GO:0002829

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Name negative regulation of type 2 immune response
Categary Process
Go Slim No
Go Link GO:0002829
Unique Molecular Interactions 88
Total Molecular Interactions 115
Total Single Events 669
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of type 2 immune response. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of type 2 immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
2 INT100678 IL4 Positive_regulation of STAT6 1 0.49 2.63 1.08
3 INT181434 Binding of Ccr2 and Ccl2 1 0.27 6.06 1.04
4 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98
5 INT133076 STAT6 Positive_regulation of OPRM1 1 0.38 0 0.95
6 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
7 INT133073 IL4 Positive_regulation of Phosphorylation of STAT6 1 0.39 0 0.9
8 INT100677 IL13 Positive_regulation of STAT6 1 0.36 1.95 0.81
9 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
10 INT199476 Il4 Positive_regulation of Transcription of Stat6 1 0.01 0.97 0.77
11 INT199489 Stat6 Positive_regulation of Oprm1 1 0.02 0.85 0.68
12 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67
13 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67
14 INT281130 Ccl2 Regulation of Gene_expression of Ccr2 1 0.04 1.09 0.64
15 INT281134 Ccl2 Positive_regulation of Gene_expression of Ccr2 1 0.08 1.09 0.64
16 INT281122 Ccl2 Regulation of Ccr2 1 0.04 1.09 0.63
17 INT100681 Negative_regulation of IL13 Positive_regulation of STAT6 1 0.30 1.39 0.57
18 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55
19 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
20 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
21 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55
22 INT172096 Binding of HLA-E and Il27ra 2 0.01 1.32 0.48
23 INT184117 Il12a Positive_regulation of Stat6 1 0.07 0.28 0.48
24 INT281126 Binding of Ccr2 and Cxcr4 1 0.30 0.32 0.44
25 INT181448 Eae1 Positive_regulation of Gene_expression of Ccr2 1 0.04 4.98 0.42
26 INT172094 Binding of Atp9a and Il27ra 1 0.01 0.98 0.4
27 INT297424 Gene_expression of Stat6 Regulation of Ppara 1 0.17 1.19 0.38
28 INT297426 Stat6 Regulation of Ppara 1 0.17 1.19 0.38
29 INT163909 CCL2 Positive_regulation of Positive_regulation of Ccr2 1 0.05 0.19 0.36
30 INT163906 CCL2 Positive_regulation of CCR2 1 0.18 0.2 0.35
31 INT163908 CCL2 Positive_regulation of Ccr2 1 0.05 0.2 0.35
32 INT94474 Binding of Cd3e and Il27ra 1 0.02 0 0.34
33 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
34 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
35 INT186345 Binding of Gast and Stat6 1 0.03 2.19 0.3
36 INT100682 IL13 Positive_regulation of Positive_regulation of STAT6 1 0.26 0.74 0.3
37 INT306107 Binding of CCL2 and Ccr2 1 0.06 0 0.28
38 INT100683 Negative_regulation of IL4 Positive_regulation of STAT6 1 0.30 0.65 0.27
39 INT100676 IL4 Positive_regulation of Positive_regulation of STAT6 1 0.35 0.68 0.27
40 INT158222 Positive_regulation of Binding of MAPK1 and CCR2 1 0.26 0.3 0.2
41 INT226720 Binding of Prkca and Il27ra 1 0.00 0.52 0.2
42 INT158207 Positive_regulation of Binding of TNFSF14 and CCR2 1 0.07 0.3 0.2
