GO:0002291

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Name T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Categary Process
Go Slim No
Go Link GO:0002291
Unique Molecular Interactions 180
Total Molecular Interactions 297
Total Single Events 3332
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. They are ordered first by their pain relevance and then by number of times they were reported for T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
2 INT107268 Binding of ITGAL and NCR3 1 0.01 2.76 2.07
3 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83
4 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
5 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
6 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
7 INT177232 ICAM1 Regulation of Gene_expression of Vcam1 1 0.03 5.52 1.28
8 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
9 INT151657 Vcam1 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
10 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
11 INT334129 Acsm3 Positive_regulation of Gene_expression of Icam1 1 0.22 2.89 1.22
12 INT107265 Binding of HLA-DRB1 and ITGAL 1 0.01 1.41 1.1
13 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07
14 INT139230 Icam1 Negative_regulation of Cmklr1 1 0.19 1.13 1.07
15 INT139227 Icam1 Negative_regulation of Timp1 1 0.37 1.13 1.06
16 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
17 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
18 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
19 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
20 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91
21 INT282129 Il10 Positive_regulation of Icam1 1 0.56 3.12 0.82
22 INT81716 ITGAL Regulation of ITGB2 2 0.30 1.24 0.78
23 INT81717 ITGAL Regulation of Gene_expression of ITGAM 1 0.30 0.17 0.78
24 INT81718 ITGAL Regulation of Gene_expression of FCGR3B 1 0.28 0.17 0.78
25 INT81711 ITGAL Regulation of Gene_expression of ITGB2 1 0.30 0.17 0.78
26 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77
27 INT81713 ITGAL Regulation of ITGAM 1 0.30 0.17 0.77
28 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75
29 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
30 INT334133 Acsm3 Positive_regulation of Icam1 1 0.23 1.61 0.66
31 INT66603 TFF2 Positive_regulation of Gene_expression of ICAM1 1 0.02 0 0.64
32 INT346141 ADM Positive_regulation of Gene_expression of ICAM1 1 0.19 1.75 0.63
33 INT66601 WDR87 Positive_regulation of Gene_expression of ICAM1 1 0.00 0 0.63
34 INT66604 SARDH Positive_regulation of Gene_expression of ICAM1 1 0.01 0 0.63
35 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
36 INT265651 Binding of ITGAL and MYCN 1 0.00 0.46 0.62
37 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61
38 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57
39 INT66600 TFF2 Regulation of Positive_regulation of ICAM1 1 0.01 0 0.56
40 INT133049 TNF Positive_regulation of ICAM1 4 0.47 2.49 0.54
41 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51
42 INT137137 Binding of HIVEP1 and ICAM1 1 0.01 0.68 0.51
43 INT92997 Positive_regulation of SFTPA1 Positive_regulation of Binding of ICAM1 1 0.15 0.26 0.51
44 INT56449 Aap Positive_regulation of Icam1 1 0.31 0.75 0.5
45 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5
46 INT135586 CSF2 Regulation of ICAM1 1 0.13 1.3 0.49
47 INT333151 asa Regulation of Gene_expression of Icam1 1 0.09 0.59 0.48
