GO:0003056

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Name regulation of vascular smooth muscle contraction
Categary Process
Go Slim No
Go Link GO:0003056
Unique Molecular Interactions 77
Total Molecular Interactions 88
Total Single Events 1083
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of vascular smooth muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported for regulation of vascular smooth muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
2 INT160653 Binding of P2rx1 and Ptgfr 1 0.28 0.66 1.14
3 INT70270 Binding of ADRA2B and Pnoc 2 0.02 0.15 1.08
4 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
5 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
6 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
7 INT215584 P2rx1 Regulation of Localization of Gabrg1 1 0.01 0 0.92
8 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
9 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
10 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
11 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
12 INT151783 Regulation of Binding of Calca and P2rx1 1 0.42 0.51 0.64
13 INT151778 Binding of Calca and P2rx1 1 0.35 0.5 0.64
14 INT78580 Binding of Adra2b and Oprd1 1 0.01 0.07 0.57
15 INT152281 Binding of P2rx1 and Trpv1 1 0.15 0.42 0.49
16 INT135799 Binding of Adra1d and Adra2b 1 0.02 0 0.48
17 INT71839 Chrm3 Positive_regulation of Qrfp 1 0.09 0 0.47
18 INT151782 Phosphorylation of Creb1 Positive_regulation of Gene_expression of P2rx1 1 0.41 0.07 0.44
19 INT151781 Calca Positive_regulation of Gene_expression of P2rx1 1 0.50 0.07 0.44
20 INT217034 P2RX1 Regulation of Gene_expression of Ik 1 0.00 0.34 0.42
21 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
22 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37
23 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
24 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
25 INT258857 Binding of P2rx1 and P2ry2 1 0.22 0.81 0.29
26 INT346224 Braf Negative_regulation of Phosphorylation of Map2k1 1 0.14 0.62 0.22
27 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2
28 INT326940 Chrm3 Positive_regulation of Nalcn 1 0.06 0.21 0.19
29 INT254683 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Plaur 1 0.01 0.07 0.18
30 INT254698 Gopc Positive_regulation of Positive_regulation of Map2k1 1 0.06 0.07 0.18
31 INT264277 Binding of Car2 and P2rx1 1 0.10 0 0.16
32 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16
33 INT264276 Binding of Ednrb and P2rx1 1 0.00 0.17 0.16
34 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
35 INT303744 Binding of Chrm3 and Ins1 1 0.04 1.03 0.15
36 INT303745 Positive_regulation of Binding of Chrm3 and Ins1 1 0.05 1.04 0.15
37 INT303747 Binding of Chrm3 and Chrm1 1 0.03 1.02 0.15
38 INT336665 Binding of P2rx1 and P2rx2 1 0.07 0 0.14
39 INT304499 Map2k1 Positive_regulation of Mapk1 1 0.12 0.8 0.1
40 INT313486 GOPC Positive_regulation of P2RX1 1 0.13 0 0.1
41 INT313484 Binding of P2RX1 and SST 1 0.04 0 0.09
42 INT224531 Positive_regulation of Map2k1 Positive_regulation of Positive_regulation of Ankh 1 0.07 0.54 0.09
43 INT304456 Binding of P2rx1 and P2rx4 1 0.14 0 0.07
44 INT264780 Binding of ADRA2B and Regulation of MRGPRX1 1 0.00 0 0.05
45 INT194699 MAP2K1 Positive_regulation of MAPK8 1 0.05 0 0.04
46 INT194703 MAP2K1 Positive_regulation of MAP2K6 1 0.21 0 0.04
47 INT194677 Binding of GADD45A and MAP2K1 1 0.27 0 0.04
48 INT194719 MAP2K1 Positive_regulation of MAPK1 1 0.27 0 0.04
49 INT194701 MAP2K1 Positive_regulation of MAP2K4 1 0.21 0 0.04
50 INT194732 MAP2K1 Positive_regulation of Gene_expression of MAPK1 1 0.27 0 0.04
51 INT194691 MAP2K1 Positive_regulation of MAP2K3 1 0.23 0 0.04
52 INT295479 PRKCA Positive_regulation of MAP2K1 1 0.14 0.35 0.03
53 INT267093 FGFR1 Positive_regulation of Gene_expression of P2rx1 1 0.03 0.2 0.03
54 INT282799 Chrm2 Positive_regulation of Chrm3 1 0.16 0.29 0.03
55 INT269502 Lta Negative_regulation of Map2k1 1 0.17 0.48 0.03
56 INT313485 MTOR Positive_regulation of Gene_expression of P2RX1 1 0.16 0 0.03
57 INT295474 IRF6 Positive_regulation of MAP2K1 1 0.18 0.41 0.03
58 INT254689 Gene_expression of Map2k2 Positive_regulation of Map2k1 1 0.30 0.4 0
59 INT224024 Binding of P2RX1 and WDTC1 1 0.01 0.71 0
60 INT254707 Positive_regulation of Map2k1 Regulation of Gene_expression of BAK1 1 0.05 0.67 0
61 INT254692 Positive_regulation of Map2k1 Regulation of Gene_expression of Mdk 1 0.05 0.42 0
62 INT339800 P2RX1 Regulation of Negative_regulation of GOPC 1 0.04 0 0
63 INT224027 Binding of P2RX1 and P2RY12 1 0.10 0.71 0
64 INT254693 Gene_expression of Map2k1 Regulation of Map2k2 1 0.29 0.78 0
65 INT84499 Chrm3 Positive_regulation of Ephb1 1 0.40 0 0
66 INT254686 Gene_expression of Map2k1 Regulation of Gene_expression of Mdk 1 0.08 0.42 0
67 INT254703 Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 0.91 0
68 INT254696 Map2k2 Regulation of Map2k1 1 0.18 0.78 0
69 INT254706 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0
70 INT254704 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 1.43 0
71 INT254702 Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0
72 INT84498 Negative_regulation of Chrm3 Positive_regulation of Ephb1 1 0.34 0 0
73 INT254684 Map2k2 Positive_regulation of Map2k1 1 0.45 0.4 0
74 INT202892 Chrm3 Regulation of Negative_regulation of Camk4 1 0.02 0.37 0
75 INT336606 Binding of Mapk8 and Map2k1 1 0.09 0.72 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of vascular smooth muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported in regulation of vascular smooth muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
2 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75
3 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69
4 INT70775 Positive_regulation of Positive_regulation of P2rx1 15 0.49 8.65 8.49
5 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
6 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
7 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
8 INT95172 Localization of P2rx1 14 0.78 6.77 7.81
9 INT90943 Negative_regulation of P2rx1 13 0.42 8.21 7.22
10 INT114014 Positive_regulation of Gene_expression of P2rx1 13 0.69 7.77 7.15
11 INT91351 Gene_expression of P2rx1 28 0.75 5.89 6.78
12 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
13 INT71758 Gene_expression of P2RX1 40 0.75 9.01 6.14
14 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
15 INT71759 Positive_regulation of P2RX1 13 0.67 3.53 4.9
16 INT30160 Positive_regulation of ADRA2B 14 0.29 1.92 4.37
17 INT144396 Positive_regulation of P2rx1 11 0.49 3.25 4.23
18 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
19 INT95171 Binding of P2rx1 12 0.36 4.69 3.92
20 INT8711 Binding of Adra2b 6 0.42 0.08 3.78
21 INT30181 Gene_expression of Adra2b 10 0.62 1.89 3.48
22 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02
23 INT26833 Negative_regulation of P2rx1 9 0.41 1.5 2.89
24 INT30870 Negative_regulation of Adra2b 8 0.44 4.5 2.8
25 INT53540 Gene_expression of ADRA2B 10 0.46 1.78 2.33
26 INT121435 Negative_regulation of Gene_expression of P2rx1 3 0.43 1.82 2.21
27 INT47543 Positive_regulation of Chrm3 11 0.38 5.23 2.17
28 INT127756 Negative_regulation of Map2k1 10 0.41 6.69 2.04
29 INT215166 Binding of P2rx1 5 0.35 0.41 1.97
30 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
31 INT106984 Regulation of P2RX1 12 0.60 2.05 1.75
32 INT146948 Negative_regulation of Positive_regulation of P2rx1 2 0.34 2.23 1.74
33 INT149435 Regulation of Positive_regulation of P2rx1 2 0.30 1.55 1.67
34 INT151777 Regulation of Gene_expression of P2rx1 3 0.60 1.97 1.48
35 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
36 INT175525 Positive_regulation of Phosphorylation of Map2k1 8 0.33 7.02 1.37
37 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
38 INT215162 Phosphorylation of P2rx1 2 0.43 0.12 1.34
39 INT155662 Positive_regulation of Localization of P2rx1 2 0.47 1.92 1.26
40 INT30161 Negative_regulation of Positive_regulation of ADRA2B 2 0.05 0.25 1.24
41 INT231592 Binding of ADRA2B 5 0.18 0.13 1.23
42 INT82729 Transcription of Adra2b 1 0.02 1.05 1.23
43 INT71757 Localization of P2RX1 4 0.73 2.11 1.22
44 INT74849 Positive_regulation of Chrm3 5 0.64 1.71 1.2
45 INT132283 Regulation of P2rx1 3 0.13 0 1.2
46 INT160652 Positive_regulation of Binding of P2rx1 1 0.36 0.67 1.15
47 INT41043 Regulation of Adra2b 3 0.39 0.47 1.03
48 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02