43 INT226756 Positive_regulation of Binding of Prkca and Il27ra 1 0.00 0.52 0.2
44 INT158224 TNFSF14 Positive_regulation of CCR2 1 0.07 0.3 0.2
45 INT158204 Negative_regulation of Binding of MAPK1 and CCR2 1 0.22 0.3 0.2
46 INT158198 Negative_regulation of Binding of AHSA1 and CCR2 1 0.21 0.3 0.2
47 INT158206 Binding of TNFSF14 and CCR2 1 0.05 0.3 0.2
48 INT158216 Negative_regulation of Binding of TNFSF14 and CCR2 1 0.06 0.3 0.2
49 INT158217 Binding of AHSA1 and CCR2 1 0.18 0.3 0.2
50 INT158234 Binding of MAPK1 and CCR2 1 0.19 0.3 0.2
51 INT158235 Positive_regulation of Binding of AHSA1 and CCR2 1 0.24 0.3 0.2
52 INT181440 Binding of Ccr2 and Eae1 1 0.03 1.3 0.19
53 INT332247 Egf Positive_regulation of Stat6 1 0.13 1.23 0.19
54 INT332253 Il13 Positive_regulation of Stat6 1 0.08 1.18 0.19
55 INT332245 Pdgfa Positive_regulation of Stat6 1 0.07 1.22 0.19
56 INT188470 Binding of Gpi1 and Il27ra 1 0.00 0.86 0.16
57 INT261760 Il4 Positive_regulation of Phosphorylation of Stat6 1 0.50 0.48 0.16
58 INT186380 Binding of SOAT1 and Stat6 1 0.02 0.11 0.15
59 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
60 INT186357 Binding of Irf1 and Stat6 1 0.04 2.09 0.14
61 INT352416 Ccl2 Positive_regulation of Ccr2 1 0.23 0.26 0.14
62 INT332250 Stat6 Positive_regulation of Gene_expression of Pdgfa 1 0.05 1.33 0.12
63 INT332252 Stat6 Positive_regulation of Gene_expression of Il13 1 0.08 1.32 0.12
64 INT261762 Il3 Positive_regulation of Stat6 1 0.15 0 0.11
65 INT261761 Ifng Positive_regulation of Stat6 1 0.13 0 0.1
66 INT350700 Binding of Bcl6 and thd 1 0.00 0.21 0.08
67 INT337178 CCR2 Regulation of Gene_expression of CCR6 1 0.14 0.72 0.08
68 INT350692 Binding of Bcl6 and Hand1 1 0.02 0.16 0.08
69 INT350720 Binding of Bcl6 and TBX21 1 0.07 0.22 0.08
70 INT186366 Binding of Stat1 and Stat6 1 0.12 1.04 0.07
71 INT270568 Binding of UTS2R and STAT6 1 0.04 2 0.05
72 INT186359 Stat6 Negative_regulation of Il4 1 0.06 0.78 0.04
73 INT186360 Stat6 Negative_regulation of Transcription of Nos2 1 0.08 0.78 0.04
74 INT186363 Binding of Stat6 and Positive_regulation of Positive_regulation of Irf2 1 0.05 0.4 0.03
75 INT186354 Stat6 Positive_regulation of Positive_regulation of Irf2 1 0.06 0.4 0.03
76 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0
77 INT144033 STAT6 Positive_regulation of Positive_regulation of STAT3 1 0.04 0.08 0
78 INT163078 IL4 Positive_regulation of Gene_expression of STAT6 1 0.26 0 0
79 INT164900 STAT6 Positive_regulation of Gene_expression of IL1RL1 1 0.42 0.06 0
80 INT184093 Negative_regulation of Il4 Positive_regulation of Stat6 1 0.08 0.93 0
81 INT243624 Stat6 Negative_regulation of Gene_expression of Twist1 1 0.30 0 0
82 INT207266 INS Negative_regulation of BCL6 1 0.29 0.08 0
83 INT322470 Binding of Bcl6 and Hif1a 1 0.06 0.52 0
84 INT305632 Binding of BCL6 and MME 1 0.00 1.37 0
85 INT268508 MIR221 Positive_regulation of BCL6 1 0.03 1.36 0
86 INT144034 STAT6 Positive_regulation of STAT3 1 0.04 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of type 2 immune response. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of type 2 immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
2 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81
3 INT151434 Positive_regulation of Ccr2 26 0.68 18.34 16.34
4 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75
5 INT161222 Positive_regulation of Ccr2 13 0.55 13.77 8.89
6 INT88047 Positive_regulation of Gene_expression of Ccr2 15 0.60 10.5 8.63
7 INT102548 Negative_regulation of Ccr2 14 0.59 19.84 7.22
8 INT161221 Positive_regulation of Positive_regulation of Ccr2 3 0.50 4.55 3.98
9 INT222241 Binding of Ccr2 5 0.42 4.09 3.71
10 INT281144 Regulation of Gene_expression of Ccr2 2 0.44 2.38 3.29
11 INT120067 Positive_regulation of Gene_expression of CCR2 10 0.46 5.13 3.02
12 INT163080 Gene_expression of STAT6 5 0.59 3.18 2.94
13 INT222237 Negative_regulation of Gene_expression of Ccr2 3 0.37 3.39 2.91
14 INT151436 Regulation of Ccr2 4 0.44 2.81 2.82
15 INT222226 Negative_regulation of Ccr2 6 0.57 3.69 2.66
16 INT163082 Negative_regulation of STAT6 2 0.42 2.35 2.28
17 INT146504 Regulation of Ccr2 5 0.39 3.58 2.21
18 INT50994 Binding of Il27ra 5 0.11 1.77 2.15
19 INT129240 Positive_regulation of Stat6 6 0.67 1.96 1.92
20 INT181341 Binding of Ccr2 8 0.32 6.47 1.77
21 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75
22 INT100692 Phosphorylation of STAT6 5 0.78 3.42 1.7
23 INT102550 Positive_regulation of Gene_expression of Ccr2 6 0.69 4.53 1.67
24 INT186286 Phosphorylation of Stat6 18 0.79 5.07 1.61
25 INT89858 Positive_regulation of STAT6 10 0.66 7.81 1.47
26 INT181373 Negative_regulation of Gene_expression of Ccr2 5 0.59 5.92 1.44
27 INT199482 Transcription of Stat6 1 0.25 1.75 1.39
28 INT281139 Phosphorylation of Ccr2 2 0.79 1.2 1.18
29 INT281141 Positive_regulation of Phosphorylation of Ccr2 2 0.49 1.2 1.18
30 INT62959 Positive_regulation of CCR2 4 0.61 1.47 1.13
31 INT222235 Localization of Ccr2 7 0.73 5.32 1.12
32 INT158242 Negative_regulation of Gene_expression of CCR2 3 0.37 2.13 1.12
33 INT151435 Negative_regulation of Positive_regulation of Ccr2 1 0.53 0.7 1.08
34 INT194657 Negative_regulation of CCR2 2 0.29 2.3 1.07
35 INT231793 Negative_regulation of Il27ra 4 0.08 3.04 0.98
36 INT133077 Positive_regulation of Phosphorylation of STAT6 1 0.43 0 0.95
37 INT161223 Negative_regulation of Positive_regulation of Ccr2 1 0.43 0.83 0.81
38 INT176606 Gene_expression of Stat6 9 0.65 6.87 0.77
39 INT148839 Regulation of Gene_expression of CCR2 2 0.26 1.78 0.76
40 INT163084 Negative_regulation of Gene_expression of STAT6 2 0.42 0.58 0.74
41 INT222239 Transcription of Ccr2 2 0.61 1.15 0.73
42 INT129448 Positive_regulation of Stat6 1 0.27 0.17 0.7
43 INT136269 Transcription of CCR2 2 0.61 1.27 0.69
44 INT186299 Negative_regulation of Stat6 6 0.42 3.61 0.62
45 INT165851 Phosphorylation of Stat6 1 0.54 0.69 0.59
46 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58
47 INT239551 Binding of CCR2 2 0.39 0 0.52
48 INT222242 Positive_regulation of Transcription of Ccr2 1 0.44 0.66 0.52
49 INT114293 Binding of Stat6 2 0.44 1.29 0.5
50 INT100691 Negative_regulation of Phosphorylation of STAT6 1 0.40 1.11 0.5
51 INT236350 Transcription of Ccr2 2 0.72 3.59 0.49
52 INT114290 Negative_regulation of Binding of Stat6 1 0.53 0.91 0.49
53 INT272877 Localization of Ccr2 2 0.75 1.68 0.46
54 INT281147 Regulation of Binding of Ccr2 1 0.39 0.86 0.46
55 INT207299 Binding of BCL6 6 0.30 3.5 0.41
56 INT239027 Regulation of Regulation of Il27ra 1 0.02 1.03 0.41
57 INT239031 Regulation of Il27ra 1 0.05 1.03 0.41
58 INT174433 Gene_expression of Il27ra 1 0.06 1.21 0.41
59 INT243603 Localization of Stat6 6 0.68 2.96 0.4
60 INT98294 Binding of STAT6 2 0.40 1.63 0.39
61 INT163905 Positive_regulation of Positive_regulation of Ccr2 1 0.13 0.16 0.37
62 INT340642 Regulation of Gene_expression of Ccr2 1 0.62 2.26 0.35
63 INT226435 Regulation of STAT6 4 0.37 2.98 0.34
64 INT100686 Negative_regulation of Positive_regulation of STAT6 3 0.40 1.45 0.33
65 INT121388 Positive_regulation of BCL6 2 0.28 2.71 0.32
66 INT235466 Localization of BCL6 3 0.27 5 0.29
67 INT100693 Regulation of Positive_regulation of STAT6 2 0.26 0.76 0.26
68 INT100690 Positive_regulation of Positive_regulation of STAT6 1 0.48 0.66 0.26
69 INT261750 Negative_regulation of Phosphorylation of Stat6 1 0.42 0.48 0.25
70 INT136270 Positive_regulation of Transcription of CCR2 1 0.09 0.82 0.22
71 INT158246 Phosphorylation of CCR2 1 0.55 0.32 0.21
72 INT144881 Positive_regulation of Gene_expression of BCL6 5 0.43 1.6 0.18
73 INT158245 Negative_regulation of Positive_regulation of CCR2 1 0.37 0.26 0.17
74 INT236693 Positive_regulation of Gene_expression of Bcl6 3 0.15 2.06 0.14
75 INT258953 Negative_regulation of Gene_expression of Bcl6 1 0.19 1.53 0.14
76 INT235514 Positive_regulation of Transcription of Stat6 1 0.12 0.89 0.14
77 INT235506 Transcription of Stat6 1 0.17 0.89 0.14
78 INT254238 Positive_regulation of Il27ra 3 0.06 0.93 0.12
79 INT261753 Positive_regulation of Phosphorylation of Stat6 2 0.45 2.49 0.12
80 INT258955 Localization of Bcl6 1 0.23 0.83 0.11
81 INT337246 Regulation of CCR2 1 0.35 0.75 0.09
82 INT236358 Regulation of Transcription of Ccr2 1 0.24 1 0.09
83 INT350635 Transcription of Bcl6 1 0.09 0.16 0.08
84 INT350649 Negative_regulation of Transcription of Bcl6 1 0.06 0.16 0.08
85 INT176605 Positive_regulation of Gene_expression of Stat6 1 0.49 1.06 0.08
86 INT352409 Regulation of Positive_regulation of Ccr2 1 0.44 0.15 0.07
87 INT270577 Localization of STAT6 1 0.62 0.51 0.04
88 INT261752 Protein_catabolism of Stat6 1 0.86 0.15 0.04
89 INT207276 Transcription of BCL6 3 0.45 0.64 0.03
90 INT144882 Negative_regulation of Gene_expression of BCL6 2 0.26 0.93 0
91 INT322454 Positive_regulation of Bcl6 2 0.10 1.6 0
92 INT163083 Transcription of STAT6 1 0.52 0 0
93 INT207269 Regulation of BCL6 1 0.38 0.1 0
94 INT184046 Positive_regulation of Positive_regulation of Stat6 1 0.32 0.92 0
95 INT277670 Negative_regulation of Gene_expression of Stat6 1 0.14 2.12 0
96 INT277668 Positive_regulation of Localization of Stat6 1 0.14 2 0
97 INT277796 Binding of Bcl6 1 0.17 1.33 0
98 INT163081 Positive_regulation of Transcription of STAT6 1 0.46 0 0
99 INT347438 Regulation of Gene_expression of BCL6 1 0.07 0.7 0
100 INT163085 Negative_regulation of Transcription of STAT6 1 0.42 0 0
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