48 INT333156 Tlx2 Regulation of Gene_expression of Icam1 1 0.06 0.59 0.48
49 INT71178 Binding of ITGB2 and Icam1 1 0.45 1.2 0.47
50 INT103929 Cps1 Negative_regulation of Gene_expression of Icam1 1 0.01 0.13 0.47
51 INT103931 Cps1 Negative_regulation of Icam1 1 0.01 0.07 0.46
52 INT102691 RETNLB Positive_regulation of ITGAL 1 0.01 0.45 0.45
53 INT321860 Timp1 Negative_regulation of Icam1 1 0.22 1.13 0.39
54 INT249090 FOXL1 Regulation of Regulation of ICAM1 1 0.12 1.03 0.37
55 INT210952 Il1 Positive_regulation of Gene_expression of Icam1 1 0.01 0.86 0.37
56 INT230499 Gene_expression of Il1rn Negative_regulation of Gene_expression of Icam1 1 0.01 0.85 0.36
57 INT189491 Icam1 Positive_regulation of Transcription of Ccl5 1 0.19 0.64 0.36
58 INT78893 TNF Regulation of Gene_expression of ICAM1 1 0.24 0.38 0.35
59 INT193492 Binding of Icam1 and Sele 1 0.06 1.05 0.34
60 INT230745 Negative_regulation of Ace Negative_regulation of Icam1 1 0.05 1.22 0.29
61 INT170128 Binding of ITGAL and ITGB2 2 0.04 1.6 0.28
62 INT282128 Gene_expression of Il10 Positive_regulation of Positive_regulation of Icam1 1 0.37 1.12 0.28
63 INT62550 Il1f5 Regulation of Gene_expression of Icam1 1 0.05 0.44 0.28
64 INT306942 Tnfsf12 Positive_regulation of Gene_expression of ICAM1 1 0.04 1.78 0.27
65 INT170258 Pecam1 Positive_regulation of Icam1 1 0.02 0.79 0.27
66 INT239396 Atp7b Negative_regulation of Gene_expression of Icam1 1 0.07 1.69 0.26
67 INT324064 Olfr1328 Negative_regulation of Gene_expression of Icam1 1 0.02 0.58 0.26
68 INT128644 Binding of Icam1 and Selp 2 0.39 0.57 0.25
69 INT129220 IFNG Positive_regulation of ICAM1 1 0.09 0.1 0.25
70 INT62549 Il1b Regulation of Icam1 1 0.13 0.39 0.25
71 INT62548 Il1b Regulation of Gene_expression of Icam1 1 0.22 0.39 0.25
72 INT179200 Binding of ICAM1 and IL8 1 0.03 1.02 0.25
73 INT129219 IFNG Positive_regulation of Gene_expression of ICAM1 1 0.13 0.1 0.25
74 INT284589 Binding of ICAM1 and Crp 1 0.00 1.08 0.22
75 INT343910 TLR4 Regulation of Gene_expression of Icam1 1 0.04 1.3 0.22
76 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
77 INT141490 Negative_regulation of TNF Positive_regulation of ICAM1 1 0.29 0.58 0.21
78 INT139454 Binding of IGF2R and Icam1 1 0.00 0.4 0.21
79 INT158199 Negative_regulation of Binding of ICAM1 and AHSA1 1 0.15 0.3 0.2
80 INT158220 Positive_regulation of Binding of ICAM1 and TNFSF14 1 0.05 0.3 0.2
81 INT158223 Binding of ICAM1 and TNFSF14 1 0.04 0.3 0.2
82 INT158218 Binding of ICAM1 and AHSA1 1 0.14 0.3 0.2
83 INT158227 Negative_regulation of Binding of ICAM1 and MAPK1 1 0.16 0.3 0.2
84 INT158236 Positive_regulation of Binding of ICAM1 and MAPK1 1 0.19 0.3 0.2
85 INT158226 Binding of ICAM1 and MAPK1 1 0.14 0.3 0.2
86 INT158213 Positive_regulation of Binding of ICAM1 and AHSA1 1 0.18 0.3 0.2
87 INT158229 Negative_regulation of Binding of ICAM1 and TNFSF14 1 0.05 0.3 0.2
88 INT125152 IL1B Regulation of Gene_expression of ICAM1 1 0.50 0.1 0.2
89 INT158215 TNFSF14 Positive_regulation of ICAM1 1 0.05 0.3 0.2
90 INT214590 TIMP1 Regulation of ICAM1 1 0.10 0.29 0.19
91 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
92 INT214591 FOXC1 Regulation of ICAM1 1 0.05 0.29 0.19
93 INT273723 Binding of Icam1 and Trav6-3 1 0.05 1.97 0.19
94 INT214592 OAP Regulation of Gene_expression of ICAM1 1 0.02 0.77 0.19
95 INT277791 Binding of Icam1 and Itgal 1 0.03 0.37 0.17
