GO:0002686

From wiki-pain
Jump to: navigation, search
Name negative regulation of leukocyte migration
Categary Process
Go Slim No
Go Link GO:0002686
Unique Molecular Interactions 99
Total Molecular Interactions 131
Total Single Events 1293
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of leukocyte migration. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of leukocyte migration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
2 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
3 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
4 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
5 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
6 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
7 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
8 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
9 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
10 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
11 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
12 INT325267 Il33 Positive_regulation of Gene_expression of Il4 1 0.16 1.59 0.69
13 INT325263 Il33 Positive_regulation of Gene_expression of Il5 1 0.16 1.59 0.69
14 INT325270 Il33 Positive_regulation of Gene_expression of Il6 1 0.20 1.59 0.69
15 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
16 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
17 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53
18 INT325259 Il33 Positive_regulation of Gene_expression of Spg21 1 0.07 1.23 0.53
19 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49
20 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
21 INT325269 Il33 Positive_regulation of Spg21 1 0.05 1.11 0.48
22 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
23 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
24 INT165677 NFE2L2 Negative_regulation of Positive_regulation of HMOX1 1 0.40 0.32 0.44
25 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
26 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
27 INT165678 NFE2L2 Negative_regulation of HMOX1 1 0.40 0.31 0.43
28 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
29 INT164890 Binding of IL1RAP and IL33 1 0.09 0.2 0.36
30 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35
31 INT164904 Binding of IL1A and IL33 1 0.39 0.19 0.35
32 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34
33 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33
34 INT325266 Positive_regulation of Spg21 Positive_regulation of Il33 1 0.05 0.75 0.32
35 INT325265 Il33 Positive_regulation of Gene_expression of Ik 1 0.01 0.67 0.32
36 INT215645 Binding of Adora1 and Kcnj5 1 0.00 0.08 0.29
37 INT215653 Binding of Adora1 and Adora3 1 0.39 0.07 0.27
38 INT311046 Binding of CSF2 and IL33 1 0.00 1.86 0.26
39 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
40 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
41 INT215652 Binding of Adora1 and Npy1r 1 0.39 0.22 0.24
42 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
43 INT325276 Il33 Positive_regulation of Gene_expression of TNF 1 0.04 0.82 0.23
44 INT169567 IL33 Regulation of Pscs 1 0.03 0.46 0.19
45 INT164892 IL33 Regulation of Gene_expression of IL1RAP 1 0.06 0.2 0.18
46 INT319381 Binding of ST2 and IL33 1 0.13 1.01 0.18
47 INT302381 Il33 Regulation of Gene_expression of Il4 1 0.01 0.76 0.16
48 INT231757 TLR4 Positive_regulation of Negative_regulation of HMOX1 1 0.26 1.37 0.15
49 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15
50 INT249322 Positive_regulation of Adora1 Regulation of Rit2 1 0.10 0 0.14
51 INT169562 PDGFD Positive_regulation of Gene_expression of IL33 1 0.03 0.35 0.13
52 INT231761 TNF Negative_regulation of HMOX1 1 0.19 1.2 0.12
53 INT249321 Positive_regulation of Adora1 Regulation of Preb 1 0.20 0.09 0.12
54 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11
55 INT231768 Binding of HMOX1 and TLR4 1 0.23 0.95 0.11
56 INT231772 TNF Positive_regulation of Gene_expression of HMOX1 1 0.21 0.96 0.1
57 INT346526 Binding of ADORA1 and PTH1R 1 0.01 0 0.1
58 INT231773 IRF6 Negative_regulation of Gene_expression of HMOX1 1 0.06 1.27 0.09
59 INT226515 Binding of Il1rl1 and Il33 1 0.02 0.36 0.08
60 INT231760 TNF Positive_regulation of Protein_catabolism of HMOX1 1 0.31 0.41 0.06
61 INT231758 IRF6 Regulation of Gene_expression of HMOX1 1 0.08 0.23 0.05
62 INT325255 Chchd8 Regulation of Il33 1 0.00 0.33 0.05
63 INT325261 Ralbp1 Positive_regulation of Gene_expression of Il33 1 0.01 0 0.05
64 INT231766 TLR4 Negative_regulation of Gene_expression of HMOX1 1 0.28 0.71 0.05
65 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04
