GO:0002250

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Name adaptive immune response
Categary Process
Go Slim No
Go Link GO:0002250
Unique Molecular Interactions 408
Total Molecular Interactions 549
Total Single Events 3170
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for adaptive immune response. They are ordered first by their pain relevance and then by number of times they were reported for adaptive immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
2 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
3 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
4 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
5 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
6 INT165183 Ifnb1 Positive_regulation of P2rx4 1 0.04 1.73 1.73
7 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
8 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
9 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
10 INT92057 Ifng Positive_regulation of Gene_expression of Ik 1 0.03 0.45 1.49
11 INT83626 Ifng Positive_regulation of Gene_expression of Cd59 1 0.33 2.19 1.41
12 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
13 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
14 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 0.02 0.97 1.1
15 INT113235 Tacr1 Regulation of Gene_expression of Ifng 1 0.26 1 1.04
16 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
17 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
18 INT88879 Ifng Positive_regulation of Nfkb1 1 0.01 0.26 1.01
19 INT94493 Avp Positive_regulation of Gene_expression of Ifng 1 0.05 1.73 0.97
20 INT77142 Binding of IFNG and IL4 2 0.03 1.16 0.95
21 INT94501 Il2 Positive_regulation of Gene_expression of Ifng 1 0.03 1.63 0.92
22 INT85879 Il12a Positive_regulation of Gene_expression of Ifng 1 0.20 0.89 0.92
23 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
24 INT187225 Vip Negative_regulation of Gene_expression of Tnfrsf11a 1 0.27 1.92 0.87
25 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
26 INT120999 Binding of Oprm1 and Ifng 1 0.22 0.57 0.84
27 INT94331 IFNG Positive_regulation of CXCL10 4 0.11 1.31 0.82
28 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
29 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
30 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
31 INT146460 IFNG Positive_regulation of Gene_expression of TNFRSF10D 1 0.03 1.46 0.72
32 INT151679 Ifng Negative_regulation of Oas1b 1 0.12 1.24 0.71
33 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
34 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
35 INT151676 Ifng Negative_regulation of Art2a-ps 1 0.00 1.25 0.71
36 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
37 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
38 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65
39 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
40 INT142076 IL4 Negative_regulation of Gene_expression of IFNG 1 0.01 1.58 0.64
41 INT192332 UBR7 Negative_regulation of TXK 1 0.00 1.38 0.63
42 INT56235 Ifng Positive_regulation of Gene_expression of RT1-EC2 1 0.23 0.33 0.62
43 INT154530 Positive_regulation of Ifng Negative_regulation of Il10 1 0.33 0.63 0.61
44 INT154533 Ifng Negative_regulation of Il4 1 0.11 0.62 0.6
45 INT117707 Oprm1 Positive_regulation of PIK3CG 1 0.00 0.08 0.6
46 INT154531 Ifng Negative_regulation of Il10 1 0.30 0.61 0.6
47 INT56451 Ifng Positive_regulation of Tnf 1 0.00 1.92 0.59
