GO:0003203

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Name endocardial cushion morphogenesis
Categary Process
Go Slim No
Go Link GO:0003203
Unique Molecular Interactions 104
Total Molecular Interactions 140
Total Single Events 1287
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endocardial cushion morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for endocardial cushion morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
2 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
3 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
4 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
5 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
6 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
7 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
8 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
9 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
10 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
11 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
12 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
13 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
14 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
15 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
16 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
17 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
18 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
19 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
20 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
21 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
22 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
23 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
24 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
25 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
26 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
27 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
28 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
29 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
30 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
31 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
32 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
33 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
34 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
35 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
36 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
37 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
38 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
39 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08
40 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
41 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
42 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
43 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
44 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
45 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
46 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
47 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
48 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
49 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
50 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
51 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
52 INT233854 Twist1 Positive_regulation of Itk 1 0.03 0.58 0.04
53 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
54 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
55 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
56 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
57 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
58 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03
59 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03
60 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
61 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03
62 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
63 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
64 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03
65 INT244856 Lbx1 Regulation of Isl1 1 0.60 0 0
66 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
67 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0
68 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0
69 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0
70 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
71 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
72 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
73 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
74 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
75 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 0.07 0.58 0
76 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0
77 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0
78 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
79 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
80 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
81 INT323254 Binding of Ptprv and Isl1 1 0.00 0.6 0
82 INT244860 Lbx1 Negative_regulation of Isl1 1 0.16 0 0
83 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
84 INT121479 Twist1 Negative_regulation of Ins1 1 0.10 0 0
85 INT344001 INCENP Positive_regulation of Gene_expression of BMP2 1 0.01 0 0
86 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
87 INT286188 Twist1 Positive_regulation of Serpina5 1 0.02 0 0
88 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0
89 INT280166 Binding of MAPK8 and Twist1 1 0.19 0.78 0
90 INT295129 Proc Regulation of Bmp2 1 0.00 0.48 0
91 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
92 INT243623 Il12a Positive_regulation of Twist1 1 0.17 0 0
93 INT243624 Stat6 Negative_regulation of Gene_expression of Twist1 1 0.30 0 0
94 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0
95 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0
96 INT280167 Twist1 Positive_regulation of MAPK8 1 0.29 0.94 0
97 INT280163 Twist1 Positive_regulation of Mod2 1 0.07 1.67 0
98 INT326726 Twist1 Regulation of Itk 1 0.02 0.84 0
99 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0
100 INT260529 Twist1 Positive_regulation of Gene_expression of Vegfa 1 0.04 0.54 0
101 INT323252 Binding of H2-Ab1 and Isl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for endocardial cushion morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in endocardial cushion morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
2 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
3 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
4 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
5 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
6 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
7 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
8 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
9 INT116540 Binding of Twist1 35 0.48 16.32 2.85
10 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
11 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
12 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
13 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
14 INT10873 Localization of Twist1 21 0.74 10.43 1.37
15 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
16 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
17 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
18 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
19 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
20 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
21 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
22 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
23 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
24 INT114664 Binding of BMP2 12 0.37 6.54 0.91
25 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
26 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
27 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
28 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
29 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
30 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
31 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
32 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
33 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
34 INT85808 Localization of BMP2 7 0.77 1.94 0.51
35 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
36 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
37 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
38 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
39 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
40 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
41 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
42 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
43 INT172806 Localization of ISL1 4 0.26 2.64 0.29
44 INT78132 Binding of Isl1 1 0.16 0 0.27
45 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
46 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
47 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
48 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
49 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
50 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
51 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
52 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
53 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
54 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
55 INT243778 Binding of Isl1 1 0.26 0 0.19
56 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
57 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
58 INT98772 Localization of Isl1 2 0.65 0 0.16
59 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
60 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
61 INT98774 Regulation of Localization of Isl1 1 0.08 0 0.13
62 INT273333 Negative_regulation of Regulation of Twist1 1 0.18 0.3 0.12
63 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
64 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
65 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
66 INT207829 Positive_regulation of Localization of ISL1 1 0.02 0.1 0.1
67 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
68 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
69 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
70 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
71 INT173473 Positive_regulation of Positive_regulation of Isl1 1 0.02 0.06 0.09
72 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
73 INT173470 Positive_regulation of Phosphorylation of Isl1 1 0.02 0 0.09
74 INT173471 Phosphorylation of Isl1 1 0.04 0 0.09
75 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
76 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
77 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
78 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
79 INT298237 Regulation of Isl1 1 0.03 0.24 0.06
80 INT196025 Negative_regulation of Bmp2 2 0.34 0.14 0.05
81 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05
82 INT229753 Positive_regulation of Gene_expression of Bmp2 2 0.11 1.22 0.04
83 INT287236 Positive_regulation of Positive_regulation of BMP2 1 0.29 0.08 0.04
84 INT225365 Binding of Sox9 2 0.28 0.48 0.03
85 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
86 INT352541 Transcription of ISL1 1 0.36 0.2 0.03
87 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
88 INT245757 Localization of SOX9 4 0.62 0.8 0
89 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
90 INT263106 Positive_regulation of Binding of Twist1 3 0.35 1.21 0
91 INT280152 Positive_regulation of Positive_regulation of Twist1 3 0.43 1.95 0
92 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0
93 INT145300 Positive_regulation of Positive_regulation of Bmp2 2 0.34 1.03 0
94 INT180121 Phosphorylation of Isl1 1 0.27 0 0
95 INT196031 Binding of Bmp2 1 0.16 0 0
96 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
97 INT180097 Positive_regulation of Phosphorylation of Isl1 1 0.17 0 0
98 INT278735 Negative_regulation of Gene_expression of Bmp2 1 0.43 0.06 0
99 INT280151 Positive_regulation of Regulation of Twist1 1 0.41 0.67 0
100 INT227625 Regulation of ISL1 1 0.05 0.35 0
101 INT349880 Regulation of Binding of Twist1 1 0.31 0.98 0
102 INT211943 Transcription of Sox9 1 0.50 0.3 0
103 INT349873 Regulation of Regulation of Twist1 1 0.31 0.97 0
104 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
105 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0
106 INT120087 Negative_regulation of Gene_expression of Bmp2 1 0.11 0.14 0
107 INT275080 Positive_regulation of Negative_regulation of Twist1 1 0.05 0.11 0
108 INT322886 Transcription of Sox9 1 0.50 0.25 0
109 INT243609 Negative_regulation of Transcription of Twist1 1 0.42 0 0
110 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
111 INT243602 Regulation of Localization of Twist1 1 0.45 0 0
112 INT243780 Positive_regulation of Gene_expression of Isl1 1 0.35 0 0
113 INT183071 Negative_regulation of Gene_expression of ISL1 1 0.20 0.34 0
114 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
115 INT278040 Negative_regulation of Localization of BMP2 1 0.32 0.32 0
116 INT245765 Binding of SOX9 1 0.31 0.87 0
117 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
118 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
119 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
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