GO:0002480

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Name antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
Categary Process
Go Slim No
Go Link GO:0002480
Unique Molecular Interactions 148
Total Molecular Interactions 262
Total Single Events 2121
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent. They are ordered first by their pain relevance and then by number of times they were reported for antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4
2 INT172047 Binding of HLA-A and LRRC23 1 0.22 3.32 1.64
3 INT174503 Binding of HLA-B and KIR3DL1 6 0.37 3.48 1.61
4 INT107965 Binding of HLA-B and Mefv 2 0.34 3.91 1.61
5 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
6 INT55837 Binding of HLA-B and PHB2 3 0.20 3.52 1.37
7 INT184402 Binding of HLA-DRB4 and HLA-E 1 0.00 3.1 1.19
8 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14
9 INT107269 Binding of HLA-A and NCR3 1 0.35 1.42 1.1
10 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 0.02 0.97 1.1
11 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1
12 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
13 INT143323 Binding of HLA-B and HP 1 0.04 0.95 0.93
14 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
15 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88
16 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
17 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71
18 INT240729 Binding of CRP and HLA-A 1 0.11 2.18 0.71
19 INT28711 Binding of HLA-B and MRAP 2 0.23 0.96 0.69
20 INT169101 Binding of HLA-A and HLA-DRB1 1 0.24 1.09 0.63
21 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
22 INT122096 Binding of HLA-B and SFTPA1 2 0.04 1.81 0.6
23 INT174504 Binding of HLA-B and KIR3DL2 2 0.24 1.69 0.59
24 INT87683 Binding of HLA-B and Prnd 1 0.00 0.59 0.59
25 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58
26 INT162742 Binding of HLA-A and KIR3DL1 1 0.40 0.68 0.58
27 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
28 INT341593 Binding of HLA-E and IL23R 1 0.15 1.15 0.5
29 INT36143 Binding of SERPINH1 and HLA-B 1 0.00 0.66 0.49
30 INT348173 Binding of HLA-B and IL23R 1 0.15 0.92 0.49
31 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49
32 INT172096 Binding of HLA-E and Il27ra 2 0.01 1.32 0.48
33 INT328936 Binding of HLA-B and KIR3DS1 1 0.25 0.7 0.48
34 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47
35 INT48848 Binding of HLA-B and HLA-E 3 0.34 1.95 0.45
36 INT45035 Binding of HLA-B and HLA-DRB4 2 0.16 0.74 0.44
37 INT79151 Binding of HLA-B and OLAH 1 0.01 0.79 0.44
38 INT174507 Binding of HLA-B and LILRB4 1 0.02 1.16 0.43
39 INT79150 HLA-B Positive_regulation of OLAH 1 0.02 0.77 0.43
40 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42
41 INT328935 Binding of HLA-G and KIR2DS4 1 0.39 0.75 0.41
42 INT184406 Binding of HLA-DRB1 and HLA-E 1 0.00 1.03 0.4
43 INT349290 Binding of HLA-B and SPATA19 1 0.00 1.25 0.4
44 INT183924 Binding of CHI3L1 and HLA-E 1 0.08 0.9 0.39
45 INT127587 Binding of HLA-B and CD300A 1 0.00 0.84 0.38
46 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
47 INT118285 Binding of EFNA1 and HLA-B 1 0.03 0.29 0.37
