GO:0002540

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Name leukotriene production involved in inflammatory response
Categary Process
Go Slim No
Go Link GO:0002540
Unique Molecular Interactions 127
Total Molecular Interactions 172
Total Single Events 1586
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for leukotriene production involved in inflammatory response. They are ordered first by their pain relevance and then by number of times they were reported for leukotriene production involved in inflammatory response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48162 RIMS3 Regulation of Localization of LTC4S 1 0.10 2.14 3.25
2 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18
3 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14
4 INT68160 Alox5 Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.13
5 INT110671 Binding of Cnr1 and Alox5 1 0.07 0.2 1.13
6 INT68164 Mthfs Positive_regulation of Positive_regulation of Alox5 1 0.00 0.64 1.13
7 INT68167 Alox5 Positive_regulation of Positive_regulation of Mthfs 1 0.00 0.64 1.13
8 INT110669 Binding of Alox5 and Trpv1 1 0.07 0.2 1.13
9 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
10 INT68156 Pla2g1b Positive_regulation of Positive_regulation of Alox5 1 0.03 0.64 1.13
11 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
12 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
13 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 1.47 0.94
14 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9
15 INT57746 Il1 Regulation of Gene_expression of Ltc4s 1 0.36 0.33 0.88
16 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
17 INT352201 Negative_regulation of ALOX5 Negative_regulation of Cpox 1 0.02 0.89 0.81
18 INT203164 PTGER2 Regulation of ALOX5 1 0.00 0.9 0.78
19 INT203171 PTGER2 Negative_regulation of ALOX5 1 0.01 0.89 0.77
20 INT312101 ELANE Regulation of ALOX5AP 1 0.21 1.11 0.73
21 INT159569 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Fos 1 0.37 0.4 0.7
22 INT164286 Alox5ap Positive_regulation of Cysltr2 1 0.19 1.11 0.61
23 INT164285 Ltc4s Positive_regulation of Cysltr2 1 0.20 1.11 0.61
24 INT164283 Ltb4r Positive_regulation of Ltc4s 1 0.37 1.1 0.6
25 INT164284 Ltb4r Positive_regulation of Alox5ap 1 0.34 1.1 0.6
26 INT270100 Negative_regulation of Binding of ALOX5 and PLA2G2A 1 0.01 0.51 0.59
27 INT35398 Fnd3c2 Negative_regulation of Binding of Alox5 1 0.00 0 0.58
28 INT335432 Ltc4s Regulation of Cysltr2 1 0.11 0.38 0.58
29 INT335436 Ltc4s Regulation of Gene_expression of Cysltr2 1 0.18 0.38 0.58
30 INT270102 ALOX5 Negative_regulation of PLA2G2A 1 0.01 0.49 0.57
31 INT251163 Gene_expression of Alox5 Positive_regulation of Trpv1 1 0.02 0.11 0.48
32 INT312112 ELANE Regulation of Transcription of ALOX5 1 0.09 0.82 0.47
33 INT193219 Binding of LTC4S and CYSLTR2 2 0.28 2.2 0.44
34 INT158267 Olr1745 Negative_regulation of Alox5 1 0.05 0.94 0.43
35 INT203163 LTB4R Regulation of Gene_expression of ALOX5 1 0.00 0.98 0.41
36 INT159571 Trpv1 Positive_regulation of Gene_expression of Alox5 1 0.37 0.58 0.4
37 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4
