GO:0002542

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Name Factor XII activation
Categary Process
Go Slim No
Go Link GO:0002542
Unique Molecular Interactions 18
Total Molecular Interactions 30
Total Single Events 184
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Factor XII activation. They are ordered first by their pain relevance and then by number of times they were reported for Factor XII activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45
2 INT119717 Binding of ADRA1D and F12 1 0.35 0.23 0.23
3 INT332700 Binding of F12 and KNG1 1 0.15 1.05 0.21
4 INT250550 Binding of F12 and CHDH 1 0.05 2.26 0.17
5 INT232015 SERPING1 Negative_regulation of F12 2 0.24 1.19 0.12
6 INT232017 F12 Positive_regulation of PLG 1 0.03 0.52 0.11
7 INT232019 F12 Positive_regulation of TRGC1 1 0.00 0.57 0.09
8 INT310201 Binding of F12 and Chdh 1 0.04 1.06 0.08
9 INT232009 Positive_regulation of F12 Negative_regulation of Localization of KNG1 1 0.01 0.19 0.05
10 INT265735 VEGFA Positive_regulation of Binding of KLKB1 1 0.04 0.36 0.04
11 INT327162 Binding of SERPING1 and F12 1 0.05 0.29 0.04
12 INT265745 FLT1 Positive_regulation of Binding of KLKB1 1 0.04 0.36 0.04
13 INT265760 Binding of KLKB1 and VEGFA 1 0.04 0.14 0
14 INT265754 Binding of FLT1 and KLKB1 1 0.03 0.07 0
15 INT265747 Binding of KLKB1 and KL 1 0.02 0 0
16 INT265728 Positive_regulation of Binding of KLKB1 and VEGFA 1 0.04 0 0
17 INT310200 Binding of Serping1 and F12 1 0.21 0.05 0
18 INT265738 NRP1 Positive_regulation of KLKB1 1 0.03 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Factor XII activation. They are ordered first by their pain relevance and then by number of times they were reported in Factor XII activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06
2 INT46201 Gene_expression of KLKB1 21 0.53 3.01 2.87
3 INT11481 Positive_regulation of F12 11 0.58 5.53 1.8
4 INT153156 Negative_regulation of KLKB1 5 0.48 7.88 1.6
5 INT23251 Positive_regulation of KLKB1 10 0.67 2.98 1.59
6 INT77164 Binding of F12 8 0.47 2.66 1.48
7 INT11496 Negative_regulation of F12 6 0.59 3.41 1.27
8 INT10133 Negative_regulation of F12 16 0.49 5.21 1.26
9 INT27155 Binding of F12 8 0.36 1.61 1.21
10 INT44001 Negative_regulation of Positive_regulation of F12 5 0.59 2.53 0.73
11 INT46202 Positive_regulation of Gene_expression of KLKB1 2 0.04 0 0.68
12 INT90699 Regulation of F12 4 0.45 2.7 0.67
13 INT265802 Regulation of KLKB1 9 0.04 1.01 0.64
14 INT221932 Gene_expression of F12 4 0.66 2.61 0.5
15 INT36793 Binding of KLKB1 3 0.40 0.51 0.42
16 INT10129 Gene_expression of F12 4 0.65 3.4 0.37
17 INT77162 Regulation of Binding of F12 2 0.33 0.52 0.28
18 INT36795 Localization of KLKB1 3 0.78 1.05 0.27
19 INT77165 Regulation of Positive_regulation of F12 1 0.38 0.28 0.23
20 INT77160 Positive_regulation of Binding of F12 1 0.42 0.28 0.23
21 INT77156 Regulation of Binding of F12 1 0.13 0.25 0.23
22 INT77153 Positive_regulation of Binding of F12 1 0.14 0.26 0.22
23 INT119715 Localization of F12 3 0.67 1.24 0.17
24 INT58589 Regulation of F12 3 0.39 1.9 0.16
25 INT96541 Negative_regulation of Binding of F12 2 0.41 0.32 0.16
26 INT119714 Protein_catabolism of F12 1 0.84 0.14 0.14
27 INT10128 Negative_regulation of Gene_expression of F12 2 0.01 0.33 0.12
28 INT316316 Negative_regulation of Binding of F12 1 0.18 1.1 0.12
29 INT232026 Positive_regulation of Gene_expression of F12 1 0.03 0.58 0.11
30 INT310198 Positive_regulation of Positive_regulation of F12 1 0.38 1.63 0.09
31 INT123574 Localization of F12 1 0.15 0.25 0.09
32 INT265776 Regulation of Binding of KLKB1 1 0.04 0.36 0.04
33 INT265791 Protein_catabolism of KLKB1 1 0.07 0 0
34 INT326466 Regulation of Gene_expression of F12 1 0.03 0.6 0
35 INT326467 Regulation of Gene_expression of F12 1 0.44 0.6 0
36 INT265786 Positive_regulation of Positive_regulation of KLKB1 1 0.04 0.24 0
37 INT265789 Negative_regulation of Protein_catabolism of KLKB1 1 0.03 0 0
38 INT265782 Regulation of Gene_expression of KLKB1 1 0.04 0 0
39 INT250579 Transcription of F12 1 0.62 0.77 0
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