GO:0002437

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Name inflammatory response to antigenic stimulus
Categary Process
Go Slim No
Go Link GO:0002437
Unique Molecular Interactions 94
Total Molecular Interactions 130
Total Single Events 871
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for inflammatory response to antigenic stimulus. They are ordered first by their pain relevance and then by number of times they were reported for inflammatory response to antigenic stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
2 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
3 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
4 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98
5 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
6 INT275390 Binding of Ccr5 and Htatsf1 1 0.01 3.26 0.97
7 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
8 INT103930 Cps1 Negative_regulation of Gene_expression of Il2ra 1 0.02 0.25 0.93
9 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
10 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
11 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86
12 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86
13 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
14 INT178577 CNTN2 Positive_regulation of IL2RA 1 0.03 2.16 0.75
15 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
16 INT281130 Ccl2 Regulation of Gene_expression of Ccr2 1 0.04 1.09 0.64
17 INT281134 Ccl2 Positive_regulation of Gene_expression of Ccr2 1 0.08 1.09 0.64
18 INT329961 Binding of IL2RA and PTPN22 1 0.35 1.87 0.63
19 INT281122 Ccl2 Regulation of Ccr2 1 0.04 1.09 0.63
20 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55
21 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
22 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
23 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55
24 INT275387 Binding of Lamp1 and Ccr5 1 0.01 1.45 0.52
25 INT275405 Binding of GOLPH3 and Ccr5 1 0.00 1.46 0.52
26 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
27 INT103936 Cps1 Negative_regulation of Il2ra 1 0.02 0.07 0.46
28 INT275407 Binding of ERVW-1 and Ccr5 1 0.00 1.74 0.46
29 INT281126 Binding of Ccr2 and Cxcr4 1 0.30 0.32 0.44
30 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37
31 INT123511 TIAF1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0.6 0.37
32 INT163909 CCL2 Positive_regulation of Positive_regulation of Ccr2 1 0.05 0.19 0.36
33 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
34 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
35 INT163908 CCL2 Positive_regulation of Ccr2 1 0.05 0.2 0.35
36 INT351007 Binding of IL2 and IL2RA 1 0.33 1.33 0.26
37 INT226533 Il25 Positive_regulation of Gene_expression of IL13 1 0.01 0.64 0.24
38 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24
39 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23
40 INT338421 Il2ra Negative_regulation of Gene_expression of Ik 1 0.00 1.27 0.22
41 INT18965 TNF Positive_regulation of IL2RA 1 0.06 0.83 0.2
42 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
43 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
44 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2
45 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2
46 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2
47 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
48 INT266404 Binding of HMGB1 and Thbd 1 0.06 0.3 0.2
49 INT226335 Binding of IL20 and IL20RB 1 0.03 0.29 0.19
50 INT226370 Binding of IL24 and IL20RB 1 0.03 0.28 0.19
51 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16
52 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
53 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
54 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
55 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
56 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14
57 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14
58 INT352417 Ccl2 Positive_regulation of Ccr5 1 0.06 0.26 0.14
59 INT338427 Il25 Positive_regulation of Ik 1 0.00 0.61 0.14
60 INT352416 Ccl2 Positive_regulation of Ccr2 1 0.23 0.26 0.14
61 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
62 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
63 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
64 INT338425 Il9 Positive_regulation of Gene_expression of Il5ra 1 0.07 0.26 0.07
65 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07
66 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
67 INT178574 IL2RA Positive_regulation of Gene_expression of Cd3e 1 0.04 0.16 0.05
68 INT349314 Binding of Notch1 and Notch3 1 0.11 0.67 0.04
69 INT248953 Il2ra Regulation of Gene_expression of Cd4 1 0.20 0 0.04
70 INT226506 Maf Positive_regulation of Positive_regulation of Il2ra 1 0.02 0.22 0.04
71 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03
72 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
73 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0
74 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
75 INT301246 Binding of HMGB1 and Hbp1 1 0.03 0.74 0
76 INT22669 Binding of ITPA and PNMA1 1 0.02 0 0
77 INT327873 Postn Regulation of Notch1 1 0.41 0 0
78 INT356083 Binding of App and Notch1 1 0.02 0.2 0
79 INT193949 Alph1 Positive_regulation of Notch1 1 0.01 0.08 0
80 INT163092 Notch2 Positive_regulation of Gene_expression of Fos 1 0.08 0.07 0
81 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0
82 INT193950 Alph1 Positive_regulation of Positive_regulation of Notch1 1 0.01 0.07 0
83 INT22668 PNMA1 Regulation of SERPINE1 1 0.03 0 0
84 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
85 INT264727 Binding of Notch1 and Mir199b 1 0.00 0.86 0
86 INT22675 Binding of USP6 and PNMA1 1 0.02 0 0
87 INT264728 Mir199b Regulation of Notch1 1 0.01 0.85 0
88 INT264726 Binding of Notch1 and Gtf3a 1 0.00 1.68 0
89 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0
90 INT193947 Notch1 Positive_regulation of Alph1 1 0.01 0.07 0
91 INT299456 Binding of Gabpa and Notch1 1 0.21 0.09 0
92 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
93 INT256386 Il2ra Positive_regulation of Cd4 1 0.41 0.15 0
94 INT273887 Binding of Jag1 and Notch2 1 0.02 1.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for inflammatory response to antigenic stimulus. They are ordered first by their pain relevance and then by number of times they were reported in inflammatory response to antigenic stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
2 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66
3 INT151434 Positive_regulation of Ccr2 26 0.68 18.34 16.34
4 INT87393 Gene_expression of Ccr5 19 0.65 11 10.51
5 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98
6 INT88047 Positive_regulation of Gene_expression of Ccr2 15 0.60 10.5 8.63
7 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95
8 INT103847 Positive_regulation of Ccr5 11 0.55 6.04 5.79
9 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
10 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55
11 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
12 INT103843 Positive_regulation of Gene_expression of Ccr5 5 0.42 2.31 3.89
13 INT184288 Localization of HMGB1 20 0.61 14.5 3.84
14 INT222241 Binding of Ccr2 5 0.42 4.09 3.71
15 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
16 INT10188 Positive_regulation of Il2ra 19 0.45 11.6 3.37
17 INT281144 Regulation of Gene_expression of Ccr2 2 0.44 2.38 3.29
18 INT61087 Positive_regulation of Gene_expression of Il2ra 12 0.35 9.1 3.25
19 INT10189 Negative_regulation of Gene_expression of Il2ra 8 0.32 8.05 2.91
20 INT222237 Negative_regulation of Gene_expression of Ccr2 3 0.37 3.39 2.91
21 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
22 INT151436 Regulation of Ccr2 4 0.44 2.81 2.82
23 INT222226 Negative_regulation of Ccr2 6 0.57 3.69 2.66
24 INT87395 Binding of Ccr5 5 0.29 2.5 2.6
25 INT184272 Binding of HMGB1 14 0.37 8.78 2.49
26 INT83325 Regulation of Gene_expression of Il2ra 8 0.48 3.59 2.36
27 INT96743 Transcription of Ccr5 2 0.54 2.72 2.17
28 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
29 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
30 INT47914 Regulation of Il2ra 5 0.18 3.05 1.86
31 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
32 INT87394 Negative_regulation of Ccr5 3 0.32 1.3 1.74
33 INT25163 Positive_regulation of Gene_expression of IL2RA 8 0.45 5.37 1.71
34 INT46766 Negative_regulation of Il2ra 9 0.57 5.27 1.64
35 INT157357 Binding of IL2RA 6 0.44 5.18 1.63
36 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58
37 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
38 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53
39 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
40 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
41 INT110780 Localization of Notch1 2 0.06 0.47 1.19
42 INT281139 Phosphorylation of Ccr2 2 0.79 1.2 1.18
43 INT281141 Positive_regulation of Phosphorylation of Ccr2 2 0.49 1.2 1.18
44 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16
45 INT35095 Negative_regulation of Notch2 3 0.36 0.06 1.15
46 INT222235 Localization of Ccr2 7 0.73 5.32 1.12
47 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
48 INT151435 Negative_regulation of Positive_regulation of Ccr2 1 0.53 0.7 1.08
49 INT6833 Binding of Notch1 4 0.36 0.05 0.94
50 INT87396 Negative_regulation of Gene_expression of Ccr5 1 0.12 1.02 0.92
51 INT82443 Negative_regulation of Positive_regulation of Il2ra 1 0.05 0 0.86
52 INT64827 Binding of Il2ra 5 0.36 6.57 0.79
53 INT50954 Regulation of IL2RA 5 0.25 3.09 0.77
