GO:0002581

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Name negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
Categary Process
Go Slim No
Go Link GO:0002581
Unique Molecular Interactions 42
Total Molecular Interactions 70
Total Single Events 322
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
2 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
3 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
4 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52
5 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
6 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
7 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
8 INT203733 Thbs1 Positive_regulation of Negative_regulation of Ppara 1 0.36 1.55 0.26
9 INT252356 Binding of THBS1 and Cd47 1 0.00 0.44 0.24
10 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21
11 INT337260 ELL Positive_regulation of Gene_expression of THBS1 1 0.11 0.82 0.18
12 INT337263 ELL Regulation of Gene_expression of THBS1 1 0.10 0.82 0.18
13 INT231677 Binding of CD47 and THBS1 1 0.18 0 0.16
14 INT252352 Binding of THBS1 and Sirpa 1 0.00 0.26 0.15
15 INT294439 KLK4 Negative_regulation of THBS1 1 0.01 0 0.1
16 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
17 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07
18 INT203732 Thbs1 Regulation of Gene_expression of Ppara 1 0.33 0.94 0.05
19 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
20 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
21 INT337270 E2F1 Positive_regulation of Transcription of THBS1 1 0.67 0.19 0
22 INT337268 E2F1 Regulation of Transcription of THBS1 1 0.44 0 0
23 INT337274 E2F1 Regulation of THBS1 1 0.44 0 0
24 INT99770 Thbs1 Regulation of PGR 1 0.01 0 0
25 INT337269 Binding of E2F1 and Positive_regulation of Gene_expression of THBS1 1 0.45 0.21 0
26 INT337262 PRB1 Negative_regulation of THBS1 1 0.18 0.61 0
27 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0
28 INT99769 Thbs1 Regulation of THBS1 1 0.00 0 0
29 INT277490 Binding of F2 and Thbs1 1 0.09 0 0
30 INT337264 Binding of E2F1 and THBS1 1 0.47 0.78 0
31 INT268524 MYC Regulation of THBS1 1 0.02 1.85 0
32 INT337273 E2F1 Regulation of Gene_expression of THBS1 1 0.60 0 0
33 INT337266 E2F1 Positive_regulation of Gene_expression of THBS1 1 0.67 0.21 0
34 INT99772 Pgr Regulation of THBS1 1 0.00 0 0
35 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0
36 INT277489 Binding of Thbs1 and Gopc 1 0.14 0 0
37 INT337265 Negative_regulation of E2F1 Positive_regulation of THBS1 1 0.42 0 0
38 INT337272 E2F1 Positive_regulation of THBS1 1 0.49 1.27 0
39 INT337267 THBS1 Positive_regulation of E2F1 1 0.49 0.05 0
40 INT99771 Oxtr Regulation of THBS1 1 0.01 0 0
41 INT268511 MIR19B1 Regulation of THBS1 1 0.20 0.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51
2 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45
3 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97
4 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83
5 INT288546 Regulation of Positive_regulation of THBS1 1 0.36 2.65 1.27
6 INT150805 Localization of THBS1 4 0.46 2.88 1.23
7 INT203729 Binding of Thbs1 1 0.27 3.83 1.1
8 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08
9 INT99767 Regulation of THBS1 18 0.42 11.51 1.03
10 INT130363 Localization of Thbs1 9 0.75 4.99 0.76
11 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59
12 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57
13 INT150808 Negative_regulation of Localization of THBS1 1 0.25 0.5 0.53
14 INT268576 Positive_regulation of Gene_expression of THBS1 2 0.64 2.26 0.47
15 INT203728 Regulation of Binding of Thbs1 1 0.33 2.76 0.42
16 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41
17 INT130927 Negative_regulation of Thbs1 19 0.59 3.72 0.36
18 INT130368 Transcription of Thbs1 2 0.69 1.39 0.23
19 INT130360 Positive_regulation of Transcription of Thbs1 1 0.46 1.41 0.23
20 INT222635 Gene_expression of Thbs1 4 0.39 15.2 0.2
21 INT178504 Positive_regulation of Localization of THBS1 2 0.05 1.9 0.19
22 INT231474 Binding of THBS1 4 0.34 2.04 0.16
23 INT348150 Binding of Thbs1 1 0.24 2.06 0.15
24 INT348149 Regulation of Gene_expression of Thbs1 1 0.31 1.94 0.1
25 INT348145 Localization of Thbs1 1 0.41 6.72 0.1
26 INT222588 Negative_regulation of Gene_expression of Thbs1 2 0.30 7.93 0.07
27 INT222624 Negative_regulation of Thbs1 2 0.30 8.42 0.04
28 INT99763 Regulation of Thbs1 2 0.23 2.08 0.04
29 INT348152 Positive_regulation of Localization of Thbs1 1 0.24 0.85 0.04
30 INT348157 Regulation of Transcription of Thbs1 1 0.14 0.96 0.04
31 INT348147 Transcription of Thbs1 1 0.27 0.96 0.04
32 INT294469 Transcription of THBS1 2 0.66 0.46 0.03
33 INT231690 Negative_regulation of Binding of THBS1 1 0.16 0.37 0.03
34 INT337281 Regulation of Gene_expression of THBS1 1 0.57 0.48 0
35 INT277482 Negative_regulation of Transcription of Thbs1 1 0.43 0 0
36 INT252974 Positive_regulation of Negative_regulation of THBS1 1 0.03 0.09 0
37 INT348156 Positive_regulation of Gene_expression of Thbs1 1 0.24 0.9 0
38 INT228789 Positive_regulation of Negative_regulation of Thbs1 1 0.26 0.07 0
39 INT348146 Positive_regulation of Thbs1 1 0.25 2.41 0
40 INT277481 Negative_regulation of Negative_regulation of Thbs1 1 0.59 0 0
41 INT252970 Negative_regulation of Positive_regulation of THBS1 1 0.04 0.2 0
42 INT348158 Negative_regulation of Positive_regulation of Thbs1 1 0.22 0.65 0
43 INT207312 Phosphorylation of THBS1 1 0.43 0.28 0
44 INT277486 Negative_regulation of Positive_regulation of Thbs1 1 0.43 0 0
45 INT337279 Positive_regulation of Binding of THBS1 1 0.46 0 0
46 INT320827 Negative_regulation of Gene_expression of THBS1 1 0.03 1.52 0
47 INT337283 Positive_regulation of Regulation of THBS1 1 0.46 0 0
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