96 INT303967 Lep Positive_regulation of Gene_expression of Icam1 1 0.24 0.58 0.16
97 INT171945 PECAM1 Positive_regulation of Gene_expression of ICAM1 1 0.06 1.66 0.16
98 INT171544 PECAM1 Positive_regulation of ICAM1 1 0.01 0.47 0.16
99 INT171944 ICAM1 Positive_regulation of Gene_expression of PECAM1 1 0.06 1.66 0.16
100 INT273715 Positive_regulation of Binding of Icam1 and Trav6-3 1 0.07 1.51 0.16
101 INT273714 Positive_regulation of Binding of Icam1 and Itgb2 1 0.17 1.46 0.15
102 INT273717 Binding of Icam1 and Itgb2 1 0.17 1.45 0.15
103 INT63981 Sele Regulation of Positive_regulation of Icam1 1 0.17 0.71 0.15
104 INT213010 Hdl1 Negative_regulation of Gene_expression of Icam1 1 0.15 1.01 0.15
105 INT63980 Icam1 Regulation of Positive_regulation of Sele 1 0.17 0.71 0.15
106 INT79229 Binding of Icam1 and Ltbr 1 0.09 0.37 0.14
107 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
108 INT173406 Binding of ITGAL and Itgb2 1 0.02 0.41 0.13
109 INT342406 AAVS1 Positive_regulation of Icam1 1 0.26 0.19 0.11
110 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11
111 INT269785 Crp Positive_regulation of ICAM1 1 0.00 1.68 0.11
112 INT297938 Binding of ICAM1 and PAOD1 1 0.06 0.86 0.11
113 INT243215 Myst2 Negative_regulation of Gene_expression of Icam1 1 0.01 0.68 0.1
114 INT120700 PRSS1 Positive_regulation of ICAM1 1 0.15 0.29 0.1
115 INT277089 VEGFA Positive_regulation of Icam1 1 0.02 1.74 0.09
116 INT232652 Binding of CD2 and ITGAL 1 0.03 0.28 0.09
117 INT355580 VEGFA Positive_regulation of ICAM1 1 0.09 1.39 0.09
118 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
119 INT279400 GANAB Regulation of ITGAL 1 0.01 0.75 0.09
120 INT267626 Il1 Positive_regulation of ICAM1 1 0.00 0.79 0.09
121 INT173371 GPER Regulation of ITGAL 1 0.01 0.23 0.08
122 INT323640 Vcam1 Positive_regulation of Gene_expression of Icam1 1 0.42 1.75 0.08
123 INT346136 ADM Positive_regulation of ICAM1 1 0.20 0.92 0.08
124 INT267137 ICAM1 Regulation of ITGAL 2 0.12 0.57 0.07
125 INT284501 Positive_regulation of Binding of ICAM1 and ITGAL 1 0.06 0.2 0.07
126 INT284503 Binding of ICAM1 and ITGAM 1 0.05 0.2 0.07
127 INT186814 MIR181A2HG Regulation of ICAM1 1 0.01 1.05 0.07
128 INT313506 Binding of ICAM1 and SNRNP70 1 0.02 1.08 0.06
129 INT284504 ITGAL Positive_regulation of Gene_expression of ITGAM 1 0.03 0.2 0.06
130 INT260811 Binding of ITGA4 and ITGAL 1 0.02 0 0.03
131 INT313501 Binding of ALOX12 and ICAM1 1 0.10 0.54 0.03
132 INT285407 ELF3 Regulation of ICAM1 1 0.03 0.91 0.03
133 INT251006 ICAM1 Positive_regulation of SELL 1 0.02 0.56 0
134 INT170121 ITGAL Regulation of CD44 1 0.07 1.07 0
135 INT325942 Binding of Icam1 and Ezr 1 0.15 0.39 0
136 INT285289 TNF Positive_regulation of Icam1 1 0.23 1.44 0
137 INT170119 PECAM1 Regulation of Positive_regulation of ITGAL 1 0.01 1.07 0
138 INT170587 GOPC Regulation of Gene_expression of ICAM1 1 0.13 0 0
139 INT74217 Oprl1 Negative_regulation of Positive_regulation of Icam1 1 0.18 0.11 0
140 INT79649 RIMS3 Regulation of Positive_regulation of ITGAL 1 0.00 0 0
141 INT170123 ITGAL Regulation of Positive_regulation of PECAM1 1 0.01 1.07 0
142 INT273716 Binding of Cd28 and Icam1 1 0.09 0 0
143 INT301095 Binding of ITGAL and CHDH 1 0.00 0.71 0
144 INT249996 Binding of ICAM1 and GPHA2 1 0.02 2.25 0
145 INT249995 Positive_regulation of Binding of ICAM1 and GPHA2 1 0.02 2.43 0