54 INT222239 Transcription of Ccr2 2 0.61 1.15 0.73
55 INT57510 Regulation of Notch2 1 0.05 0 0.73
56 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
57 INT115892 Positive_regulation of Phosphorylation of Ccr5 1 0.00 0 0.66
58 INT115896 Phosphorylation of Ccr5 1 0.01 0 0.65
59 INT226409 Gene_expression of Il25 3 0.09 2.38 0.63
60 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
61 INT184277 Regulation of Localization of HMGB1 1 0.37 1.15 0.58
62 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
63 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
64 INT79888 Gene_expression of Notch2 3 0.43 0.39 0.54
65 INT222242 Positive_regulation of Transcription of Ccr2 1 0.44 0.66 0.52
66 INT103844 Regulation of Gene_expression of Ccr5 1 0.22 0.55 0.51
67 INT343799 Negative_regulation of Transcription of HMGB1 1 0.32 0.37 0.5
68 INT220339 Transcription of HMGB1 2 0.53 2.03 0.49
69 INT281147 Regulation of Binding of Ccr2 1 0.39 0.86 0.46
70 INT87392 Regulation of Ccr5 1 0.17 0.53 0.46
71 INT178589 Localization of IL2RA 3 0.68 1.99 0.45
72 INT219178 Negative_regulation of Localization of HMGB1 1 0.22 1.26 0.45
73 INT226410 Positive_regulation of Gene_expression of Il25 2 0.07 1.55 0.44
74 INT222240 Positive_regulation of Transcription of Ccr5 1 0.37 0.7 0.4
75 INT35096 Negative_regulation of Negative_regulation of Notch2 1 0.36 0 0.4
76 INT228102 Localization of Il2ra 2 0.52 0.74 0.37
77 INT163905 Positive_regulation of Positive_regulation of Ccr2 1 0.13 0.16 0.37
78 INT322707 Protein_catabolism of Ccr5 1 0.22 0.32 0.37
79 INT174795 Positive_regulation of Il25 1 0.08 0.81 0.31
80 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3
81 INT254175 Binding of Il25 1 0.04 0.15 0.24
82 INT150252 Negative_regulation of IL2RA 3 0.41 1.73 0.23
83 INT316049 Regulation of Regulation of Notch1 1 0.03 0.92 0.23
84 INT226386 Regulation of Il25 1 0.04 0.63 0.23
85 INT220336 Negative_regulation of HMGB1 3 0.43 0.97 0.21
86 INT266367 Positive_regulation of Binding of HMGB1 1 0.26 0.31 0.21
87 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2
88 INT193945 Binding of Notch1 7 0.15 1.28 0.19
89 INT69685 Gene_expression of Il5ra 2 0.22 0.25 0.19
90 INT226387 Transcription of Il25 1 0.08 0.82 0.19
91 INT266364 Protein_catabolism of HMGB1 1 0.34 0.29 0.19
92 INT226496 Localization of IL20RB 1 0.34 0.23 0.18
93 INT266353 Negative_regulation of Binding of HMGB1 1 0.22 0.22 0.17
94 INT338415 Negative_regulation of Il25 1 0.10 0.77 0.16
95 INT11050 Regulation of Gene_expression of IL2RA 3 0.41 1.4 0.15
96 INT157356 Negative_regulation of Gene_expression of IL2RA 1 0.07 1.14 0.14
97 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13
98 INT316042 Negative_regulation of Gene_expression of Notch1 1 0.27 1.7 0.12
99 INT69679 Negative_regulation of Gene_expression of Il5ra 1 0.07 0 0.12
100 INT206737 Negative_regulation of Gene_expression of HMGB1 3 0.32 3.48 0.09
101 INT322703 Negative_regulation of Binding of Ccr5 1 0.32 0.41 0.09
102 INT123904 Positive_regulation of Positive_regulation of Il2ra 1 0.14 0.34 0.08
103 INT327728 Regulation of Gene_expression of Notch1 2 0.27 0.73 0.07
104 INT352409 Regulation of Positive_regulation of Ccr2 1 0.44 0.15 0.07
105 INT276306 Transcription of Il2ra 1 0.07 1.04 0.07
106 INT193845 Localization of Notch1 2 0.78 0.32 0.05
107 INT193850 Regulation of Localization of Notch1 1 0.14 0.33 0.05
108 INT351018 Phosphorylation of IL2RA 1 0.79 0.64 0.05
109 INT351014 Transcription of IL2RA 1 0.48 1.54 0.05
110 INT298336 Phosphorylation of Notch1 1 0.02 0.13 0.04
111 INT299469 Regulation of HMGB1 2 0.18 2.27 0.03
112 INT266358 Regulation of Binding of HMGB1 1 0.14 0 0.03
113 INT232397 Protein_catabolism of Notch1 3 0.64 1.56 0
114 INT163086 Positive_regulation of Notch2 2 0.31 1.29 0
115 INT299470 Regulation of Gene_expression of HMGB1 1 0.18 1.58 0
116 INT297242 Transcription of Notch1 1 0.19 0.25 0
117 INT125015 Regulation of Positive_regulation of Il2ra 1 0.06 0 0
118 INT264724 Negative_regulation of Positive_regulation of Notch1 1 0.03 0.77 0
119 INT22678 Binding of PNMA1 1 0.02 0 0
120 INT160503 Negative_regulation of Binding of Il2ra 1 0.03 0 0
121 INT163089 Negative_regulation of Gene_expression of Notch2 1 0.07 0.07 0
122 INT163088 Positive_regulation of Gene_expression of Notch2 1 0.08 0.07 0
123 INT163087 Positive_regulation of Negative_regulation of Notch2 1 0.08 0.06 0
124 INT264723 Negative_regulation of Gene_expression of Notch1 1 0.03 0.83 0
125 INT327858 Positive_regulation of Protein_catabolism of Notch1 1 0.45 0.13 0
126 INT327861 Positive_regulation of Localization of Notch1 1 0.67 0 0
127 INT273836 Positive_regulation of Regulation of Notch1 1 0.15 0.05 0
128 INT237159 Phosphorylation of Il2ra 1 0.15 0 0
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