GO:0002296

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Name T-helper 1 cell lineage commitment
Categary Process
Go Slim No
Go Link GO:0002296
Unique Molecular Interactions 162
Total Molecular Interactions 186
Total Single Events 1561
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for T-helper 1 cell lineage commitment. They are ordered first by their pain relevance and then by number of times they were reported for T-helper 1 cell lineage commitment. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT190772 Il4 Negative_regulation of Gene_expression of Ptger2 1 0.03 1.28 1.49
2 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
3 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
4 INT190775 Gene_expression of Il4 Negative_regulation of Positive_regulation of FOSL1 1 0.39 2.42 1.4
5 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
6 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
7 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99
8 INT129214 RYBP Positive_regulation of Gene_expression of Il4 1 0.01 1.04 0.94
9 INT199495 Il4 Positive_regulation of Positive_regulation of Oprm1 1 0.00 0.98 0.78
10 INT199476 Il4 Positive_regulation of Transcription of Stat6 1 0.01 0.97 0.77
11 INT150995 Sfpq Positive_regulation of Gene_expression of Il4 1 0.06 0.71 0.74
12 INT209037 Il4 Positive_regulation of Csf2 1 0.03 0.38 0.73
13 INT209038 Il4 Positive_regulation of Ccr1 1 0.01 0.38 0.73
14 INT209058 Il4 Positive_regulation of Elf1 1 0.08 0.38 0.73
15 INT209034 Il4 Positive_regulation of Il17a 1 0.04 0.38 0.73
16 INT199488 Il4 Positive_regulation of Transcription of Oprm1 1 0.01 0.84 0.73
17 INT209064 Il4 Positive_regulation of Cxcl1 1 0.05 0.38 0.73
18 INT116020 Positive_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7
19 INT116021 Binding of Il4 and Mavs 1 0.02 0.08 0.7
20 INT116019 Negative_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7
21 INT325267 Il33 Positive_regulation of Gene_expression of Il4 1 0.16 1.59 0.69
22 INT199489 Stat6 Positive_regulation of Oprm1 1 0.02 0.85 0.68
23 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67
24 INT154533 Ifng Negative_regulation of Il4 1 0.11 0.62 0.6
25 INT151460 Olr1745 Positive_regulation of Il4 1 0.04 0.83 0.59
26 INT228497 Il4 Regulation of Ncoa5 1 0.01 1.24 0.57
27 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56
28 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
29 INT351332 Positive_regulation of Il4 Positive_regulation of Gene_expression of Il10 1 0.09 1.78 0.53
30 INT274170 Il13 Regulation of Il4 3 0.09 2.75 0.51
31 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
32 INT131364 Bcar3 Positive_regulation of Il4 1 0.00 0.37 0.51
33 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
34 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
35 INT70925 Binding of Ifng and Il4 2 0.14 0.9 0.5
36 INT184099 Il4 Positive_regulation of Stat4 1 0.13 0.28 0.49
37 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48
38 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48
39 INT184117 Il12a Positive_regulation of Stat6 1 0.07 0.28 0.48
40 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48
41 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48
42 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48
43 INT185067 Bpifa2 Positive_regulation of Il4 1 0.20 0.84 0.48
44 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46
45 INT147977 Tnf Positive_regulation of Il4 1 0.01 1.12 0.41
46 INT228739 Il4 Positive_regulation of Gene_expression of Ccl17 1 0.14 0.66 0.39
47 INT237417 Il1rn Regulation of Il4 1 0.02 0.96 0.39
48 INT297423 Gene_expression of Il4 Regulation of Ppara 1 0.07 1.19 0.38
49 INT254278 Binding of Il13 and Il4 1 0.02 0.74 0.38
50 INT297424 Gene_expression of Stat6 Regulation of Ppara 1 0.17 1.19 0.38
51 INT297425 Il4 Regulation of Ppara 1 0.07 1.17 0.38
52 INT297426 Stat6 Regulation of Ppara 1 0.17 1.19 0.38
