GO:0002768

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Name immune response-regulating cell surface receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0002768
Unique Molecular Interactions 88
Total Molecular Interactions 156
Total Single Events 927
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for immune response-regulating cell surface receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for immune response-regulating cell surface receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
2 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
3 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
4 INT131853 CD40 Negative_regulation of Gene_expression of CD40LG 1 0.09 1.54 1.05
5 INT140934 Binding of Cd40 and Ean5 1 0.09 1.03 0.98
6 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
7 INT92998 Positive_regulation of SFTPA1 Positive_regulation of Localization of CD40 1 0.15 0.34 0.61
8 INT92999 Binding of CD40 and VCAM1 1 0.39 0.33 0.57
9 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55
10 INT249600 IFNA1 Positive_regulation of Gene_expression of Cd40 1 0.49 1.13 0.52
11 INT189846 Binding of Cd40 and Churc1 1 0.01 0.73 0.41
12 INT206208 MRO Negative_regulation of CD24 1 0.02 1.87 0.32
13 INT343906 Hmgb1 Positive_regulation of Gene_expression of Cd40 1 0.05 0.41 0.24
14 INT188696 Binding of Cd40 and Eae1 1 0.05 1.57 0.21
15 INT238001 Cxcl10 Positive_regulation of Gene_expression of Cd40 1 0.17 0.91 0.21
16 INT311987 Binding of Cd40 and Negative_regulation of Regulation of Hand1 1 0.28 0.27 0.21
17 INT322733 CD40LG Positive_regulation of Gene_expression of CD40 1 0.08 0.62 0.18
18 INT340816 Tnfrsf14 Regulation of Gene_expression of Btla 1 0.11 1.09 0.18
19 INT322734 Binding of CD40LG and Positive_regulation of CD40 1 0.07 0.62 0.18
20 INT336751 Binding of Selp and Cd40 1 0.03 2.49 0.18
21 INT337180 CD40 Positive_regulation of Gene_expression of CD83 1 0.17 1.07 0.17
22 INT206212 UTS2R Positive_regulation of CD24 1 0.09 0.71 0.15
23 INT310257 Tlr4 Positive_regulation of Gene_expression of Cd40 1 0.13 0.06 0.15
24 INT340822 Trav6-3 Regulation of Gene_expression of Btla 1 0.07 0.97 0.15
25 INT188697 Il6 Positive_regulation of Cd40 1 0.05 0.18 0.14
26 INT249598 Stat1 Positive_regulation of Gene_expression of Cd40 1 0.41 0.46 0.14
27 INT272776 CD40 Positive_regulation of Gene_expression of IGHG3 1 0.01 0.18 0.14
28 INT206209 MRO Negative_regulation of Transcription of CD24 1 0.02 0.76 0.14
29 INT324128 Binding of Cd4 and Cd40 2 0.29 0.3 0.13
30 INT331564 Binding of Apcs and Cd40 1 0.12 0.74 0.13
31 INT324082 CD40 Positive_regulation of MAPK9 1 0.21 0.64 0.13
32 INT129091 Binding of PIK3CG and Lyn 1 0.00 0.47 0.12
33 INT129075 Binding of Pik3r1 and Lyn 1 0.00 0.47 0.12
34 INT129093 Binding of Lyn and TCHP 1 0.00 0.49 0.12
35 INT129092 Binding of GRP and Lyn 1 0.00 0.48 0.12
36 INT330380 CD40 Regulation of Gene_expression of IFNA1 1 0.17 0.78 0.1
37 INT189848 IFN1@ Positive_regulation of Gene_expression of Cd40 1 0.69 0 0.09
38 INT249601 IFNA1 Negative_regulation of Gene_expression of Cd40 1 0.42 0.51 0.09
39 INT252344 Binding of Cd40 and Mthfd1 2 0.16 0.34 0.08
40 INT277807 CD40LG Regulation of CD40 1 0.21 0.17 0.08
41 INT231504 Binding of Tlr4 and Cd40 1 0.09 0.18 0.08
42 INT337166 PTGER2 Positive_regulation of Gene_expression of CD40 1 0.02 0.77 0.07
43 INT234381 Binding of CD40 and PPARA 1 0.19 1.39 0.07
44 INT220903 Regulation of Binding of Crp and Cd40 1 0.05 0.37 0.05
45 INT220906 Binding of Crp and Cd40 1 0.04 0.37 0.05
46 INT284559 Gopc Positive_regulation of Cd40 1 0.19 0.23 0.05
47 INT342886 Binding of C3 and CD40 1 0.02 0.66 0.05
48 INT234380 Negative_regulation of Binding of CD40 and CD40LG 1 0.16 1.4 0.04
49 INT227774 Negative_regulation of Binding of Cd40 and Cd40lg 1 0.31 0.29 0.03
50 INT340823 Btla Regulation of Ly6g6d 1 0.04 0.99 0.03
