GO:0003081

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Name regulation of systemic arterial blood pressure by renin-angiotensin
Categary Process
Go Slim No
Go Link GO:0003081
Unique Molecular Interactions 92
Total Molecular Interactions 122
Total Single Events 1523
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of systemic arterial blood pressure by renin-angiotensin. They are ordered first by their pain relevance and then by number of times they were reported for regulation of systemic arterial blood pressure by renin-angiotensin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
2 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
3 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
4 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
5 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
6 INT154766 Nox1 Positive_regulation of Localization of Prkce 1 0.47 0.45 0.66
7 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
8 INT223865 Enpep Positive_regulation of Ltp 1 0.02 0 0.59
9 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
10 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
11 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
12 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39
13 INT229222 Negative_regulation of ACE Negative_regulation of Protein_catabolism of KNG1 1 0.06 0.53 0.37
14 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
15 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32
16 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
17 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
18 INT33584 Enpep Positive_regulation of Cpe 1 0.03 0 0.27
19 INT33583 Enpep Regulation of Positive_regulation of Cpe 1 0.03 0 0.27
20 INT180718 Binding of SARS and ACE2 3 0.12 7.76 0.25
21 INT191500 ACE Positive_regulation of Localization of KNG1 1 0.10 0.17 0.24
22 INT326404 Binding of Cck and Enpep 1 0.01 0.19 0.23
23 INT265828 ACE Regulation of Gene_expression of KNG1 1 0.32 0.83 0.22
24 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17
25 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17
26 INT265827 ACE Negative_regulation of ANGPT2 1 0.09 0.59 0.17
27 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
28 INT277012 Binding of PAPPA and ACE2 1 0.02 1.26 0.15
29 INT344946 AGT Regulation of Negative_regulation of ACE 1 0.21 0.61 0.14
30 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13
31 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
32 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12
33 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
34 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1
35 INT336990 Binding of AGTR1 and BDKRB2 1 0.03 0 0.1
36 INT270731 Binding of AGTR1 and ACE 1 0.02 0.67 0.09
37 INT265829 ACE Positive_regulation of Protein_catabolism of KNG1 1 0.33 0.73 0.09
38 INT279707 Positive_regulation of AGTR1 Regulation of TYRP1 1 0.00 0 0.09
39 INT279706 Positive_regulation of AGTR1 Regulation of TRPC6 1 0.00 0 0.09
40 INT344945 Negative_regulation of ACE Positive_regulation of REN 1 0.23 0.64 0.09
41 INT55502 NDUFC1 Regulation of Nox1 1 0.00 0 0.08
42 INT26310 IL1B Positive_regulation of ACE2 1 0.18 0.46 0.07
43 INT351651 Enpep Positive_regulation of Agt 1 0.22 0.93 0.07
44 INT281900 Positive_regulation of Binding of AGT and AGTR1 1 0.12 0.16 0.07
45 INT200634 Binding of Agtr2 and Ace2 1 0.00 0.91 0.06
