GO:0002755

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Name MyD88-dependent toll-like receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0002755
Unique Molecular Interactions 1124
Total Molecular Interactions 1537
Total Single Events 9926
Pain Genes Associated 53

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MyD88-dependent toll-like receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for MyD88-dependent toll-like receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
2 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
3 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
4 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
5 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
6 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
7 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
8 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
9 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
10 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
11 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
12 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
13 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
14 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
15 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
16 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
17 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
18 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
19 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
20 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
21 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
22 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
23 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
24 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
25 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
26 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
27 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
28 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
29 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16
30 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
31 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
32 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
33 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
34 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
35 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
36 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
37 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
38 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
39 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
40 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
41 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
42 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
43 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
44 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
45 INT94206 SP5 Regulation of Gene_expression of FOS 1 0.22 0.7 0.98
46 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
47 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
48 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
49 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
50 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
51 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
52 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
53 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
54 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
55 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
56 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
57 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
58 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89
59 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
60 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
61 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
62 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
63 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
64 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
65 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
66 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
67 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
68 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
69 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
70 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
71 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
72 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8
73 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
74 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
75 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
76 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
77 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
78 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
79 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
80 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
81 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
82 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
83 INT186445 Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
84 INT186443 Phosphorylation of Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
85 INT186444 Creb1 Regulation of FOS 1 0.49 0.43 0.72
86 INT186442 Phosphorylation of Creb1 Regulation of FOS 1 0.49 0.43 0.72
87 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
88 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
89 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
90 INT103134 DCSTAMP Positive_regulation of NFKB1 2 0.07 1.43 0.7
91 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
92 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
93 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
94 INT66581 Binding of JUN and Rare2 1 0.00 0.07 0.69
95 INT66582 Binding of FOS and Rare2 1 0.00 0.07 0.69
96 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66
97 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
98 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
99 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
100 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
101 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
102 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
103 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
104 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
105 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
106 INT66207 Positive_regulation of TNF Positive_regulation of NFKB1 1 0.42 0.08 0.61
107 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
108 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
109 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
110 INT224419 Binding of NFKB2 and TNFRSF11B 1 0.11 1.37 0.6
111 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
112 INT224420 Regulation of Binding of NFKB2 and TNFRSF11B 1 0.13 1.39 0.6
113 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
114 INT81916 HSF1 Positive_regulation of FOS 1 0.76 0.66 0.59
115 INT81918 HSF1 Negative_regulation of FOS 1 0.64 0.66 0.59
116 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
117 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
118 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
119 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
120 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
121 INT27871 Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56
122 INT27872 Positive_regulation of Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56
123 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
124 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
125 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
126 INT113548 NFKB1 Regulation of Localization of PLAU 1 0.26 1.93 0.55
127 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
128 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
129 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
130 INT156246 NFKB1 Regulation of Gene_expression of TNF 1 0.17 0.35 0.54
131 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
132 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54