146 INT170590 RELA Negative_regulation of Gene_expression of ICAM1 1 0.42 0.49 0
147 INT285288 TNF Positive_regulation of Gene_expression of Icam1 1 0.17 2.83 0
148 INT273718 Binding of Icam1 and Vtcn1 1 0.00 0 0
149 INT170588 RELA Regulation of Gene_expression of ICAM1 1 0.26 0 0
150 INT170589 NFKB1 Regulation of Gene_expression of ICAM1 1 0.27 0 0
151 INT155171 ICAM1 Regulation of Gene_expression of NOS1 1 0.09 0.08 0
152 INT170114 ITGAM Regulation of Positive_regulation of ITGAL 1 0.04 1.07 0
153 INT170115 PECAM1 Regulation of ITGAL 1 0.00 1.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. They are ordered first by their pain relevance and then by number of times they were reported in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6
2 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71
3 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71
4 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28
5 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55
6 INT48407 Positive_regulation of Gene_expression of Icam1 61 0.70 57.91 21.54
7 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61
8 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72
9 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9
10 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16
11 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97
12 INT65713 Localization of ICAM1 42 0.81 39.55 11.49
13 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96
14 INT56450 Negative_regulation of Gene_expression of Icam1 33 0.52 27.21 10.15
15 INT80549 Binding of ICAM1 53 0.47 42.76 9.72
16 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5
17 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06
18 INT62944 Regulation of Icam1 33 0.47 23.52 7.94
19 INT48404 Regulation of Gene_expression of Icam1 21 0.62 15.1 7.81
20 INT144945 Negative_regulation of Icam1 27 0.50 26.23 7.08
21 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15
22 INT71727 Negative_regulation of Icam1 25 0.45 17.76 5.73
23 INT65712 Positive_regulation of Localization of ICAM1 14 0.70 16.72 5.5
24 INT144946 Localization of Icam1 21 0.75 21.84 5.33
25 INT56445 Regulation of Icam1 14 0.39 15.4 5.32
26 INT49405 Gene_expression of Itgal 40 0.75 27.3 4.8
27 INT87322 Binding of ITGAL 23 0.47 15.73 4.68
28 INT170738 Binding of Icam1 23 0.37 25.49 4.09
29 INT62545 Regulation of Gene_expression of Icam1 17 0.49 14.26 4.06
30 INT70996 Positive_regulation of Positive_regulation of Icam1 8 0.60 6.02 3.74
31 INT70994 Negative_regulation of Positive_regulation of Icam1 8 0.51 3.49 3.12
32 INT74216 Binding of Icam1 16 0.48 10.11 2.69
33 INT135470 Transcription of Icam1 10 0.63 12.04 2.41
34 INT61418 Positive_regulation of ITGAL 24 0.14 12.86 2.3
35 INT72865 Localization of Icam1 12 0.68 8.18 2.24
36 INT56446 Positive_regulation of Positive_regulation of Icam1 7 0.40 8.84 1.64
37 INT12942 Regulation of ITGAL 8 0.35 3.29 1.57
38 INT70993 Regulation of Positive_regulation of Icam1 2 0.45 1.22 1.57
39 INT78816 Positive_regulation of Positive_regulation of ICAM1 9 0.68 8.36 1.55
40 INT49404 Binding of Itgal 11 0.36 9.16 1.53
41 INT93005 Positive_regulation of Binding of ICAM1 5 0.68 4.55 1.42
42 INT83464 Positive_regulation of Localization of Icam1 3 0.46 3.71 1.4
43 INT62824 Negative_regulation of Positive_regulation of ICAM1 7 0.53 2.94 1.39
44 INT63339 Transcription of ICAM1 6 0.69 3.92 1.37
