GO:0003100

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Name regulation of systemic arterial blood pressure by endothelin
Categary Process
Go Slim No
Go Link GO:0003100
Unique Molecular Interactions 388
Total Molecular Interactions 553
Total Single Events 4114
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of systemic arterial blood pressure by endothelin. They are ordered first by their pain relevance and then by number of times they were reported for regulation of systemic arterial blood pressure by endothelin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
3 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
4 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
5 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
6 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
7 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
8 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
9 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
10 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
11 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
12 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
13 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
14 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
15 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
16 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
17 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
18 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
19 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
20 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
21 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
22 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
23 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
24 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
25 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
26 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
27 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73
28 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
29 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
30 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
31 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
32 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
33 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
34 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
35 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
36 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
37 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
38 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
39 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
40 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
41 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
42 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
43 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59
44 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
45 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
46 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
47 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
48 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
49 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
50 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
51 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
52 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
53 INT94018 Binding of EDN2 and EDN3 1 0.19 0 0.48
54 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
55 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46
56 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
57 INT95276 Obfc2a Negative_regulation of Nos3 1 0.02 1.02 0.46
58 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
59 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46
60 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
61 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
62 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
63 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
64 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
65 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
66 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
67 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
68 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
69 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
70 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
71 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
72 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
73 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
74 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
75 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
76 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
77 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
78 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
79 INT333158 asa Positive_regulation of Nos3 1 0.11 0.18 0.32
80 INT333166 Tlx2 Positive_regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
81 INT333155 Tlx2 Regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
82 INT333152 Tlx2 Positive_regulation of Nos3 1 0.08 0.18 0.32
83 INT333169 asa Positive_regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
84 INT333164 asa Regulation of Nos3 1 0.11 0.18 0.32
85 INT333149 asa Regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
86 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
87 INT333167 Tlx2 Regulation of Nos3 1 0.08 0.18 0.32
88 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
89 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
90 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
91 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
92 INT191501 NLRP3 Positive_regulation of ECE1 1 0.01 1.09 0.28
93 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
94 INT141871 Binding of Nos3 and Slc2a4 1 0.25 0.51 0.28
95 INT54639 Edn3 Negative_regulation of Edn2 1 0.00 0 0.28
96 INT191495 NLRP3 Positive_regulation of Protein_catabolism of ECE1 1 0.01 1.09 0.28
97 INT72820 EDN3 Positive_regulation of Avp 1 0.31 0.64 0.27
