GO:0003007

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Name heart morphogenesis
Categary Process
Go Slim No
Go Link GO:0003007
Unique Molecular Interactions 1091
Total Molecular Interactions 1599
Total Single Events 13157
Pain Genes Associated 52

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heart morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for heart morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
8 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
9 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
10 INT151514 Olfr155 Negative_regulation of Gene_expression of VEGFA 1 0.00 1.8 1.42
11 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
12 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
13 INT351205 VEGFA Positive_regulation of Binding of MRGPRX1 1 0.08 0.65 1.35
14 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
15 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
16 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
17 INT136644 T(1;9)27H Negative_regulation of Gene_expression of Hand1 1 0.15 1.14 1.27
18 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
19 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
20 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
21 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
22 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
23 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
24 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11
25 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
26 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
27 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
28 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
29 INT228498 Il10 Negative_regulation of Hand1 1 0.03 1.4 0.99
30 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99
31 INT228495 Il13 Negative_regulation of Hand1 1 0.01 1.4 0.98
32 INT161231 Positive_regulation of Htr1a Positive_regulation of Gene_expression of VEGFA 1 0.67 0.16 0.95
33 INT137922 VEGFA Positive_regulation of Oprm1 1 0.06 0 0.94
34 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
35 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
36 INT137921 VEGFA Positive_regulation of Ephb2 1 0.03 0 0.93
37 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
38 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
39 INT74872 Igh-Dex Positive_regulation of Chd7 1 0.01 0.5 0.89
40 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
41 INT116108 VEGFA Positive_regulation of SEC23IP 1 0.10 0.3 0.83
42 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
43 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
44 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
45 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
46 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
47 INT161949 TGFB2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.97 0.74
48 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74
49 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
50 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
51 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
52 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
53 INT120018 VEGFA Positive_regulation of CCL3 1 0.01 1 0.7
54 INT120020 VEGFA Positive_regulation of CCL2 1 0.00 1 0.7
55 INT120036 VEGFA Positive_regulation of Prap1 1 0.00 1 0.7
56 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
57 INT287099 Binding of Bdnf and T 1 0.10 1.1 0.69
58 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
59 INT167355 VEGFA Regulation of RYBP 1 0.01 0.53 0.68
60 INT168295 PROC Regulation of Gene_expression of VEGFA 2 0.00 1.6 0.67
61 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
62 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
63 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
64 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
65 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
66 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
67 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
68 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
69 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
70 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
71 INT248172 Epo Regulation of Cysltr1 1 0.01 0.74 0.63
72 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63
73 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
74 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
75 INT248170 Epo Regulation of Ltp 1 0.11 0.74 0.62
76 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
77 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61
78 INT224731 Binding of VEGFA and Cia1 1 0.01 0.91 0.61
79 INT224733 Negative_regulation of Binding of VEGFA and Cia1 1 0.01 0.91 0.61
80 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61
81 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61
82 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
83 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 0.27 2.73 0.6
84 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
85 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
86 INT299286 VEGFA Positive_regulation of PI3 1 0.16 0.46 0.6
87 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
88 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
89 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
90 INT109065 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.00 0 0.58
91 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58
92 INT327339 Gtf3a Positive_regulation of VEGFA 1 0.00 2.34 0.58
93 INT304326 Ptger1 Positive_regulation of Gene_expression of VEGFA 1 0.19 1.37 0.57
94 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
95 INT112025 Binding of Hand1 and Il10 2 0.15 0.56 0.55
96 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
97 INT355881 Il17a Regulation of Gene_expression of Hand1 1 0.18 1.51 0.54
98 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
99 INT184111 Epo Positive_regulation of Il7 1 0.06 0.26 0.52
100 INT194918 Csf2 Positive_regulation of Gene_expression of VEGFA 1 0.02 0.85 0.52