45 INT261599 Transcription of Icam1 6 0.50 4.55 1.07
46 INT49406 Positive_regulation of Itgal 7 0.43 8.58 0.95
47 INT199009 Negative_regulation of Transcription of Icam1 4 0.38 3.81 0.95
48 INT81723 Regulation of Gene_expression of ITGAL 2 0.32 0.2 0.92
49 INT115964 Negative_regulation of ITGAL 7 0.34 3.76 0.86
50 INT347211 Regulation of Localization of Icam1 1 0.54 7.36 0.79
51 INT186135 Negative_regulation of Binding of ITGAL 5 0.34 3.27 0.74
52 INT66607 Regulation of Positive_regulation of ICAM1 3 0.42 2.81 0.71
53 INT102695 Localization of ITGAL 2 0.73 1.26 0.61
54 INT297304 Regulation of Transcription of Icam1 2 0.21 2.08 0.6
55 INT63357 Negative_regulation of Gene_expression of ITGAL 3 0.33 1.88 0.56
56 INT261598 Positive_regulation of Transcription of Icam1 3 0.24 2.56 0.55
57 INT157574 Positive_regulation of Localization of Icam1 1 0.46 0.56 0.51
58 INT78813 Positive_regulation of Transcription of ICAM1 1 0.46 0.16 0.5
59 INT133729 Positive_regulation of Gene_expression of ITGAL 8 0.49 2.96 0.48
60 INT112949 Negative_regulation of Binding of Icam1 2 0.24 1.75 0.47
61 INT174159 Regulation of Binding of Icam1 1 0.03 1.31 0.47
62 INT277788 Negative_regulation of Gene_expression of Itgal 4 0.29 2.05 0.39
63 INT158244 Phosphorylation of ICAM1 2 0.67 1.33 0.39
64 INT236453 Negative_regulation of Positive_regulation of Icam1 2 0.43 1.95 0.38
65 INT177231 Regulation of Regulation of ICAM1 1 0.06 0.66 0.37
66 INT267145 Negative_regulation of Binding of ICAM1 5 0.57 4.12 0.33
67 INT79260 Negative_regulation of Itgal 2 0.37 2.11 0.33
68 INT214613 Regulation of Binding of ICAM1 2 0.28 1.41 0.32
69 INT204566 Negative_regulation of Localization of Icam1 2 0.19 2.11 0.3
70 INT114900 Negative_regulation of Positive_regulation of ITGAL 1 0.01 1.32 0.29
71 INT297295 Negative_regulation of Transcription of Icam1 1 0.27 1.57 0.29
72 INT12940 Positive_regulation of Transcription of ITGAL 1 0.02 0.09 0.26
73 INT12941 Transcription of ITGAL 1 0.03 0.09 0.26
74 INT294738 Positive_regulation of Transcription of Icam1 2 0.44 1.74 0.24
75 INT136287 Regulation of Positive_regulation of Icam1 1 0.39 1.32 0.24
76 INT61416 Positive_regulation of Positive_regulation of ITGAL 4 0.11 0.85 0.23
77 INT79259 Regulation of Itgal 4 0.40 2.94 0.23
78 INT117808 Positive_regulation of Gene_expression of Itgal 3 0.10 2.12 0.23
79 INT146186 Negative_regulation of Negative_regulation of Icam1 1 0.11 0.86 0.17
80 INT235724 Localization of Itgal 2 0.07 0.94 0.15
81 INT112950 Positive_regulation of Binding of Icam1 1 0.28 0.73 0.15
82 INT288159 Regulation of Gene_expression of Itgal 1 0.15 1.16 0.14
83 INT214610 Regulation of Localization of ICAM1 1 0.28 0 0.11
84 INT330980 Regulation of Negative_regulation of Icam1 1 0.21 0.68 0.09
85 INT117809 Positive_regulation of Positive_regulation of Itgal 1 0.04 0.84 0.09
86 INT277786 Negative_regulation of Binding of Itgal 1 0.29 0.22 0.07
87 INT267150 Regulation of Transcription of ICAM1 2 0.26 0.86 0.06
88 INT107191 Positive_regulation of Regulation of Icam1 1 0.44 0.87 0.05
89 INT83483 Regulation of Regulation of ITGAL 2 0.01 0.3 0.04
90 INT83476 Positive_regulation of Regulation of ITGAL 1 0.00 0 0
91 INT79661 Phosphorylation of ITGAL 1 0.01 0 0
92 INT139002 Negative_regulation of Negative_regulation of ICAM1 1 0.02 0.1 0
93 INT349474 Regulation of Binding of Icam1 1 0.25 0 0
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