133 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
134 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
135 INT105110 Cxcl12 Positive_regulation of NFKB1 1 0.06 0.54 0.53
136 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
137 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
138 INT105108 Negative_regulation of Cxcl12 Positive_regulation of NFKB1 1 0.05 0.54 0.53
139 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
140 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
141 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
142 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
143 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
144 INT191947 NFKB2 Positive_regulation of Gene_expression of NOS2 1 0.08 1.51 0.52
145 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
146 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
147 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
148 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
149 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
150 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
151 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
152 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
153 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
154 INT139834 NFKB1 Regulation of Gene_expression of SELE 1 0.18 0.49 0.5
155 INT139835 NFKB1 Regulation of SELE 1 0.41 0.49 0.5
156 INT324816 Hspd1 Positive_regulation of Gene_expression of Ik 1 0.00 1.59 0.5
157 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
158 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
159 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
160 INT115184 Regulation of CASP1 Positive_regulation of MAPK9 1 0.09 0 0.49
161 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
162 INT135588 Positive_regulation of IKBKE Positive_regulation of NFKB1 1 0.18 1.29 0.48
163 INT115183 CASP1 Positive_regulation of Positive_regulation of MAPK9 1 0.16 0 0.48
164 INT135587 IKBKE Positive_regulation of NFKB1 1 0.18 1.28 0.48
165 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
166 INT115185 CASP1 Positive_regulation of MAPK9 1 0.15 0 0.48
167 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
168 INT191948 NFKB1 Regulation of Gene_expression of NOS2 1 0.38 1 0.47
169 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
170 INT191950 NFKB2 Regulation of Gene_expression of NOS2 1 0.08 1 0.47
171 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
172 INT102556 HGF Positive_regulation of Phosphorylation of ELK1 1 0.10 0.46 0.47
173 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
174 INT106073 IL1B Positive_regulation of Positive_regulation of NFKB1 1 0.41 0.7 0.47
175 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
176 INT117703 OPRK1 Positive_regulation of Positive_regulation of JUN 1 0.01 0.08 0.47
177 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
178 INT142826 UPF1 Positive_regulation of CREB1 1 0.11 0 0.46
179 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
180 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
181 INT116929 OPRK1 Positive_regulation of JUN 1 0.28 0.15 0.46
182 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
183 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
184 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44
185 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
186 INT346237 MAP2K6 Positive_regulation of MAP2K3 1 0.49 1 0.44
187 INT230461 Binding of TLR1 and TLR2 3 0.33 2.06 0.43
188 INT104016 RPGR Positive_regulation of Gene_expression of FOS 1 0.16 0 0.43
189 INT103132 Positive_regulation of DCSTAMP Positive_regulation of JUN 1 0.03 0.73 0.43
190 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43
191 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
192 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
193 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43
194 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
195 INT103128 Positive_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.07 0.73 0.43
196 INT103129 DCSTAMP Positive_regulation of JUN 1 0.03 0.72 0.43
197 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
198 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
199 INT185381 TNF Regulation of TLR2 2 0.31 1.9 0.41
200 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41

Single Events

The table below shows the top 100 pain related interactions that have been reported for MyD88-dependent toll-like receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in MyD88-dependent toll-like receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
2 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
3 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
4 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
5 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
6 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
7 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
8 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
9 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
10 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
11 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
12 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
13 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
14 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95
15 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
16 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
17 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
18 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
19 INT134651 Binding of TLR4 89 0.48 66.96 23.19
20 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
21 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
22 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
23 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
24 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
25 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
26 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
27 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
28 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
29 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
30 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
31 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
32 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
33 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
34 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
35 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
36 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
37 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
38 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
39 INT15246 Regulation of FOS 32 0.60 15.34 12.94
40 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
41 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
42 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65
43 INT150540 Binding of TLR2 50 0.45 35.86 10.43
44 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38
45 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
46 INT60198 Binding of JUN 54 0.48 11.56 10.27
47 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
48 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
49 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14
50 INT66213 Localization of RELA 63 0.78 14.71 8.77
51 INT17333 Positive_regulation of Positive_regulation of FOS 17 0.67 6.06 8.4
52 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
53 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
54 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
55 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
56 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63
57 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
58 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
59 INT75497 Regulation of JUN 28 0.61 11.04 7.09
60 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
61 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
62 INT60196 Binding of FOS 33 0.47 13.11 6.95
63 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
64 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56
65 INT5847 Transcription of FOS 31 0.69 11.11 6.41
