GO:0003148

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Name outflow tract septum morphogenesis
Categary Process
Go Slim No
Go Link GO:0003148
Unique Molecular Interactions 62
Total Molecular Interactions 83
Total Single Events 485
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for outflow tract septum morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for outflow tract septum morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
3 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
4 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89
5 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87
6 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
7 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
8 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
9 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
10 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
11 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
12 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
13 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
14 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 0.01 0 0.29
15 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
16 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
17 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
18 INT306425 Positive_regulation of Binding of TBX1 and VCF 1 0.02 1.15 0.18
19 INT306426 Binding of TBX1 and VCF 1 0.01 1.09 0.17
20 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
21 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
22 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
23 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
24 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
25 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
26 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
27 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
28 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
29 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
30 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
31 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
32 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
33 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06
34 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
35 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
36 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
37 INT305383 Binding of NKX2-5 and FLNA 1 0.10 0.7 0.04
38 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
39 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
40 INT244856 Lbx1 Regulation of Isl1 1 0.60 0 0
41 INT274435 Binding of Zfpm2 and Mir130a 1 0.30 0.26 0
42 INT269944 Gata6 Regulation of Gene_expression of Foxj1 1 0.19 0 0
43 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0
44 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
45 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0
46 INT274432 Mir130a Regulation of Zfpm2 1 0.22 0.08 0
47 INT274431 Mir130a Regulation of Gene_expression of Zfpm2 1 0.50 0.79 0
48 INT323254 Binding of Ptprv and Isl1 1 0.00 0.6 0
49 INT244860 Lbx1 Negative_regulation of Isl1 1 0.16 0 0
50 INT217780 MIR181A1 Regulation of GATA6 1 0.17 0.7 0
51 INT274434 Binding of Gata4 and Zfpm2 1 0.12 0.56 0
52 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
53 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0
54 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
55 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0
56 INT274433 Binding of Zfpm2 and Uts2r 1 0.08 0.17 0
57 INT274436 Mir130a Regulation of Transcription of Zfpm2 1 0.22 0 0
58 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0
59 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0
60 INT269956 Gata6 Regulation of Gene_expression of Scgb1a1 1 0.17 0 0
61 INT323252 Binding of H2-Ab1 and Isl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for outflow tract septum morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in outflow tract septum morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
2 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
3 INT101246 Gene_expression of Gata6 6 0.68 3.03 2.68
4 INT101252 Negative_regulation of Gene_expression of Gata6 1 0.51 1.3 1.74
5 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
6 INT101244 Regulation of Gata6 3 0.40 1.52 1.7
7 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
8 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
9 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
10 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
11 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
12 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
13 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
14 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
15 INT109075 Positive_regulation of Transcription of NKX2-5 1 0.67 0 1.02
16 INT109074 Transcription of NKX2-5 1 0.69 0 1.01
17 INT101248 Negative_regulation of Gata6 1 0.37 0.83 0.85
18 INT101251 Negative_regulation of Positive_regulation of Gata6 1 0.38 0.83 0.85
19 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
20 INT101250 Positive_regulation of Gata6 1 0.41 0.83 0.84
21 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
22 INT109062 Gene_expression of NKX2-5 7 0.75 3.31 0.82
23 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82
24 INT101245 Transcription of Gata6 2 0.47 0.85 0.82
25 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