51 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
52 INT206207 Binding of SLEB1 and CD24 1 0.03 0.87 0.03
53 INT288007 Binding of CD28 and CD40 1 0.05 0.51 0.03
54 INT206211 MRO Regulation of Negative_regulation of CD24 1 0.01 0.1 0.03
55 INT200814 Epo Positive_regulation of Lyn 1 0.36 1.42 0.03
56 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
57 INT252339 Binding of Cd40 and Positive_regulation of Mthfd1 1 0.04 0.19 0
58 INT349016 Negative_regulation of Binding of Cd80 and Cd40 1 0.25 0 0
59 INT220901 Regulation of Binding of Saa1 and Cd40 1 0.04 0.36 0
60 INT170586 CD40 Negative_regulation of Positive_regulation of RELA 1 0.12 0.24 0
61 INT276390 Positive_regulation of CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0
62 INT276378 CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0
63 INT290160 Atp6v1e1 Positive_regulation of Cd40 1 0.24 0.5 0
64 INT278388 Msu Positive_regulation of Phosphorylation of Lyn 1 0.17 0.12 0
65 INT252341 Cd40 Positive_regulation of Gene_expression of Cd80 1 0.12 0.1 0
66 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0
67 INT248298 Binding of Cd40 and Rf 1 0.08 0 0
68 INT314970 Binding of Cd40 and Lbr 1 0.03 0.07 0
69 INT252334 Positive_regulation of Binding of Cd40 and Cd40lg 1 0.11 0.1 0
70 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0
71 INT284553 Adc Positive_regulation of Gene_expression of Cd40 1 0.18 0.35 0
72 INT347226 Hck Regulation of Gene_expression of Lyn 1 0.10 0.08 0
73 INT288008 Binding of CD40 and LRRC23 1 0.02 0.45 0
74 INT220900 Binding of C4bp and Cd40 1 0.21 0.72 0
75 INT191801 Binding of SELP and CD24 1 0.12 0.67 0
76 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0
77 INT220908 Binding of Saa1 and Cd40 1 0.04 0.36 0
78 INT352086 Binding of CD40 and ADAM11 1 0.08 0.77 0
79 INT200818 Akt1 Positive_regulation of Negative_regulation of Lyn 1 0.25 1.02 0
80 INT349017 Binding of Cd80 and Cd40 1 0.22 0 0
81 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0
82 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 0.14 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for immune response-regulating cell surface receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in immune response-regulating cell surface receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7
2 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86
3 INT133156 Binding of Cd40 77 0.48 45.92 13.77
4 INT93003 Binding of CD40 28 0.47 20.25 7.13
5 INT142607 Positive_regulation of Gene_expression of Cd40 41 0.62 13.85 5.51
6 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56
7 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
8 INT140932 Binding of Cd40 1 0.44 4.19 3.6
9 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35
10 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34
11 INT142606 Regulation of Gene_expression of Cd40 13 0.56 6.15 3.27
12 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1
13 INT140929 Gene_expression of Cd40 9 0.72 8.76 2.88
14 INT96151 Negative_regulation of Gene_expression of Cd40 20 0.58 6.06 2.58
15 INT248297 Negative_regulation of Cd40 14 0.58 8.96 2.34
16 INT146945 Positive_regulation of Lyn 6 0.49 2.81 2.25
17 INT340809 Gene_expression of Btla 1 0.77 27.14 1.69
18 INT93001 Localization of CD40 4 0.78 1.97 1.45
19 INT206244 Binding of CD24 7 0.48 5.71 1.43
20 INT188691 Negative_regulation of Binding of Cd40 3 0.42 2.49 1.31
21 INT191804 Transcription of CD24 10 0.72 12.43 1.25
22 INT189836 Regulation of Cd40 10 0.40 3.02 1.1
23 INT274898 Positive_regulation of Positive_regulation of Lyn 1 0.35 1.51 1.05
24 INT140930 Positive_regulation of Gene_expression of Cd40 4 0.64 3.26 0.99
25 INT146939 Negative_regulation of Lyn 3 0.53 2.97 0.95
26 INT340797 Positive_regulation of Gene_expression of Btla 1 0.69 12.73 0.95
27 INT149383 Binding of Lyn 1 0.36 1.14 0.91
