GO:0003158

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Name endothelium development
Categary Process
Go Slim No
Go Link GO:0003158
Unique Molecular Interactions 60
Total Molecular Interactions 136
Total Single Events 998
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endothelium development. They are ordered first by their pain relevance and then by number of times they were reported for endothelium development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
2 INT152490 Slc40a1 Negative_regulation of Faah 1 0.01 0.73 0.98
3 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48
4 INT241853 Binding of SLC40A1 and HAMP 3 0.41 5.35 0.43
5 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3
6 INT139538 Binding of CD34 and KIT 2 0.39 2.73 0.14
7 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
8 INT148594 Binding of BCL2 and CD34 1 0.39 1.17 0.13
9 INT277986 Negative_regulation of Epo Positive_regulation of Localization of Cd34 1 0.08 0.77 0.12
10 INT118052 Binding of Pecam1 and Cd34 1 0.22 0.51 0.1
11 INT299955 Binding of KDR and FTSJ3 1 0.04 1.07 0.09
12 INT299953 Binding of CD34 and FTSJ3 1 0.04 1.07 0.09
13 INT318387 Binding of Slc40a1 and Hrct1 1 0.02 0.88 0.08
14 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08
15 INT265750 Binding of FLT1 and KDR 1 0.37 0.54 0.07
16 INT209615 Binding of KRT20 and Cd34 1 0.00 1.05 0.06
17 INT292811 Zfp787 Negative_regulation of Phosphorylation of Kdr 1 0.01 0.45 0.06
18 INT209611 Binding of Mme and Cd34 1 0.00 1.05 0.06
19 INT118227 Binding of ACTG2 and CD34 1 0.15 1.17 0.06
20 INT209610 Binding of Cd22 and Cd34 1 0.01 1.05 0.06
21 INT105268 VEGFA Positive_regulation of KDR 2 0.18 0.22 0.05
22 INT105267 Negative_regulation of VEGFA Positive_regulation of KDR 1 0.16 0.22 0.05
23 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05
24 INT338827 Binding of Slc40a1 and HAMP 1 0.00 0.27 0.05
25 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05
26 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04
27 INT315913 VEGFA Regulation of KDR 1 0.03 0.32 0.04
28 INT292083 Binding of KDR and TXK 1 0.04 1.52 0.04
29 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04
30 INT292095 Negative_regulation of Binding of KDR and TXK 1 0.04 1.53 0.04
31 INT224305 Positive_regulation of Binding of KDR and VEGFA 2 0.45 0.36 0.03
32 INT224304 KDR Positive_regulation of Binding of VEGFA 1 0.24 0.36 0.03
33 INT224306 KDR Positive_regulation of VEGFA 1 0.24 0.36 0.03
34 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0
35 INT198016 Localization of KDR Negative_regulation of VEGFA 1 0.08 0.95 0
36 INT298684 ecs Positive_regulation of Gene_expression of KDR 1 0.01 1.2 0
37 INT290592 Binding of KDR and Cdh5 1 0.07 0.08 0
38 INT312330 Binding of Kdr and Flt1 1 0.12 0.37 0
39 INT300447 Kdr Regulation of VEGFA 1 0.07 0.25 0
40 INT292082 MIR1200 Negative_regulation of KDR 1 0.00 1.24 0
41 INT308314 Binding of CD34 and Pfpl 1 0.03 0.57 0
42 INT322844 Binding of KDR and PIK3CD 1 0.04 0 0
43 INT173054 NRP1 Positive_regulation of KDR 1 0.08 0.34 0
44 INT322850 Binding of KDR and PDCD10 1 0.14 0 0
45 INT300437 Kdr Regulation of Gene_expression of Flt1 1 0.42 0.26 0
