GO:0002467

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Name germinal center formation
Categary Process
Go Slim No
Go Link GO:0002467
Unique Molecular Interactions 63
Total Molecular Interactions 76
Total Single Events 449
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for germinal center formation. They are ordered first by their pain relevance and then by number of times they were reported for germinal center formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07
2 INT182207 Binding of CXCR2 and CXCL13 1 0.42 1.26 0.95
3 INT182210 Binding of CXCR4 and CXCL13 1 0.32 1.25 0.95
4 INT182189 Binding of CXCL1 and CXCL13 1 0.14 1.24 0.93
5 INT182209 Binding of CXCL12 and CXCL13 1 0.30 1.24 0.93
6 INT182196 Binding of IL8 and CXCL13 1 0.27 1.24 0.93
7 INT182204 Binding of CXCL5 and CXCL13 1 0.30 1.24 0.93
8 INT325807 CXCL13 Positive_regulation of CISH 1 0.16 3.65 0.89
9 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
10 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
11 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
12 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
13 INT224419 Binding of NFKB2 and TNFRSF11B 1 0.11 1.37 0.6
14 INT224420 Regulation of Binding of NFKB2 and TNFRSF11B 1 0.13 1.39 0.6
15 INT191947 NFKB2 Positive_regulation of Gene_expression of NOS2 1 0.08 1.51 0.52
16 INT191950 NFKB2 Regulation of Gene_expression of NOS2 1 0.08 1 0.47
17 INT236832 CSF2 Regulation of CXCL13 1 0.09 0.34 0.45
18 INT344748 NFKB2 Regulation of Gene_expression of GAD1 1 0.07 0.87 0.33
19 INT222976 NFKBIB Negative_regulation of NFKB2 1 0.01 1.58 0.32
20 INT191949 NFKB2 Positive_regulation of NOS2 1 0.05 1.16 0.31
21 INT224422 Regulation of Binding of NFKB2 and TNFSF11 1 0.13 0.69 0.3
22 INT224418 Binding of NFKB2 and TNFSF11 1 0.11 0.68 0.3
23 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26
24 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
25 INT221416 Binding of IL1B and Positive_regulation of NFKB2 1 0.02 0.88 0.23
26 INT269994 Binding of Nfkb2 and Tpx2 1 0.04 0.51 0.21
27 INT269995 Positive_regulation of Binding of Nfkb2 and Tpx2 1 0.05 0.51 0.21
28 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18
29 INT91455 IL1B Positive_regulation of Phosphorylation of NFKB2 1 0.05 0.47 0.12
30 INT91458 IL1B Positive_regulation of Positive_regulation of NFKB2 1 0.08 0.47 0.12
31 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11
32 INT263450 NFKB2 Positive_regulation of Protein_catabolism of NFKBIA 1 0.17 0.17 0.09
33 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
34 INT350700 Binding of Bcl6 and thd 1 0.00 0.21 0.08
35 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
36 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08
37 INT350692 Binding of Bcl6 and Hand1 1 0.02 0.16 0.08
38 INT350720 Binding of Bcl6 and TBX21 1 0.07 0.22 0.08
39 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
40 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
41 INT236466 SNRPB Positive_regulation of NFKB2 1 0.00 0.21 0.05
42 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
43 INT172716 Binding of BCL3 and NFKB1 1 0.06 0.15 0.03
44 INT354097 Timp1 Negative_regulation of Localization of NFKB2 1 0.04 0.94 0
45 INT149193 TNF Positive_regulation of Gene_expression of NFKB2 1 0.11 0.07 0
46 INT292150 Binding of NFKB2 and REL 1 0.01 0.4 0
47 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
48 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
49 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0
50 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
51 INT149194 TNF Positive_regulation of NFKB2 1 0.16 0.05 0
52 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
53 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
54 INT292159 Binding of NFKB2 and RELA 1 0.02 0.4 0
55 INT285396 Binding of Adam17 and R3hcc1 1 0.15 0.93 0
56 INT322470 Binding of Bcl6 and Hif1a 1 0.06 0.52 0
57 INT354096 Timp1 Negative_regulation of Positive_regulation of NFKB2 1 0.04 0.94 0
58 INT149189 Negative_regulation of TNF Positive_regulation of NFKB2 1 0.13 0.05 0
59 INT149190 TNF Positive_regulation of Transcription of NFKB2 1 0.11 0.13 0
60 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for germinal center formation. They are ordered first by their pain relevance and then by number of times they were reported in germinal center formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96
2 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
3 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81
4 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6
5 INT149197 Negative_regulation of NFKB2 14 0.25 10.55 4.46
6 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
7 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
8 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73
9 INT236842 Positive_regulation of Gene_expression of CXCL13 6 0.32 3.91 2.55
10 INT182238 Binding of CXCL13 5 0.33 5.32 2.37
11 INT243689 Regulation of NFKB2 1 0.35 2.72 1.97
12 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
13 INT264881 Localization of CXCL13 4 0.42 9.52 1.85
14 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
15 INT221433 Binding of NFKB2 6 0.11 4.74 1.7
16 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56
17 INT130260 Gene_expression of Nfkb2 7 0.60 3.85 1.43
18 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
19 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
20 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22
21 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
22 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
23 INT236841 Negative_regulation of Gene_expression of CXCL13 3 0.27 2.17 0.83
24 INT182227 Transcription of CXCL13 2 0.60 2.07 0.81
25 INT95667 Positive_regulation of Nfkb2 3 0.22 3.95 0.8
26 INT191952 Negative_regulation of Positive_regulation of NFKB2 4 0.11 3.31 0.76
27 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
28 INT325809 Positive_regulation of Positive_regulation of CXCL13 1 0.28 1.19 0.64
29 INT191951 Negative_regulation of Gene_expression of NFKB2 2 0.24 1.34 0.62
30 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58
31 INT211808 Localization of NFKB2 4 0.19 4.17 0.58
32 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
33 INT221432 Positive_regulation of Binding of NFKB2 2 0.12 1.59 0.53
34 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
35 INT263327 Positive_regulation of Positive_regulation of NFKB2 2 0.08 2.95 0.42
36 INT251556 Localization of Adam17 2 0.38 2 0.39
37 INT319417 Positive_regulation of Localization of CXCL13 1 0.23 3.84 0.36
38 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
39 INT78862 Negative_regulation of Adam17 3 0.36 1.76 0.32
40 INT149196 Transcription of NFKB2 4 0.15 1.35 0.31
41 INT187284 Positive_regulation of Gene_expression of Adam17 3 0.20 1.32 0.29
42 INT221435 Positive_regulation of Localization of NFKB2 1 0.16 0.6 0.29
43 INT236843 Negative_regulation of CXCL13 1 0.27 0.24 0.29
44 INT262903 Negative_regulation of Binding of NFKB2 1 0.06 0.85 0.27
45 INT319429 Positive_regulation of Transcription of CXCL13 1 0.23 1.19 0.26
46 INT180101 Phosphorylation of Adam17 3 0.37 0.25 0.24
47 INT78865 Localization of Adam17 1 0.43 0.34 0.23
48 INT202355 Transcription of Mef2c 3 0.69 0.6 0.21
49 INT325808 Regulation of Gene_expression of CXCL13 1 0.25 0.95 0.21
50 INT248543 Positive_regulation of Mef2c 7 0.69 2.82 0.18
51 INT54080 Regulation of Nfkb2 2 0.02 0.11 0.17
52 INT277602 Binding of Mef2c 10 0.39 4.35 0.16
53 INT138679 Regulation of ADAM17 1 0.19 1.13 0.16
54 INT138680 Binding of ADAM17 1 0.36 1.42 0.16
55 INT236693 Positive_regulation of Gene_expression of Bcl6 3 0.15 2.06 0.14
56 INT258953 Negative_regulation of Gene_expression of Bcl6 1 0.19 1.53 0.14
57 INT169349 Regulation of Adam17 1 0.37 0.97 0.13
58 INT354094 Negative_regulation of Localization of NFKB2 1 0.08 1.35 0.12
59 INT269968 Positive_regulation of Binding of Nfkb2 1 0.33 0.26 0.11
60 INT258955 Localization of Bcl6 1 0.23 0.83 0.11
61 INT91460 Phosphorylation of NFKB2 1 0.06 0.46 0.11
62 INT307233 Localization of BCL3 1 0.19 0.84 0.11
63 INT269964 Binding of Nfkb2 1 0.25 0.26 0.11
64 INT138677 Negative_regulation of Transcription of ADAM17 1 0.42 1.18 0.1
65 INT187285 Protein_catabolism of Adam17 1 0.12 0.94 0.09
66 INT356064 Regulation of Negative_regulation of Adam17 1 0.23 0.24 0.08
67 INT356054 Regulation of Phosphorylation of Adam17 1 0.20 0.25 0.08
68 INT180096 Positive_regulation of Phosphorylation of Adam17 1 0.07 0 0.08
69 INT290404 Positive_regulation of Negative_regulation of Mef2c 1 0.50 0.72 0.08
70 INT350635 Transcription of Bcl6 1 0.09 0.16 0.08
71 INT202480 Localization of Nfkb2 1 0.56 0.37 0.08
72 INT350649 Negative_regulation of Transcription of Bcl6 1 0.06 0.16 0.08
73 INT277578 Regulation of Negative_regulation of Mef2c 2 0.45 1.17 0.07
74 INT290417 Positive_regulation of Gene_expression of Mef2c 1 0.50 1.25 0.06
75 INT307236 Negative_regulation of Localization of BCL3 1 0.10 0.33 0.05
76 INT180094 Binding of Adam17 1 0.06 0 0.05
77 INT290407 Positive_regulation of Binding of Mef2c 1 0.44 0.93 0.04
78 INT290419 Regulation of Gene_expression of Mef2c 1 0.62 0.41 0.03
79 INT290399 Negative_regulation of Gene_expression of Mef2c 1 0.59 0.59 0.03
80 INT322454 Positive_regulation of Bcl6 2 0.10 1.6 0
81 INT348458 Regulation of Gene_expression of NFKB2 1 0.19 0.87 0
82 INT290400 Regulation of Regulation of Mef2c 1 0.45 0.24 0
83 INT150259 Regulation of Negative_regulation of Nfkb2 1 0.02 0.11 0
84 INT290429 Negative_regulation of Negative_regulation of Mef2c 1 0.37 0.05 0
85 INT150262 Negative_regulation of Nfkb2 1 0.05 0.11 0
86 INT290425 Negative_regulation of Binding of Mef2c 1 0.37 0 0
87 INT277796 Binding of Bcl6 1 0.17 1.33 0
88 INT290409 Negative_regulation of Transcription of Mef2c 1 0.43 0.08 0
89 INT287489 Negative_regulation of Negative_regulation of NFKB2 1 0.13 0.45 0
90 INT150260 Negative_regulation of Regulation of Nfkb2 1 0.04 0.11 0
91 INT307232 Negative_regulation of BCL3 1 0.09 0.24 0
92 INT149195 Negative_regulation of Transcription of NFKB2 1 0.09 0.05 0
93 INT277587 Localization of Mef2c 1 0.65 0.43 0
94 INT354095 Protein_catabolism of NFKB2 1 0.12 0.99 0
95 INT285394 Binding of Adam17 1 0.31 0.93 0
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