53 INT70924 Binding of Il2 and Il4 1 0.07 0.34 0.36
54 INT181438 Il4 Regulation of Gene_expression of Ccl2 1 0.38 0.74 0.35
55 INT151677 Il4 Negative_regulation of Art2a-ps 1 0.00 0.61 0.35
56 INT151680 Il4 Negative_regulation of Oas1b 1 0.07 0.61 0.35
57 INT187818 Gene_expression of Il10 Positive_regulation of Gene_expression of Il4 1 0.09 0.69 0.35
58 INT54504 Pomc Positive_regulation of Gene_expression of Il4 1 0.13 0 0.34
59 INT140183 Il4 Positive_regulation of Gene_expression of Il10 1 0.12 0.73 0.34
60 INT140181 Gene_expression of Il4 Positive_regulation of Gene_expression of Il10 1 0.17 0.73 0.34
61 INT294762 Il4 Regulation of Il13 2 0.09 0.92 0.32
62 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
63 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
64 INT186345 Binding of Gast and Stat6 1 0.03 2.19 0.3
65 INT297422 Lvs Positive_regulation of Gene_expression of Il4 1 0.04 1.2 0.3
66 INT228734 Rae1 Negative_regulation of Il4 1 0.08 0.68 0.29
67 INT213802 Il4 Regulation of Gene_expression of Insrr 1 0.00 0.76 0.29
68 INT278214 Ciita Regulation of Gene_expression of Il4 1 0.45 1.53 0.28
69 INT185078 Bpifa2 Regulation of Il4 1 0.08 0.4 0.28
70 INT87369 Il4 Positive_regulation of Penk 1 0.37 0 0.28
71 INT251567 Il4 Negative_regulation of Gene_expression of Il10 1 0.01 0.96 0.27
72 INT251581 Il4 Negative_regulation of Gene_expression of TNF 1 0.05 0.95 0.26
73 INT194810 Il4 Regulation of Positive_regulation of Nfatc1 1 0.02 0.15 0.25
74 INT346912 Il6 Positive_regulation of Gene_expression of Il4 1 0.07 0.62 0.24
75 INT215396 Il4 Positive_regulation of Gene_expression of Ppara 1 0.03 0.23 0.23
76 INT186371 Il4 Negative_regulation of Positive_regulation of Il12a 1 0.06 0.3 0.23
77 INT67085 Penk Positive_regulation of Positive_regulation of Il4 1 0.06 0.08 0.23
78 INT254281 Il4 Negative_regulation of Gene_expression of Acp5 1 0.02 0.41 0.22
79 INT355877 Binding of Hand1 and Il4 1 0.14 0.25 0.22
80 INT332247 Egf Positive_regulation of Stat6 1 0.13 1.23 0.19
81 INT332253 Il13 Positive_regulation of Stat6 1 0.08 1.18 0.19
82 INT332245 Pdgfa Positive_regulation of Stat6 1 0.07 1.22 0.19
83 INT284889 Gene_expression of Hand1 Positive_regulation of Gene_expression of Il4 1 0.21 0.4 0.18
84 INT329841 Il4 Regulation of Hand1 1 0.04 0.87 0.18
85 INT185077 Bpifa2 Positive_regulation of Gene_expression of Il4 1 0.15 0.22 0.18
86 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
87 INT266616 Il4 Positive_regulation of Il12a 1 0.01 0.4 0.17
88 INT315491 Hspg2 Negative_regulation of Gene_expression of Il4 1 0.04 0.22 0.17
89 INT261760 Il4 Positive_regulation of Phosphorylation of Stat6 1 0.50 0.48 0.16
90 INT302381 Il33 Regulation of Gene_expression of Il4 1 0.01 0.76 0.16
91 INT56596 Pomc Positive_regulation of Localization of Il4 1 0.20 0 0.15
92 INT186380 Binding of SOAT1 and Stat6 1 0.02 0.11 0.15
93 INT184098 Binding of Il4 and Socs5 1 0.09 2.05 0.15
94 INT305846 Polk Positive_regulation of Gene_expression of Il4 1 0.13 0.24 0.15
95 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14
96 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
97 INT334527 Sema3a Negative_regulation of Gene_expression of Il4 1 0.15 0.48 0.14
98 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
99 INT186357 Binding of Irf1 and Stat6 1 0.04 2.09 0.14
100 INT338422 Il4 Positive_regulation of Gtf3a 1 0.00 0.75 0.13
101 INT299262 Dep1 Positive_regulation of Gene_expression of Il4 1 0.03 0.82 0.13
102 INT330370 Positive_regulation of Binding of IL10 and Il4 1 0.01 0.47 0.13
103 INT194383 Il13 Positive_regulation of Gene_expression of Il4 1 0.00 1.75 0.13
104 INT194817 CD28 Positive_regulation of Il4 1 0.15 0.41 0.13
105 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
106 INT330369 Binding of IL10 and Il4 1 0.01 0.47 0.13
107 INT347017 Cd86 Positive_regulation of Gene_expression of Il4 1 0.03 0 0.13
108 INT69687 Tgfb1 Positive_regulation of Gene_expression of Il4 1 0.23 0 0.12