101 INT194919 Kitl Positive_regulation of Gene_expression of VEGFA 1 0.01 0.85 0.52
102 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
103 INT184088 Epo Positive_regulation of Il2 1 0.07 0.26 0.52
104 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
105 INT127430 VEGFA Negative_regulation of Gene_expression of TIMP1 1 0.43 0.6 0.5
106 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
107 INT327332 VEGFA Positive_regulation of Gene_expression of Hgfac 1 0.00 2.02 0.49
108 INT288376 IL17A Regulation of VEGFA 1 0.00 1.16 0.49
109 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48
110 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48
111 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48
112 INT305547 VEGFA Positive_regulation of Gtf3a 2 0.00 1.83 0.48
113 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48
114 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
115 INT331928 Negative_regulation of Cpox Negative_regulation of VEGFA 1 0.01 0.97 0.47
116 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
117 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
118 INT314053 VEGFA Positive_regulation of Gene_expression of Mmp2 1 0.02 0.2 0.47
119 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47
120 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47
121 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
122 INT338083 Binding of LEFTY1 and PYCARD 1 0.02 0 0.46
123 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
124 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
125 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
126 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
127 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
128 INT224698 Il17a Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46
129 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
130 INT224699 Il18 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46
131 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
132 INT224451 Il1 Positive_regulation of Gene_expression of VEGFA 1 0.10 1.08 0.45
133 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
134 INT224434 TNF Positive_regulation of VEGFA 1 0.10 2.04 0.44
135 INT311587 CXCL10 Regulation of Gene_expression of VEGFA 1 0.23 0.45 0.43
136 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43
137 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43
138 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42
139 INT153720 Binding of VEGFA and Pscs 1 0.32 3.12 0.41
140 INT295709 PTGER2 Regulation of VEGFA 1 0.01 1.61 0.41
141 INT160245 Binding of Col11a1 and Crygs 1 0.00 0.17 0.4
142 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
143 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
144 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
145 INT304319 Ptger1 Positive_regulation of Gene_expression of Vegfa 1 0.37 1.19 0.39
146 INT285205 Binding of VEGFA and SLEB1 1 0.05 5.12 0.38
147 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
148 INT342623 Binding of VEGFA and Col18a1 1 0.02 1.15 0.37
149 INT342606 Binding of MMP14 and VEGFA 1 0.08 1.16 0.37
150 INT277353 VEGFA Regulation of Mtor 1 0.02 1.11 0.37
151 INT277355 VEGFA Regulation of Trerf1 1 0.08 1.17 0.37
152 INT277354 Gene_expression of VEGFA Regulation of Mtor 1 0.02 1.1 0.37
153 INT277352 Gene_expression of VEGFA Regulation of Trerf1 1 0.08 1.16 0.37
154 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
155 INT329449 IL17A Regulation of Gene_expression of Vegfa 1 0.28 0.63 0.36
156 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
157 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
158 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
159 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
160 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35
161 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34
162 INT352231 VEGFA Negative_regulation of Cntf 1 0.04 0.22 0.34
163 INT352230 VEGFA Negative_regulation of Gene_expression of Cntf 1 0.04 0.22 0.34
164 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
165 INT352232 VEGFA Negative_regulation of Vegfa 1 0.02 0.21 0.34
166 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
167 INT112024 Binding of Hand1 and Ighg1 2 0.30 0.84 0.33
168 INT110691 Lta Positive_regulation of Gene_expression of VEGFA 1 0.24 0.48 0.33
169 INT295717 VEGFA Regulation of MMP9 1 0.01 0.98 0.33
170 INT112018 Binding of Hand1 and IgG2a 2 0.22 0.84 0.32
171 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
172 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
173 INT189494 Negative_regulation of Ccr5 Negative_regulation of Gene_expression of Hand1 1 0.16 0.66 0.32
174 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
175 INT112022 Binding of Hand1 and Ifng 1 0.09 0.3 0.32
176 INT241138 Ighg1 Positive_regulation of Hand1 1 0.06 0.64 0.32
177 INT329448 IL17A Positive_regulation of Gene_expression of Vegfa 1 0.45 0.59 0.32
178 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
179 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
180 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
181 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
182 INT188707 Binding of IFNA1 and Hand1 1 0.01 0.56 0.32
183 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
184 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3
185 INT143688 Binding of Dlc1 and Trpv1 1 0.01 0.45 0.3
186 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
187 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
188 INT243631 Binding of Hand1 and Nfatc1 1 0.04 0.76 0.3
189 INT210953 Binding of VEGFA and Csf2 1 0.00 0.47 0.3
190 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
191 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.43 0.3
192 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
193 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
194 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 0.01 0 0.29
195 INT220194 PTGER2 Negative_regulation of COL2A1 1 0.26 0.55 0.29
196 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