48 INT87024 Positive_regulation of ZAK Positive_regulation of Localization of IFNG 2 0.05 0.81 0.58
49 INT169290 CNR1 Positive_regulation of Negative_regulation of TXK 1 0.10 0.18 0.58
50 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
51 INT137162 IFNG Positive_regulation of Gene_expression of CXCL9 1 0.45 0.62 0.54
52 INT88024 Ifng Positive_regulation of Gene_expression of Faslg 2 0.50 1.19 0.53
53 INT138928 Ifng Positive_regulation of Transcription of Cxcl9 1 0.31 0.65 0.51
54 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51
55 INT143504 IFNG Positive_regulation of Gene_expression of Aif1 1 0.04 1.26 0.51
56 INT70925 Binding of Ifng and Il4 2 0.14 0.9 0.5
57 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
58 INT138927 Ifng Positive_regulation of Gene_expression of Stat1 1 0.29 0.7 0.49
59 INT142155 Ifng Positive_regulation of Il5 1 0.08 0 0.48
60 INT231732 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
61 INT231733 Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
62 INT196634 IFNG Negative_regulation of DNAH8 1 0.03 1.49 0.47
63 INT99790 Ifng Positive_regulation of Cxcr2 1 0.12 0.28 0.46
64 INT126337 Pax3 Positive_regulation of Gene_expression of Ifng 1 0.05 0.56 0.44
65 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
66 INT126340 Pax3 Regulation of Gene_expression of Ifng 1 0.03 0.56 0.44
67 INT126338 Insrr Regulation of Gene_expression of Ifng 1 0.00 0.56 0.43
68 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
69 INT337325 PIK3CD Positive_regulation of Phosphorylation of IL2RG 1 0.00 0 0.43
70 INT189154 MTNR1B Positive_regulation of Gene_expression of IFNG 1 0.01 0.06 0.43
71 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
72 INT210225 Ptpn2 Positive_regulation of Gene_expression of Ifng 1 0.15 1.44 0.42
73 INT17305 Ifng Positive_regulation of RT1-CE1 1 0.06 0.46 0.41
74 INT17308 Ifng Positive_regulation of Atp8a1 1 0.64 0.45 0.41
75 INT172125 Binding of Tnfrsf11b and Tnfrsf11a 2 0.17 2.12 0.39
76 INT141016 Il18 Positive_regulation of Gene_expression of Ifng 1 0.39 0.27 0.39
77 INT140574 Ifnb1 Positive_regulation of Il6 1 0.05 0.9 0.39
78 INT224423 Binding of TNFRSF11B and TNFRSF11A 3 0.19 2.36 0.37
79 INT152361 Binding of Ifng and T2dm2 1 0.00 0.86 0.37
80 INT140569 Ifng Positive_regulation of Gene_expression of Il6 1 0.00 0.82 0.36
81 INT140571 Ifng Positive_regulation of Ifnb1 1 0.01 0.82 0.36
82 INT88192 IFNG Regulation of Gene_expression of ZAK 1 0.01 0.75 0.36
83 INT140575 Il6 Positive_regulation of Ifnb1 1 0.02 0.82 0.36
84 INT152315 Ifng Regulation of Ednrb 1 0.19 0.22 0.36
85 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
86 INT140572 Ifng Positive_regulation of Gene_expression of Ifnb1 1 0.01 0.82 0.36
87 INT140573 Positive_regulation of Ifng Positive_regulation of Ifnb1 1 0.01 0.83 0.36
88 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
89 INT144045 IFNG Negative_regulation of Gene_expression of PTGES 1 0.63 0.47 0.35
90 INT189492 Ifng Positive_regulation of Localization of Darc 1 0.00 0.53 0.34
91 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
92 INT140667 IFNG Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34
93 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33
94 INT134888 Negative_regulation of TNFRSF11A Negative_regulation of Gene_expression of CCL2 1 0.24 0.38 0.33
95 INT112023 Binding of Ifng and Il10 1 0.03 0.31 0.33