109 INT332250 Stat6 Positive_regulation of Gene_expression of Pdgfa 1 0.05 1.33 0.12
110 INT194814 Cd3e Positive_regulation of Gene_expression of Il4 1 0.05 0 0.12
111 INT332252 Stat6 Positive_regulation of Gene_expression of Il13 1 0.08 1.32 0.12
112 INT261762 Il3 Positive_regulation of Stat6 1 0.15 0 0.11
113 INT253078 Prok2 Negative_regulation of Il4 1 0.23 0.08 0.1
114 INT261761 Ifng Positive_regulation of Stat6 1 0.13 0 0.1
115 INT265211 Il4 Negative_regulation of Il23a 1 0.01 0.07 0.1
116 INT155945 Il4 Negative_regulation of Gene_expression of Tgif2 1 0.06 0.15 0.1
117 INT201348 Binding of Il4 and Ik 1 0.01 0.67 0.09
118 INT344427 Il4 Regulation of Gene_expression of Siglec5 1 0.14 0.35 0.09
119 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
120 INT311988 Il4 Positive_regulation of Mthfd1 1 0.08 0.28 0.08
121 INT278218 Hand1 Negative_regulation of Gene_expression of Il4 1 0.20 0.37 0.08
122 INT188361 Il4 Positive_regulation of Socs1 1 0.14 0.15 0.08
123 INT300655 Il4 Positive_regulation of Gene_expression of IFN1@ 1 0.22 0.82 0.08
124 INT194824 Il4 Positive_regulation of MAPK1 1 0.26 0 0.07
125 INT186366 Binding of Stat1 and Stat6 1 0.12 1.04 0.07
126 INT194834 Il4 Positive_regulation of Positive_regulation of MAPK1 1 0.18 0 0.06
127 INT194831 CD28 Positive_regulation of Gene_expression of Il4 1 0.15 0 0.06
128 INT228749 Il10 Regulation of Gene_expression of Il4 1 0.11 0.21 0.05
129 INT342042 Il4 Positive_regulation of Gene_expression of Il13 1 0.03 0 0.05
130 INT228763 Il4 Regulation of Gene_expression of Il13 1 0.15 0.21 0.05
131 INT228741 Il13 Regulation of Gene_expression of Il4 1 0.15 0.21 0.05
132 INT228756 Il5 Regulation of Gene_expression of Il4 1 0.13 0.21 0.05
133 INT228755 Il4 Regulation of Gene_expression of Il5 1 0.13 0.21 0.05
134 INT294765 Negative_regulation of Serpinb1-ps1 Positive_regulation of Il4 1 0.02 0.24 0.05
135 INT347016 Cd86 Regulation of Gene_expression of Il4 1 0.03 0.19 0.04
136 INT344430 Il4 Positive_regulation of Siglec5 1 0.23 0 0.04
137 INT344432 Il4 Positive_regulation of Gene_expression of Siglec5 1 0.32 0 0.04
138 INT186359 Stat6 Negative_regulation of Il4 1 0.06 0.78 0.04
139 INT186362 Il4 Negative_regulation of Transcription of Nos2 1 0.04 0.77 0.04
140 INT186360 Stat6 Negative_regulation of Transcription of Nos2 1 0.08 0.78 0.04
141 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
142 INT294759 Serpinb1-ps1 Positive_regulation of Il4 1 0.02 0.24 0.04
143 INT186363 Binding of Stat6 and Positive_regulation of Positive_regulation of Irf2 1 0.05 0.4 0.03
144 INT329973 Il4 Regulation of Gene_expression of Hspb8 1 0.00 0.68 0.03
145 INT186384 Il4 Negative_regulation of Gene_expression of IFNA1 1 0.01 0.48 0.03
146 INT261383 Nsdhl Positive_regulation of Gene_expression of Il4 1 0.03 0.46 0.03
147 INT186354 Stat6 Positive_regulation of Positive_regulation of Irf2 1 0.06 0.4 0.03
148 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0
149 INT347013 Il4 Regulation of Gene_expression of Cd86 1 0.02 0.07 0
150 INT270204 TNF Positive_regulation of Il4 1 0.01 0.53 0
151 INT305852 Polk Positive_regulation of Positive_regulation of Il4 1 0.13 0.08 0
152 INT304167 Il4 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.94 0
153 INT184093 Negative_regulation of Il4 Positive_regulation of Stat6 1 0.08 0.93 0
154 INT278207 Ciita Negative_regulation of Transcription of Il4 1 0.31 0.79 0
155 INT243624 Stat6 Negative_regulation of Gene_expression of Twist1 1 0.30 0 0
156 INT304174 Binding of IL1B and Il4 1 0.00 0.96 0
157 INT134561 Cpe Negative_regulation of Gene_expression of Il4 1 0.11 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for T-helper 1 cell lineage commitment. They are ordered first by their pain relevance and then by number of times they were reported in T-helper 1 cell lineage commitment. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12