48 INT204091 Binding of HLA-G and KIR2DL1 1 0.15 0.86 0.32
49 INT227760 Binding of HLA-A and HLA-B 1 0.20 3.35 0.3
50 INT160923 Binding of ACLS and HLA-B 1 0.03 1.44 0.29
51 INT160924 Binding of ACLS and HLA-A 1 0.01 1.44 0.29
52 INT250951 Binding of HLA-E and SFTPA1 1 0.01 0.44 0.29
53 INT250958 Binding of HLA-A and SFTPA1 1 0.01 0.45 0.29
54 INT45048 Binding of HLA-B and TNFRSF10B 1 0.21 0.44 0.29
55 INT141882 Binding of CD8A and HLA-A 1 0.32 0.9 0.29
56 INT174499 Binding of CD4 and HLA-E 1 0.04 1.08 0.29
57 INT181843 PHB2 Regulation of HLA-B 1 0.03 1.4 0.28
58 INT71640 Binding of HLA-A and TYR 1 0.16 0.36 0.27
59 INT71642 Binding of HLA-A and PMEL 2 0.20 1.05 0.26
60 INT71643 Binding of HLA-A and TYRP1 1 0.24 0.36 0.26
61 INT174506 Binding of HLA-B and HLA-G 1 0.01 0.41 0.26
62 INT71641 Binding of MLANA and HLA-A 1 0.28 0.36 0.26
63 INT162743 Binding of HLA-A and TNFRSF10B 1 0.40 0.4 0.25
64 INT260870 Binding of HLA-E and IL7R 1 0.19 0.5 0.22
65 INT156251 Binding of HLA-A and Drb1 2 0.15 0.64 0.19
66 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19
67 INT66279 Binding of FLNB and HLA-B 1 0.41 0.57 0.19
68 INT42467 PTGER1 Negative_regulation of LNPEP 1 0.02 0 0.18
69 INT76078 Binding of HLA-A and TNFRSF10A 1 0.34 0.91 0.18
70 INT313799 Binding of HLA-B and TYRP1 1 0.01 0.54 0.18
71 INT111863 Negative_regulation of Binding of AGT and LNPEP 1 0.09 0 0.16
72 INT111861 Binding of AGT and LNPEP 1 0.07 0 0.16
73 INT19645 Binding of HLA-B and KLRD1 1 0.00 0.73 0.15
74 INT115356 Binding of HLA-G and ATP8A1 1 0.00 0.52 0.15
75 INT258906 Binding of HLA-B and HLA-DRB1 1 0.31 1.36 0.15
76 INT194134 Binding of HLA-E and IGAD1 1 0.02 1.01 0.15
77 INT194136 Binding of HLA-E and INS 1 0.01 0.95 0.15
78 INT194135 Binding of CD79A and HLA-E 1 0.07 1.01 0.15
79 INT68736 Binding of HLA-B and Tyr 1 0.01 0.23 0.14
80 INT98565 HLA-B Positive_regulation of Cd8a 1 0.03 0.63 0.14
81 INT142845 Binding of HLA-B and SAT1 1 0.35 0.61 0.12
82 INT181844 Binding of CD8A and HLA-B 1 0.14 1.82 0.12
83 INT298059 Binding of HLA-A and Vip 1 0.00 0.97 0.12
84 INT289629 Binding of HLA-DMB and HLA-E 1 0.10 0.84 0.11
85 INT289627 Binding of HLA-E and RS1 1 0.01 0.83 0.11
86 INT2993 Binding of HLA-B and SUGT1 1 0.00 0.6 0.1
87 INT92671 Binding of CEL and HLA-B 1 0.38 0.19 0.1
88 INT88238 HLA-B Regulation of Gene_expression of Gbp1 1 0.03 0.27 0.1
89 INT167041 Binding of HLA-A and Aip 1 0.02 0.54 0.1
90 INT219155 Binding of HLA-G and LILRB2 1 0.15 0.23 0.1
91 INT152034 Binding of HLA-A and RDBP 1 0.05 0.34 0.1
92 INT111866 Binding of LNPEP and CNOT4 1 0.02 0 0.09
93 INT132266 Binding of HLA-B and B2m 1 0.02 0.14 0.09
94 INT125089 Binding of HLA-B and TDGF1 1 0.24 0.18 0.09
95 INT111865 Binding of LNPEP and ANGPT4 1 0.06 0 0.09
96 INT147774 Binding of HLA-B and ABCB6 2 0.40 1.03 0.08
97 INT294116 CIITA Regulation of Gene_expression of HLA-E 1 0.05 0.05 0.08
98 INT331310 Binding of HLA-A and HLA-DOA 1 0.00 0.85 0.06
99 INT75234 Binding of HLA-B and BW6 1 0.39 0.06 0.06
100 INT56584 B2M Regulation of CDA 1 0.00 0.39 0.05
101 INT356238 Binding of HLA-E and PI3 1 0.02 0 0.05
102 INT97430 Binding of B2M and HLA-B 1 0.00 0.66 0.04