197 INT252604 Negative_regulation of Cxcl10 Negative_regulation of Gene_expression of Hand1 1 0.24 0.5 0.29
198 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29
199 INT266800 Dlst Positive_regulation of Localization of VEGFA 1 0.02 0.88 0.29
200 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29

Single Events

The table below shows the top 100 pain related interactions that have been reported for heart morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in heart morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
2 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
3 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
4 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
5 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53
6 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
7 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
8 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
9 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
10 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
11 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52
12 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
13 INT8691 Localization of Insr 85 0.80 9.27 30.32
14 INT5300 Regulation of Insr 54 0.60 11.33 29.26
15 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
16 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
17 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
18 INT48692 Binding of VEGFA 345 0.48 210.3 21.31
19 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14
20 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
21 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03
22 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96
23 INT104045 Regulation of Hand1 65 0.35 51.32 16.26
24 INT13716 Positive_regulation of TH 33 0.68 19.11 16
25 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89
26 INT173505 Localization of Hand2 63 0.57 45.32 13.66
27 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
28 INT20378 Localization of Hand1 53 0.71 41.96 13.31
29 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5
30 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39
31 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
32 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
33 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88
34 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
35 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
36 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
37 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
38 INT39301 Gene_expression of Chd7 50 0.26 27.06 8.13
39 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
40 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
41 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
42 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
43 INT81608 Gene_expression of Col11a1 13 0.15 1.58 6.87
44 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
45 INT3506 Localization of TH 12 0.81 0.78 6.66
46 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63
47 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
48 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88
49 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78
50 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
51 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
52 INT30317 Regulation of TH 14 0.43 7.27 5.38
53 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05
54 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
55 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9
56 INT181186 Binding of Rxra 78 0.35 14.93 4.87
57 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
58 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
59 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
60 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79
61 INT204449 Gene_expression of T 17 0.32 9.77 4.77
62 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
63 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
64 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
65 INT37912 Negative_regulation of Chd7 10 0.26 5.84 4.46
66 INT60575 Binding of Fkbp1a 9 0.26 2.09 4.46
67 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
68 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
69 INT51084 Binding of Insr 13 0.30 4.25 4.23
70 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22
71 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17
72 INT83035 Binding of INSR 16 0.47 9.29 4.11
73 INT151736 Binding of Hand1 15 0.26 9.77 4.04
74 INT156131 Binding of Hand2 14 0.25 10.35 3.99
75 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
76 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
77 INT118835 Positive_regulation of Vegfa 18 0.59 11.2 3.91
78 INT10116 Localization of INSR 11 0.57 5.43 3.48
79 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
80 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
81 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
82 INT99687 Negative_regulation of Transcription of VEGFA 17 0.43 10.3 3.25
83 INT111547 Negative_regulation of Phosphorylation of VEGFA 13 0.42 5.08 3.22
84 INT39867 Binding of Col2a1 9 0.35 7.65 3.18
85 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16
86 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
87 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02
88 INT137609 Localization of Vegfa 22 0.78 14.67 3.01
89 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
90 INT130080 Negative_regulation of Rxra 6 0.53 2.08 2.92
91 INT94463 Regulation of Gene_expression of Hand1 10 0.36 5.17 2.72
92 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
93 INT43719 Positive_regulation of Vegfa 21 0.69 5.15 2.64
94 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
95 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
96 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
97 INT77852 Binding of Chd7 8 0.31 4.1 2.51
98 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
99 INT113164 Regulation of Regulation of VEGFA 6 0.36 5.96 2.43
