GO:0003136

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Name negative regulation of heart induction by canonical Wnt receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0003136
Unique Molecular Interactions 41
Total Molecular Interactions 48
Total Single Events 332
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of heart induction by canonical Wnt receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of heart induction by canonical Wnt receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
2 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
3 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
4 INT234992 Car2 Positive_regulation of Jup 1 0.02 0.27 0.2
5 INT340608 Binding of Creb1 and Wnt3a 1 0.30 0.24 0.14
6 INT201762 JUP Regulation of Gene_expression of Ccnd1 1 0.03 0.8 0.13
7 INT201791 JUP Regulation of Gene_expression of Myc 1 0.49 0.8 0.13
8 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
9 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
10 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07
11 INT339108 Binding of ESR1 and JUP 1 0.38 0.62 0.07
12 INT349914 Binding of Cdh1 and Jup 1 0.11 0.47 0.07
13 INT234968 IgG Negative_regulation of Jup 1 0.02 1.09 0.06
14 INT192044 Binding of DSP and Jup 2 0.24 2.39 0
15 INT234995 Binding of CDH16 and Jup 1 0.00 0.27 0
16 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
17 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
18 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
19 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
20 INT234969 Jup Regulation of Gene_expression of Dsp 1 0.01 0.54 0
21 INT251072 Wnt3a Positive_regulation of Axin2 1 0.23 0.29 0
22 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
23 INT235007 Binding of DSG1 and Jup 1 0.08 0.36 0
24 INT235005 Positive_regulation of Binding of DSG1 and Jup 1 0.08 0.36 0
25 INT326893 Binding of Tcf4 and Wnt3a 1 0.13 0 0
26 INT234983 IgG Positive_regulation of Protein_catabolism of Jup 1 0.03 0.61 0
27 INT192045 Jup Positive_regulation of RYR2 1 0.11 0.29 0
28 INT234970 Binding of Jup and Lat 1 0.01 0 0
29 INT326896 Wnt3a Positive_regulation of Transcription of PLD2 1 0.24 0.06 0
30 INT266555 Mapk8 Regulation of JUP 1 0.08 0.1 0
31 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
32 INT251070 Wnt3a Positive_regulation of Cldn3 1 0.30 0.29 0
33 INT234987 Binding of Jup and Dsp 1 0.01 0.18 0
34 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
35 INT326894 Wnt3a Positive_regulation of Transcription of Pld1 1 0.24 0.06 0
36 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
37 INT192042 Binding of Jup and Ryr2 1 0.17 1.09 0
38 INT234982 Binding of Jup and Pkp1 1 0.00 0 0
39 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of heart induction by canonical Wnt receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of heart induction by canonical Wnt receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
2 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
3 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
4 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
5 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
6 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
7 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
8 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
9 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
10 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
11 INT242171 Protein_catabolism of JUP 4 0.96 0.91 1.01
12 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
13 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
14 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
15 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
16 INT266535 Phosphorylation of JUP 3 0.79 0.63 0.49
17 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
18 INT242168 Transcription of JUP 4 0.67 1.17 0.46
19 INT340598 Binding of Wnt3a 1 0.33 0.15 0.46
20 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
21 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
22 INT340606 Positive_regulation of Wnt3a 1 0.61 0.49 0.4
23 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
24 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
25 INT242169 Positive_regulation of Protein_catabolism of JUP 1 0.49 0.23 0.34
26 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32
27 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
28 INT51514 Positive_regulation of Wnt3a 3 0.04 3.32 0.28
29 INT221860 Negative_regulation of Jup 9 0.15 6.82 0.26
30 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
31 INT234903 Gene_expression of Jup 1 0.23 7.1 0.2
32 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
33 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
34 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
35 INT205083 Positive_regulation of JUP 6 0.49 5.51 0.13
36 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
37 INT51512 Negative_regulation of Positive_regulation of Wnt3a 1 0.04 1.3 0.13
38 INT51513 Positive_regulation of Positive_regulation of Wnt3a 1 0.04 1.31 0.13
39 INT242173 Positive_regulation of Gene_expression of JUP 2 0.49 2.37 0.09
40 INT214463 Binding of Wnt3a 2 0.26 0.23 0.08
41 INT309877 Localization of JUP 2 0.73 1.38 0.08
42 INT339206 Negative_regulation of Localization of JUP 1 0.41 1.1 0.08
43 INT234894 Negative_regulation of Protein_catabolism of Jup 1 0.17 2.87 0.08
44 INT234866 Regulation of Jup 2 0.08 0.58 0.06
45 INT234899 Positive_regulation of Protein_catabolism of Jup 1 0.21 0.88 0.06
46 INT329585 Regulation of Negative_regulation of Jup 1 0.01 0.23 0.06
47 INT234931 Protein_catabolism of Jup 1 0.29 2.23 0.06
48 INT234915 Positive_regulation of Gene_expression of Jup 1 0.15 2.7 0.06
49 INT234890 Phosphorylation of Jup 1 0.24 1.56 0.03
50 INT234867 Localization of Jup 1 0.24 2.84 0.03
51 INT266537 Positive_regulation of Phosphorylation of JUP 2 0.49 0.29 0
52 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
53 INT266534 Negative_regulation of Phosphorylation of JUP 2 0.41 0.15 0
54 INT242174 Negative_regulation of Gene_expression of JUP 2 0.41 2.58 0
55 INT221864 Binding of JUP 2 0.36 1.05 0
56 INT214465 Localization of Wnt3a 2 0.52 0.29 0
57 INT221859 Binding of Jup 2 0.14 2.21 0
58 INT251053 Gene_expression of Wnt3a 2 0.47 0.5 0
59 INT326853 Positive_regulation of Gene_expression of Wnt3a 1 0.36 0.2 0
60 INT309874 Positive_regulation of Binding of JUP 1 0.49 0.32 0
61 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
62 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
63 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
64 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
65 INT234877 Positive_regulation of Binding of Jup 1 0.21 0.24 0
66 INT242170 Negative_regulation of JUP 1 0.42 0.85 0
67 INT251054 Regulation of Localization of Wnt3a 1 0.27 0.07 0
68 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
69 INT251066 Regulation of Gene_expression of Wnt3a 1 0.31 0.07 0
70 INT309876 Regulation of JUP 1 0.60 0.67 0
71 INT234918 Positive_regulation of Jup 1 0.15 1.08 0
72 INT309875 Regulation of Gene_expression of JUP 1 0.44 0.39 0
73 INT326843 Negative_regulation of Gene_expression of Wnt3a 1 0.22 0.29 0
74 INT234896 Negative_regulation of Gene_expression of Jup 1 0.13 0.54 0
75 INT355092 Positive_regulation of Transcription of JUP 1 0.49 0.05 0
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