GO:0003139

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Name secondary heart field specification
Categary Process
Go Slim No
Go Link GO:0003139
Unique Molecular Interactions 29
Total Molecular Interactions 36
Total Single Events 442
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for secondary heart field specification. They are ordered first by their pain relevance and then by number of times they were reported for secondary heart field specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
2 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
3 INT237453 Binding of STAR and MESP1 1 0.00 0.47 0.42
4 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
5 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
6 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
7 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
8 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
9 INT306560 BMP4 Positive_regulation of MAPK1 1 0.09 0.09 0.03
10 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
11 INT244856 Lbx1 Regulation of Isl1 1 0.60 0 0
12 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
13 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
14 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0
15 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
16 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
17 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
18 INT323254 Binding of Ptprv and Isl1 1 0.00 0.6 0
19 INT244860 Lbx1 Negative_regulation of Isl1 1 0.16 0 0
20 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
21 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
22 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
23 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0
24 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
25 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0
26 INT323252 Binding of H2-Ab1 and Isl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for secondary heart field specification. They are ordered first by their pain relevance and then by number of times they were reported in secondary heart field specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
2 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
3 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
4 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
5 INT237456 Gene_expression of MESP1 1 0.03 1.33 1.12
6 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
7 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
8 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
9 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
10 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
11 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
12 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
13 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
14 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
15 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
16 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
17 INT237457 Positive_regulation of Gene_expression of MESP1 1 0.02 0.45 0.4
18 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
19 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
20 INT172806 Localization of ISL1 4 0.26 2.64 0.29
21 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28
22 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28
23 INT78132 Binding of Isl1 1 0.16 0 0.27
24 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
25 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
26 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
27 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25
28 INT202355 Transcription of Mef2c 3 0.69 0.6 0.21
29 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
30 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
31 INT243778 Binding of Isl1 1 0.26 0 0.19
32 INT248543 Positive_regulation of Mef2c 7 0.69 2.82 0.18
33 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
34 INT277602 Binding of Mef2c 10 0.39 4.35 0.16
35 INT98772 Localization of Isl1 2 0.65 0 0.16
36 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
37 INT98774 Regulation of Localization of Isl1 1 0.08 0 0.13
38 INT207829 Positive_regulation of Localization of ISL1 1 0.02 0.1 0.1
39 INT287912 Localization of BMP4 1 0.18 1.13 0.1
40 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
41 INT173473 Positive_regulation of Positive_regulation of Isl1 1 0.02 0.06 0.09
42 INT173470 Positive_regulation of Phosphorylation of Isl1 1 0.02 0 0.09
43 INT173471 Phosphorylation of Isl1 1 0.04 0 0.09
44 INT290404 Positive_regulation of Negative_regulation of Mef2c 1 0.50 0.72 0.08
45 INT277578 Regulation of Negative_regulation of Mef2c 2 0.45 1.17 0.07
46 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
47 INT290417 Positive_regulation of Gene_expression of Mef2c 1 0.50 1.25 0.06
48 INT298237 Regulation of Isl1 1 0.03 0.24 0.06
49 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
50 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
51 INT290407 Positive_regulation of Binding of Mef2c 1 0.44 0.93 0.04
52 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
53 INT290419 Regulation of Gene_expression of Mef2c 1 0.62 0.41 0.03
54 INT290399 Negative_regulation of Gene_expression of Mef2c 1 0.59 0.59 0.03
55 INT352541 Transcription of ISL1 1 0.36 0.2 0.03
56 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
57 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
58 INT196027 Binding of Bmp4 2 0.13 0.97 0
59 INT142119 Regulation of Bmp4 2 0.58 0.29 0
60 INT180121 Phosphorylation of Isl1 1 0.27 0 0
61 INT180097 Positive_regulation of Phosphorylation of Isl1 1 0.17 0 0
62 INT290400 Regulation of Regulation of Mef2c 1 0.45 0.24 0
63 INT227625 Regulation of ISL1 1 0.05 0.35 0
64 INT339667 Localization of Bmp4 1 0.38 0.27 0
65 INT290429 Negative_regulation of Negative_regulation of Mef2c 1 0.37 0.05 0
66 INT290425 Negative_regulation of Binding of Mef2c 1 0.37 0 0
67 INT290409 Negative_regulation of Transcription of Mef2c 1 0.43 0.08 0
68 INT243780 Positive_regulation of Gene_expression of Isl1 1 0.35 0 0
69 INT183071 Negative_regulation of Gene_expression of ISL1 1 0.20 0.34 0
70 INT351554 Negative_regulation of Gene_expression of BMP4 1 0.26 0 0
71 INT277587 Localization of Mef2c 1 0.65 0.43 0
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