GO:0002821

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Name positive regulation of adaptive immune response
Categary Process
Go Slim No
Go Link GO:0002821
Unique Molecular Interactions 93
Total Molecular Interactions 132
Total Single Events 634
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of adaptive immune response. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of adaptive immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
2 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
3 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
4 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 0.00 1.56 0.87
5 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
6 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
7 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55
8 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
9 INT187100 Binding of Cd4 and Cd44 1 0.02 1.09 0.47
10 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
11 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
12 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
13 INT32212 POMC Regulation of Gene_expression of Mif 1 0.00 1.01 0.35
14 INT337085 Binding of Cxcr4 and Mif 1 0.21 1.89 0.3
15 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
16 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
17 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23
18 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18
19 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17
20 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
21 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17
22 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
23 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
24 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
25 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
26 INT43495 Cd74 Regulation of Gene_expression of Ifng 1 0.47 0 0.14
27 INT298052 Binding of Cd74 and Vip 1 0.00 1.05 0.13
28 INT204899 Tlr4 Positive_regulation of Cd44 1 0.23 0.09 0.09
29 INT204885 Tlr4 Negative_regulation of Positive_regulation of Cd44 1 0.21 0.09 0.09
30 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
31 INT204889 Tlr4 Negative_regulation of Cd44 1 0.10 0.09 0.09
32 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
33 INT337090 Mif Positive_regulation of Gene_expression of Mapk1 1 0.10 1.11 0.08
34 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
35 INT337087 Negative_regulation of Binding of Mif and Cops5 1 0.13 1.64 0.08
36 INT337088 Binding of Mif and Cops5 1 0.12 1.63 0.08
37 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
38 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08
39 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
40 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
41 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
42 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
43 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
44 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
45 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
46 INT186183 Binding of SCARB2 and SASH3 1 0.00 0.49 0.04
47 INT274577 Binding of MEFV and SASH3 1 0.01 0.45 0.04
48 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
49 INT348820 Cd74 Regulation of Gene_expression of TFDP3 1 0.07 0.16 0.04
50 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
51 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
52 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
53 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
54 INT176543 Binding of Cd44 and Spp1 2 0.31 0.57 0
55 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
56 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
57 INT274591 Binding of PSTPIP1 and SASH3 1 0.01 0 0
58 INT325945 Binding of Cd44 and Ezr 1 0.25 0.39 0
59 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
60 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
61 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
62 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
63 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
64 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
65 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
66 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
67 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
68 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
69 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
70 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
71 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
72 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
73 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
74 INT294316 IL6ST Positive_regulation of Gene_expression of IL11 1 0.22 0 0
75 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
76 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
77 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
78 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
79 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
80 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
81 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
82 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
83 INT274590 Positive_regulation of Binding of MEFV and SASH3 1 0.01 0.27 0
84 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
85 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
86 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
87 INT328775 Binding of Cd44 and Epcam 1 0.08 1.34 0
88 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
89 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of adaptive immune response. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of adaptive immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79
2 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
3 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
4 INT48411 Gene_expression of Cd44 35 0.77 27.05 4.29
5 INT187168 Binding of Cd74 13 0.27 11.2 3.44
6 INT130226 Positive_regulation of Gene_expression of Mif 4 0.58 15.75 3.03
7 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
8 INT203137 Binding of Mif 6 0.31 9.46 2.71
9 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
10 INT40748 Negative_regulation of Mif 6 0.56 8.33 2.46
11 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
12 INT103304 Positive_regulation of Mif 6 0.48 8.66 2.05
13 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
14 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
15 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
16 INT41418 Regulation of Mif 2 0.40 3.86 1.24
17 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
18 INT102827 Protein_catabolism of Mif 1 0.33 0 1.06
19 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
20 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
21 INT174420 Positive_regulation of Gene_expression of Cd74 3 0.20 1.92 0.81
22 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
23 INT204842 Positive_regulation of Cd44 9 0.49 6.6 0.77
24 INT2108 Localization of Mif 5 0.77 2.7 0.73
25 INT187096 Negative_regulation of Cd44 6 0.30 5.92 0.7
26 INT187087 Binding of Cd44 5 0.47 2.79 0.66
27 INT32209 Regulation of Gene_expression of Mif 3 0.59 3.41 0.66
28 INT130229 Regulation of Negative_regulation of Mif 1 0.39 1.36 0.66
29 INT288158 Negative_regulation of Gene_expression of Cd44 5 0.30 5.73 0.59
30 INT337079 Negative_regulation of Gene_expression of Mif 1 0.41 4.17 0.51
31 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
32 INT174418 Regulation of Gene_expression of Cd74 1 0.04 0.9 0.46
33 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45
34 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
35 INT254172 Negative_regulation of Gene_expression of Cd74 1 0.24 1.03 0.44
36 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
37 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
38 INT136518 Regulation of IL6ST 2 0.29 0.31 0.36
39 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
40 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
41 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
42 INT48656 Positive_regulation of Gene_expression of Cd44 7 0.69 5.93 0.21
43 INT337077 Positive_regulation of Localization of Mif 1 0.58 0.96 0.21
44 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
45 INT214464 Regulation of Gene_expression of Cd44 3 0.34 2.95 0.17
46 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
47 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
48 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
49 INT136520 Positive_regulation of Regulation of IL6ST 1 0.09 0.08 0.13
50 INT131015 Negative_regulation of Cd74 1 0.17 0.25 0.12
51 INT337076 Positive_regulation of Negative_regulation of Mif 1 0.48 1.44 0.12
52 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
53 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
54 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
55 INT288160 Regulation of Cd44 1 0.42 0.67 0.1
56 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
57 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
58 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
59 INT206151 Positive_regulation of Gene_expression of IL6ST 2 0.24 0.35 0.06
60 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
61 INT294329 Regulation of Gene_expression of IL6ST 1 0.22 0 0.05
62 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
63 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
64 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
65 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
66 INT324127 Positive_regulation of Cd74 2 0.07 1.34 0.04
67 INT200859 Transcription of Cd44 2 0.41 0.71 0.04
68 INT186196 Binding of SASH3 1 0.01 0.49 0.04
69 INT294344 Localization of IL6ST 1 0.39 0 0.04
70 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
71 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
72 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
73 INT204861 Localization of Cd44 1 0.46 0.06 0.03
74 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
75 INT204349 Regulation of SIRT1 8 0.61 1.99 0
76 INT256134 Localization of Sirt1 5 0.50 2.99 0
77 INT204353 Transcription of SIRT1 3 0.68 0.67 0
78 INT324126 Negative_regulation of Binding of Cd74 1 0.08 0.31 0
79 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
80 INT289569 Transcription of Sirt1 1 0.71 0.25 0
81 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
82 INT300287 Localization of Sirt1 1 0.66 1.46 0
83 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
84 INT235270 Positive_regulation of Binding of Cd44 1 0.26 1.11 0
85 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
86 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
87 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
88 INT337082 Phosphorylation of Mif 1 0.68 0.97 0
89 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
90 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
91 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
92 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
93 INT206153 Phosphorylation of IL6ST 1 0.22 0.05 0
94 INT301984 Negative_regulation of Positive_regulation of Cd44 1 0.17 1.28 0
95 INT324125 Positive_regulation of Binding of Cd74 1 0.09 0.62 0
96 INT206156 Positive_regulation of Phosphorylation of IL6ST 1 0.14 0.05 0
97 INT204331 Binding of SIRT1 1 0.47 0.39 0
98 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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