103 INT177948 IFNG Positive_regulation of Gene_expression of HLA-E 1 0.04 0.59 0.03
104 INT298058 Binding of HLA-A and Bpifa2 1 0.00 0.66 0.03
105 INT331324 Binding of HLA-G and Atp8a1 1 0.03 0.16 0.03
106 INT236235 HLA-A Positive_regulation of CD8A 1 0.01 1 0.03
107 INT331309 Binding of HLA-DOA and HLA-G 1 0.00 0.16 0.03
108 INT177947 IFN1@ Positive_regulation of Gene_expression of HLA-E 1 0.09 0.59 0.03
109 INT207031 Binding of HLA-C and HLA-E 1 0.35 0.1 0
110 INT186502 Binding of AMELX and HLA-A 1 0.00 0.71 0
111 INT92381 Binding of HLA-B and Tap1 1 0.01 0 0
112 INT129874 Binding of CST3 and CTSS 1 0.42 2.45 0
113 INT276136 Binding of DIO2 and HLA-E 1 0.26 0 0
114 INT252020 Binding of HLA-A and ELOVL1 1 0.01 1.41 0
115 INT300244 Binding of HLA-B and HSR 1 0.08 0.95 0
116 INT336764 ERAP2 Regulation of Gene_expression of HLA-E 1 0.24 0 0
117 INT247114 Binding of HLA-A and MPZ 1 0.00 6.26 0
118 INT275123 Binding of HLA-E and SUGT1 1 0.00 0.93 0
119 INT164332 Binding of HLA-E and KLRC2 1 0.00 0 0
120 INT111860 Negative_regulation of Binding of LNPEP and ANGPT4 1 0.07 0 0
121 INT215470 Binding of HLA-B and CRAMP1L 1 0.05 0.94 0
122 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
123 INT110162 Binding of HLA-B and HLA-DQB1 1 0.09 0 0
124 INT201080 Binding of APOE and HLA-C 1 0.41 0.31 0
125 INT261977 Binding of HLA-A and PDCD1 1 0.07 0.52 0
126 INT276138 Binding of COL19A1 and HLA-E 1 0.01 0.62 0
127 INT349077 Binding of HLA-E and KLRD1 1 0.00 0.16 0
128 INT250954 Binding of HLA-B and USO1 1 0.06 0.18 0
129 INT90819 Binding of HLA-B and MICA 1 0.05 0 0
130 INT74066 Binding of DR1 and HLA-B 1 0.00 0.08 0
131 INT258911 Binding of CD4 and HLA-G 1 0.04 0.06 0
132 INT336762 Negative_regulation of ERAP2 Negative_regulation of HLA-E 1 0.23 0.31 0
133 INT250955 Binding of HLA-B and SETDB1 1 0.01 0.08 0
134 INT150180 KIT Negative_regulation of Gene_expression of HLA-B 1 0.39 0.09 0
135 INT201082 Binding of APOE and HLA-B 1 0.54 1.54 0
136 INT258907 Binding of CD8A and HLA-G 1 0.05 0.07 0
137 INT301676 Binding of CD8A and HLA-E 1 0.02 2.24 0
138 INT313800 Binding of HLA-B and TYR 1 0.04 0.1 0
139 INT285399 Binding of DEFB1 and HLA-B 1 0.01 1.33 0
140 INT201079 Binding of HLA-B and HLA-C 1 0.40 1.36 0
141 INT336763 Binding of CD19 and HLA-A 1 0.01 0 0
142 INT174502 HLA-B Regulation of CD4 1 0.13 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent. They are ordered first by their pain relevance and then by number of times they were reported in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1878 Binding of HLA-B 440 0.48 321.16 127.36
2 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37
3 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72
4 INT19330 Binding of HLA-A 99 0.48 76.26 22.85
5 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08
6 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1
7 INT11699 Binding of HLA-E 85 0.47 52.51 13.41
8 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46
9 INT3353 Localization of HLA-B 25 0.75 16.05 8.62
10 INT28671 Positive_regulation of Gene_expression of HLA-E 43 0.67 22.85 8.39
11 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06
12 INT5284 Regulation of HLA-B 25 0.59 12.91 7.74