49 INT107143 Negative_regulation of P2RX1 11 0.56 2.92 1.01
50 INT267071 Positive_regulation of Gene_expression of P2rx1 2 0.49 1.77 0.98
51 INT106960 Gene_expression of Chrm3 15 0.69 6.29 0.96
52 INT127103 Negative_regulation of Gene_expression of P2rx1 5 0.41 0.46 0.91
53 INT192123 Transcription of P2rx1 4 0.27 1.24 0.91
54 INT148401 Regulation of Chrm3 3 0.19 1.19 0.91
55 INT73950 Negative_regulation of Chrm3 1 0.41 0 0.88
56 INT148118 Positive_regulation of Gene_expression of P2RX1 4 0.48 0.78 0.83
57 INT71778 Positive_regulation of Gene_expression of MAP2K1 2 0.36 0.37 0.81
58 INT211909 Regulation of Positive_regulation of Map2k1 1 0.21 0.47 0.76
59 INT149689 Binding of Chrm3 3 0.24 1.54 0.65
60 INT224011 Binding of P2RX1 7 0.45 1.12 0.6
61 INT104335 Localization of Chrm3 2 0.62 0.58 0.57
62 INT217018 Regulation of Regulation of P2RX1 3 0.26 0.34 0.54
63 INT215787 Localization of P2rx1 3 0.68 0.49 0.54
64 INT104120 Positive_regulation of Positive_regulation of MAP2K1 1 0.49 0 0.54
65 INT172502 Binding of Chrm3 2 0.08 3.3 0.53
66 INT104336 Positive_regulation of Localization of Chrm3 1 0.38 0.14 0.5
67 INT236915 Binding of Map2k1 2 0.15 1.51 0.49
68 INT68529 Negative_regulation of ADRA2B 3 0.14 0.79 0.47
69 INT313494 Regulation of Gene_expression of P2RX1 3 0.42 0 0.45
70 INT61414 Positive_regulation of Gene_expression of ADRA2B 2 0.18 0.13 0.44
71 INT215494 Positive_regulation of Phosphorylation of P2rx1 1 0.26 0 0.42
72 INT138282 Positive_regulation of Gene_expression of Map2k1 13 0.49 7.46 0.39
73 INT217012 Transcription of P2RX1 1 0.21 0.26 0.39
74 INT239115 Regulation of Binding of P2rx1 1 0.16 0 0.39
75 INT6492 Regulation of ADRA2B 2 0.06 0.31 0.38
76 INT215503 Negative_regulation of Positive_regulation of P2rx1 1 0.23 0 0.38
77 INT304528 Gene_expression of Map2k1 3 0.58 1.76 0.37
78 INT341920 Negative_regulation of Binding of P2rx1 1 0.20 0.06 0.36
79 INT97767 Positive_regulation of Adra2b 3 0.45 1.75 0.34
80 INT304526 Binding of Map2k1 1 0.11 0.6 0.32
81 INT201347 Negative_regulation of Gene_expression of Chrm3 4 0.30 2.48 0.31
82 INT261826 Phosphorylation of ADRA2B 1 0.03 0.38 0.29
83 INT240205 Regulation of MAP2K1 3 0.26 0.44 0.28
84 INT175506 Regulation of Positive_regulation of Map2k1 2 0.32 1.58 0.23
85 INT255069 Positive_regulation of Binding of ADRA2B 1 0.18 0.13 0.23
86 INT304519 Positive_regulation of Gene_expression of Map2k1 1 0.15 0.41 0.22
87 INT224005 Negative_regulation of Gene_expression of P2RX1 3 0.40 0.48 0.17
88 INT254671 Regulation of Map2k1 5 0.43 1.83 0.14
89 INT356473 Transcription of ADRA2B 1 0.20 0.08 0.14
90 INT265533 Negative_regulation of Phosphorylation of Map2k1 1 0.41 0 0.14
91 INT175527 Localization of Map2k1 4 0.31 2.41 0.13
92 INT254673 Positive_regulation of Positive_regulation of Map2k1 3 0.35 1.65 0.11
93 INT341919 Positive_regulation of Binding of P2rx1 1 0.23 0 0.11
94 INT303728 Gene_expression of Chrm3 1 0.14 0.98 0.09
95 INT303727 Positive_regulation of Gene_expression of Chrm3 1 0.10 0.99 0.09
96 INT72309 Positive_regulation of Positive_regulation of ADRA2B 1 0.01 0.17 0.09
97 INT339811 Regulation of Positive_regulation of P2RX1 1 0.42 0 0.08
98 INT215418 Positive_regulation of Phosphorylation of MAP2K1 1 0.03 0.51 0.08
99 INT38754 Regulation of Negative_regulation of Adra2b 1 0.34 0.44 0.08
100 INT215420 Phosphorylation of MAP2K1 1 0.05 0.51 0.08
101 INT215817 Transcription of P2rx1 1 0.18 0 0.04
102 INT201344 Positive_regulation of Gene_expression of Chrm3 1 0.19 0.34 0.04
103 INT313493 Positive_regulation of Negative_regulation of P2RX1 1 0.48 0 0.04
104 INT281764 Negative_regulation of Gene_expression of Map2k1 1 0.18 1.11 0.04
105 INT329571 Binding of MAP2K1 2 0.11 0.4 0
106 INT281758 Positive_regulation of Protein_catabolism of Map2k1 1 0.29 0.13 0
107 INT281756 Protein_catabolism of Map2k1 1 0.42 0.13 0
108 INT175533 Regulation of Gene_expression of Map2k1 1 0.20 1.55 0
109 INT157839 Positive_regulation of Gene_expression of Adra2b 1 0.03 0 0
110 INT84493 Positive_regulation of Positive_regulation of Chrm3 1 0.33 0 0
111 INT202865 Regulation of Gene_expression of Chrm3 1 0.07 0.37 0
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