GO:0003198

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Name epithelial to mesenchymal transition involved in endocardial cushion formation
Categary Process
Go Slim No
Go Link GO:0003198
Unique Molecular Interactions 51
Total Molecular Interactions 74
Total Single Events 281
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for epithelial to mesenchymal transition involved in endocardial cushion formation. They are ordered first by their pain relevance and then by number of times they were reported for epithelial to mesenchymal transition involved in endocardial cushion formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
3 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
4 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83
5 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
6 INT329587 Binding of PTX3 and HEY1 1 0.00 2.03 0.5
7 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
8 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
9 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
10 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
11 INT180570 Binding of HEYL and Positive_regulation of DMD 1 0.00 1.08 0.28
12 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
13 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
14 INT180564 HEYL Regulation of Regulation of DMD 1 0.00 0.88 0.28
15 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
16 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
17 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2
18 INT180562 Binding of CYP27A1 and HEYL 1 0.02 0.29 0.16
19 INT97547 KITLG Negative_regulation of Msx1 1 0.00 0.08 0.15
20 INT97542 Pomc Negative_regulation of Msx1 1 0.13 0.07 0.15
21 INT97545 Gtf3a Negative_regulation of Msx1 1 0.02 0.08 0.15
22 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
23 INT180567 HEYL Regulation of Positive_regulation of IBSP 1 0.01 0.18 0.12
24 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12
25 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
26 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11
27 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
28 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
29 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
30 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
31 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09
32 INT180561 HEYL Negative_regulation of IBSP 1 0.01 0.19 0.09
33 INT288374 Binding of MLANA and Msx1 1 0.09 0 0.08
34 INT141997 HEY1 Negative_regulation of CDC42BPA 1 0.00 0 0.08
35 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
36 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
37 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
38 INT214146 Msx1 Positive_regulation of Gene_expression of Nucb2 1 0.05 0.19 0.05
39 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
40 INT266445 Binding of HEY1 and GOPC 1 0.00 2.92 0.04
41 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
42 INT233853 Zeb1 Positive_regulation of Snai2 1 0.09 0.58 0.04
43 INT266454 Binding of HEY1 and Acot1 1 0.00 1.19 0.04
44 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
45 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03
46 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03
47 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0
48 INT233401 COPD Regulation of HEY1 1 0.07 1.67 0
49 INT278752 Binding of NUP98 and HEY1 1 0.48 0 0
50 INT278773 NUP98 Regulation of HEY1 1 0.45 0 0
51 INT278775 Binding of HOXA9 and HEY1 1 0.44 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for epithelial to mesenchymal transition involved in endocardial cushion formation. They are ordered first by their pain relevance and then by number of times they were reported in epithelial to mesenchymal transition involved in endocardial cushion formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
2 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89
3 INT187286 Binding of HEY1 17 0.32 31.21 4.52
4 INT176618 Gene_expression of HEY1 29 0.59 36 4.37
5 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
6 INT121337 Negative_regulation of HEY1 7 0.20 12.91 1.89
7 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
8 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
9 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2
10 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19
11 INT180580 Binding of HEYL 7 0.17 4.49 1.15
12 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
13 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
14 INT187289 Regulation of HEY1 5 0.39 7.8 1.03
15 INT187288 Positive_regulation of Gene_expression of HEY1 5 0.17 8.42 0.89
16 INT95617 Regulation of Msx1 2 0.56 1.05 0.73
17 INT121333 Localization of HEY1 11 0.65 18.17 0.72
18 INT174537 Positive_regulation of HEYL 7 0.39 3.07 0.68
19 INT75043 Binding of Msx1 6 0.35 2.36 0.65
20 INT32921 Positive_regulation of Msx1 4 0.47 0.99 0.57
21 INT180578 Regulation of HEYL 3 0.06 3.15 0.49
22 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
23 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
24 INT187287 Negative_regulation of Gene_expression of HEY1 2 0.16 2.96 0.45
25 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
26 INT247307 Negative_regulation of Msx1 3 0.22 0.11 0.42
27 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
28 INT120958 Protein_catabolism of HEY1 1 0.44 0.14 0.28
29 INT214128 Negative_regulation of Gene_expression of Msx1 3 0.53 1.25 0.26
30 INT250836 Binding of Fgf8 3 0.35 0.66 0.24
31 INT250833 Localization of Fgf8 1 0.74 0.46 0.21
32 INT250842 Negative_regulation of Binding of Fgf8 1 0.43 0.33 0.21
33 INT180592 Negative_regulation of Gene_expression of HEYL 1 0.03 0.3 0.15
34 INT250835 Positive_regulation of Fgf8 1 0.50 0.42 0.14
35 INT214127 Localization of Msx1 1 0.06 0.21 0.13
36 INT180593 Positive_regulation of Gene_expression of HEYL 1 0.03 0.18 0.12
37 INT266451 Regulation of Gene_expression of HEY1 1 0.02 2.03 0.09
38 INT206911 Gene_expression of Msx2 4 0.71 1.26 0
39 INT206909 Negative_regulation of Gene_expression of Msx2 2 0.53 0.29 0
40 INT206916 Positive_regulation of Gene_expression of Msx2 1 0.40 0.36 0
41 INT220772 Transcription of Msx2 1 0.46 0.08 0
42 INT180583 Negative_regulation of HEYL 1 0.03 0 0
43 INT210818 Phosphorylation of HEYL 1 0.04 0.08 0
44 INT266450 Negative_regulation of Regulation of HEY1 1 0.02 0.72 0
45 INT308354 Gene_expression of Snai2 1 0.58 1.14 0
46 INT250830 Regulation of Protein_catabolism of Fgf8 1 0.45 0.08 0
47 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0
48 INT308358 Positive_regulation of Gene_expression of Snai2 1 0.45 1.14 0
49 INT250846 Positive_regulation of Protein_catabolism of Fgf8 1 0.50 0.07 0
50 INT305345 Positive_regulation of Snai2 1 0.16 1.4 0
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