98 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
99 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
100 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
101 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
102 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
103 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
104 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
105 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
106 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
107 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
108 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
109 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
110 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22
111 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
112 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
113 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
114 INT122576 Pik3cd Positive_regulation of Phosphorylation of Nos3 1 0.28 0.45 0.21
115 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
116 INT239227 Prkca Regulation of Nos3 1 0.02 0.97 0.2
117 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
118 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
119 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19
120 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
121 INT137417 MAPK7 Regulation of Gene_expression of NOS3 1 0.00 0.5 0.19
122 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
123 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
124 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
125 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
126 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
127 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
128 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
129 INT269333 Binding of BDKRB2 and NOS3 1 0.02 0 0.17
130 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
131 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
132 INT94017 Binding of EDN3 and INSRR 1 0.03 0 0.16
133 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
134 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
135 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
136 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
137 INT94013 Positive_regulation of Binding of EDN2 and INSRR 1 0.04 0 0.16
138 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
139 INT94023 Positive_regulation of Binding of EDN2 and EDN3 1 0.25 0 0.16
140 INT94019 Positive_regulation of Binding of EDN3 and INSRR 1 0.04 0 0.16
141 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
142 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
143 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
144 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
145 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
146 INT161797 Binding of ECE1 and ING1 1 0.01 0.68 0.14
147 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
148 INT161795 Positive_regulation of Binding of ECE1 and ING1 1 0.02 0.68 0.14
149 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
150 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
151 INT72818 Edn3 Negative_regulation of Avp 1 0.08 0.34 0.14
152 INT72819 Regulation of EDN3 Positive_regulation of Avp 1 0.28 0.32 0.13
153 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
154 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
155 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
156 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
157 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
158 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
159 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
160 INT269332 Binding of NOS3 and TMPO 1 0.01 0 0.12
161 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12
162 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
163 INT213042 Apoa1 Positive_regulation of Nos3 1 0.10 2.17 0.11
164 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
165 INT288616 EPO Positive_regulation of Nos3 1 0.08 0.69 0.11
166 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
167 INT302511 Binding of OPA1 and Nos3 1 0.02 1.57 0.1
168 INT172816 Crp Positive_regulation of Transcription of Nos3 1 0.06 0.91 0.1
169 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
170 INT172817 Crp Positive_regulation of Regulation of Nos3 1 0.09 0.84 0.1
171 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1
172 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
173 INT181570 Binding of Edn1 and Mapk1 1 0.13 2.72 0.1
174 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
175 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
176 INT252790 Binding of NOS1 and NOS3 1 0.03 0.37 0.1
177 INT249848 Fgf2 Positive_regulation of Gene_expression of Nos3 1 0.33 0.44 0.1
178 INT172819 Crp Positive_regulation of Gene_expression of Nos3 1 0.06 0.91 0.1
179 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
180 INT249851 VEGFA Positive_regulation of Gene_expression of Nos3 1 0.05 0.44 0.1
181 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
182 INT172821 Crp Positive_regulation of Negative_regulation of Nos3 1 0.06 0.84 0.1
183 INT213023 Hdl1 Regulation of Nos3 2 0.09 4.06 0.09
184 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
185 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
186 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09
187 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09
188 INT252803 Binding of NOS3 and ISYNA1 1 0.02 0.32 0.09
189 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
190 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
191 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
192 INT178072 Gene_expression of EDNRB Positive_regulation of EDN3 1 0.05 1.11 0.08
193 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
194 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08
195 INT181583 Binding of Edn1 and Positive_regulation of NOS1 1 0.02 0.86 0.08
196 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
197 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08
198 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