2 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42
3 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4
4 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75
5 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34
6 INT20379 Localization of Il4 85 0.73 51.22 20.55
7 INT69303 Positive_regulation of Gene_expression of Il4 27 0.68 20.01 14.8
8 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15
9 INT55886 Negative_regulation of Gene_expression of Il4 47 0.57 26.04 11.42
10 INT49884 Negative_regulation of Gene_expression of Il4 18 0.55 14.06 8.9
11 INT79693 Regulation of Il4 30 0.51 21.96 8.6
12 INT70303 Negative_regulation of Il4 19 0.52 12.9 8.54
13 INT50040 Localization of Il4 15 0.67 8.26 7.69
14 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39
15 INT58484 Regulation of Il4 12 0.45 8.67 6.09
16 INT67397 Transcription of Il4 15 0.54 11.36 6.06
17 INT67228 Regulation of Gene_expression of Il4 11 0.50 6.67 5.2
18 INT56594 Positive_regulation of Localization of Il4 17 0.48 10.17 4.15
19 INT62497 Binding of Il4 7 0.26 4.19 3.88
20 INT92200 Negative_regulation of Localization of Il4 10 0.51 5.66 3.65
21 INT70919 Binding of Il4 19 0.36 6.58 3.59
22 INT97438 Transcription of Il4 17 0.67 9.17 3.4
23 INT157049 Regulation of Localization of Il4 2 0.25 1.46 2.33
24 INT92119 Negative_regulation of Positive_regulation of Il4 3 0.14 1.88 2.2
25 INT129240 Positive_regulation of Stat6 6 0.67 1.96 1.92
26 INT76417 Positive_regulation of Positive_regulation of Il4 3 0.09 0.34 1.7
27 INT97434 Positive_regulation of Positive_regulation of Il4 8 0.40 3.51 1.66
28 INT186286 Phosphorylation of Stat6 18 0.79 5.07 1.61
29 INT184241 Regulation of Localization of Il4 4 0.15 3.89 1.58
30 INT118400 Positive_regulation of Transcription of Il4 2 0.35 1.78 1.53
31 INT199482 Transcription of Stat6 1 0.25 1.75 1.39
32 INT147976 Regulation of Positive_regulation of Il4 2 0.32 2.25 1.23
33 INT59319 Negative_regulation of Positive_regulation of Il4 6 0.57 3.48 1.17
34 INT176606 Gene_expression of Stat6 9 0.65 6.87 0.77
35 INT129448 Positive_regulation of Stat6 1 0.27 0.17 0.7
36 INT186299 Negative_regulation of Stat6 6 0.42 3.61 0.62
37 INT165851 Phosphorylation of Stat6 1 0.54 0.69 0.59
38 INT186292 Positive_regulation of Negative_regulation of Il4 3 0.14 1.57 0.58
39 INT82425 Positive_regulation of Localization of Il4 1 0.45 0.69 0.58
40 INT237765 Phosphorylation of Il4 3 0.33 1.28 0.51
41 INT114293 Binding of Stat6 2 0.44 1.29 0.5
42 INT114290 Negative_regulation of Binding of Stat6 1 0.53 0.91 0.49
43 INT177622 Negative_regulation of Localization of Il4 2 0.03 1.42 0.42
44 INT243603 Localization of Stat6 6 0.68 2.96 0.4
45 INT97436 Positive_regulation of Transcription of Il4 3 0.51 1.8 0.38
46 INT335847 Positive_regulation of Phosphorylation of Il4 1 0.17 0.85 0.32
47 INT278194 Protein_catabolism of Il4 2 0.57 1.12 0.3
48 INT67400 Negative_regulation of Transcription of Il4 1 0.04 1.71 0.29
49 INT261750 Negative_regulation of Phosphorylation of Stat6 1 0.42 0.48 0.25
50 INT97435 Regulation of Transcription of Il4 2 0.45 0.32 0.18
51 INT235514 Positive_regulation of Transcription of Stat6 1 0.12 0.89 0.14
52 INT235506 Transcription of Stat6 1 0.17 0.89 0.14
53 INT261753 Positive_regulation of Phosphorylation of Stat6 2 0.45 2.49 0.12
54 INT278201 Negative_regulation of Transcription of Il4 1 0.27 0.28 0.08
55 INT176605 Positive_regulation of Gene_expression of Stat6 1 0.49 1.06 0.08
56 INT338402 Regulation of Positive_regulation of Il4 1 0.19 0.53 0.07
57 INT298029 Positive_regulation of Regulation of Il4 1 0.15 0.39 0.04
58 INT261752 Protein_catabolism of Stat6 1 0.86 0.15 0.04
59 INT184046 Positive_regulation of Positive_regulation of Stat6 1 0.32 0.92 0
60 INT277670 Negative_regulation of Gene_expression of Stat6 1 0.14 2.12 0
61 INT277668 Positive_regulation of Localization of Stat6 1 0.14 2 0
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