100 INT322648 Gene_expression of Pbrm1 1 0.62 39.51 2.43
101 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
102 INT124862 Gene_expression of Col5a1 4 0.17 2.05 2.32
103 INT123528 Negative_regulation of Gene_expression of Vegfa 10 0.57 7.08 2.31
104 INT43723 Regulation of Vegfa 9 0.34 4.96 2.28
105 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
106 INT169318 Positive_regulation of Rxra 15 0.42 4.35 2.12
107 INT53434 Positive_regulation of T 7 0.07 3.67 2.09
108 INT228061 Positive_regulation of Localization of Hand1 8 0.26 6.39 2.06
109 INT105247 Positive_regulation of Gene_expression of Vegfa 12 0.67 12.07 2.05
110 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
111 INT112015 Negative_regulation of Regulation of Hand1 5 0.33 3.48 2.05
112 INT136818 Positive_regulation of Phosphorylation of VEGFA 4 0.46 0.81 2.02
113 INT130082 Regulation of Rxra 6 0.42 3.78 1.96
114 INT80798 Positive_regulation of Chd7 16 0.14 7.95 1.95
115 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
116 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92
117 INT199724 Positive_regulation of Gene_expression of Rxra 11 0.45 6.22 1.88
118 INT114059 Localization of Insr 10 0.46 3.49 1.87
119 INT178030 Localization of Epo 11 0.78 6.03 1.86
120 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
121 INT3505 Binding of TH 5 0.39 2.6 1.8
122 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78
123 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
124 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
125 INT232645 Transcription of INSR 2 0.09 1.19 1.71
126 INT118833 Positive_regulation of Gene_expression of Vegfa 11 0.65 8.14 1.7
127 INT12442 Localization of Vegfa 11 0.73 4.85 1.68
128 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
129 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64
130 INT145545 Transcription of TH 3 0.67 1.48 1.64
131 INT105248 Negative_regulation of Vegfa 8 0.47 6.19 1.61
132 INT285510 Regulation of Localization of Hand1 6 0.14 6.13 1.61
133 INT144993 Gene_expression of Epor 4 0.75 5.7 1.61
134 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
135 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
136 INT144992 Positive_regulation of Epor 3 0.67 2.09 1.57
137 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
138 INT19342 Regulation of Insr 12 0.24 6.11 1.54
139 INT89871 Gene_expression of Gata4 11 0.69 1.05 1.53
140 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
141 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53
142 INT89116 Regulation of Positive_regulation of VEGFA 8 0.43 6.62 1.5
143 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
144 INT178029 Gene_expression of Epo 25 0.76 14.98 1.46
145 INT32184 Negative_regulation of Col2a1 9 0.42 3.05 1.43
146 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
147 INT109536 Negative_regulation of Vegfa 15 0.46 10.35 1.39
148 INT190880 Binding of Ncor2 11 0.27 2.24 1.34
149 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
150 INT54831 Regulation of Gene_expression of Col2a1 4 0.39 2.3 1.31
151 INT117232 Localization of COL2A1 11 0.72 7.34 1.3
152 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
153 INT124861 Positive_regulation of Col5a1 2 0.09 0.75 1.27
154 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24
155 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
156 INT178023 Regulation of Epo 11 0.45 3.87 1.22
157 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
158 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
159 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2
160 INT39711 Negative_regulation of FOXC1 4 0.41 4.29 1.2
161 INT176463 Protein_catabolism of Col2a1 4 0.35 1.94 1.2
162 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
163 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
164 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
165 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18
166 INT137607 Positive_regulation of Localization of Vegfa 7 0.49 3.72 1.18
167 INT87346 Binding of PTK2 6 0.37 4.03 1.18
168 INT188376 Negative_regulation of Gene_expression of Vegfa 5 0.30 5.29 1.18
169 INT226407 Negative_regulation of T 2 0.21 1.81 1.18
170 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
171 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
172 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
173 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11
174 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
175 INT237904 Negative_regulation of Localization of Hand1 5 0.24 3.52 1.09
176 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
177 INT208427 Regulation of T 3 0.25 3.28 1.08
178 INT54835 Regulation of Col2a1 5 0.59 2.08 1.07
179 INT156427 Localization of FOXC1 2 0.73 1.36 1.07
180 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
181 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
182 INT84235 Positive_regulation of Col11a1 2 0.01 0.09 1.03
183 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
184 INT109075 Positive_regulation of Transcription of NKX2-5 1 0.67 0 1.02
185 INT109069 Transcription of Gata4 4 0.64 0.52 1.01
186 INT109070 Positive_regulation of Transcription of Gata4 1 0.03 0 1.01
187 INT109074 Transcription of NKX2-5 1 0.69 0 1.01
188 INT214609 Positive_regulation of Gene_expression of FOXC1 1 0.08 1.78 1
189 INT37914 Regulation of Negative_regulation of Chd7 1 0.12 0 1
190 INT112717 Negative_regulation of Binding of VEGFA 21 0.56 11.07 0.99
191 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99
192 INT46334 Binding of FOXC1 2 0.36 2.66 0.99
193 INT43131 Regulation of FOXC1 3 0.36 1.09 0.98
194 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
195 INT81878 Gene_expression of TGFB2 3 0.42 2.02 0.97
196 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
197 INT178026 Positive_regulation of Epo 12 0.70 8.14 0.95
198 INT208792 Negative_regulation of Gene_expression of TH 6 0.35 1.11 0.94
199 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
200 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
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