GO:0002286

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Name T cell activation involved in immune response
Categary Process
Go Slim No
Go Link GO:0002286
Unique Molecular Interactions 94
Total Molecular Interactions 146
Total Single Events 1332
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for T cell activation involved in immune response. They are ordered first by their pain relevance and then by number of times they were reported for T cell activation involved in immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
2 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
3 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
4 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
5 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
6 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
7 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
8 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
9 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
10 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88
11 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
12 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
13 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
14 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
15 INT124292 Binding of Trpv1 and F2rl1 1 0.46 1.1 0.81
16 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
17 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77
18 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76
19 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
20 INT252857 Binding of F2rl1 and Trpa1 1 0.22 0.84 0.63
21 INT138332 Binding of P2rx3 and F2rl1 1 0.35 0.25 0.59
22 INT112312 tryptase Positive_regulation of F2rl1 2 0.08 0.23 0.57
23 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46
24 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46
25 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 0.09 1.26 0.42
26 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
27 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 0.09 1.15 0.4
28 INT150333 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0.67 0.38
29 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31
30 INT224462 Positive_regulation of F2RL1 Positive_regulation of MMP1 1 0.10 0.47 0.28
31 INT292570 Binding of F2RL1 and HTR1A 1 0.07 0.8 0.28
32 INT292568 Binding of F2RL1 and MRGPRX1 1 0.07 0.81 0.28
33 INT292571 Positive_regulation of F2RL1 Positive_regulation of Localization of IL6 1 0.07 0.8 0.27
34 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
35 INT292563 F2RL1 Negative_regulation of TNF 1 0.15 0.73 0.25
36 INT341538 F2 Positive_regulation of F2RL1 1 0.02 0.68 0.24
37 INT292556 Binding of F2RL1 and TLR4 1 0.05 0.52 0.22
38 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
39 INT207151 PLA2G6 Positive_regulation of Localization of F2rl1 1 0.16 0.73 0.18
40 INT341531 F2RL1 Regulation of CD55 1 0.33 0.41 0.18
41 INT207147 Pla2g1b Positive_regulation of Localization of F2rl1 1 0.03 0.73 0.18
42 INT211311 Trav6-3 Positive_regulation of Gene_expression of Lcp1 1 0.13 0.2 0.15
43 INT105253 Positive_regulation of Binding of Rnpep and F2rl1 1 0.02 0 0.15
44 INT105252 Binding of Rnpep and F2rl1 1 0.01 0 0.15
45 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
46 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
47 INT341529 PRSS1 Positive_regulation of Gene_expression of F2RL1 1 0.06 0 0.11
48 INT341543 PRSS1 Positive_regulation of Transcription of F2RL1 1 0.06 0 0.11
49 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
50 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
51 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
52 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
53 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
54 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
55 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
56 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
57 INT175631 F2RL1 Positive_regulation of Positive_regulation of MMP1 1 0.08 0.69 0.04
58 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
59 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
60 INT105260 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0 0.03
61 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
62 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03
63 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
64 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03
65 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
66 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
67 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
68 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
69 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
70 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
71 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
72 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
73 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
74 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
75 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
76 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
77 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
78 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
79 INT243314 MTTP Regulation of Gene_expression of CD1C 1 0.03 0.12 0
80 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
81 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
82 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
83 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
84 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
85 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
86 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
87 INT341540 Positive_regulation of F2RL1 Positive_regulation of Gene_expression of AREG 1 0.18 0.51 0
88 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for T cell activation involved in immune response. They are ordered first by their pain relevance and then by number of times they were reported in T cell activation involved in immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
2 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
3 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
4 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
5 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
6 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
7 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
8 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
9 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
10 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
11 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
12 INT90848 Localization of F2rl1 23 0.80 3.15 5.2
13 INT105256 Positive_regulation of Gene_expression of F2rl1 6 0.68 10.09 4.83
14 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
