GO:0003180

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Name aortic valve morphogenesis
Categary Process
Go Slim No
Go Link GO:0003180
Unique Molecular Interactions 210
Total Molecular Interactions 272
Total Single Events 1897
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for aortic valve morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for aortic valve morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
2 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
3 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
4 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
5 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
6 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
7 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
8 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
9 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
10 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
11 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
12 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
13 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
14 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
15 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
16 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
17 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
18 INT118285 Binding of EFNA1 and HLA-B 1 0.03 0.29 0.37
19 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
20 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
21 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
22 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
23 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
24 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
25 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
26 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
27 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
28 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
29 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
30 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
31 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
32 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
33 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
34 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
35 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
36 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
37 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
38 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
39 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
40 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
41 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
42 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
43 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
44 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
45 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
46 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
47 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
48 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
49 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
50 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
51 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
52 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
53 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
54 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
55 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
56 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07
57 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07
58 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
59 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07
60 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
61 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
62 INT189557 Binding of NOTCH1 and ROBO4 1 0.01 0.22 0.06
63 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
64 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
65 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
66 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
67 INT235640 Binding of GATA3 and Mrgpre 1 0.01 0.8 0.04
68 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
69 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
70 INT349314 Binding of Notch1 and Notch3 1 0.11 0.67 0.04
71 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
72 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
73 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
74 INT233854 Twist1 Positive_regulation of Itk 1 0.03 0.58 0.04
75 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
76 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
77 INT347165 Binding of NOTCH1 and PAX5 1 0.05 0.86 0.03
78 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03
79 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03
80 INT347163 NOTCH1 Positive_regulation of MSC 1 0.03 0.85 0.03
81 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03
82 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
83 INT347164 NOTCH1 Negative_regulation of Gene_expression of EBF1 1 0.03 0.85 0.03
84 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
85 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03
86 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
87 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0
88 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0
89 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
90 INT235649 TP73 Regulation of EFNA1 1 0.09 0.97 0
91 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0
92 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0
93 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0
94 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
95 INT327873 Postn Regulation of Notch1 1 0.41 0 0
96 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
97 INT356083 Binding of App and Notch1 1 0.02 0.2 0
98 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 0.07 0.58 0
99 INT193949 Alph1 Positive_regulation of Notch1 1 0.01 0.08 0
100 INT235648 Binding of EFNA1 and EPHA2 1 0.23 1.3 0
101 INT212409 Binding of Efna1 and Epha1 1 0.02 0.39 0
102 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0
103 INT193950 Alph1 Positive_regulation of Positive_regulation of Notch1 1 0.01 0.07 0
104 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
105 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
106 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
107 INT121479 Twist1 Negative_regulation of Ins1 1 0.10 0 0
108 INT235650 TP53 Regulation of EFNA1 1 0.06 0.97 0
109 INT264727 Binding of Notch1 and Mir199b 1 0.00 0.86 0
110 INT300438 Efna1 Negative_regulation of Phosphorylation of Kdr 1 0.42 0.66 0
111 INT286188 Twist1 Positive_regulation of Serpina5 1 0.02 0 0
112 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0
113 INT235646 TP63 Regulation of EFNA1 1 0.09 0.97 0
114 INT280166 Binding of MAPK8 and Twist1 1 0.19 0.78 0
115 INT351675 Efna1 Positive_regulation of Epha2 1 0.05 0.68 0
116 INT264728 Mir199b Regulation of Notch1 1 0.01 0.85 0
117 INT243623 Il12a Positive_regulation of Twist1 1 0.17 0 0
118 INT243624 Stat6 Negative_regulation of Gene_expression of Twist1 1 0.30 0 0
119 INT285770 Binding of NOTCH1 and Das 1 0.00 1.14 0
120 INT264726 Binding of Notch1 and Gtf3a 1 0.00 1.68 0
121 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0
122 INT285769 Das Regulation of NOTCH1 1 0.00 0.78 0
123 INT193947 Notch1 Positive_regulation of Alph1 1 0.01 0.07 0
124 INT280167 Twist1 Positive_regulation of MAPK8 1 0.29 0.94 0
125 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0
126 INT299456 Binding of Gabpa and Notch1 1 0.21 0.09 0
127 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