38 INT203167 Gene_expression of PTGER2 Positive_regulation of Gene_expression of ALOX5AP 1 0.03 0.67 0.38
39 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
40 INT312102 Binding of ALOX5 and ALOX5AP 1 0.10 0.65 0.36
41 INT39208 ALOX5 Regulation of Gene_expression of IL2 1 0.04 0.06 0.34
42 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
43 INT312085 ELANE Regulation of Regulation of ALOX5 1 0.09 0.64 0.32
44 INT59189 Negative_regulation of GBE1 Negative_regulation of ALOX5 1 0.00 0.33 0.31
45 INT159572 Alox5 Regulation of Gene_expression of Fos 1 0.20 0.32 0.31
46 INT159570 Negative_regulation of Alox5 Regulation of Gene_expression of Fos 1 0.34 0.27 0.31
47 INT26737 Alox5 Regulation of Localization of Ins1 1 0.06 0.09 0.3
48 INT44984 KNG1 Regulation of Ltc4s 1 0.01 0.17 0.3
49 INT203170 Negative_regulation of CPOX Positive_regulation of ALOX5 1 0.01 0.53 0.29
50 INT48161 RIMS3 Negative_regulation of Gene_expression of LTC4S 1 0.16 0.07 0.28
51 INT301671 Ltc4s Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27
52 INT194977 Binding of Alox5 and Syt1 1 0.04 0.65 0.27
53 INT55901 Negative_regulation of Alox5 Negative_regulation of Localization of Ptafr 1 0.01 0.35 0.24
54 INT110061 Binding of Alox5 and Cpox 1 0.28 0.37 0.23
55 INT313498 Binding of ALOX5 and SNRNP70 1 0.05 2.7 0.21
56 INT249893 Ltc4s Positive_regulation of Gpr17 1 0.04 0.92 0.2
57 INT49057 Positive_regulation of CEL Positive_regulation of Localization of LTC4S 1 0.41 0.28 0.18
58 INT312091 ALOX5AP Regulation of Transcription of ALOX5 1 0.13 0.37 0.18
59 INT313554 Binding of ALOX5 and Cor 1 0.02 2.47 0.17
60 INT33362 Binding of Ltc4s and Cysltr1 1 0.16 0.21 0.17
61 INT249895 Ltc4s Positive_regulation of P2ry4 1 0.00 0.71 0.17
62 INT312089 LTB4R Positive_regulation of ALOX5AP 1 0.01 0.32 0.16
63 INT193216 Binding of LTC4S and CYSLTR1 1 0.04 0.71 0.16
64 INT312095 LTB4R Positive_regulation of ALOX5 1 0.01 0.32 0.16
65 INT312126 ELANE Positive_regulation of ALOX5AP 1 0.20 0.25 0.15
66 INT56430 Ltc4s Regulation of NA 1 0.00 0 0.14
67 INT116382 Lox Positive_regulation of Binding of Alox5 1 0.12 0.25 0.14
68 INT194975 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Nos2 1 0.13 0.69 0.13
69 INT312096 ELANE Positive_regulation of Transcription of ALOX5 1 0.06 0.27 0.13
70 INT17437 LTC4S Positive_regulation of CYSLTR1 1 0.03 0.2 0.13
71 INT270996 TBXA2R Regulation of LTC4S 1 0.24 0.83 0.13
72 INT271002 Binding of LTC4S and Aia1 1 0.00 0.98 0.12
73 INT194976 Alox5 Regulation of Gene_expression of Nos2 1 0.07 0.56 0.12
74 INT301307 Binding of GPR17 and LTC4S 1 0.00 0.42 0.11
75 INT312116 Negative_regulation of PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 0.2 0.1
76 INT312121 Negative_regulation of PTGER2 Regulation of Gene_expression of ALOX5 1 0.02 0.2 0.1
77 INT273354 Binding of ALOX5 and LTC4S 1 0.04 0.19 0.09
78 INT312103 ELANE Regulation of Gene_expression of ALOX5 1 0.06 0.15 0.08
79 INT313503 Binding of ALOX5AP and CXADRP1 1 0.01 1.51 0.08
80 INT312093 ELANE Regulation of Gene_expression of ALOX5AP 1 0.13 0.15 0.08