46 INT300443 VEGFA Positive_regulation of Phosphorylation of Kdr 1 0.08 0.64 0
47 INT314744 Binding of KDR and Akt1 1 0.13 0.66 0
48 INT249850 Binding of Ptprc and Cd34 1 0.13 0.48 0
49 INT300438 Efna1 Negative_regulation of Phosphorylation of Kdr 1 0.42 0.66 0
50 INT300436 Flt1 Negative_regulation of Kdr 1 0.35 0.4 0
51 INT347035 Binding of Kit and Cd34 1 0.02 1.38 0
52 INT198012 KDR Negative_regulation of VEGFA 1 0.08 0.93 0
53 INT351603 Binding of ERBB2 and KDR 1 0.13 0.55 0
54 INT198000 Gene_expression of KDR Negative_regulation of VEGFA 1 0.08 0.94 0
55 INT265770 Binding of KDR and GOPC 1 0.10 0 0
56 INT198010 KDR Negative_regulation of MTOR 1 0.11 0.95 0
57 INT198002 KDR Negative_regulation of PDGFA 1 0.09 0.94 0
58 INT213745 Binding of Kdr and Epc1 1 0.17 0 0
59 INT213744 Binding of Cd34 and Epc1 1 0.12 0 0
60 INT315538 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for endothelium development. They are ordered first by their pain relevance and then by number of times they were reported in endothelium development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39
2 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97
3 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35
4 INT59723 Binding of Slc40a1 5 0.35 1.31 5.17
5 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
6 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14
7 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28
8 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86
9 INT162725 Binding of Kdr 13 0.42 8.86 1.79
10 INT59722 Negative_regulation of Slc40a1 3 0.11 0.56 1.73
11 INT132882 Gene_expression of Slc40a1 4 0.17 1.35 1.6
12 INT21682 Binding of CD34 18 0.47 13.19 1.47
13 INT82345 Regulation of Slc40a1 2 0.23 0.33 1.28
14 INT105270 Positive_regulation of KDR 25 0.49 11.49 1.2
15 INT260471 Positive_regulation of Gene_expression of Kdr 9 0.61 8.37 0.99
16 INT119168 Negative_regulation of Cd34 8 0.37 4.91 0.96
17 INT126967 Localization of Cd34 9 0.79 3.69 0.87
18 INT96188 Binding of Cd34 11 0.31 10.4 0.82
19 INT173100 Binding of KDR 39 0.39 22.48 0.81
20 INT297469 Regulation of Binding of Kdr 1 0.54 2.01 0.8
21 INT127684 Negative_regulation of Kdr 6 0.37 3.19 0.7
22 INT94713 Regulation of CD34 11 0.45 8.02 0.58
23 INT128472 Negative_regulation of CD34 7 0.42 3.92 0.58
24 INT196003 Regulation of Cd34 4 0.30 3.38 0.5
25 INT87819 Localization of CD34 21 0.81 7.69 0.47
26 INT119251 Positive_regulation of Gene_expression of CD34 12 0.49 5.2 0.44
27 INT292795 Regulation of Kdr 5 0.40 3.86 0.42
28 INT131773 Regulation of KDR 12 0.49 12.01 0.39
29 INT148797 Phosphorylation of KDR 7 0.80 5.15 0.36
30 INT232153 Regulation of Negative_regulation of Cd34 1 0.05 0.07 0.35
31 INT173097 Localization of KDR 20 0.73 12.73 0.31
32 INT179687 Negative_regulation of Gene_expression of KDR 6 0.22 5.37 0.31
33 INT241859 Protein_catabolism of SLC40A1 2 0.02 1.22 0.31
34 INT173091 Transcription of KDR 3 0.55 1.39 0.27
35 INT148798 Regulation of Phosphorylation of KDR 1 0.44 0 0.27
36 INT162252 Positive_regulation of Slc40a1 4 0.36 0.79 0.25
37 INT291184 Regulation of Gene_expression of Kdr 3 0.54 4.81 0.25
38 INT125027 Positive_regulation of Kdr 15 0.50 7.73 0.24