96 INT112019 Binding of Ifng and Ighg1 1 0.10 0.3 0.33
97 INT137168 IFNG Positive_regulation of Gene_expression of CXCR3 1 0.32 0.34 0.32
98 INT167596 Il23a Positive_regulation of Gene_expression of Ifng 1 0.13 0.94 0.32
99 INT112022 Binding of Hand1 and Ifng 1 0.09 0.3 0.32
100 INT98013 Il18 Positive_regulation of Gene_expression of IFNG 1 0.66 0.44 0.32
101 INT28688 Binding of Kng1 and Ctsl1 1 0.15 0 0.31
102 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31
103 INT285077 CCL16 Positive_regulation of ITK 1 0.05 1.95 0.31
104 INT9161 Tnf Negative_regulation of Localization of Ifng 1 0.20 0.85 0.3
105 INT93987 Positive_regulation of Rab8a Positive_regulation of Localization of Ifng 1 0.10 0.38 0.29
106 INT164432 Ifng Positive_regulation of Tnf 1 0.01 1.71 0.29
107 INT164431 Ifng Positive_regulation of Il6 1 0.01 1.71 0.29
108 INT136368 RYBP Regulation of Localization of Ifng 1 0.00 0.4 0.28
109 INT171720 IL4 Positive_regulation of Positive_regulation of IFNG 1 0.01 0.67 0.28
110 INT207442 IFNG Negative_regulation of Gene_expression of PLA2G7 1 0.08 0.9 0.28
111 INT303948 LEPR Positive_regulation of PIK3CG 1 0.02 0.22 0.28
112 INT171726 TNF Positive_regulation of IFNG 1 0.01 0.6 0.27
113 INT171725 IFNG Positive_regulation of CXCL9 1 0.02 0.6 0.27
114 INT93352 Ifng Positive_regulation of Positive_regulation of Fas 1 0.26 0.17 0.27
115 INT137167 Binding of IFNG and TLR3 1 0.24 0.32 0.27
116 INT24222 Ifng Positive_regulation of Gene_expression of Serping1 1 0.00 0 0.26
117 INT24223 Ifng Negative_regulation of Gene_expression of C3 1 0.01 0 0.26
118 INT301276 Il6 Positive_regulation of Gene_expression of Tnfrsf11a 1 0.06 0.37 0.26
119 INT254224 Binding of Ltbr and Tnfrsf11a 1 0.01 0.59 0.25
120 INT129220 IFNG Positive_regulation of ICAM1 1 0.09 0.1 0.25
121 INT138925 Ifng Positive_regulation of Gene_expression of Cxcl9 1 0.25 0.32 0.25
122 INT349652 Positive_regulation of Hmox1 Negative_regulation of Positive_regulation of Itk 1 0.01 0.85 0.25
123 INT129219 IFNG Positive_regulation of Gene_expression of ICAM1 1 0.13 0.1 0.25
124 INT196609 IFNG Positive_regulation of Positive_regulation of NA 1 0.03 0.87 0.24
125 INT196622 IFNG Positive_regulation of Positive_regulation of DNAH8 1 0.03 0.87 0.24
126 INT196647 IFNG Negative_regulation of NA 1 0.04 0.79 0.24
127 INT80278 IFNG Positive_regulation of CCL13 1 0.12 0.39 0.24
128 INT138930 Ifng Positive_regulation of Cxcl9 1 0.43 0.29 0.24
129 INT80289 IFNG Positive_regulation of Gene_expression of CCL13 1 0.40 0.39 0.24
130 INT138924 Negative_regulation of Ifng Positive_regulation of Cxcl9 1 0.37 0.29 0.24
131 INT196646 IFNG Positive_regulation of Negative_regulation of DNAH8 1 0.03 0.87 0.24
132 INT121581 Negative_regulation of PIK3CG Positive_regulation of GDF15 1 0.36 0.59 0.24
133 INT80277 IFNG Positive_regulation of CCL7 1 0.13 0.39 0.24
134 INT168709 Ifng Regulation of Il10 1 0.02 0.3 0.23
135 INT163760 Ifng Positive_regulation of Phosphorylation of Stat1 1 0.12 0.08 0.23
136 INT67084 Penk Positive_regulation of Gene_expression of Ifng 1 0.06 0.08 0.23
137 INT80279 IFNG Positive_regulation of Gene_expression of CCL11 1 0.06 0.37 0.23
138 INT168710 Ifng Regulation of TGFB1 1 0.00 0.3 0.23
139 INT138929 Ifng Positive_regulation of Stat1 1 0.29 0.28 0.23
140 INT80286 IFNG Positive_regulation of Gene_expression of CCL5 1 0.24 0.37 0.23
141 INT138926 Regulation of Ifng Positive_regulation of Stat1 1 0.17 0.28 0.23
142 INT138931 Ifng Positive_regulation of Positive_regulation of Stat1 1 0.31 0.28 0.23
143 INT349653 Nfe2l2 Positive_regulation of Itk 1 0.00 0.79 0.22
144 INT88025 Ifng Negative_regulation of Gene_expression of Fas 1 0.32 0.74 0.22
145 INT94338 IFNG Positive_regulation of Phosphorylation of Stat1 1 0.01 0.26 0.21
146 INT137074 IFNG Positive_regulation of Protein_catabolism of DOHH 1 0.04 1.06 0.21
147 INT137072 IFNG Positive_regulation of DOHH 1 0.05 1.05 0.21
148 INT94339 IFNG Positive_regulation of Localization of Stat1 1 0.01 0.26 0.21
149 INT35013 IFNG Positive_regulation of ADI1 1 0.22 0.16 0.21
150 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2
151 INT196610 IFNG Negative_regulation of CFTR 1 0.17 0.21 0.19
152 INT95363 IFNG Positive_regulation of Gene_expression of NOS2 1 0.43 0 0.19
153 INT58588 IFNG Positive_regulation of ARHGAP4 1 0.31 1.22 0.19
154 INT284677 IFNG Negative_regulation of IL4 1 0.01 0.98 0.18
155 INT81298 Ifng Negative_regulation of Gene_expression of Nos2 1 0.40 0.18 0.18
156 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
157 INT121580 PIK3CG Regulation of Gene_expression of GDF15 1 0.48 0.4 0.18
158 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
159 INT140093 Ifng Regulation of Gene_expression of Gtf3a 1 0.05 0.44 0.18
160 INT140095 Stat1 Positive_regulation of Positive_regulation of Ifng 1 0.52 0.42 0.18
161 INT148531 Binding of TNFRSF11A and Tnfsf11 2 0.08 1.77 0.17
162 INT81301 Ifng Positive_regulation of Gene_expression of Tlr4 1 0.02 0.17 0.17
163 INT312858 Negative_regulation of Binding of GYPA and IFNG 1 0.20 0.41 0.17
164 INT312857 Binding of GYPA and IFNG 1 0.17 0.41 0.17
165 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
166 INT73506 Binding of IFNG and IRF6 1 0.02 0.42 0.17
167 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
168 INT249599 Ifng Positive_regulation of Gene_expression of Il6 1 0.15 0.38 0.16
169 INT196606 IFNG Positive_regulation of CFTR 1 0.16 0.45 0.16
170 INT143503 IFNG Positive_regulation of CETN1 1 0.00 0.35 0.16
171 INT43492 Pomc Regulation of Gene_expression of Ifng 1 0.34 0 0.16
172 INT111486 Binding of IFNG and IL8 1 0.13 0.28 0.15
173 INT43494 Akt1s1 Regulation of Gene_expression of Ifng 1 0.05 0 0.15
174 INT99241 IFNG Regulation of IL1B 2 0.21 1.26 0.14
175 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14
176 INT203591 Positive_regulation of PIK3CG Positive_regulation of Protein_catabolism of LAMB2 1 0.00 0.46 0.14
177 INT43497 KRT18P39 Regulation of Gene_expression of Ifng 1 0.00 0 0.14
178 INT350711 Ifnb1 Negative_regulation of Gene_expression of DICER1 1 0.03 0.15 0.14
179 INT285076 CCL16 Positive_regulation of Gene_expression of ITK 1 0.05 1.8 0.14
180 INT43496 SERPINB1 Negative_regulation of Ifng 1 0.00 0 0.14
181 INT289247 Ptger2 Positive_regulation of Gene_expression of Tnfrsf11a 1 0.00 0.76 0.14
182 INT43495 Cd74 Regulation of Gene_expression of Ifng 1 0.47 0 0.14
183 INT153740 TNFRSF11A Positive_regulation of Vcp 1 0.04 1.15 0.13
184 INT153739 TNFRSF11A Positive_regulation of Tnfrsf11b 1 0.05 1.14 0.13
185 INT153742 TNFRSF11A Positive_regulation of Tnfrsf11b 1 0.00 1.15 0.13
186 INT335460 FPR1 Positive_regulation of PIK3CD 1 0.17 0 0.13
187 INT153738 TNFRSF11A Positive_regulation of SQSTM1 1 0.05 1.22 0.13
188 INT129091 Binding of PIK3CG and Lyn 1 0.00 0.47 0.12
189 INT129073 Binding of GRP and PIK3CG 1 0.00 0.49 0.12
190 INT7204 Binding of IFNA1 and IFNG 1 0.01 1.34 0.11
191 INT99242 IFNG Regulation of IL8 1 0.23 0.57 0.1
192 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
193 INT261761 Ifng Positive_regulation of Stat6 1 0.13 0 0.1
194 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
195 INT343855 Binding of MYD88 and PIK3CG 1 0.03 0.26 0.1
196 INT99243 IFNG Regulation of HLA-DRA 1 0.25 0.57 0.1
197 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09
198 INT224021 PIK3CG Negative_regulation of EPHB2 1 0.03 0.5 0.09
199 INT328435 PIK3CD Positive_regulation of Gene_expression of VEGFA 1 0.23 0.64 0.09
200 INT43493 Cd164 Regulation of Gene_expression of Ifng 1 0.01 0 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported for adaptive immune response. They are ordered first by their pain relevance and then by number of times they were reported in adaptive immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57
2 INT10359 Gene_expression of Ifng 159 0.78 79.6 72.14
3 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6
4 INT56224 Negative_regulation of Gene_expression of Ifng 40 0.58 23.34 25.08
5 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77
6 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
7 INT8518 Localization of Ifng 53 0.81 36.68 24.13
8 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05
9 INT25222 Positive_regulation of Gene_expression of Ifng 32 0.50 24.18 19.58
10 INT19509 Localization of Ifng 55 0.78 28.25 18.67
11 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35
12 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15
13 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89
14 INT10360 Positive_regulation of Ifng 33 0.68 21.73 15.19
15 INT4931 Localization of IFNG 53 0.78 33.25 13.65
16 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14
17 INT5057 Negative_regulation of Gene_expression of IFNG 23 0.58 8.33 12.3
18 INT9160 Negative_regulation of Ifng 31 0.58 16.37 11.84
19 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91
20 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59
21 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25
22 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84
23 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
24 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37
25 INT5326 Regulation of Ifng 12 0.55 4.56 7.19
26 INT74154 Transcription of Ifng 14 0.67 10.33 6.21
27 INT15803 Regulation of IFNG 21 0.44 12.57 5.98
28 INT5186 Regulation of Ifng 11 0.45 8.78 5.9
29 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09
30 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
31 INT62132 Regulation of Gene_expression of Ifng 12 0.62 1.28 4.77
32 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75
33 INT118274 Positive_regulation of Positive_regulation of PIK3CG 8 0.64 4.81 4.62
34 INT20459 Regulation of Ripk2 5 0.44 0 4.53
35 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2
36 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17
37 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97
38 INT34054 Regulation of Gene_expression of IFNG 8 0.42 3.69 3.76
39 INT87027 Positive_regulation of Localization of IFNG 12 0.67 5.78 3.35
40 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02
41 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9
42 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
43 INT67078 Binding of Ifng 7 0.48 4.84 2.73
44 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
45 INT15197 Regulation of Gene_expression of Ifng 8 0.34 2.66 2.69
46 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
47 INT111145 Negative_regulation of Positive_regulation of Ifng 7 0.41 2.21 2.61
48 INT91669 Negative_regulation of Localization of IFNG 5 0.57 4.1 2.58
49 INT16964 Binding of IFNG 27 0.48 14.31 2.45
50 INT73980 Transcription of Ifng 12 0.72 5.42 2.4
51 INT64982 Positive_regulation of Ifnb1 10 0.48 6.16 2.35
52 INT70918 Positive_regulation of Localization of Ifng 5 0.45 2.79 2.33
53 INT67437 Negative_regulation of Localization of Ifng 7 0.47 2.23 2.28
54 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18
55 INT264967 Positive_regulation of Positive_regulation of PIK3CD 4 0.18 1.97 2.13
56 INT140818 Positive_regulation of Positive_regulation of Ifng 2 0.47 4.2 2.06
57 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
58 INT111530 Positive_regulation of Regulation of Ifng 1 0.41 0.32 2.01
59 INT118291 Binding of TXK 19 0.10 11.77 1.94
60 INT11136 Positive_regulation of Localization of Ifng 4 0.49 3.13 1.89
61 INT97019 Negative_regulation of Binding of TNFRSF11A 4 0.17 1.8 1.89
62 INT134890 Localization of TNFRSF11A 1 0.79 3.75 1.86
63 INT61627 Transcription of IFNG 6 0.69 4.28 1.83
64 INT134889 Negative_regulation of TNFRSF11A 9 0.42 12.65 1.76
65 INT171964 Positive_regulation of Gene_expression of Tnfrsf11a 5 0.37 4.11 1.73
66 INT37978 Localization of Ripk2 4 0.78 0.57 1.73
67 INT55511 Positive_regulation of Binding of Ripk2 1 0.49 0.19 1.69
68 INT113716 Positive_regulation of Transcription of Ifng 1 0.53 2.56 1.61
69 INT109010 Negative_regulation of Ifnb1 1 0.12 2.47 1.56
70 INT243799 Gene_expression of PIK3CD 15 0.45 6.63 1.5
71 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45
72 INT56228 Positive_regulation of Positive_regulation of Ifng 2 0.43 2.83 1.4
73 INT23986 Positive_regulation of Ifnb1 4 0.42 0.62 1.39
74 INT14335 Gene_expression of Ifnb1 5 0.40 2.7 1.38
75 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34
76 INT120075 Gene_expression of Itk 11 0.43 6.39 1.27
77 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
78 INT11137 Negative_regulation of Localization of Ifng 3 0.38 2.45 1.26
79 INT19923 Regulation of Localization of Ifng 3 0.22 1.1 1.25
80 INT109243 Regulation of Positive_regulation of IFNG 1 0.45 1.27 1.23
81 INT111536 Positive_regulation of Negative_regulation of Ifng 1 0.41 0.35 1.18
82 INT38502 Gene_expression of Ripk2 3 0.65 0.17 1.16
83 INT264969 Localization of PIK3CD 5 0.50 0.64 1.13
84 INT51264 Positive_regulation of TXK 21 0.54 10.69 1.1
85 INT209895 Transcription of TNFRSF11A 4 0.52 2.56 1.09
86 INT153769 Negative_regulation of Tnfrsf11a 4 0.39 2.13 1.05
87 INT122884 Positive_regulation of Transcription of Ifng 1 0.39 1.08 1.03
88 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02
89 INT119519 Positive_regulation of Gene_expression of TXK 3 0.09 2.92 1.02
90 INT129878 Positive_regulation of CTSS 6 0.70 7.86 0.97
91 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
92 INT36850 Negative_regulation of Negative_regulation of RIPK2 1 0.57 0 0.97
93 INT109470 Negative_regulation of ITK 3 0.24 2.13 0.96
94 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94
95 INT6534 Negative_regulation of Ctsl1 3 0.54 0.11 0.94
96 INT38426 Regulation of RIPK2 3 0.60 0.62 0.91
97 INT42076 Regulation of Negative_regulation of RIPK2 1 0.44 0.91 0.91
98 INT267894 Gene_expression of ITK 13 0.57 9.71 0.9
99 INT161313 Phosphorylation of ZAP70 2 0.55 0.23 0.88
100 INT126566 Binding of Ifnb1 3 0.31 2.43 0.85
101 INT55512 Positive_regulation of Localization of Ripk2 1 0.67 0.09 0.85
102 INT103303 Negative_regulation of Transcription of Ifng 6 0.43 2.7 0.83
103 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
104 INT43488 Regulation of Positive_regulation of Ifng 1 0.42 0.71 0.83
105 INT40227 Regulation of Positive_regulation of Ripk2 1 0.44 0 0.82
106 INT129877 Gene_expression of CTSS 4 0.75 4.65 0.81
107 INT64635 Binding of Ifng 2 0.36 0.57 0.81
108 INT169706 Positive_regulation of Gene_expression of Itk 2 0.32 2.08 0.81
109 INT187218 Negative_regulation of Gene_expression of Tnfrsf11a 1 0.31 1.65 0.8
110 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
111 INT11138 Regulation of Localization of Ifng 2 0.56 0.8 0.77
112 INT73240 Negative_regulation of Transcription of IFNG 1 0.41 0.92 0.76
113 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75
114 INT37975 Negative_regulation of Binding of Ripk2 1 0.57 0 0.75
115 INT136147 Regulation of Ifnb1 2 0.44 1.75 0.72
116 INT129879 Positive_regulation of Gene_expression of CTSS 3 0.47 3.25 0.7
117 INT187210 Negative_regulation of Binding of Tnfrsf11a 1 0.23 1.77 0.7
118 INT116009 Regulation of Negative_regulation of Ifng 1 0.44 0.09 0.67
119 INT190187 Regulation of Gene_expression of PIK3CG 1 0.13 0 0.65
120 INT61622 Positive_regulation of Transcription of IFNG 1 0.26 0.29 0.63
121 INT29259 Gene_expression of Ifnb1 4 0.65 1.32 0.62
122 INT264964 Positive_regulation of Localization of PIK3CD 1 0.13 0.05 0.62
123 INT56231 Regulation of Positive_regulation of Ifng 1 0.39 0.33 0.62
124 INT142184 Regulation of TXK 10 0.11 8.25 0.59
125 INT132324 Localization of SYK 2 0.78 1.9 0.59
126 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
127 INT28687 Gene_expression of Ctsl1 4 0.61 0.48 0.57
128 INT116045 Negative_regulation of Positive_regulation of Ifng 2 0.03 2.5 0.57
129 INT51843 Localization of Ctsl1 3 0.62 0.54 0.54
130 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
131 INT132781 Phosphorylation of PIK3CG 8 0.52 4.83 0.53
132 INT29258 Positive_regulation of Gene_expression of Ifnb1 2 0.42 2.16 0.51
133 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
134 INT19420 Positive_regulation of Positive_regulation of RIPK2 1 0.49 0.59 0.5
135 INT61109 Negative_regulation of Positive_regulation of IFNG 1 0.53 0.57 0.5
136 INT187215 Transcription of Tnfrsf11a 1 0.28 1.15 0.49
137 INT171683 Negative_regulation of Negative_regulation of TXK 3 0.06 1.28 0.46
138 INT36603 Positive_regulation of CTSH 1 0.01 0 0.46
139 INT6533 Binding of Ctsl1 2 0.34 0 0.45
140 INT38738 Localization of RIPK2 2 0.68 0.07 0.45
141 INT154565 Regulation of Positive_regulation of PIK3CD 2 0.09 1.59 0.45
142 INT345935 Regulation of ZAP70 1 0.01 0.41 0.45
143 INT123720 Negative_regulation of Positive_regulation of Ifnb1 1 0.34 0.26 0.45
144 INT134891 Negative_regulation of Positive_regulation of TNFRSF11A 1 0.22 0.34 0.45
145 INT123721 Negative_regulation of Negative_regulation of Ifng 1 0.34 0.26 0.45
146 INT318784 Gene_expression of ZAP70 2 0.13 1.33 0.44
147 INT76021 Negative_regulation of Positive_regulation of Ifnb1 1 0.40 0.19 0.44
148 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
149 INT337345 Regulation of Gene_expression of PIK3CD 1 0.20 0 0.43
150 INT209899 Positive_regulation of Protein_catabolism of TNFRSF11A 1 0.49 0.77 0.42
151 INT209894 Protein_catabolism of TNFRSF11A 1 0.87 0.76 0.42
152 INT269220 Positive_regulation of Gene_expression of ITK 4 0.14 3.07 0.41
153 INT335648 Localization of CTSS 1 0.08 1.39 0.41
154 INT269226 Positive_regulation of ITK 13 0.12 11.23 0.4
155 INT337344 Negative_regulation of Negative_regulation of PIK3CD 1 0.19 0 0.4
156 INT132780 Positive_regulation of Phosphorylation of PIK3CG 1 0.01 0.37 0.4
157 INT348083 Positive_regulation of Ctsl1 1 0.08 0.21 0.4
158 INT140576 Positive_regulation of Regulation of Ifnb1 1 0.30 0.9 0.39
159 INT192343 Positive_regulation of Phosphorylation of TXK 4 0.06 1.42 0.37
160 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
161 INT192347 Phosphorylation of TXK 12 0.22 6.71 0.36
162 INT140577 Positive_regulation of Gene_expression of Ifnb1 1 0.30 0.81 0.36
163 INT254264 Positive_regulation of Protein_catabolism of Tnfrsf11a 1 0.21 0.74 0.35
164 INT154175 Regulation of SYK 2 0.62 1.48 0.34
165 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
166 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
167 INT9156 Negative_regulation of Regulation of Ifng 1 0.19 0.94 0.3
168 INT6536 Negative_regulation of Binding of Ctsl1 1 0.39 0 0.3
169 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
170 INT51504 Negative_regulation of Gene_expression of Ifnb1 1 0.01 0.49 0.25
171 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
172 INT64184 Negative_regulation of Gene_expression of TNFRSF11A 7 0.57 2.81 0.22
173 INT233845 Negative_regulation of Itk 7 0.18 4.81 0.22
174 INT279293 Localization of TXK 3 0.18 1.52 0.22
175 INT176145 Positive_regulation of Gene_expression of PIK3CG 3 0.20 1.36 0.22
176 INT36060 Protein_catabolism of Ctsl1 2 0.83 0.15 0.22
177 INT278154 Regulation of Syk 1 0.05 0.98 0.22
178 INT124178 Regulation of Ctsl1 1 0.23 0.19 0.22
179 INT278147 Localization of Syk 1 0.30 0.98 0.22
180 INT312860 Positive_regulation of Binding of IFNG 1 0.42 0.09 0.21
181 INT94336 Phosphorylation of IFNG 1 0.19 0.25 0.21
182 INT100769 Negative_regulation of Transcription of Ifng 3 0.42 0.7 0.2
183 INT129875 Positive_regulation of Positive_regulation of CTSS 1 0.50 1.94 0.2
184 INT142708 Gene_expression of CTSH 1 0.75 1.51 0.18
185 INT201691 Binding of RIPK2 2 0.18 1.51 0.17
186 INT129876 Negative_regulation of Positive_regulation of CTSS 1 0.43 1.88 0.17
187 INT277845 Negative_regulation of Gene_expression of TXK 2 0.04 0.92 0.16
188 INT302261 Regulation of PIK3CD 7 0.29 5.34 0.15
189 INT240596 Negative_regulation of Gene_expression of RIPK2 1 0.06 0.91 0.15
190 INT254265 Protein_catabolism of Tnfrsf11a 1 0.29 0.32 0.15
191 INT136002 Positive_regulation of Gene_expression of RIPK2 1 0.67 0.52 0.15
192 INT287133 Negative_regulation of Binding of Ifnb1 1 0.11 0.31 0.15
193 INT154177 Negative_regulation of Phosphorylation of SYK 1 0.43 1.51 0.14
194 INT217448 Regulation of Tnfrsf11a 1 0.42 2.31 0.14
195 INT348081 Positive_regulation of Gene_expression of Ctsl1 1 0.06 0.24 0.14
196 INT243793 Phosphorylation of PIK3CD 5 0.42 1.74 0.13
197 INT104537 Positive_regulation of ZAP70 2 0.67 0.42 0.12
198 INT58590 Protein_catabolism of IFNG 2 0.84 0.75 0.1
199 INT36061 Negative_regulation of Protein_catabolism of Ctsl1 1 0.12 0.08 0.1
200 INT285096 Transcription of ITK 1 0.17 0.77 0.1
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