81 INT313509 Binding of ALOX5 and SP1 1 0.07 1.51 0.08
82 INT325488 Negative_regulation of Ephx2 Positive_regulation of Alox5 1 0.13 0.24 0.08
83 INT184889 Binding of ALOX5 and MCRS1 1 0.06 1.34 0.07
84 INT312087 PTGER2 Regulation of Gene_expression of ALOX5 1 0.01 0.13 0.07
85 INT312113 ELANE Positive_regulation of Gene_expression of ALOX5AP 1 0.23 0.14 0.07
86 INT313504 Binding of ALOX5AP and SNRNP70 1 0.04 0.5 0.05
87 INT312110 ELANE Positive_regulation of Gene_expression of ALOX5 1 0.09 0.07 0.04
88 INT312104 Binding of ALOX5 and PTGES 1 0.13 0.14 0.04
89 INT192263 LTC4S Positive_regulation of Gene_expression of TIMP1 1 0.00 0.28 0.04
90 INT312117 Negative_regulation of ELANE Positive_regulation of ALOX5AP 1 0.17 0.08 0.04
91 INT347514 Binding of CYSLTR1 and Ltc4s 1 0.01 0.58 0.03
92 INT313551 Binding of ALOX5AP and Cor 1 0.02 1.01 0.03
93 INT347516 Binding of CYSLTR2 and Ltc4s 1 0.01 0.4 0.03
94 INT184887 MCRS1 Positive_regulation of ALOX5 1 0.11 0.64 0
95 INT313499 Binding of ALOX5AP and CRP 1 0.07 0.45 0
96 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0
97 INT172893 Binding of Lta4h and Ltc4s 1 0.00 0.24 0
98 INT313507 Binding of ALOX5 and CXADRP1 1 0.01 0 0
99 INT298871 ALOX5AP Positive_regulation of RAB7A 1 0.09 0.35 0
100 INT343160 ACSL4 Regulation of Positive_regulation of ALOX5 1 0.02 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for leukotriene production involved in inflammatory response. They are ordered first by their pain relevance and then by number of times they were reported in leukotriene production involved in inflammatory response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17
2 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94
3 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29
4 INT195414 Gene_expression of ALOX5AP 65 0.72 31.22 15.25
5 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82
6 INT7997 Gene_expression of Ltc4s 51 0.76 34.28 13.8
7 INT17421 Negative_regulation of Alox5 41 0.57 15.23 10.05
8 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62
9 INT9889 Gene_expression of Alox5 34 0.63 20.83 8.85
10 INT4807 Localization of LTC4S 23 0.58 6.89 7.59
11 INT28164 Regulation of ALOX5 25 0.60 12.76 5.47
12 INT28165 Positive_regulation of ALOX5 38 0.47 10.8 5.37
13 INT6577 Regulation of Alox5 18 0.47 9.19 5.06
14 INT10606 Localization of Ltc4s 16 0.75 10.14 5.05
15 INT10605 Positive_regulation of Ltc4s 21 0.68 17.22 4.8
16 INT30355 Positive_regulation of Gene_expression of Alox5 10 0.67 14.61 4.69
17 INT15995 Positive_regulation of Alox5 18 0.49 3.94 4.63
18 INT74365 Positive_regulation of Alox5 19 0.47 11.03 4.04
19 INT20743 Positive_regulation of Gene_expression of Ltc4s 13 0.60 12.3 3.86
20 INT44254 Regulation of Gene_expression of ALOX5 12 0.43 7.06 3.65
21 INT16159 Regulation of Ltc4s 11 0.38 2.52 3.21
22 INT10476 Binding of ALOX5 26 0.36 7.69 3.2
23 INT195415 Regulation of Gene_expression of ALOX5AP 10 0.45 6.43 3.13
24 INT35448 Negative_regulation of Gene_expression of ALOX5 11 0.57 5.28 3.03
25 INT4811 Positive_regulation of Gene_expression of LTC4S 5 0.65 3.29 2.92
