GO:0003161

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Name cardiac conduction system development
Categary Process
Go Slim No
Go Link GO:0003161
Unique Molecular Interactions 29
Total Molecular Interactions 39
Total Single Events 192
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cardiac conduction system development. They are ordered first by their pain relevance and then by number of times they were reported for cardiac conduction system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
2 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
3 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
4 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 0.01 0 0.29
5 INT141634 Binding of Alb and Nrg1 1 0.00 0.3 0.26
6 INT134522 Nrg1 Regulation of Gene_expression of Mpz 1 0.60 0.29 0.25
7 INT134523 Nrg1 Positive_regulation of Gene_expression of Mpz 1 0.49 0.32 0.23
8 INT326575 Nrg1 Positive_regulation of Gene_expression of JUN 1 0.38 0.86 0.2
9 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
10 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11
11 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
12 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
13 INT341008 Nrg1 Regulation of Binding of Erbb4 1 0.04 0 0.09
14 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
15 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
16 INT305383 Binding of NKX2-5 and FLNA 1 0.10 0.7 0.04
17 INT341009 Nrg1 Positive_regulation of Gene_expression of Fabp7 1 0.10 0.49 0.04
18 INT231276 Erbb4 Positive_regulation of Nrg1 2 0.35 0.06 0.03
19 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03
20 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03
21 INT231275 Erbb4 Positive_regulation of Gene_expression of Nrg1 1 0.35 0 0.03
22 INT334869 Nrg1 Positive_regulation of Phosphorylation of C3 1 0.08 0 0.03
23 INT341005 Binding of Vim and Nrg1 1 0.05 0.14 0
24 INT341013 Binding of Erbb3 and Nrg1 1 0.04 0.14 0
25 INT341023 PIK3CB Positive_regulation of Nrg1 1 0.03 0.06 0
26 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0
27 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0
28 INT341010 Nrg1 Positive_regulation of Regulation of Vim 1 0.07 0 0
29 INT341014 Positive_regulation of Binding of Erbb3 and Nrg1 1 0.06 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cardiac conduction system development. They are ordered first by their pain relevance and then by number of times they were reported in cardiac conduction system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15771 Gene_expression of Nrg1 34 0.67 3.16 4.11
2 INT168983 Negative_regulation of Nrg1 11 0.43 3.4 2.03
3 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
4 INT105784 Binding of Nrg1 7 0.37 1.29 1.52
5 INT158056 Localization of Nrg1 13 0.79 3.11 1.28
6 INT101994 Positive_regulation of Nrg1 10 0.50 1.24 1.05
7 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
8 INT109075 Positive_regulation of Transcription of NKX2-5 1 0.67 0 1.02
9 INT109074 Transcription of NKX2-5 1 0.69 0 1.01
10 INT109062 Gene_expression of NKX2-5 7 0.75 3.31 0.82
11 INT139846 Protein_catabolism of Nrg1 5 0.60 1.78 0.74
12 INT126736 Positive_regulation of Gene_expression of Nrg1 3 0.50 0.42 0.71
13 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
14 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
15 INT15770 Negative_regulation of Gene_expression of Nrg1 3 0.43 1.27 0.5
16 INT305390 Negative_regulation of NKX2-5 2 0.37 2.24 0.49
17 INT334851 Positive_regulation of Localization of Nrg1 1 0.30 0.68 0.34
18 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25
19 INT305392 Binding of NKX2-5 1 0.22 0.93 0.21
20 INT208925 Positive_regulation of Localization of Nkx2-5 1 0.21 0.14 0.16
21 INT231261 Regulation of Nrg1 3 0.31 1.32 0.15
22 INT220571 Positive_regulation of Protein_catabolism of Nrg1 1 0.30 0.08 0.15
23 INT146415 Regulation of Nkx2-5 3 0.44 0.91 0.13
24 INT208922 Transcription of Nkx2-5 2 0.29 0.36 0.1
25 INT323415 Regulation of NKX2-5 1 0.39 0.71 0.1
26 INT208917 Positive_regulation of Transcription of Nkx2-5 1 0.21 0 0.1
27 INT323416 Localization of NKX2-5 1 0.65 1.75 0.1
28 INT208918 Positive_regulation of Gene_expression of Nkx2-5 3 0.23 0.48 0.09
29 INT329735 Negative_regulation of Protein_catabolism of Nrg1 1 0.36 0.49 0.08
30 INT305387 Positive_regulation of Gene_expression of NKX2-5 1 0.31 0.72 0.07
31 INT334840 Positive_regulation of Phosphorylation of Nrg1 1 0.30 0 0.06
32 INT220593 Negative_regulation of Localization of Nrg1 1 0.26 0.07 0.04
33 INT334841 Negative_regulation of Phosphorylation of Nrg1 1 0.26 0 0.03
34 INT340964 Positive_regulation of Negative_regulation of Nrg1 1 0.28 0.12 0.03
35 INT334845 Phosphorylation of Nrg1 1 0.49 0 0.03
36 INT340965 Negative_regulation of Binding of Nrg1 1 0.24 0 0
37 INT220588 Transcription of Nrg1 1 0.41 0.64 0
38 INT340954 Positive_regulation of Positive_regulation of Nrg1 1 0.28 0 0
39 INT340974 Negative_regulation of Negative_regulation of Nrg1 1 0.24 0 0
40 INT231271 Regulation of Localization of Nrg1 1 0.45 0 0
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