28 INT191806 Positive_regulation of Gene_expression of CD24 13 0.70 9.94 0.79
29 INT170603 Negative_regulation of Gene_expression of CD40 5 0.32 2.18 0.78
30 INT191811 Regulation of CD24 7 0.45 6 0.72
31 INT5211 Localization of Cd40 6 0.78 1.75 0.71
32 INT97130 Negative_regulation of CD40 5 0.35 1.96 0.63
33 INT269970 Positive_regulation of Positive_regulation of Cd40 2 0.50 1.79 0.57
34 INT117091 Positive_regulation of Lyn 1 0.49 0.41 0.56
35 INT188663 Regulation of Binding of Cd40 1 0.41 0.95 0.55
36 INT311966 Positive_regulation of Cd40 2 0.50 1.46 0.49
37 INT238502 Regulation of CD40 6 0.28 3.7 0.44
38 INT191803 Positive_regulation of CD24 6 0.70 5.49 0.43
39 INT216992 Regulation of Binding of CD40 1 0.13 0.06 0.41
40 INT340812 Binding of Btla 1 0.32 5.94 0.39
41 INT340794 Localization of Btla 1 0.65 4.5 0.33
42 INT191805 Negative_regulation of CD24 4 0.58 0.61 0.32
43 INT188680 Positive_regulation of Binding of Cd40 1 0.46 1.33 0.32
44 INT191809 Regulation of Gene_expression of CD24 5 0.45 3.04 0.31
45 INT340795 Negative_regulation of Localization of Btla 1 0.37 3.28 0.3
46 INT176333 Transcription of Cd40 1 0.52 0.8 0.28
47 INT340801 Negative_regulation of Binding of Btla 1 0.37 2.7 0.27
48 INT5213 Regulation of Localization of Cd40 1 0.26 0 0.27
49 INT217002 Positive_regulation of Localization of CD40 1 0.14 0 0.26
50 INT311985 Regulation of Positive_regulation of Cd40 1 0.45 0.64 0.24
51 INT332501 Negative_regulation of Negative_regulation of CD24 1 0.24 0.23 0.22
52 INT261820 Phosphorylation of Lyn 5 0.30 1.41 0.2
53 INT304142 Negative_regulation of Phosphorylation of Lyn 1 0.12 1.11 0.2
54 INT340813 Positive_regulation of Btla 1 0.46 1.83 0.19
55 INT206238 Negative_regulation of Transcription of CD24 1 0.43 1.1 0.18
56 INT206239 Regulation of Transcription of CD24 1 0.45 0.96 0.17
57 INT206805 Negative_regulation of Gene_expression of CD24 1 0.43 1.48 0.16
58 INT278361 Positive_regulation of Gene_expression of Lyn 6 0.41 0.63 0.15
59 INT191810 Positive_regulation of Transcription of CD24 3 0.60 2.88 0.15
60 INT252316 Regulation of Regulation of Cd40 2 0.24 0.71 0.15
61 INT238504 Positive_regulation of Positive_regulation of CD40 2 0.36 3.03 0.15
62 INT304452 Regulation of Lyn 1 0.17 0 0.15
63 INT234680 Localization of Cd40 1 0.18 0.16 0.14
64 INT170592 Regulation of Gene_expression of CD40 4 0.17 0 0.11
65 INT206251 Protein_catabolism of CD24 1 0.66 0.62 0.11
66 INT340805 Regulation of Binding of Btla 1 0.39 1.98 0.09
67 INT288014 Negative_regulation of Positive_regulation of CD40 1 0.17 0.63 0.09
68 INT340792 Transcription of Btla 1 0.60 1.55 0.07
69 INT311981 Regulation of Protein_catabolism of Cd40 1 0.45 0.31 0.07
70 INT311983 Protein_catabolism of Cd40 1 0.88 0.31 0.07
71 INT275162 Negative_regulation of Gene_expression of Cd40 1 0.14 1.23 0.06
72 INT241509 Negative_regulation of Gene_expression of Lyn 2 0.20 1.02 0.05
73 INT340804 Phosphorylation of Btla 1 0.71 0.67 0.05
74 INT315847 Positive_regulation of Negative_regulation of Lyn 1 0.18 0.61 0.05
75 INT340799 Positive_regulation of Phosphorylation of Btla 1 0.44 0.67 0.05
76 INT211878 Transcription of CD40 2 0.35 2.01 0.03
77 INT337233 Positive_regulation of Binding of CD40 1 0.26 0.6 0.03
78 INT206806 Phosphorylation of CD24 2 0.63 1.35 0
79 INT340808 Negative_regulation of Btla 1 0.37 0.18 0
80 INT278323 Positive_regulation of Phosphorylation of Lyn 1 0.22 0 0
81 INT278322 Negative_regulation of Localization of Lyn 1 0.20 0.11 0
82 INT191808 Localization of CD24 1 0.74 1.6 0
83 INT278356 Localization of Lyn 1 0.35 0.11 0
84 INT302001 Positive_regulation of Binding of CD24 1 0.21 0.42 0
85 INT340806 Negative_regulation of Gene_expression of Btla 1 0.42 0.34 0
86 INT284542 Negative_regulation of Positive_regulation of Cd40 1 0.27 0.28 0
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