199 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
200 INT309390 Gene_expression of Sod2 Negative_regulation of Nos3 1 0.31 0.2 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of systemic arterial blood pressure by endothelin. They are ordered first by their pain relevance and then by number of times they were reported in regulation of systemic arterial blood pressure by endothelin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
2 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
3 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
4 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
5 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
6 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
7 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
8 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
9 INT5048 Binding of Edn1 55 0.47 18.86 19.16
10 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
11 INT9191 Localization of EDN1 94 0.81 57.01 14.78
12 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
13 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
14 INT6365 Localization of Edn1 56 0.81 18.84 13.83
15 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
16 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
17 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
18 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
19 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
20 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
21 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
22 INT6361 Localization of Edn1 30 0.81 19.09 9.7
23 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
24 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
25 INT10237 Binding of EDN1 40 0.48 16 8.48
26 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
27 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86
28 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
29 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62
30 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
31 INT83712 Transcription of Nos3 19 0.69 13.09 6.31
32 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
33 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
34 INT83991 Regulation of Nos3 25 0.44 9.89 4.06
35 INT102515 Binding of Nos3 19 0.45 9.41 4.01
36 INT5782 Gene_expression of Edn3 17 0.67 3.38 3.65
37 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
38 INT70958 Binding of NOS3 19 0.37 11.84 3.29
39 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
40 INT55033 Localization of Edn3 7 0.80 1.4 3.05
41 INT53374 Binding of Edn1 17 0.43 11.66 2.98
42 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
43 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73
44 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
45 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7
46 INT145101 Transcription of Nos3 8 0.70 6.04 2.47
47 INT73809 Regulation of Nos3 18 0.45 10.05 2.27
48 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
49 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17
50 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
51 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
52 INT91594 Localization of NOS3 12 0.78 5.39 2.02
53 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
54 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
55 INT76532 Binding of Nos3 13 0.37 9.32 1.87
56 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
57 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
58 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
59 INT60999 Localization of Nos3 12 0.74 5.28 1.75
60 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
61 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
62 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
63 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
64 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
65 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
66 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
67 INT83713 Positive_regulation of Transcription of Nos3 3 0.67 2.92 1.38
68 INT89785 Regulation of Transcription of Nos3 1 0.32 0.85 1.36
69 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
70 INT136612 Positive_regulation of Positive_regulation of Nos3 5 0.43 4.22 1.26
71 INT212983 Positive_regulation of Positive_regulation of Nos3 9 0.51 7.08 1.23
72 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
73 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12
74 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
75 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
76 INT61123 Localization of Edn2 1 0.55 0.27 1.05
77 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
78 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
79 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
80 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
81 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
82 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
83 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
84 INT6243 Regulation of Edn3 2 0.35 0.2 0.83
85 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
86 INT186681 Gene_expression of Edn2 2 0.09 1.01 0.76
87 INT122572 Phosphorylation of Nos3 37 0.65 25.23 0.75
88 INT61122 Regulation of Regulation of Edn3 1 0.35 0.2 0.75
89 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
90 INT8614 Negative_regulation of Edn2 3 0.06 0.07 0.73
91 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
92 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
93 INT63556 Binding of Edn3 1 0.24 0.63 0.7
94 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
95 INT193486 Negative_regulation of Negative_regulation of Nos3 3 0.34 2.21 0.68
96 INT268451 Positive_regulation of Gene_expression of ECE1 3 0.49 1.99 0.67
97 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
98 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
99 INT50061 Negative_regulation of Edn3 4 0.58 0.77 0.65
100 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
101 INT181576 Phosphorylation of Nos3 7 0.59 1.35 0.6
102 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