46 INT200641 Binding of ACE and Agtr1a 1 0.12 0.92 0.06
47 INT281909 Binding of AGT and AGTR1 1 0.09 0.16 0.06
48 INT200638 Binding of ACE and Agtr2 1 0.10 0.93 0.06
49 INT323755 IGHG3 Negative_regulation of ACE2 1 0.01 1.09 0.05
50 INT336132 Binding of AGTR1 and ANG 1 0.00 0.38 0.05
51 INT29521 Ace Positive_regulation of ACE 1 0.19 0 0.04
52 INT204172 Regulation of Binding of Cs and Nox1 1 0.08 1.01 0.04
53 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04
54 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04
55 INT351652 Enpep Positive_regulation of Positive_regulation of Agt 1 0.19 0.05 0.04
56 INT204173 Binding of Cs and Nox1 1 0.07 1 0.04
57 INT351653 Enpep Positive_regulation of Protein_catabolism of Agt 1 0.22 0.54 0.03
58 INT279538 Binding of C4B and Positive_regulation of ENPEP 1 0.00 0.48 0.03
59 INT344879 Binding of ENPEP and Mapt 1 0.07 0.08 0
60 INT109816 Ace2 Positive_regulation of Agt 1 0.07 0.3 0
61 INT257344 Gene_expression of Cyba Positive_regulation of Nox1 1 0.23 1.15 0
62 INT341666 ALPI Positive_regulation of ENPEP 1 0.01 1.05 0
63 INT109817 Ace2 Positive_regulation of Angpt1 1 0.05 0.31 0
64 INT351656 Enpep Regulation of Agt 1 0.20 1.2 0
65 INT180749 Binding of Pmel and ACE2 1 0.20 2.14 0
66 INT109819 Ace2 Regulation of ras 1 0.07 0.3 0
67 INT333044 Positive_regulation of Binding of AGTR1 and Trpv4 1 0.48 0 0
68 INT307808 Ace Positive_regulation of Gene_expression of Ace2 1 0.22 2.43 0
69 INT333045 Binding of AGTR1 and Gopc 1 0.05 0 0
70 INT344878 ENPEP Regulation of Gene_expression of Mapt 1 0.09 0.33 0
71 INT351650 Enpep Regulation of Protein_catabolism of Agt 1 0.20 0.35 0
72 INT109815 Ace2 Positive_regulation of Ang 1 0.06 0.3 0
73 INT257346 Gene_expression of Lox Positive_regulation of Nox1 1 0.02 0.57 0
74 INT200488 Binding of ACE and SUGT1 1 0.01 0.28 0
75 INT279540 Binding of C4B and ENPEP 1 0.00 0.82 0
76 INT344881 ENPEP Regulation of Mapt 1 0.05 0.33 0
77 INT333043 Binding of AGTR1 and Trpv4 1 0.50 0 0
78 INT213584 Binding of AGTR2 and ACE 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of systemic arterial blood pressure by renin-angiotensin. They are ordered first by their pain relevance and then by number of times they were reported in regulation of systemic arterial blood pressure by renin-angiotensin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
2 INT13400 Negative_regulation of Enpep 30 0.50 4.23 15.86
3 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
4 INT20664 Binding of ACE 60 0.48 35.27 9.16
5 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31
6 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
7 INT42038 Localization of ACE 26 0.80 8.88 7.06
8 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
9 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
10 INT26477 Regulation of ACE 26 0.45 16.31 4.33
11 INT188449 Gene_expression of ENPEP 12 0.55 11.29 3.96
12 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76
13 INT4545 Negative_regulation of Nox1 15 0.53 10.08 3.4
14 INT6405 Gene_expression of Enpep 9 0.67 4.79 3.4
15 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24
16 INT39134 Positive_regulation of Ace2 3 0.14 0.57 2.13
17 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94
18 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93
19 INT39133 Binding of Ace2 3 0.30 0.8 1.89