128 INT280163 Twist1 Positive_regulation of Mod2 1 0.07 1.67 0
129 INT326726 Twist1 Regulation of Itk 1 0.02 0.84 0
130 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0
131 INT260529 Twist1 Positive_regulation of Gene_expression of Vegfa 1 0.04 0.54 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for aortic valve morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in aortic valve morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
2 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
3 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
4 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
5 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
6 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
7 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
8 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
9 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
10 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
11 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
12 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
13 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89
14 INT116540 Binding of Twist1 35 0.48 16.32 2.85
15 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
16 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
17 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
18 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
19 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
20 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
21 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
22 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
23 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
24 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
25 INT118286 Binding of EFNA1 3 0.21 4.95 1.55
26 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
27 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
28 INT111162 Negative_regulation of EFNA1 2 0.03 2.78 1.45
29 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
30 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
31 INT116008 Binding of Gata3 2 0.34 1.37 1.41
32 INT10873 Localization of Twist1 21 0.74 10.43 1.37
33 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
34 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
35 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
36 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
37 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
38 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
39 INT110780 Localization of Notch1 2 0.06 0.47 1.19
40 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
41 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
42 INT133079 Positive_regulation of Gene_expression of GATA3 3 0.50 1.03 1.11
43 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
44 INT6833 Binding of Notch1 4 0.36 0.05 0.94
45 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
46 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
47 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
48 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
49 INT111161 Positive_regulation of EFNA1 6 0.40 4.62 0.68
50 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
51 INT17840 Negative_regulation of GATA3 3 0.41 1.96 0.63
52 INT205470 Positive_regulation of GATA3 4 0.33 2.53 0.61
53 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
54 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
55 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
56 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
57 INT226481 Negative_regulation of Gene_expression of GATA3 1 0.06 1.41 0.57
58 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
59 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55
60 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
61 INT144053 Transcription of GATA3 1 0.67 0.89 0.54
62 INT149297 Protein_catabolism of NOTCH1 2 0.15 0.87 0.51
63 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
64 INT299799 Negative_regulation of Negative_regulation of GATA3 1 0.09 1.32 0.47
65 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45
66 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
67 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3
68 INT111164 Positive_regulation of Efna1 1 0.02 0.83 0.28
69 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
70 INT316049 Regulation of Regulation of Notch1 1 0.03 0.92 0.23
71 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21
72 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2
73 INT193945 Binding of Notch1 7 0.15 1.28 0.19
74 INT130096 Positive_regulation of Positive_regulation of NOTCH1 2 0.50 1.15 0.18
75 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
76 INT102354 Localization of TWIST1 3 0.75 0.17 0.15
77 INT186632 Regulation of TWIST1 4 0.37 5.28 0.14
78 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13
79 INT338718 Positive_regulation of Localization of NOTCH1 1 0.04 0.6 0.13
80 INT316042 Negative_regulation of Gene_expression of Notch1 1 0.27 1.7 0.12
81 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
82 INT273333 Negative_regulation of Regulation of Twist1 1 0.18 0.3 0.12
83 INT141999 Regulation of Gene_expression of NOTCH1 2 0.04 0.97 0.08
84 INT327728 Regulation of Gene_expression of Notch1 2 0.27 0.73 0.07
85 INT235659 Gene_expression of EFNA1 1 0.45 22.92 0.06
86 INT193845 Localization of Notch1 2 0.78 0.32 0.05
87 INT193850 Regulation of Localization of Notch1 1 0.14 0.33 0.05
88 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05
89 INT273406 Positive_regulation of Gene_expression of TWIST1 4 0.57 8.42 0.04
90 INT141476 Regulation of Gene_expression of TWIST1 2 0.50 2.57 0.04
91 INT197017 Binding of GATA3 2 0.36 0.94 0.04
92 INT298336 Phosphorylation of Notch1 1 0.02 0.13 0.04
93 INT350959 Transcription of NOTCH1 2 0.05 0.84 0.03
94 INT149440 Negative_regulation of TWIST1 4 0.41 1.5 0
95 INT263106 Positive_regulation of Binding of Twist1 3 0.35 1.21 0
96 INT280152 Positive_regulation of Positive_regulation of Twist1 3 0.43 1.95 0
97 INT232397 Protein_catabolism of Notch1 3 0.64 1.56 0
98 INT304047 Positive_regulation of Transcription of TWIST1 1 0.10 0.57 0
99 INT297242 Transcription of Notch1 1 0.19 0.25 0
100 INT338245 Positive_regulation of Positive_regulation of TWIST1 1 0.38 2.95 0
101 INT264724 Negative_regulation of Positive_regulation of Notch1 1 0.03 0.77 0
102 INT280151 Positive_regulation of Regulation of Twist1 1 0.41 0.67 0
103 INT349880 Regulation of Binding of Twist1 1 0.31 0.98 0
104 INT349873 Regulation of Regulation of Twist1 1 0.31 0.97 0
105 INT212399 Binding of Efna1 1 0.47 0.2 0
106 INT300174 Negative_regulation of Gene_expression of NOTCH1 1 0.04 0.53 0
107 INT235656 Positive_regulation of Gene_expression of EFNA1 1 0.40 8.86 0
108 INT275080 Positive_regulation of Negative_regulation of Twist1 1 0.05 0.11 0
109 INT234247 Negative_regulation of Protein_catabolism of NOTCH1 1 0.05 0 0
110 INT130094 Regulation of Positive_regulation of NOTCH1 1 0.45 0.52 0
111 INT235637 Localization of GATA3 1 0.73 0.55 0
112 INT212401 Regulation of Gene_expression of Efna1 1 0.44 0 0
113 INT243609 Negative_regulation of Transcription of Twist1 1 0.42 0 0
114 INT243602 Regulation of Localization of Twist1 1 0.45 0 0
115 INT273393 Phosphorylation of TWIST1 1 0.16 0.4 0
116 INT264723 Negative_regulation of Gene_expression of Notch1 1 0.03 0.83 0
117 INT327858 Positive_regulation of Protein_catabolism of Notch1 1 0.45 0.13 0
118 INT235657 Localization of EFNA1 1 0.43 0.9 0
119 INT327861 Positive_regulation of Localization of Notch1 1 0.67 0 0
120 INT273836 Positive_regulation of Regulation of Notch1 1 0.15 0.05 0
121 INT304055 Transcription of TWIST1 1 0.14 0.57 0
122 INT212389 Gene_expression of Efna1 1 0.75 0 0
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