26 INT76342 Positive_regulation of Gene_expression of Alox5 9 0.56 5.29 2.87
27 INT195421 Positive_regulation of Gene_expression of ALOX5AP 12 0.49 5.17 2.82
28 INT34905 Positive_regulation of Gene_expression of ALOX5 18 0.50 7.46 2.46
29 INT16089 Gene_expression of Ltc4s 11 0.77 3.37 2.29
30 INT26736 Localization of Alox5 7 0.49 3.72 2.09
31 INT20251 Binding of Alox5 7 0.32 5.33 1.93
32 INT200779 Negative_regulation of Gene_expression of ALOX5AP 7 0.41 3.75 1.79
33 INT34552 Regulation of Gene_expression of Alox5 3 0.50 5.06 1.75
34 INT39229 Regulation of Alox5 6 0.57 3.2 1.72
35 INT164275 Gene_expression of Alox5ap 3 0.55 3.79 1.72
36 INT200778 Positive_regulation of ALOX5AP 3 0.49 2.54 1.7
37 INT27608 Localization of Alox5 7 0.61 2.66 1.69
38 INT15996 Binding of Ltc4s 9 0.35 5.66 1.64
39 INT9885 Negative_regulation of Gene_expression of Alox5 3 0.14 2.28 1.59
40 INT122204 Positive_regulation of Alox5ap 1 0.26 0.23 1.53
41 INT73926 Localization of ALOX5 8 0.44 3.14 1.52
42 INT170987 Transcription of ALOX5 4 0.69 2.71 1.41
43 INT164277 Transcription of Ltc4s 3 0.47 2.69 1.36
44 INT12545 Negative_regulation of Ltc4s 8 0.42 2.53 1.07
45 INT29109 Negative_regulation of Gene_expression of Alox5 6 0.42 2.9 1.07
46 INT34553 Binding of Alox5 3 0.10 0.65 1.03
47 INT165009 Regulation of Negative_regulation of Alox5 1 0.05 1 1.01
48 INT184896 Negative_regulation of Positive_regulation of ALOX5 2 0.42 0.92 0.96
49 INT24581 Negative_regulation of LTC4S 2 0.40 2.05 0.91
50 INT291677 Transcription of Alox5 1 0.58 3.91 0.91
51 INT13543 Positive_regulation of LTC4S 5 0.58 2.26 0.88
52 INT16088 Negative_regulation of Gene_expression of Ltc4s 6 0.58 0.29 0.85
53 INT68926 Binding of ALOX5AP 8 0.36 4.02 0.84
54 INT13541 Positive_regulation of Localization of LTC4S 3 0.51 1.01 0.75
55 INT48164 Negative_regulation of Gene_expression of LTC4S 3 0.55 0.22 0.74
56 INT29056 Regulation of Gene_expression of Alox5 4 0.60 1.47 0.72
57 INT34859 Positive_regulation of Localization of Ltc4s 2 0.34 1.26 0.7
58 INT57111 Negative_regulation of Localization of Ltc4s 1 0.27 1.02 0.62
59 INT65607 Regulation of Gene_expression of LTC4S 1 0.58 0.25 0.61
60 INT164276 Localization of Alox5ap 1 0.61 1.1 0.6
61 INT49507 Negative_regulation of Ltc4s 1 0.16 0.61 0.59
62 INT28417 Negative_regulation of Regulation of Ltc4s 1 0.03 0 0.56
63 INT205494 Negative_regulation of Negative_regulation of ALOX5 2 0.32 1.2 0.54
64 INT43459 Positive_regulation of Positive_regulation of Ltc4s 2 0.11 2.47 0.5
65 INT39227 Regulation of Regulation of Alox5 2 0.36 0.38 0.45
66 INT122205 Negative_regulation of Alox5ap 1 0.24 0 0.45
67 INT44371 Positive_regulation of Positive_regulation of ALOX5 3 0.31 0.7 0.44
68 INT15997 Negative_regulation of Binding of Ltc4s 2 0.43 0.33 0.42
69 INT170989 Regulation of Transcription of ALOX5 2 0.26 0.58 0.39
70 INT6581 Regulation of Negative_regulation of Alox5 1 0.06 0 0.39
71 INT13542 Negative_regulation of Localization of LTC4S 1 0.27 1.02 0.39
72 INT195416 Regulation of ALOX5AP 2 0.53 0.8 0.38
73 INT34551 Regulation of Binding of Alox5 1 0.08 0.19 0.38
74 INT195413 Negative_regulation of ALOX5AP 5 0.37 1.39 0.37