26 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
27 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
28 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
29 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
30 INT305390 Negative_regulation of NKX2-5 2 0.37 2.24 0.49
31 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
32 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
33 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
34 INT159221 Negative_regulation of TBX1 4 0.41 4.22 0.43
35 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
36 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
37 INT65606 Binding of TBX1 2 0.30 3.13 0.41
38 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
39 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
40 INT172806 Localization of ISL1 4 0.26 2.64 0.29
41 INT269082 Gene_expression of TBX1 1 0.14 0.36 0.28
42 INT78132 Binding of Isl1 1 0.16 0 0.27
43 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
44 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
45 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
46 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25
47 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
48 INT250836 Binding of Fgf8 3 0.35 0.66 0.24
49 INT306427 Localization of TBX1 1 0.20 1.08 0.23
50 INT306428 Positive_regulation of Localization of TBX1 1 0.14 1.08 0.23
51 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
52 INT305392 Binding of NKX2-5 1 0.22 0.93 0.21
53 INT250833 Localization of Fgf8 1 0.74 0.46 0.21
54 INT250842 Negative_regulation of Binding of Fgf8 1 0.43 0.33 0.21
55 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
56 INT243778 Binding of Isl1 1 0.26 0 0.19
57 INT98772 Localization of Isl1 2 0.65 0 0.16
58 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
59 INT208925 Positive_regulation of Localization of Nkx2-5 1 0.21 0.14 0.16
60 INT250835 Positive_regulation of Fgf8 1 0.50 0.42 0.14
61 INT146415 Regulation of Nkx2-5 3 0.44 0.91 0.13
62 INT98774 Regulation of Localization of Isl1 1 0.08 0 0.13
63 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12
64 INT162568 Regulation of TBX1 3 0.35 1.54 0.11
65 INT258933 Protein_catabolism of TBX1 1 0.43 0.75 0.11
66 INT208922 Transcription of Nkx2-5 2 0.29 0.36 0.1
67 INT323415 Regulation of NKX2-5 1 0.39 0.71 0.1
68 INT208917 Positive_regulation of Transcription of Nkx2-5 1 0.21 0 0.1
69 INT323416 Localization of NKX2-5 1 0.65 1.75 0.1
70 INT207829 Positive_regulation of Localization of ISL1 1 0.02 0.1 0.1
71 INT208918 Positive_regulation of Gene_expression of Nkx2-5 3 0.23 0.48 0.09
72 INT173473 Positive_regulation of Positive_regulation of Isl1 1 0.02 0.06 0.09
73 INT173470 Positive_regulation of Phosphorylation of Isl1 1 0.02 0 0.09
74 INT173471 Phosphorylation of Isl1 1 0.04 0 0.09
75 INT305387 Positive_regulation of Gene_expression of NKX2-5 1 0.31 0.72 0.07
76 INT298237 Regulation of Isl1 1 0.03 0.24 0.06
77 INT339183 Positive_regulation of GATA6 1 0.16 0.66 0.06
78 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
79 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
80 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
81 INT352541 Transcription of ISL1 1 0.36 0.2 0.03
82 INT206911 Gene_expression of Msx2 4 0.71 1.26 0
83 INT207729 Regulation of FGFR2 4 0.22 2.35 0
84 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0
85 INT99716 Transcription of FGFR2 2 0.34 0.22 0
86 INT305351 Positive_regulation of Regulation of FGFR2 2 0.37 0.97 0
87 INT206909 Negative_regulation of Gene_expression of Msx2 2 0.53 0.29 0
88 INT99715 Regulation of Gene_expression of FGFR2 2 0.22 0.19 0
89 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0
90 INT180121 Phosphorylation of Isl1 1 0.27 0 0
91 INT274420 Positive_regulation of Gene_expression of Zfpm2 1 0.49 0.51 0
92 INT206916 Positive_regulation of Gene_expression of Msx2 1 0.40 0.36 0
93 INT202623 Negative_regulation of Gene_expression of Fgfr2 1 0.32 0 0
94 INT180097 Positive_regulation of Phosphorylation of Isl1 1 0.17 0 0
95 INT319036 Gene_expression of Fgfr2 1 0.48 0.08 0
96 INT217818 Gene_expression of GATA6 1 0.17 1.07 0
97 INT220772 Transcription of Msx2 1 0.46 0.08 0
98 INT227625 Regulation of ISL1 1 0.05 0.35 0
99 INT274412 Transcription of Zfpm2 1 0.53 0 0
100 INT274418 Regulation of Gene_expression of Zfpm2 1 0.45 1.42 0
101 INT274417 Negative_regulation of Zfpm2 1 0.43 6.99 0
102 INT274428 Regulation of Binding of Zfpm2 1 0.45 0.15 0
103 INT274405 Gene_expression of Zfpm2 1 0.77 6.51 0
104 INT274425 Negative_regulation of Gene_expression of Zfpm2 1 0.42 0.06 0
105 INT274411 Positive_regulation of Zfpm2 1 0.46 0.53 0
106 INT314739 Transcription of TBX1 1 0.32 0.8 0
107 INT243780 Positive_regulation of Gene_expression of Isl1 1 0.35 0 0
108 INT250830 Regulation of Protein_catabolism of Fgf8 1 0.45 0.08 0
109 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0
110 INT183071 Negative_regulation of Gene_expression of ISL1 1 0.20 0.34 0
111 INT99717 Positive_regulation of Transcription of FGFR2 1 0.10 0.08 0
112 INT183117 Positive_regulation of Binding of FGFR2 1 0.09 0.81 0
113 INT250846 Positive_regulation of Protein_catabolism of Fgf8 1 0.50 0.07 0
114 INT274414 Regulation of Zfpm2 1 0.61 0.59 0
115 INT328768 Positive_regulation of Gene_expression of Gata6 1 0.19 0.61 0
116 INT274408 Binding of Zfpm2 1 0.37 0.77 0
117 INT303524 Positive_regulation of Fgfr2 1 0.66 0.22 0
118 INT339154 Negative_regulation of GATA6 1 0.14 0.86 0
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