15 INT107860 Positive_regulation of Gene_expression of F2RL1 10 0.68 6.36 3.88
16 INT100729 Localization of F2RL1 7 0.75 5.29 3.37
17 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
18 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
19 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
20 INT224481 Regulation of F2RL1 4 0.37 5.07 2.74
21 INT161942 Regulation of Gene_expression of F2RL1 12 0.62 4.84 2.73
22 INT111017 Regulation of F2rl1 3 0.22 0 2.61
23 INT163544 Binding of Psen1 40 0.36 15.28 2.42
24 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37
25 INT138331 Binding of F2rl1 4 0.36 1.92 2.32
26 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29
27 INT224480 Binding of F2RL1 5 0.36 5.2 2.19
28 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
29 INT111018 Binding of F2rl1 5 0.30 3.11 2.02
30 INT60723 Localization of Psen2 5 0.68 2.11 2.02
31 INT224496 Negative_regulation of F2RL1 3 0.48 1.85 1.97
32 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
33 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
34 INT53532 Gene_expression of Lcp1 10 0.70 11.57 1.69
35 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
36 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
37 INT96651 Negative_regulation of F2rl1 4 0.37 2.26 1.4
38 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
39 INT119743 Negative_regulation of Positive_regulation of F2rl1 3 0.43 1.97 1.3
40 INT327936 Regulation of Gene_expression of F2rl1 1 0.61 2.62 1.26
41 INT224494 Regulation of Positive_regulation of F2RL1 4 0.37 1.67 1.11
42 INT159330 Positive_regulation of Localization of F2rl1 1 0.49 0.34 1.02
43 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
44 INT112311 Regulation of F2rl1 2 0.27 0.73 0.97
45 INT224489 Negative_regulation of Gene_expression of F2RL1 3 0.57 1.51 0.96
46 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
47 INT101495 Regulation of Positive_regulation of F2rl1 1 0.26 0.88 0.91
48 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
49 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
50 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
51 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
52 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
53 INT78649 Binding of Psen2 7 0.36 5.9 0.73
54 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
55 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
56 INT292595 Negative_regulation of Positive_regulation of F2RL1 3 0.40 1.29 0.63
57 INT100730 Positive_regulation of Localization of F2RL1 2 0.49 0.99 0.62
58 INT297831 Protein_catabolism of F2rl1 2 0.10 0.5 0.6
59 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
60 INT124290 Negative_regulation of Gene_expression of F2rl1 3 0.42 1.48 0.52
61 INT111019 Negative_regulation of Binding of F2rl1 1 0.35 0 0.48
62 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
63 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
64 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
65 INT193856 Localization of Psen1 19 0.73 9.79 0.41
66 INT156226 Transcription of F2rl1 1 0.23 1.25 0.41
67 INT166066 Negative_regulation of Localization of F2rl1 1 0.43 0.47 0.4
68 INT156230 Positive_regulation of Binding of F2rl1 1 0.21 1.11 0.4
69 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
70 INT112310 Negative_regulation of Regulation of F2rl1 1 0.03 0 0.39
71 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
72 INT292591 Negative_regulation of Negative_regulation of F2RL1 1 0.35 0 0.36
73 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
74 INT243709 Regulation of Lcp1 1 0.44 0.66 0.32
75 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
76 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
77 INT224491 Transcription of F2RL1 1 0.68 0.31 0.26
78 INT94657 Transcription of F2rl1 1 0.69 0.5 0.26
79 INT105257 Regulation of Localization of F2rl1 1 0.23 0 0.26
80 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
81 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
82 INT166268 Positive_regulation of Lcp1 2 0.49 2.79 0.21
83 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
84 INT207129 Localization of F2rl1 1 0.22 0.72 0.18
85 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
86 INT292590 Positive_regulation of Negative_regulation of F2RL1 1 0.38 0 0.15
87 INT166269 Negative_regulation of Positive_regulation of Lcp1 1 0.42 1.89 0.15
88 INT211307 Negative_regulation of Gene_expression of Lcp1 1 0.41 0.2 0.14
89 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
90 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
91 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
92 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
93 INT341581 Positive_regulation of Transcription of F2RL1 1 0.44 0 0.11
94 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
95 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
96 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
97 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
98 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
99 INT54839 Positive_regulation of CD1C 1 0.49 0.82 0.08
100 INT54838 Localization of CD1C 1 0.68 0.82 0.08
101 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
102 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
103 INT96587 Binding of Lcp1 1 0.18 0.46 0.08
104 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
105 INT292586 Phosphorylation of F2RL1 1 0.51 0 0.07
106 INT292582 Negative_regulation of Phosphorylation of F2RL1 1 0.35 0 0.07
107 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
108 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
109 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
110 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
111 INT224302 Negative_regulation of Transcription of PSEN2 3 0.26 0.08 0
112 INT243329 Gene_expression of CD1C 2 0.18 0.46 0
113 INT265229 Binding of PSEN2 2 0.16 1.37 0
114 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
115 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
116 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
117 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
118 INT224297 Regulation of Transcription of PSEN2 1 0.20 0.06 0
119 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
120 INT149028 Positive_regulation of Gene_expression of F2rl1 1 0.43 0 0
121 INT177774 Transcription of PSEN1 1 0.33 0.09 0
122 INT149032 Regulation of Gene_expression of F2rl1 1 0.23 0 0
123 INT292596 Positive_regulation of Binding of F2RL1 1 0.41 0 0
124 INT354892 Negative_regulation of Psen2 1 0.37 0.95 0
125 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
126 INT331463 Regulation of Gene_expression of PSEN2 1 0.04 0 0
127 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
128 INT181212 Transcription of Lcp1 1 0.02 0.71 0
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