20 INT182505 Positive_regulation of Gene_expression of AGTR1 12 0.65 13.18 1.77
21 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77
22 INT37376 Negative_regulation of Negative_regulation of Enpep 2 0.21 0.07 1.76
23 INT37350 Negative_regulation of ENPEP 7 0.42 1.15 1.7
24 INT104031 Regulation of ENPEP 18 0.33 13.48 1.69
25 INT22716 Protein_catabolism of ENPEP 5 0.96 0.1 1.49
26 INT182514 Binding of AGTR1 18 0.47 13.35 1.48
27 INT154763 Gene_expression of Nox1 3 0.67 1.83 1.48
28 INT154764 Localization of Nox1 1 0.65 1.07 1.47
29 INT182511 Regulation of AGTR1 7 0.44 8.25 1.4
30 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37
31 INT7304 Binding of Enpep 3 0.23 0.71 1.22
32 INT281919 Localization of ACE2 4 0.75 2.69 1.02
33 INT182516 Negative_regulation of Negative_regulation of ACE 9 0.42 6.84 0.99
34 INT107288 Positive_regulation of ACE2 4 0.66 5.48 0.99
35 INT124615 Transcription of ENPEP 1 0.19 0.2 0.99
36 INT182512 Positive_regulation of Positive_regulation of AGTR1 5 0.47 4.88 0.97
37 INT42504 Negative_regulation of Nox1 5 0.43 0.55 0.91
38 INT114769 Regulation of Enpep 6 0.14 0.58 0.89
39 INT81206 Binding of ENPEP 11 0.47 5.19 0.88
40 INT123089 Negative_regulation of Protein_catabolism of ENPEP 1 0.41 0 0.83
41 INT83995 Positive_regulation of Gene_expression of ACE 8 0.68 8.09 0.82
42 INT10729 Positive_regulation of ENPEP 13 0.38 9.65 0.8
43 INT102894 Localization of AGTR1 5 0.73 1.75 0.74
44 INT342130 Negative_regulation of Localization of ACE2 1 0.01 1.16 0.74
45 INT259902 Regulation of Gene_expression of ACE 3 0.45 1.87 0.7
46 INT48903 Protein_catabolism of ACE2 1 0.08 1.13 0.66
47 INT66783 Positive_regulation of Negative_regulation of Nox1 1 0.63 0.81 0.66
48 INT72446 Negative_regulation of Binding of ACE 4 0.42 2.48 0.62
49 INT66903 Positive_regulation of Nox1 3 0.25 1.1 0.62
50 INT56045 Positive_regulation of Localization of ACE 3 0.69 1.38 0.6
51 INT147440 Gene_expression of Nox1 3 0.57 1.61 0.6
52 INT33579 Positive_regulation of Enpep 4 0.33 5.09 0.58
53 INT267971 Regulation of Localization of AGTR1 1 0.16 1.46 0.57
54 INT3907 Gene_expression of Ace2 5 0.54 2.35 0.46
55 INT180739 Binding of ACE2 5 0.37 7.88 0.45
56 INT107385 Regulation of Negative_regulation of AGTR1 2 0.15 1.26 0.42
57 INT182507 Negative_regulation of Gene_expression of AGTR1 1 0.40 1.13 0.4
58 INT330125 Transcription of AGTR1 1 0.52 1.29 0.39
59 INT181635 Positive_regulation of Protein_catabolism of ACE 1 0.15 0.41 0.38
60 INT44053 Regulation of Negative_regulation of Enpep 1 0.17 0.24 0.37
61 INT297776 Protein_catabolism of Enpep 3 0.41 4.62 0.36
62 INT229626 Negative_regulation of Localization of ACE 3 0.41 2 0.36
63 INT102889 Positive_regulation of Localization of AGTR1 3 0.38 0.43 0.34
64 INT96863 Transcription of ACE 3 0.69 0.38 0.29
65 INT230864 Regulation of Binding of ACE 1 0.22 0.79 0.29
66 INT288846 Negative_regulation of Transcription of ACE 1 0.43 0 0.29
67 INT90784 Positive_regulation of Gene_expression of Ace2 3 0.40 1.34 0.27
68 INT187828 Negative_regulation of Gene_expression of ACE2 2 0.29 0.54 0.26
69 INT187827 Regulation of Gene_expression of ACE2 1 0.02 0.45 0.26
70 INT263255 Negative_regulation of Negative_regulation of AGTR1 2 0.30 2.88 0.25
71 INT27669 Negative_regulation of Ace2 2 0.42 0.68 0.22
72 INT108414 Negative_regulation of Regulation of ACE 1 0.43 0.67 0.17