66 INT231759 IL10 Positive_regulation of Gene_expression of HMOX1 1 0.06 0.7 0.04
67 INT231775 TLR4 Regulation of Gene_expression of HMOX1 1 0.29 0.68 0.04
68 INT231774 Gene_expression of TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
69 INT231762 TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
70 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03
71 INT164899 IL33 Positive_regulation of IFNG 1 0.25 0.05 0
72 INT158907 Ogt Negative_regulation of Gene_expression of Ada 1 0.44 0 0
73 INT204927 Binding of LGMN and IL33 1 0.00 0.52 0
74 INT164895 IL33 Positive_regulation of Gene_expression of CCL2 1 0.16 0.05 0
75 INT164901 IL33 Positive_regulation of Gene_expression of CXCL10 1 0.16 0.05 0
76 INT164906 IL33 Positive_regulation of Gene_expression of IL4 1 0.43 0.05 0
77 INT164910 IL33 Positive_regulation of Gene_expression of CXCL1 1 0.12 0.05 0
78 INT276606 Binding of DBT and IL33 1 0.01 0 0
79 INT330735 GSTK1 Regulation of HMOX1 1 0.08 0.25 0
80 INT104529 Ada Negative_regulation of Positive_regulation of FSCN1 1 0.03 0 0
81 INT104530 Ada Negative_regulation of FSCN1 1 0.03 0 0
82 INT325271 Positive_regulation of Il33 Regulation of Gene_expression of Il1rl1 1 0.22 0 0
83 INT312950 Binding of ADA and HBN1 1 0.01 0.49 0
84 INT164912 IL33 Positive_regulation of Gene_expression of IL8 1 0.45 0.05 0
85 INT164903 IL33 Positive_regulation of Gene_expression of CXCL2 1 0.12 0.05 0
86 INT164889 IL33 Positive_regulation of Gene_expression of IFNG 1 0.25 0.05 0
87 INT164909 IL33 Positive_regulation of Phosphorylation of NFKBIA 1 0.53 0.05 0
88 INT276608 Binding of UBE2S and IL33 1 0.00 0.32 0
89 INT164893 IL33 Positive_regulation of Gene_expression of IL6 1 0.46 0.05 0
90 INT158906 Ogt Negative_regulation of Ada 1 0.33 0 0
91 INT301906 Binding of HMOX1 and HSD11B1 1 0.05 2.41 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of leukocyte migration. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of leukocyte migration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
2 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
3 INT32802 Negative_regulation of Ada 21 0.57 4.03 14.87
4 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
5 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
6 INT19155 Binding of Adora1 25 0.47 6.41 10.72
7 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
8 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
9 INT226402 Gene_expression of Il33 60 0.77 23.82 8.67
10 INT4663 Positive_regulation of Ada 17 0.69 9.48 7.93
11 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
12 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
13 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
14 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
15 INT9167 Binding of Adora1 6 0.40 0.53 6.9
16 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
17 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74
18 INT29674 Gene_expression of Ada 16 0.78 4.59 5.69
19 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63
20 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18
21 INT36256 Regulation of Ada 9 0.62 4.99 5.07
22 INT9767 Negative_regulation of Ada 5 0.55 0.06 5.06
23 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87
24 INT134590 Localization of ADA 7 0.65 8.43 3.96
25 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
26 INT215604 Localization of Adora1 10 0.78 1.47 3.49
27 INT72798 Binding of ADA 12 0.47 7.84 3.39
28 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32
29 INT19392 Gene_expression of Ada 9 0.77 7.4 3.17
30 INT164920 Gene_expression of IL33 22 0.76 13.63 3.16
31 INT34604 Binding of Ada 11 0.31 4.15 3.1
32 INT9766 Positive_regulation of Ada 2 0.47 0.4 3.09
33 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
34 INT131494 Regulation of ADA 8 0.52 7.37 2.97
35 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
36 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
37 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
38 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
39 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
40 INT81312 Positive_regulation of Gene_expression of Ada 2 0.50 1.58 2.26
41 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
42 INT325254 Positive_regulation of Il33 19 0.69 6.56 2.09
43 INT61806 Regulation of Negative_regulation of Ada 1 0.30 0.63 1.89
44 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86
45 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
46 INT325244 Localization of Il33 1 0.80 4.17 1.8
47 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
48 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