103 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
104 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
105 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56
106 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
107 INT87230 Localization of ECE1 5 0.80 1.51 0.53
108 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
109 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
110 INT8663 Positive_regulation of EDN2 3 0.38 0.65 0.5
111 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
112 INT145100 Regulation of Transcription of Nos3 4 0.44 2.05 0.46
113 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
114 INT55370 Positive_regulation of Localization of Edn3 2 0.47 1.13 0.44
115 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
116 INT144095 Localization of Nos3 8 0.57 4.5 0.43
117 INT92195 Negative_regulation of Edn3 3 0.43 1.92 0.43
118 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
119 INT193491 Negative_regulation of Positive_regulation of Nos3 2 0.36 1.67 0.4
120 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
121 INT168066 Transcription of Edn3 1 0.38 0.87 0.38
122 INT95273 Regulation of Negative_regulation of Nos3 2 0.20 0.85 0.37
123 INT8664 Positive_regulation of EDN3 2 0.38 0 0.37
124 INT129487 Negative_regulation of EDN3 1 0.38 0.35 0.35
125 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
126 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
127 INT53375 Binding of Edn3 1 0.36 0 0.32
128 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
129 INT131110 Localization of EDN3 1 0.03 0.74 0.31
130 INT131109 Positive_regulation of Localization of EDN3 1 0.02 0.76 0.31
131 INT16366 Gene_expression of Edn3 4 0.49 1.35 0.29
132 INT191535 Protein_catabolism of ECE1 1 0.07 1.03 0.28
133 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
134 INT212933 Regulation of Binding of Nos3 2 0.34 0.88 0.24
135 INT172796 Regulation of Negative_regulation of Nos3 1 0.16 1.4 0.23
136 INT8660 Positive_regulation of Positive_regulation of EDN2 2 0.38 0.23 0.22
137 INT316565 Negative_regulation of Regulation of Nos3 1 0.32 1.01 0.22
138 INT8665 Positive_regulation of Positive_regulation of EDN3 1 0.38 0 0.22
139 INT73810 Negative_regulation of Regulation of Nos3 2 0.36 1.01 0.21
140 INT118276 Regulation of Positive_regulation of Nos3 1 0.09 0 0.21
141 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
142 INT269409 Regulation of Phosphorylation of NOS3 1 0.18 0 0.2
143 INT163997 Positive_regulation of Negative_regulation of Nos3 1 0.49 1.15 0.2
144 INT92815 Positive_regulation of Negative_regulation of NOS3 1 0.12 1.03 0.2
145 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
146 INT53376 Positive_regulation of Regulation of Edn3 1 0.48 0 0.19
147 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
148 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
149 INT53373 Regulation of Edn3 2 0.45 1.38 0.18
150 INT141866 Regulation of Localization of Nos3 1 0.42 0.24 0.18
151 INT257201 Positive_regulation of Negative_regulation of Nos3 1 0.12 0 0.18
152 INT269403 Regulation of Positive_regulation of NOS3 1 0.18 0 0.17
153 INT26353 Binding of Edn2 1 0.01 0 0.17
154 INT87231 Binding of ECE1 4 0.37 0.47 0.16
155 INT55371 Positive_regulation of Edn3 1 0.69 0.38 0.14
156 INT145102 Positive_regulation of Transcription of Nos3 1 0.45 0.46 0.14
157 INT323040 Gene_expression of EDN2 1 0.32 0.13 0.13
158 INT161805 Positive_regulation of ECE1 1 0.12 0.61 0.13
159 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
160 INT290701 Protein_catabolism of Nos3 1 0.54 0.42 0.13
161 INT212996 Negative_regulation of Positive_regulation of Nos3 3 0.35 2.11 0.12
162 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
163 INT269395 Regulation of Binding of NOS3 2 0.39 1.84 0.12
164 INT323261 Positive_regulation of Binding of Nos3 1 0.18 0.25 0.12
165 INT186558 Negative_regulation of Positive_regulation of NOS3 2 0.37 0.26 0.1
166 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
167 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
168 INT87232 Regulation of ECE1 1 0.45 0.16 0.1
169 INT323038 Regulation of Positive_regulation of EDN2 1 0.21 0 0.1
170 INT172791 Negative_regulation of Transcription of Nos3 1 0.17 0.9 0.1
171 INT309385 Positive_regulation of Phosphorylation of Nos3 5 0.48 2.98 0.09
172 INT305235 Negative_regulation of Phosphorylation of Nos3 5 0.41 4.17 0.09
173 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09
174 INT49260 Negative_regulation of ECE1 7 0.57 0.24 0.08
175 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
176 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
177 INT178109 Binding of EDN3 1 0.06 1.65 0.07
178 INT175698 Positive_regulation of Localization of Nos3 2 0.27 1.19 0.04
179 INT343710 Positive_regulation of Localization of Nos3 1 0.38 0.22 0.03
180 INT270323 Gene_expression of EDN3 1 0.01 0.76 0.03
181 INT269496 Regulation of Binding of Nos3 3 0.25 0.46 0
182 INT355212 Positive_regulation of Phosphorylation of Nos3 1 0.23 0.18 0
183 INT336827 Regulation of Regulation of NOS3 1 0.23 0.51 0
184 INT309384 Regulation of Phosphorylation of Nos3 1 0.31 0.39 0
185 INT249944 Positive_regulation of Regulation of Nos3 1 0.35 0.07 0
186 INT323037 Negative_regulation of EDN2 1 0.20 0.23 0
187 INT226251 Protein_catabolism of EDN3 1 0.02 0 0
188 INT22196 Positive_regulation of Gene_expression of Edn3 1 0.17 0.15 0
189 INT280682 Positive_regulation of Transcription of Edn1 1 0.34 0 0
190 INT49261 Negative_regulation of Protein_catabolism of EDN1 1 0.58 0 0
191 INT174535 Negative_regulation of Negative_regulation of NOS3 1 0.11 0.32 0
192 INT323036 Regulation of EDN2 1 0.13 0 0
193 INT323041 Binding of EDN2 1 0.18 0.12 0
194 INT343712 Regulation of Positive_regulation of Nos3 1 0.50 0.93 0
195 INT226248 Negative_regulation of Negative_regulation of ECE1 1 0.05 0 0
196 INT323039 Regulation of Binding of EDN2 1 0.21 0.12 0
197 INT140156 Positive_regulation of Transcription of NOS3 1 0.31 0 0
198 INT159478 Negative_regulation of Phosphorylation of NOS3 1 0.51 0 0
199 INT181578 Negative_regulation of Phosphorylation of Edn1 1 0.37 0.1 0
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