73 INT42556 Negative_regulation of Ace2 2 0.44 2.11 0.16
74 INT288916 Negative_regulation of Positive_regulation of AGTR1 2 0.44 1.2 0.13
75 INT351645 Negative_regulation of Gene_expression of Enpep 1 0.24 0.96 0.13
76 INT323762 Regulation of ACE2 1 0.39 1.63 0.12
77 INT109812 Gene_expression of Ace2 4 0.76 5.44 0.11
78 INT109811 Negative_regulation of Gene_expression of Ace2 1 0.42 0.73 0.11
79 INT79993 Positive_regulation of Positive_regulation of ACE 2 0.49 0.78 0.1
80 INT242222 Positive_regulation of Negative_regulation of AGTR1 1 0.35 1.77 0.1
81 INT71291 Binding of Nox1 1 0.11 0.25 0.08
82 INT71290 Regulation of Nox1 1 0.08 0.25 0.08
83 INT281931 Transcription of ACE2 2 0.69 0.57 0.07
84 INT333041 Regulation of Positive_regulation of AGTR1 1 0.44 0 0.07
85 INT323758 Negative_regulation of Transcription of ACE2 1 0.43 0.47 0.07
86 INT184935 Protein_catabolism of Ace2 1 0.08 0.21 0.06
87 INT2492 Regulation of Ace2 1 0.13 0 0.06
88 INT17491 Regulation of Gene_expression of Enpep 2 0.36 0.46 0.05
89 INT281926 Positive_regulation of Gene_expression of ACE2 2 0.47 1.19 0.04
90 INT179198 Regulation of Gene_expression of AGTR1 2 0.25 2.04 0.04
91 INT351648 Positive_regulation of Protein_catabolism of Enpep 1 0.19 0.81 0.04
92 INT204169 Regulation of Nox1 1 0.16 1 0.04
93 INT323759 Regulation of Binding of ACE2 1 0.45 0.22 0.04
94 INT204164 Negative_regulation of Positive_regulation of Nox1 1 0.17 1.02 0.03
95 INT209756 Positive_regulation of Negative_regulation of ACE2 1 0.49 0.38 0
96 INT351646 Positive_regulation of Positive_regulation of Enpep 1 0.21 0.61 0
97 INT279584 Negative_regulation of Regulation of ENPEP 1 0.01 1.04 0
98 INT204167 Positive_regulation of Nox1 1 0.19 1 0
99 INT343519 Phosphorylation of ENPEP 1 0.61 0.32 0
100 INT288912 Protein_catabolism of AGTR1 1 0.66 0.29 0
101 INT193366 Positive_regulation of Gene_expression of ENPEP 1 0.04 0 0
102 INT204162 Negative_regulation of Binding of Nox1 1 0.17 0.06 0
103 INT204166 Regulation of Negative_regulation of Nox1 1 0.11 0.96 0
104 INT323761 Negative_regulation of Binding of ACE2 1 0.43 0 0
105 INT270742 Negative_regulation of Phosphorylation of ACE 1 0.40 0.65 0
106 INT257320 Negative_regulation of Gene_expression of Nox1 1 0.22 0.58 0
107 INT333040 Regulation of Binding of AGTR1 1 0.44 0 0
108 INT351637 Positive_regulation of Gene_expression of Enpep 1 0.24 0.91 0
109 INT204163 Binding of Nox1 1 0.15 0.06 0
110 INT270740 Phosphorylation of ACE 1 0.76 0.65 0
111 INT104034 Localization of ENPEP 1 0.24 0.08 0
112 INT247964 Regulation of Negative_regulation of ENPEP 1 0.14 0 0
113 INT351636 Negative_regulation of Protein_catabolism of Enpep 1 0.18 0.6 0
114 INT351644 Transcription of Enpep 1 0.25 0.55 0
115 INT354750 Negative_regulation of Negative_regulation of Ace2 1 0.30 0.73 0
116 INT104038 Regulation of Localization of ENPEP 1 0.13 0.09 0
117 INT307793 Transcription of Ace2 1 0.25 2.08 0
118 INT326403 Localization of Enpep 1 0.21 0 0
119 INT188450 Negative_regulation of Gene_expression of ENPEP 1 0.06 0.91 0
120 INT279560 Positive_regulation of Regulation of ENPEP 1 0.02 1.05 0
121 INT104036 Positive_regulation of Positive_regulation of ENPEP 1 0.12 0.06 0
122 INT354752 Positive_regulation of Negative_regulation of Ace2 1 0.35 0.1 0
123 INT351639 Negative_regulation of Positive_regulation of Enpep 1 0.18 0.36 0
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