75 INT38789 Regulation of LTC4S 3 0.51 1.1 0.37
76 INT132064 Regulation of Binding of Ltc4s 1 0.22 1.02 0.37
77 INT309930 Regulation of Gene_expression of Ltc4s 1 0.08 2.79 0.34
78 INT44274 Negative_regulation of Regulation of ALOX5 2 0.33 0.28 0.31
79 INT162441 Positive_regulation of Localization of Alox5 1 0.34 0.27 0.3
80 INT20229 Negative_regulation of Positive_regulation of Ltc4s 2 0.23 0.87 0.29
81 INT162442 Positive_regulation of Positive_regulation of Alox5 1 0.34 0.26 0.29
82 INT291679 Regulation of Transcription of Alox5 1 0.25 0.94 0.28
83 INT291672 Phosphorylation of Alox5 1 0.66 0.63 0.28
84 INT291667 Regulation of Phosphorylation of Alox5 1 0.22 0.63 0.28
85 INT171007 Transcription of LTC4S 1 0.16 0.61 0.28
86 INT273358 Binding of LTC4S 4 0.17 0.88 0.27
87 INT59192 Regulation of Positive_regulation of ALOX5 1 0.15 0.29 0.24
88 INT96930 Positive_regulation of Positive_regulation of Alox5 2 0.43 0.15 0.23
89 INT96929 Phosphorylation of Alox5 1 0.04 0.22 0.22
90 INT203173 Localization of ALOX5AP 3 0.48 0.78 0.21
91 INT259884 Negative_regulation of Binding of ALOX5AP 1 0.10 0.46 0.21
92 INT291680 Positive_regulation of Transcription of Alox5 1 0.41 0.37 0.19
93 INT312127 Positive_regulation of Positive_regulation of ALOX5AP 1 0.35 0.37 0.19
94 INT33357 Positive_regulation of Gene_expression of Ltc4s 1 0.45 0.22 0.18
95 INT312137 Transcription of ALOX5AP 1 0.50 0.37 0.18
96 INT21351 Negative_regulation of Gene_expression of Ltc4s 3 0.19 1.14 0.17
97 INT194974 Regulation of Binding of Alox5 1 0.15 0.53 0.17
98 INT259885 Regulation of Binding of ALOX5 1 0.07 0.51 0.16
99 INT116380 Protein_catabolism of Alox5 1 0.31 0.25 0.14
100 INT312135 Negative_regulation of Regulation of ALOX5AP 1 0.30 0.19 0.13
101 INT194971 Negative_regulation of Negative_regulation of Alox5 1 0.14 0.81 0.13
102 INT96931 Negative_regulation of Binding of Alox5 2 0.14 0.46 0.12
103 INT26732 Negative_regulation of Localization of Alox5 2 0.28 0.06 0.11
104 INT116377 Transcription of Alox5 1 0.16 0.25 0.11
105 INT166890 Regulation of Binding of ALOX5AP 1 0.44 0.1 0.1
106 INT96928 Positive_regulation of Binding of Alox5 1 0.03 0.09 0.09
107 INT60010 Regulation of Positive_regulation of Ltc4s 1 0.06 0 0.08
108 INT76914 Regulation of Localization of LTC4S 1 0.15 0.31 0.08
109 INT327731 Positive_regulation of Ltc4s 2 0.24 0.91 0.07
110 INT172862 Regulation of Localization of Alox5 1 0.04 0.67 0.06
111 INT312131 Positive_regulation of Transcription of ALOX5 1 0.16 0.12 0.06
112 INT312129 Positive_regulation of Transcription of ALOX5AP 1 0.35 0.1 0.05
113 INT344420 Localization of Ltc4s 1 0.27 0.4 0.05
114 INT184891 Positive_regulation of Localization of ALOX5 2 0.16 0.72 0.03
115 INT291671 Negative_regulation of Transcription of Alox5 1 0.35 0.4 0.03
116 INT312132 Regulation of Regulation of ALOX5AP 1 0.28 0.06 0.03
117 INT16160 Regulation of Localization of Ltc4s 1 0.17 0.2 0.03
118 INT312136 Regulation of Regulation of ALOX5 1 0.14 0.06 0.03
119 INT235707 Binding of Ltc4s 1 0.10 0 0
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