66 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4
67 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
68 INT97797 Localization of TLR4 18 0.77 13.78 6
69 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
70 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
71 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79
72 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
73 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
74 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
75 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39
76 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
77 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31
78 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29
79 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
80 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
81 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
82 INT145756 Gene_expression of Tlr2 23 0.74 20.77 5.18
83 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01
84 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73
85 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6
86 INT54911 Localization of FOS 20 0.78 3.27 4.56
87 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
88 INT149197 Negative_regulation of NFKB2 14 0.25 10.55 4.46
89 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4
90 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39
91 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
92 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
93 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
94 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
95 INT67936 Transcription of JUN 18 0.52 9.52 4.13
96 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
97 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
98 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
99 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
100 INT56077 Protein_catabolism of NFKB1 16 0.98 8.03 3.94
101 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83
102 INT56075 Transcription of NFKB1 13 0.71 9.03 3.83
103 INT142754 Binding of Myd88 20 0.36 9.61 3.8
104 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
105 INT73981 Gene_expression of Hspd1 18 0.75 5.69 3.72
106 INT264972 Positive_regulation of MAP2K3 4 0.65 6.92 3.68
107 INT79231 Positive_regulation of Gene_expression of NFKB1 18 0.67 9.16 3.66
108 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63
109 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
110 INT119420 Phosphorylation of MAP2K6 8 0.79 4.89 3.52
111 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43
112 INT264970 Positive_regulation of Localization of TLR2 1 0.11 4.21 3.37
113 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27
114 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23
115 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
116 INT139801 Phosphorylation of NFKB1 9 0.66 5.2 3.13
117 INT66212 Negative_regulation of Localization of RELA 13 0.57 2.48 3.09
118 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
119 INT186805 Transcription of TLR2 12 0.63 9.66 3.04
120 INT68651 Negative_regulation of Positive_regulation of JUN 11 0.58 4.28 3.04
121 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
122 INT12770 Negative_regulation of Positive_regulation of IKBKG 7 0.56 0.34 3.02
123 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
124 INT103910 Binding of NOD2 19 0.47 12.24 2.93
125 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
126 INT102565 Positive_regulation of Phosphorylation of RPS6KA1 1 0.25 2.77 2.85
127 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
128 INT108358 Phosphorylation of FOS 12 0.80 6.33 2.79
129 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73
130 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
131 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71
132 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71
133 INT107968 Positive_regulation of NFKBIA 9 0.46 5.27 2.69
134 INT47974 Negative_regulation of Protein_catabolism of NFKBIA 7 0.49 2.38 2.69
135 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
136 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
137 INT133029 Regulation of TLR2 18 0.56 11.31 2.62
138 INT186799 Localization of TLR2 5 0.68 2.51 2.58
139 INT122003 Phosphorylation of NFKBIA 9 0.59 5.44 2.51
140 INT71305 Regulation of Gene_expression of NFKB1 9 0.61 5.41 2.44
141 INT102646 Positive_regulation of MAP2K6 3 0.63 4.37 2.44
142 INT12769 Localization of IKBKG 6 0.15 1.66 2.43
143 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
144 INT123682 Localization of JUN 8 0.50 4.15 2.38
145 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
146 INT48980 Positive_regulation of Transcription of FOS 10 0.67 3.07 2.34
147 INT60199 Positive_regulation of Binding of JUN 5 0.49 1.3 2.34
148 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
149 INT117924 Gene_expression of MAP2K3 2 0.72 5.82 2.32
150 INT150547 Phosphorylation of MAP2K3 2 0.79 4.92 2.3
151 INT132893 Binding of CHUK 1 0.00 0.63 2.25
152 INT27880 Positive_regulation of HSPD1 17 0.65 18.16 2.23
153 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
154 INT152436 Positive_regulation of Gene_expression of HSPD1 12 0.67 10.06 2.16
155 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
156 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13
157 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
158 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02
159 INT148456 Gene_expression of LY96 7 0.19 4.35 2.02
160 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
161 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
162 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
163 INT123530 Phosphorylation of RELA 9 0.80 3.46 1.99
164 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98
165 INT243689 Regulation of NFKB2 1 0.35 2.72 1.97
166 INT26317 Gene_expression of NFKBIA 5 0.45 2.97 1.96
167 INT56080 Transcription of NFKBIA 2 0.40 2.16 1.93
168 INT130208 Positive_regulation of Phosphorylation of JUN 4 0.38 3.07 1.92
169 INT56078 Negative_regulation of Protein_catabolism of NFKB1 7 0.42 4.44 1.83
170 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
171 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
172 INT109921 Phosphorylation of MAPK9 9 0.67 5.07 1.81
173 INT27881 Binding of HSPD1 10 0.31 9.2 1.78
174 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
175 INT119422 Negative_regulation of Phosphorylation of MAP2K6 3 0.38 2.09 1.76
176 INT76608 Regulation of Negative_regulation of NFKB1 1 0.33 0.53 1.75
177 INT55169 Binding of RELA 40 0.36 4.91 1.74
178 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74
179 INT108875 Positive_regulation of Localization of RELA 9 0.49 1.43 1.72
180 INT221433 Binding of NFKB2 6 0.11 4.74 1.7
181 INT126236 Positive_regulation of Positive_regulation of NFKBIA 4 0.46 2.18 1.69
182 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
183 INT165446 Positive_regulation of Phosphorylation of NFKB1 3 0.56 1.88 1.66
184 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
185 INT233975 Positive_regulation of Gene_expression of Myd88 7 0.66 4.17 1.65
186 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
187 INT173173 Regulation of Positive_regulation of MAPK14 6 0.38 2.59 1.64
188 INT132890 Positive_regulation of Binding of CHUK 1 0.00 0.44 1.6
189 INT157769 Binding of LY96 8 0.47 2.5 1.59
190 INT69917 Negative_regulation of CREB1 8 0.58 2.28 1.59
191 INT175307 Regulation of Gene_expression of TLR2 9 0.56 7.08 1.58
192 INT132891 Gene_expression of CHUK 1 0.01 0.47 1.58
193 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53
194 INT47972 Positive_regulation of Protein_catabolism of NFKBIA 5 0.46 2.09 1.53
195 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
196 INT171029 Positive_regulation of Transcription of JUN 4 0.14 2.87 1.48
197 INT109916 Positive_regulation of Positive_regulation of MAP2K6 2 0.45 2.28 1.45
198 INT157362 Negative_regulation of MAPK9 7 0.35 4.27 1.44
199 INT173654 Localization of MAPK14 12 0.62 3.16 1.43
200 INT34912 Regulation of IKBKG 5 0.08 2.41 1.42
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