13 INT17618 Gene_expression of B2M 36 0.66 16.39 6.68
14 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97
15 INT64767 Negative_regulation of Gene_expression of HLA-E 18 0.57 12.64 5.23
16 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07
17 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88
18 INT10586 Localization of B2M 15 0.68 8.67 3.46
19 INT19331 Positive_regulation of HLA-A 12 0.49 7.72 3.28
20 INT16959 Positive_regulation of Binding of HLA-B 8 0.50 6.77 2.96
21 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94
22 INT65472 Binding of HLA-G 9 0.36 6.06 2.6
23 INT19492 Regulation of B2M 16 0.60 10.97 2.55
24 INT41549 Positive_regulation of Localization of B2M 5 0.59 4.26 2.42
25 INT50006 Regulation of HLA-E 12 0.44 8.78 2.37
26 INT34644 Binding of HLA-C 19 0.47 9.41 2.2
27 INT12061 Negative_regulation of LNPEP 19 0.58 5.52 2.14
28 INT117545 Regulation of Gene_expression of HLA-A 2 0.33 2.3 1.99
29 INT21782 Negative_regulation of B2M 11 0.46 5.49 1.92
30 INT101013 Regulation of HLA-A 7 0.33 6.7 1.8
31 INT122951 Regulation of Binding of HLA-B 4 0.39 3.08 1.65
32 INT62430 Negative_regulation of HLA-A 5 0.32 4.3 1.63
33 INT9784 Binding of B2M 9 0.47 6.18 1.44
34 INT96137 Gene_expression of LNPEP 8 0.68 5.27 1.43
35 INT69398 Regulation of Gene_expression of HLA-E 14 0.60 3.54 1.27
36 INT59024 Regulation of Regulation of B2M 2 0.03 0.31 1.17
37 INT147336 Gene_expression of HLA-G 12 0.75 7.27 1.08
38 INT79191 Positive_regulation of Gene_expression of B2M 3 0.03 2.11 1.08
39 INT96138 Positive_regulation of LNPEP 6 0.45 3.81 1.07
40 INT129878 Positive_regulation of CTSS 6 0.70 7.86 0.97
41 INT64903 Positive_regulation of HLA-C 3 0.49 2.54 0.93
42 INT748 Transcription of HLA-B 6 0.67 1.56 0.91
43 INT240736 Localization of HLA-A 7 0.21 6.88 0.86
44 INT42469 Regulation of LNPEP 9 0.60 0.46 0.83
45 INT328959 Localization of HLA-G 3 0.73 2.22 0.83
46 INT129877 Gene_expression of CTSS 4 0.75 4.65 0.81
47 INT11698 Positive_regulation of Gene_expression of HLA-A 5 0.67 4.64 0.76
48 INT105483 Protein_catabolism of LNPEP 3 0.42 3.26 0.74
49 INT10710 Positive_regulation of Positive_regulation of HLA-B 2 0.38 0.83 0.73
50 INT129879 Positive_regulation of Gene_expression of CTSS 3 0.47 3.25 0.7
51 INT5285 Regulation of Gene_expression of HLA-B 4 0.41 3.39 0.68
52 INT11700 Negative_regulation of Gene_expression of HLA-B 3 0.50 2.61 0.6
53 INT177951 Transcription of HLA-E 7 0.67 2.36 0.52
54 INT328952 Negative_regulation of Localization of HLA-G 1 0.41 1.07 0.43
55 INT335648 Localization of CTSS 1 0.08 1.39 0.41
56 INT328956 Positive_regulation of Localization of HLA-G 1 0.49 1.03 0.4
57 INT208567 Negative_regulation of Gene_expression of B2M 1 0.36 0.76 0.38
58 INT177954 Negative_regulation of Positive_regulation of HLA-E 2 0.07 0.61 0.33
59 INT188706 Localization of HLA-E 8 0.33 2.43 0.32
60 INT201084 Localization of HLA-C 2 0.73 1.04 0.3
61 INT44012 Phosphorylation of HLA-B 3 0.81 0.96 0.27
62 INT336997 Negative_regulation of Gene_expression of LNPEP 2 0.16 0.93 0.27
63 INT147335 Positive_regulation of Gene_expression of HLA-G 2 0.49 2.38 0.27
64 INT97755 Regulation of Gene_expression of LNPEP 1 0.54 0.52 0.26
65 INT351659 Positive_regulation of Gene_expression of LNPEP 1 0.18 1.27 0.25
66 INT160925 Transcription of HLA-A 1 0.31 1.41 0.24
67 INT102851 Binding of LNPEP 4 0.48 1.53 0.23
68 INT294137 Positive_regulation of Positive_regulation of HLA-E 1 0.09 0.33 0.2
69 INT129875 Positive_regulation of Positive_regulation of CTSS 1 0.50 1.94 0.2
70 INT177956 Positive_regulation of Transcription of HLA-E 3 0.49 1.02 0.19
71 INT336998 Negative_regulation of Positive_regulation of LNPEP 1 0.02 0.09 0.19
72 INT250970 Positive_regulation of Localization of HLA-B 1 0.48 0.57 0.17
73 INT129876 Negative_regulation of Positive_regulation of CTSS 1 0.43 1.88 0.17
74 INT156328 Protein_catabolism of HLA-B 1 0.09 0.17 0.17
75 INT111871 Negative_regulation of Regulation of LNPEP 1 0.42 0 0.16
76 INT351661 Positive_regulation of Protein_catabolism of LNPEP 1 0.21 0.42 0.14
77 INT328942 Negative_regulation of Binding of HLA-G 1 0.41 0.39 0.13
78 INT197053 Negative_regulation of Binding of HLA-E 1 0.20 1.07 0.12
79 INT351662 Regulation of Protein_catabolism of LNPEP 1 0.19 0.06 0.1
80 INT60498 Negative_regulation of Positive_regulation of B2M 1 0.09 0.54 0.1
81 INT321875 Regulation of HLA-G 1 0.00 0.99 0.05
82 INT39126 Regulation of Localization of B2M 1 0.23 0.5 0.05
83 INT254338 Positive_regulation of Localization of HLA-E 1 0.03 0.26 0.03
84 INT351824 Regulation of Binding of HLA-E 1 0.03 0.89 0.03
85 INT356246 Negative_regulation of Transcription of HLA-E 1 0.41 0.05 0.03
86 INT39124 Regulation of Gene_expression of B2M 2 0.23 0.6 0
87 INT201086 Regulation of Phosphorylation of HLA-B 2 0.45 0.41 0
88 INT215472 Protein_catabolism of HLA-A 2 0.53 0.34 0
89 INT54611 Positive_regulation of Regulation of HLA-B 1 0.37 0 0
90 INT308196 Negative_regulation of Negative_regulation of HLA-E 1 0.28 0 0
91 INT276139 Regulation of Negative_regulation of HLA-E 1 0.39 0.07 0
92 INT351660 Positive_regulation of Positive_regulation of LNPEP 1 0.21 0.61 0
93 INT201088 Negative_regulation of Binding of HLA-C 1 0.42 0.61 0
94 INT250968 Positive_regulation of Phosphorylation of HLA-B 1 0.48 0.08 0
95 INT275143 Positive_regulation of Binding of HLA-E 1 0.16 0.32 0
96 INT175639 Binding of CTSS 1 0.36 1.44 0
97 INT264190 Negative_regulation of Gene_expression of HLA-A 1 0.04 0.57 0
98 INT245872 Positive_regulation of HLA-G 1 0.02 0.78 0
99 INT214061 Negative_regulation of HLA-G 1 0.41 0.34 0
100 INT201087 Regulation of Phosphorylation of HLA-C 1 0.44 0.32 0
101 INT195883 Phosphorylation of LNPEP 1 0.01 0 0
102 INT351658 Regulation of Positive_regulation of LNPEP 1 0.19 0.34 0
103 INT111868 Positive_regulation of Binding of LNPEP 1 0.50 0 0
104 INT256002 Localization of LNPEP 1 0.07 0.49 0
105 INT221119 Negative_regulation of Negative_regulation of HLA-A 1 0.01 0.61 0
106 INT201083 Gene_expression of HLA-C 1 0.66 0.17 0
107 INT136090 Positive_regulation of Transcription of HLA-B 1 0.34 0.15 0
108 INT145383 Negative_regulation of HLA-C 1 0.12 0 0
109 INT150063 Positive_regulation of Positive_regulation of HLA-A 1 0.05 0.08 0
110 INT201089 Phosphorylation of HLA-C 1 0.80 0.32 0
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