49 INT34605 Localization of Ada 7 0.80 0.13 1.61
50 INT100420 Regulation of HMOX1 10 0.35 6.68 1.48
51 INT137927 Positive_regulation of Positive_regulation of Ada 1 0.03 1.31 1.47
52 INT30277 Protein_catabolism of Ada 3 0.52 0.9 1.42
53 INT165680 Transcription of HMOX1 7 0.71 11.2 1.41
54 INT241721 Positive_regulation of Transcription of Adora1 3 0.50 1.39 1.41
55 INT181873 Regulation of Localization of ADA 1 0.07 1.98 1.41
56 INT241737 Transcription of Adora1 3 0.72 0.89 1.32
57 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28
58 INT76254 Positive_regulation of Positive_regulation of ADORA1 2 0.43 1.27 1.14
59 INT192073 Positive_regulation of Gene_expression of ADA 8 0.47 10.35 1.12
60 INT238636 Regulation of Ada 2 0.15 1.12 1.06
61 INT116529 Binding of HMOX1 10 0.47 15.38 1.04
62 INT105445 Localization of HMOX1 5 0.71 3.11 0.98
63 INT238637 Binding of Ada 2 0.26 1.01 0.94
64 INT215606 Positive_regulation of Localization of Adora1 3 0.49 0.44 0.87
65 INT92880 Localization of ADORA1 2 0.80 0.09 0.84
66 INT68200 Protein_catabolism of Ada 2 0.44 0.68 0.83
67 INT325230 Positive_regulation of Gene_expression of Il33 1 0.50 1.47 0.83
68 INT279366 Positive_regulation of Localization of ADA 2 0.42 4.37 0.76
69 INT113512 Regulation of Gene_expression of ADORA1 1 0.11 0.19 0.73
70 INT204929 Binding of IL33 18 0.08 4.74 0.7
71 INT40605 Negative_regulation of Negative_regulation of Ada 1 0.32 0 0.7
72 INT226421 Regulation of Il33 2 0.45 2.7 0.68
73 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
74 INT226403 Regulation of Gene_expression of Il33 2 0.61 1.94 0.63
75 INT215607 Positive_regulation of Negative_regulation of Adora1 1 0.45 0 0.63
76 INT210028 Protein_catabolism of ADA 1 0.07 0.13 0.62
77 INT273000 Localization of IL33 5 0.45 1.77 0.56
78 INT165681 Positive_regulation of Transcription of HMOX1 2 0.69 4.29 0.53
79 INT216748 Regulation of Localization of ADORA1 1 0.07 0.09 0.53
80 INT279525 Negative_regulation of Transcription of Adora1 1 0.43 0.26 0.51
81 INT249309 Regulation of Gene_expression of Adora1 6 0.39 0.51 0.49
82 INT273003 Positive_regulation of IL33 4 0.26 3.27 0.49
83 INT215600 Regulation of Binding of Adora1 1 0.08 0.09 0.48
84 INT325251 Positive_regulation of Localization of Il33 1 0.69 1.03 0.45
85 INT143682 Negative_regulation of Gene_expression of Ada 2 0.54 0.28 0.44
86 INT143683 Negative_regulation of Gene_expression of ADA 1 0.09 0.28 0.44
87 INT56363 Regulation of Gene_expression of Ada 1 0.06 0.59 0.42
88 INT325250 Regulation of Positive_regulation of Il33 2 0.45 1.16 0.39
89 INT273005 Negative_regulation of IL33 4 0.07 2.4 0.38
90 INT279524 Protein_catabolism of Adora1 1 0.88 0.34 0.38
91 INT279523 Positive_regulation of Protein_catabolism of Adora1 1 0.50 0.34 0.38
92 INT325234 Negative_regulation of Il33 1 0.43 0.67 0.37
93 INT157157 Negative_regulation of Localization of HMOX1 1 0.37 0.74 0.37
94 INT325231 Negative_regulation of Negative_regulation of Il33 1 0.43 0.67 0.34
95 INT281659 Regulation of Transcription of HMOX1 2 0.27 2.12 0.33
96 INT279365 Regulation of Regulation of ADA 1 0.23 0 0.33
97 INT92881 Transcription of ADORA1 1 0.69 0 0.31
98 INT224100 Regulation of Negative_regulation of ADORA1 1 0.01 0.05 0.3
99 INT135772 Regulation of Positive_regulation of HMOX1 3 0.39 1.52 0.29
100 INT186700 Localization of Adora1 1 0.23 0 0.23
101 INT325246 Regulation of Localization of Il33 1 0.27 0.23 0.16
102 INT249313 Negative_regulation of Gene_expression of Adora1 1 0.37 0 0.14
103 INT127623 Protein_catabolism of ADORA1 1 0.49 0.19 0.14
104 INT169566 Positive_regulation of Gene_expression of IL33 1 0.41 0.38 0.14
105 INT201467 Protein_catabolism of HMOX1 2 0.77 0.83 0.13
106 INT325249 Binding of Il33 1 0.37 0.72 0.13
107 INT319432 Positive_regulation of Localization of IL33 1 0.26 1.02 0.13
108 INT164918 Regulation of Gene_expression of IL33 2 0.44 1.09 0.12
109 INT169564 Negative_regulation of Gene_expression of IL33 1 0.38 0.3 0.11
110 INT323226 Negative_regulation of Localization of ADA 1 0.35 3.05 0.1
111 INT110170 Positive_regulation of Positive_regulation of ADA 1 0.49 0.46 0.1
112 INT241720 Regulation of Transcription of Adora1 1 0.40 0.27 0.07
113 INT293311 Positive_regulation of Positive_regulation of HMOX1 3 0.69 1.99 0.04
114 INT325253 Negative_regulation of Positive_regulation of Il33 1 0.42 0 0.03
115 INT325247 Negative_regulation of Gene_expression of Il33 1 0.42 0 0.03
116 INT325237 Transcription of Il33 1 0.68 0.15 0
117 INT276617 Negative_regulation of Localization of IL33 1 0.03 0.28 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox