GO:0002830

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Name positive regulation of type 2 immune response
Categary Process
Go Slim No
Go Link GO:0002830
Unique Molecular Interactions 83
Total Molecular Interactions 121
Total Single Events 890
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of type 2 immune response. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of type 2 immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
2 INT325267 Il33 Positive_regulation of Gene_expression of Il4 1 0.16 1.59 0.69
3 INT325263 Il33 Positive_regulation of Gene_expression of Il5 1 0.16 1.59 0.69
4 INT325270 Il33 Positive_regulation of Gene_expression of Il6 1 0.20 1.59 0.69
5 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
6 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
7 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
8 INT220051 Fcgr4 Positive_regulation of Gene_expression of Ido1 1 0.01 1.24 0.55
9 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53
10 INT325259 Il33 Positive_regulation of Gene_expression of Spg21 1 0.07 1.23 0.53
11 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
12 INT325269 Il33 Positive_regulation of Spg21 1 0.05 1.11 0.48
13 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
14 INT104447 Ido1 Negative_regulation of Binding of Atp7b 1 0.00 0.68 0.43
15 INT220050 Ctla4 Positive_regulation of Ido1 1 0.31 1.45 0.38
16 INT164890 Binding of IL1RAP and IL33 1 0.09 0.2 0.36
17 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
18 INT164904 Binding of IL1A and IL33 1 0.39 0.19 0.35
19 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34
20 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33
21 INT325266 Positive_regulation of Spg21 Positive_regulation of Il33 1 0.05 0.75 0.32
22 INT325265 Il33 Positive_regulation of Gene_expression of Ik 1 0.01 0.67 0.32
23 INT270046 Ido1 Positive_regulation of Positive_regulation of Hmox1 1 0.15 0.8 0.27
24 INT311046 Binding of CSF2 and IL33 1 0.00 1.86 0.26
25 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
26 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
27 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23
28 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23
29 INT325276 Il33 Positive_regulation of Gene_expression of TNF 1 0.04 0.82 0.23
30 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22
31 INT220053 Il10 Positive_regulation of Ido1 1 0.14 0.74 0.19
32 INT169567 IL33 Regulation of Pscs 1 0.03 0.46 0.19
33 INT164892 IL33 Regulation of Gene_expression of IL1RAP 1 0.06 0.2 0.18
34 INT319381 Binding of ST2 and IL33 1 0.13 1.01 0.18
35 INT302381 Il33 Regulation of Gene_expression of Il4 1 0.01 0.76 0.16
36 INT204791 Binding of Spg7 and Nod2 1 0.03 0.5 0.16
37 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
38 INT318305 Binding of NOD2 and NLRP3 1 0.08 1.76 0.15
39 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15
40 INT43495 Cd74 Regulation of Gene_expression of Ifng 1 0.47 0 0.14
41 INT323345 Ido1 Positive_regulation of Gene_expression of Tlr4 1 0.14 0.69 0.13
42 INT268083 Ido1 Negative_regulation of Tyrp1 1 0.22 0 0.13
43 INT298052 Binding of Cd74 and Vip 1 0.00 1.05 0.13
44 INT268082 Ido1 Positive_regulation of Gpr35 1 0.04 0 0.13
45 INT169562 PDGFD Positive_regulation of Gene_expression of IL33 1 0.03 0.35 0.13
46 INT87839 Binding of Cd74 and Dcn 1 0.36 0.21 0.13
47 INT145830 Mdp1 Positive_regulation of Nod2 1 0.34 0.52 0.13
48 INT172824 Positive_regulation of Binding of Tnfsf4 and T2dm2 1 0.00 2.97 0.12
49 INT170330 Regulation of Regulation of Gene_expression of Ido1 1 0.01 0.38 0.08
50 INT226515 Binding of Il1rl1 and Il33 1 0.02 0.36 0.08
51 INT226906 Binding of Ido1 and Il6 1 0.07 0.67 0.08
52 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08
53 INT325255 Chchd8 Regulation of Il33 1 0.00 0.33 0.05
54 INT325261 Ralbp1 Positive_regulation of Gene_expression of Il33 1 0.01 0 0.05
55 INT268088 Tdo2 Positive_regulation of Gene_expression of Ido1 1 0.41 0.09 0.04
56 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
57 INT348820 Cd74 Regulation of Gene_expression of TFDP3 1 0.07 0.16 0.04
58 INT170337 Gene_expression of Ido1 Positive_regulation of MRXS5 1 0.01 0.12 0.03
59 INT170326 Ido1 Positive_regulation of Cpox 1 0.07 0.12 0.03
60 INT170338 Gene_expression of Ido1 Positive_regulation of IGHD2-15 1 0.02 0.12 0.03
61 INT170327 Ido1 Positive_regulation of Gene_expression of Cpox 1 0.07 0.12 0.03
62 INT222259 EIF4E Regulation of Negative_regulation of NOD2 1 0.13 0.1 0
63 INT164899 IL33 Positive_regulation of IFNG 1 0.25 0.05 0
64 INT204927 Binding of LGMN and IL33 1 0.00 0.52 0
65 INT164895 IL33 Positive_regulation of Gene_expression of CCL2 1 0.16 0.05 0
66 INT164901 IL33 Positive_regulation of Gene_expression of CXCL10 1 0.16 0.05 0
67 INT164906 IL33 Positive_regulation of Gene_expression of IL4 1 0.43 0.05 0
68 INT164910 IL33 Positive_regulation of Gene_expression of CXCL1 1 0.12 0.05 0
69 INT276606 Binding of DBT and IL33 1 0.01 0 0
70 INT172831 Binding of INS and Tnfsf4 1 0.02 1.07 0
71 INT325271 Positive_regulation of Il33 Regulation of Gene_expression of Il1rl1 1 0.22 0 0
72 INT164912 IL33 Positive_regulation of Gene_expression of IL8 1 0.45 0.05 0
73 INT164903 IL33 Positive_regulation of Gene_expression of CXCL2 1 0.12 0.05 0
74 INT164889 IL33 Positive_regulation of Gene_expression of IFNG 1 0.25 0.05 0
75 INT164909 IL33 Positive_regulation of Phosphorylation of NFKBIA 1 0.53 0.05 0
76 INT276608 Binding of UBE2S and IL33 1 0.00 0.32 0
77 INT164893 IL33 Positive_regulation of Gene_expression of IL6 1 0.46 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of type 2 immune response. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of type 2 immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98
2 INT226402 Gene_expression of Il33 60 0.77 23.82 8.67
3 INT170295 Positive_regulation of Ido1 40 0.67 28.89 7.61
4 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
5 INT170315 Positive_regulation of Gene_expression of Ido1 50 0.67 25.39 6.06
6 INT11298 Gene_expression of Ido1 6 0.58 6.71 4.85
7 INT170311 Negative_regulation of Ido1 16 0.48 14.47 4.81
8 INT143557 Positive_regulation of Ido1 6 0.40 5.34 4.8
9 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
10 INT187168 Binding of Cd74 13 0.27 11.2 3.44
11 INT164920 Gene_expression of IL33 22 0.76 13.63 3.16
12 INT103910 Binding of NOD2 19 0.47 12.24 2.93
13 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
14 INT243350 Binding of CD74 2 0.11 4.86 2.72
15 INT170323 Regulation of Gene_expression of Ido1 11 0.60 8.74 2.33
16 INT325254 Positive_regulation of Il33 19 0.69 6.56 2.09
17 INT143561 Positive_regulation of Positive_regulation of Ido1 1 0.36 1.84 1.89
18 INT253975 Binding of Cd74 4 0.27 4.57 1.88
19 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
20 INT325244 Localization of Il33 1 0.80 4.17 1.8
21 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
22 INT150248 Positive_regulation of Gene_expression of Ido1 2 0.43 2.68 1.77
23 INT271443 Regulation of Cd74 1 0.33 2.73 1.4
24 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31
25 INT204766 Gene_expression of Nod2 4 0.75 4.14 1.3
26 INT220046 Positive_regulation of Negative_regulation of Ido1 1 0.41 2.98 1.12
27 INT88177 Negative_regulation of Ido1 3 0.25 0.51 1.02
28 INT154227 Regulation of Gene_expression of NOD2 3 0.44 3.38 0.99
29 INT116058 Gene_expression of Cd74 2 0.56 0.55 0.89
30 INT220043 Positive_regulation of Positive_regulation of Ido1 2 0.41 1.94 0.83
31 INT325230 Positive_regulation of Gene_expression of Il33 1 0.50 1.47 0.83
32 INT174420 Positive_regulation of Gene_expression of Cd74 3 0.20 1.92 0.81
33 INT143559 Positive_regulation of Protein_catabolism of Ido1 1 0.29 0.93 0.79
34 INT143560 Protein_catabolism of Ido1 1 0.52 0.93 0.79
35 INT143558 Negative_regulation of Negative_regulation of Ido1 1 0.25 0.49 0.76
36 INT204929 Binding of IL33 18 0.08 4.74 0.7
37 INT226421 Regulation of Il33 2 0.45 2.7 0.68
38 INT226403 Regulation of Gene_expression of Il33 2 0.61 1.94 0.63
39 INT116060 Negative_regulation of Gene_expression of Cd74 1 0.12 0 0.61
40 INT273000 Localization of IL33 5 0.45 1.77 0.56
41 INT174797 Regulation of Tnfsf4 1 0.03 4.05 0.54
42 INT271439 Positive_regulation of Localization of Cd74 1 0.36 1.01 0.52
43 INT170299 Negative_regulation of Gene_expression of Ido1 12 0.57 2.59 0.5
44 INT273003 Positive_regulation of IL33 4 0.26 3.27 0.49
45 INT271435 Localization of Cd74 1 0.54 0.95 0.49
46 INT220048 Protein_catabolism of Ido1 1 0.81 1.03 0.47
47 INT204781 Positive_regulation of Nod2 6 0.45 2.79 0.46
48 INT174418 Regulation of Gene_expression of Cd74 1 0.04 0.9 0.46
49 INT172800 Binding of Tnfsf4 2 0.04 4.58 0.45
50 INT325251 Positive_regulation of Localization of Il33 1 0.69 1.03 0.45
51 INT172801 Positive_regulation of Tnfsf4 4 0.08 7.95 0.44
52 INT254172 Negative_regulation of Gene_expression of Cd74 1 0.24 1.03 0.44
53 INT222266 Transcription of NOD2 5 0.68 0.76 0.43
54 INT270034 Negative_regulation of Positive_regulation of Ido1 1 0.19 2.23 0.42
55 INT325250 Regulation of Positive_regulation of Il33 2 0.45 1.16 0.39
56 INT270027 Regulation of Positive_regulation of Ido1 1 0.23 1.17 0.39
57 INT170318 Regulation of Ido1 6 0.38 2.63 0.38
58 INT273005 Negative_regulation of IL33 4 0.07 2.4 0.38
59 INT171764 Localization of NOD2 2 0.74 0.86 0.37
60 INT62874 Gene_expression of CD74 1 0.00 0.64 0.37
61 INT325234 Negative_regulation of Il33 1 0.43 0.67 0.37
62 INT325231 Negative_regulation of Negative_regulation of Il33 1 0.43 0.67 0.34
63 INT183240 Negative_regulation of NOD2 6 0.43 1.52 0.33
64 INT244148 Positive_regulation of Positive_regulation of NOD2 1 0.47 0.68 0.31
65 INT222270 Regulation of Localization of NOD2 1 0.45 0.63 0.28
66 INT174805 Gene_expression of Tnfsf4 1 0.04 3.49 0.28
67 INT346895 Positive_regulation of Gene_expression of Nod2 1 0.33 0.74 0.28
68 INT346896 Binding of Nod2 1 0.21 0.72 0.26
69 INT346899 Regulation of Positive_regulation of Nod2 1 0.18 0.75 0.22
70 INT325246 Regulation of Localization of Il33 1 0.27 0.23 0.16
71 INT11299 Binding of Ido1 1 0.31 0.15 0.15
72 INT169566 Positive_regulation of Gene_expression of IL33 1 0.41 0.38 0.14
73 INT172790 Negative_regulation of Tnfsf4 1 0.05 2.43 0.14
74 INT325249 Binding of Il33 1 0.37 0.72 0.13
75 INT222274 Regulation of Regulation of NOD2 1 0.27 0.45 0.13
76 INT319432 Positive_regulation of Localization of IL33 1 0.26 1.02 0.13
77 INT164918 Regulation of Gene_expression of IL33 2 0.44 1.09 0.12
78 INT131015 Negative_regulation of Cd74 1 0.17 0.25 0.12
79 INT172785 Positive_regulation of Binding of Tnfsf4 1 0.05 2.89 0.12
80 INT170320 Binding of Ido1 1 0.36 0.19 0.11
81 INT169564 Negative_regulation of Gene_expression of IL33 1 0.38 0.3 0.11
82 INT170297 Positive_regulation of Regulation of Ido1 1 0.39 0.29 0.1
83 INT204777 Negative_regulation of Localization of Nod2 1 0.28 0.61 0.09
84 INT339608 Localization of Ido1 1 0.14 0.41 0.08
85 INT204779 Localization of Nod2 1 0.48 0.6 0.08
86 INT204770 Regulation of Nod2 1 0.29 0.66 0.07
87 INT174802 Positive_regulation of Regulation of Tnfsf4 1 0.03 0.92 0.06
88 INT222267 Regulation of Transcription of NOD2 1 0.45 0 0.05
89 INT324127 Positive_regulation of Cd74 2 0.07 1.34 0.04
90 INT174799 Regulation of Binding of Tnfsf4 1 0.03 0.92 0.04
91 INT346893 Negative_regulation of Gene_expression of Nod2 1 0.28 0.13 0.04
92 INT325253 Negative_regulation of Positive_regulation of Il33 1 0.42 0 0.03
93 INT325247 Negative_regulation of Gene_expression of Il33 1 0.42 0 0.03
94 INT194148 Positive_regulation of CD74 2 0.27 0.68 0
95 INT324126 Negative_regulation of Binding of Cd74 1 0.08 0.31 0
96 INT150246 Negative_regulation of Gene_expression of Ido1 1 0.07 0 0
97 INT325237 Transcription of Il33 1 0.68 0.15 0
98 INT284053 Positive_regulation of Positive_regulation of Nod2 1 0.25 0.08 0
99 INT170301 Negative_regulation of Negative_regulation of Ido1 1 0.36 0.32 0
100 INT276617 Negative_regulation of Localization of IL33 1 0.03 0.28 0
101 INT170310 Transcription of Ido1 1 0.61 0.52 0
102 INT150247 Transcription of Ido1 1 0.10 0 0
103 INT150249 Negative_regulation of Transcription of Ido1 1 0.08 0 0
104 INT222273 Positive_regulation of Regulation of NOD2 1 0.46 0.09 0
105 INT324125 Positive_regulation of Binding of Cd74 1 0.09 0.62 0
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