39 INT232504 Negative_regulation of Gene_expression of CD34 4 0.38 1.89 0.23
40 INT243267 Positive_regulation of SLC40A1 4 0.41 2.72 0.22
41 INT241863 Binding of SLC40A1 4 0.28 3.86 0.22
42 INT241865 Positive_regulation of Protein_catabolism of SLC40A1 1 0.02 0.61 0.22
43 INT318204 Positive_regulation of Positive_regulation of KDR 2 0.14 0.68 0.19
44 INT135706 Negative_regulation of Binding of CD34 1 0.40 1.19 0.16
45 INT137457 Positive_regulation of Localization of Cd34 1 0.46 0.55 0.16
46 INT105269 Negative_regulation of Positive_regulation of KDR 2 0.41 1.35 0.15
47 INT297468 Transcription of Kdr 6 0.63 1.85 0.14
48 INT243268 Gene_expression of SLC40A1 6 0.60 4.18 0.13
49 INT232508 Regulation of Gene_expression of CD34 4 0.43 2.73 0.13
50 INT292809 Phosphorylation of Kdr 3 0.72 1.99 0.12
51 INT292807 Negative_regulation of Phosphorylation of Kdr 3 0.37 1.56 0.12
52 INT204146 Localization of Slc40a1 1 0.05 0.99 0.11
53 INT204144 Negative_regulation of Localization of Slc40a1 1 0.03 0.99 0.11
54 INT224335 Negative_regulation of Phosphorylation of KDR 5 0.35 5.24 0.09
55 INT318386 Negative_regulation of Gene_expression of Slc40a1 1 0.11 0.48 0.09
56 INT258561 Negative_regulation of Negative_regulation of KDR 1 0.11 0.91 0.09
57 INT206683 Negative_regulation of Binding of KDR 3 0.34 2.54 0.08
58 INT179116 Localization of Kdr 1 0.58 4.65 0.06
59 INT189580 Positive_regulation of Gene_expression of KDR 9 0.49 5.9 0.05
60 INT198034 Positive_regulation of Localization of KDR 3 0.29 2.17 0.05
61 INT308300 Positive_regulation of Localization of CD34 3 0.44 1.82 0.05
62 INT229654 Positive_regulation of Gene_expression of Cd34 2 0.45 1.19 0.05
63 INT221855 Regulation of Positive_regulation of CD34 1 0.31 0.83 0.04
64 INT296384 Regulation of SLC40A1 2 0.01 0.83 0.03
65 INT291191 Negative_regulation of Gene_expression of Kdr 4 0.24 4.46 0
66 INT265799 Regulation of Binding of KDR 2 0.38 0.64 0
67 INT296387 Localization of SLC40A1 2 0.44 0.94 0
68 INT300429 Negative_regulation of Transcription of Kdr 2 0.38 0.49 0
69 INT265783 Regulation of Localization of KDR 2 0.37 0.64 0
70 INT315565 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.73 0
71 INT315591 Negative_regulation of Positive_regulation of SLC40A1 1 0.25 0.46 0
72 INT315575 Transcription of SLC40A1 1 0.40 0.85 0
73 INT265779 Positive_regulation of Protein_catabolism of KDR 1 0.41 0.08 0
74 INT315592 Positive_regulation of Gene_expression of SLC40A1 1 0.41 3.52 0
75 INT320552 Transcription of CD34 1 0.67 1.23 0
76 INT300433 Positive_regulation of Phosphorylation of Kdr 1 0.61 1.1 0
77 INT179106 Positive_regulation of Localization of Kdr 1 0.33 0.44 0
78 INT315593 Regulation of Transcription of SLC40A1 1 0.26 1.7 0
79 INT315580 Negative_regulation of Localization of SLC40A1 1 0.25 0.64 0
80 INT322861 Positive_regulation of Binding of KDR 1 0.13 0 0
81 INT308295 Positive_regulation of Positive_regulation of CD34 1 0.60 0.44 0
82 INT265808 Protein_catabolism of KDR 1 0.81 0.08 0
83 INT179113 Negative_regulation of Localization of Kdr 1 0.31 0.41 0
84 INT294258 Phosphorylation of CD34 1 0.69 0.06 0
85 INT315558 Negative_regulation of SLC40A1 1 0.25 0.63 0
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