation of Gene_expression of Clec7a 1 0.04 0.38 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox