GO:0002281

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Name macrophage activation involved in immune response
Categary Process
Go Slim No
Go Link GO:0002281
Unique Molecular Interactions 110
Total Molecular Interactions 144
Total Single Events 2278
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for macrophage activation involved in immune response. They are ordered first by their pain relevance and then by number of times they were reported for macrophage activation involved in immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91649 Binding of Lbp and SPECC1 1 0.12 2.88 2.78
2 INT212505 Binding of pr and Lbp 1 0.01 4.26 2.62
3 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
4 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
5 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
6 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
7 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
8 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
9 INT174910 Binding of LBP and IFIH1 1 0.04 1.01 1.01
10 INT317584 Binding of Lbp and Pgp 1 0.24 1.08 0.99
11 INT109842 Prkce Positive_regulation of Localization of Trpv1 1 0.13 1.31 0.91
12 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
13 INT317585 Binding of Lbp and Ppap2b 1 0.03 0.78 0.72
14 INT148454 Gene_expression of Inhbe Positive_regulation of Prkce 1 0.08 0.67 0.69
15 INT282665 Binding of Gfap and Ticam1 1 0.01 0 0.69
16 INT154766 Nox1 Positive_regulation of Localization of Prkce 1 0.47 0.45 0.66
17 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
18 INT112513 Binding of Prkaca and Prkce 1 0.04 0.4 0.64
19 INT112516 Binding of Prkce and Trib3 1 0.01 0.4 0.64
20 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 0.42 0.48 0.55
21 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
22 INT144128 Binding of Gja1 and Prkce 1 0.40 0.5 0.52
23 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52
24 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 0.08 0.29 0.51
25 INT301285 Binding of Tyrobp and Clec5a 1 0.32 1.63 0.49
26 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
27 INT285715 Binding of Lbp and Set 1 0.06 0.33 0.33
28 INT285718 Binding of DNMT3B and Lbp 1 0.08 0.33 0.33
29 INT306323 Tlr4 Positive_regulation of Ticam1 3 0.25 0.55 0.3
30 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
31 INT306333 Lbp Positive_regulation of Binding of Ly96 1 0.09 0.24 0.22
32 INT306328 Binding of Lbp and Tlr4 1 0.31 0.23 0.21
33 INT343837 TICAM1 Positive_regulation of IRF3 1 0.03 0.19 0.19
34 INT343831 TICAM1 Positive_regulation of Gene_expression of TLR4 1 0.11 0.19 0.19
35 INT343852 Binding of TRAF1 and TICAM1 1 0.03 0.19 0.17
36 INT343850 Binding of TRAF4 and TICAM1 1 0.03 0.19 0.17
37 INT343915 Binding of Traf1 and TICAM1 1 0.08 0.19 0.17
38 INT306326 Tlr4 Positive_regulation of Localization of Lbp 1 0.30 0.31 0.16
39 INT306329 Lbp Regulation of Tlr4 1 0.29 0.32 0.16
40 INT329796 TICAM1 Positive_regulation of IFNA1 2 0.02 0.89 0.15
41 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
42 INT343836 Binding of IRF6 and LBP 1 0.02 0.8 0.14
43 INT134614 Prkce Regulation of Trpv1 1 0.30 0.15 0.13
44 INT324831 Binding of TRIM63 and Ticam1 1 0.01 0.09 0.12
45 INT110107 Acot1 Positive_regulation of Localization of Prkce 1 0.11 0 0.12
46 INT254229 Binding of Ticam1 and Positive_regulation of Binding of IFNA1 1 0.02 0.3 0.12
47 INT254207 Ticam1 Positive_regulation of Ik 1 0.00 0.14 0.12
48 INT254227 Binding of Ripk1 and Ticam1 3 0.07 0.18 0.11
49 INT254215 Binding of Tlr4 and Ticam1 2 0.09 0.76 0.11
50 INT334264 Binding of Gtf3a and Ticam1 1 0.00 0.18 0.11
51 INT254220 Binding of Ticam1 and Sarm1 1 0.09 0.22 0.11
52 INT324869 Binding of Jun and Ticam1 1 0.01 0.76 0.11
53 INT324870 Binding of Ticam1 and Tlr3 1 0.03 0.76 0.11
54 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1
55 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
56 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
57 INT285423 LBP Positive_regulation of Gene_expression of IRF6 1 0.07 0.19 0.09
58 INT343845 TICAM1 Positive_regulation of TIRAP 1 0.05 0.25 0.09
59 INT226787 Trglyd Positive_regulation of Lbp 1 0.04 1.67 0.07
60 INT278441 Lbp Positive_regulation of Gene_expression of ITGAX 1 0.44 1.18 0.07
61 INT226786 Scl1 Positive_regulation of Lbp 1 0.04 1.68 0.07
62 INT346499 Mal Positive_regulation of TICAM1 1 0.06 0.66 0.07
63 INT346449 TICAM1 Positive_regulation of TBK1 1 0.01 0.45 0.06
64 INT346454 TICAM1 Positive_regulation of IKBKE 1 0.01 0.45 0.06
65 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05
66 INT306006 Binding of CD14 and LBP 1 0.06 0.63 0.04
67 INT350800 Binding of TLR3 and TICAM1 1 0.01 0 0.04
68 INT348028 Binding of Traf3 and Ticam1 1 0.01 0.56 0.03
69 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0
70 INT343842 Binding of TRAM1 and TICAM1 1 0.01 0.12 0
71 INT278400 Negative_regulation of Syk Negative_regulation of Positive_regulation of Hps5 1 0.16 0 0
72 INT278382 Binding of Syk and Nlrp3 1 0.24 0 0
73 INT278401 Syk Regulation of Positive_regulation of Hps5 1 0.19 0 0
74 INT278410 Gopc Positive_regulation of Phosphorylation of Syk 1 0.10 0.23 0
75 INT169448 Binding of Prkce and Trpv4 1 0.04 0.08 0
76 INT278387 Syk Regulation of Positive_regulation of Il1 1 0.06 0 0
77 INT278372 Binding of Syk and Pycard 1 0.06 0 0
78 INT278399 Syk Positive_regulation of Localization of Ctsb 1 0.09 0.28 0
79 INT278438 Lbp Positive_regulation of Il2 1 0.12 0.89 0
80 INT343824 Binding of TICAM1 and TICAM2 1 0.03 0.12 0
81 INT278405 Tlr4 Positive_regulation of Syk 1 0.06 0 0
82 INT209444 Stam Positive_regulation of Syk 1 0.01 0.26 0
83 INT278392 Syk Regulation of Positive_regulation of Ctsb 1 0.06 0 0
84 INT285427 LBP Positive_regulation of Localization of IL8 1 0.10 0.19 0
85 INT155552 Binding of FANCB and LBP 1 0.39 0.06 0
86 INT254231 Binding of TRAM1 and Ticam1 1 0.03 0 0
87 INT278396 Msu Positive_regulation of Phosphorylation of Syk 1 0.25 0.27 0
88 INT154173 Binding of SIPA1 and SYK 1 0.16 0.46 0
89 INT278380 Syk Positive_regulation of Pik3r1 1 0.13 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for macrophage activation involved in immune response. They are ordered first by their pain relevance and then by number of times they were reported in macrophage activation involved in immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1026 Binding of Lbp 207 0.48 150.96 119.16
2 INT9664 Binding of LBP 127 0.48 94.9 63.42
3 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16
4 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05
5 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71
6 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23
7 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73
8 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89
9 INT1030 Localization of Lbp 52 0.74 38.92 24.91
10 INT52179 Regulation of Lbp 39 0.61 25.4 18.32
11 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
12 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
13 INT57000 Localization of LBP 21 0.78 11.01 10.01
14 INT72148 Positive_regulation of Prkce 17 0.68 5.06 9.44
15 INT32624 Regulation of LBP 15 0.60 11.48 8.71
16 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57
17 INT110104 Localization of Prkce 17 0.79 3.75 6.92
18 INT183910 Negative_regulation of Gene_expression of Lbp 10 0.35 9.78 6.15
19 INT101497 Phosphorylation of Prkce 9 0.81 2.55 5.59
20 INT91946 Regulation of Prkce 6 0.44 4.13 5.46
21 INT1029 Positive_regulation of Gene_expression of Lbp 17 0.50 11.03 5.18
22 INT109838 Phosphorylation of Prkce 6 0.67 5.26 4.95
23 INT60758 Gene_expression of Prkce 8 0.20 4.12 4.59
24 INT11106 Gene_expression of Lbp 10 0.67 10.29 4.52
25 INT133733 Positive_regulation of Localization of Lbp 6 0.43 9.19 3.61
26 INT11101 Regulation of Gene_expression of Lbp 6 0.61 5.43 3.49
27 INT109840 Localization of Prkce 5 0.74 3.01 3.45
28 INT11107 Binding of Lbp 12 0.42 4.42 3.41
29 INT110100 Negative_regulation of Prkce 5 0.57 0.68 3.16
30 INT128184 Positive_regulation of Positive_regulation of Prkce 4 0.41 1.3 2.64
31 INT128185 Gene_expression of Prkce 4 0.69 1.39 2.23
32 INT228889 Protein_catabolism of LBP 4 0.77 5.14 2.13
33 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
34 INT136941 Positive_regulation of Localization of Prkce 3 0.43 1.42 2.06
35 INT124052 Binding of Prkce 2 0.06 2.52 2.03
36 INT134919 Binding of Ticam1 6 0.18 1.12 1.94
37 INT166311 Positive_regulation of Gene_expression of LBP 7 0.49 4.15 1.81
38 INT203541 Regulation of Binding of LBP 1 0.39 1.96 1.79
39 INT91947 Negative_regulation of Negative_regulation of Prkce 1 0.42 0.69 1.3
40 INT110099 Positive_regulation of Localization of Prkce 4 0.68 1.3 1.25
41 INT91949 Regulation of Positive_regulation of Prkce 1 0.44 0.72 1.24
42 INT110106 Regulation of Prkce 4 0.44 0.4 1.2
43 INT110102 Negative_regulation of Localization of Prkce 3 0.49 0.17 1.13
44 INT131238 Negative_regulation of Positive_regulation of Prkce 1 0.41 0.44 1.12
45 INT134917 Localization of Ticam1 2 0.51 0.6 0.99
46 INT158064 Negative_regulation of Gene_expression of LBP 1 0.41 1.54 0.97
47 INT341431 Regulation of Positive_regulation of LBP 1 0.24 1.14 0.96
48 INT135111 Regulation of Gene_expression of Prkce 1 0.51 0.15 0.96
49 INT135115 Regulation of Localization of Prkce 1 0.38 0.15 0.96
50 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
51 INT163869 Regulation of Binding of Lbp 3 0.45 1.07 0.93
52 INT160599 Regulation of Gene_expression of LBP 2 0.44 1.23 0.92
53 INT61775 Negative_regulation of Binding of Lbp 1 0.42 0.88 0.88
54 INT220161 Negative_regulation of Binding of LBP 2 0.43 1.35 0.87
55 INT134912 Positive_regulation of Localization of Ticam1 1 0.24 0.32 0.87
56 INT136944 Positive_regulation of Positive_regulation of Prkce 2 0.46 0.8 0.85
57 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
58 INT351306 Positive_regulation of Localization of LBP 1 0.47 1.82 0.82
59 INT154792 Regulation of Regulation of LBP 1 0.26 0.5 0.81
60 INT154793 Regulation of Localization of LBP 1 0.44 0.5 0.81
61 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
62 INT101084 Positive_regulation of Negative_regulation of Lbp 1 0.43 0.98 0.77
63 INT109839 Positive_regulation of Phosphorylation of Prkce 1 0.18 1.27 0.71
64 INT154761 Positive_regulation of Gene_expression of Prkce 1 0.44 0.5 0.7
65 INT154762 Negative_regulation of Phosphorylation of Prkce 1 0.38 0.48 0.69
66 INT151891 Negative_regulation of Localization of Lbp 1 0.42 0.8 0.63
67 INT132324 Localization of SYK 2 0.78 1.9 0.59
68 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
69 INT152068 Regulation of Gene_expression of Prkce 1 0.05 0.74 0.56
70 INT209443 Negative_regulation of Tyrobp 8 0.45 1.45 0.55
71 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
72 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
73 INT136942 Negative_regulation of Positive_regulation of Prkce 1 0.39 0.66 0.48
74 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
75 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
76 INT174552 Gene_expression of Tyrobp 6 0.60 2.29 0.42
77 INT209428 Positive_regulation of Tyrobp 2 0.44 0.79 0.4
78 INT55437 Transcription of Lbp 2 0.60 0.48 0.38
79 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
80 INT250167 Negative_regulation of Ticam1 3 0.29 2.03 0.37
81 INT209435 Regulation of Tyrobp 2 0.40 1.55 0.37
82 INT176613 Localization of Tyrobp 2 0.66 0.93 0.37
83 INT154175 Regulation of SYK 2 0.62 1.48 0.34
84 INT209424 Binding of Tyrobp 5 0.43 2.03 0.33
85 INT176608 Negative_regulation of Localization of Tyrobp 1 0.35 0.89 0.33
86 INT176615 Positive_regulation of Localization of Tyrobp 1 0.41 0.88 0.33
87 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
88 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
89 INT135025 Regulation of Gene_expression of Lbp 1 0.44 2.22 0.28
90 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
91 INT254195 Gene_expression of Ticam1 3 0.29 0.46 0.24
92 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
93 INT140351 Binding of Prkce 2 0.28 0.32 0.22
94 INT278154 Regulation of Syk 1 0.05 0.98 0.22
95 INT278147 Localization of Syk 1 0.30 0.98 0.22
96 INT169685 Regulation of Positive_regulation of Prkce 1 0.61 0.36 0.22
97 INT324768 Positive_regulation of Ticam1 2 0.16 0.14 0.18
98 INT306317 Localization of Lbp 1 0.53 0.31 0.16
99 INT306309 Positive_regulation of Localization of Lbp 1 0.33 0.32 0.16
100 INT275937 Phosphorylation of Syk 3 0.54 1.67 0.15
101 INT174551 Positive_regulation of Gene_expression of Tyrobp 2 0.44 0.88 0.15
102 INT324781 Protein_catabolism of Ticam1 1 0.27 0.74 0.15
103 INT254190 Positive_regulation of Binding of Ticam1 1 0.22 0.32 0.15
104 INT193474 Positive_regulation of Phosphorylation of Lbp 1 0.19 0.25 0.15
105 INT193473 Phosphorylation of Lbp 1 0.30 0.25 0.15
106 INT154177 Negative_regulation of Phosphorylation of SYK 1 0.43 1.51 0.14
107 INT275411 Binding of Syk 1 0.09 0.12 0.1
108 INT195755 Negative_regulation of Negative_regulation of Lbp 1 0.11 0.98 0.09
109 INT220332 Transcription of LBP 2 0.50 2.2 0.08
110 INT135023 Negative_regulation of Positive_regulation of Lbp 1 0.29 0.97 0.08
111 INT220337 Negative_regulation of Negative_regulation of LBP 1 0.35 0.35 0.08
112 INT135021 Regulation of Positive_regulation of Lbp 1 0.31 0.98 0.08
113 INT199076 Positive_regulation of Syk 3 0.31 0.12 0.07
114 INT254184 Positive_regulation of Gene_expression of Ticam1 1 0.22 0.11 0.06
115 INT135030 Regulation of Lbp 2 0.45 0.63 0.04
116 INT209433 Negative_regulation of Binding of Tyrobp 1 0.33 0.17 0.04
117 INT278363 Binding of Syk 1 0.32 0.3 0.04
118 INT276348 Positive_regulation of Positive_regulation of SYK 1 0.22 0.66 0.04
119 INT276371 Positive_regulation of Gene_expression of SYK 1 0.22 0.67 0.03
120 INT350784 Positive_regulation of TICAM1 1 0.05 0 0.03
121 INT137124 Negative_regulation of Lbp 2 0.37 0 0
122 INT329818 Binding of TICAM1 2 0.07 0.12 0
123 INT115667 Regulation of Negative_regulation of Lbp 2 0.45 0 0
124 INT209436 Transcription of Tyrobp 1 0.61 0.26 0
125 INT125910 Regulation of Localization of Lbp 1 0.21 0 0
126 INT154178 Binding of SYK 1 0.37 0.46 0
127 INT167265 Positive_regulation of Positive_regulation of Lbp 1 0.43 0 0
128 INT278354 Positive_regulation of Phosphorylation of Syk 1 0.31 0.23 0
129 INT275951 Negative_regulation of Phosphorylation of Syk 1 0.34 0.2 0
130 INT134805 Positive_regulation of Positive_regulation of LBP 1 0.45 0.15 0
131 INT278348 Positive_regulation of Gene_expression of Syk 1 0.33 0 0
132 INT162927 Protein_catabolism of Lbp 1 0.86 0 0
133 INT278326 Regulation of Positive_regulation of Syk 1 0.18 0 0
134 INT103299 Positive_regulation of Binding of Lbp 1 0.39 0 0
135 INT194939 Regulation of Phosphorylation of SYK 1 0.18 0.31 0
136 INT209425 Negative_regulation of Negative_regulation of Tyrobp 1 0.33 0.29 0
137 INT169684 Positive_regulation of Phosphorylation of Prkce 1 0.49 0.05 0
138 INT254192 Regulation of Binding of Ticam1 1 0.20 0 0
139 INT278346 Positive_regulation of Negative_regulation of Syk 1 0.33 0 0
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