GO:0003266

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Name regulation of secondary heart field cardioblast proliferation
Categary Process
Go Slim No
Go Link GO:0003266
Unique Molecular Interactions 103
Total Molecular Interactions 114
Total Single Events 986
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of secondary heart field cardioblast proliferation. They are ordered first by their pain relevance and then by number of times they were reported for regulation of secondary heart field cardioblast proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
2 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
3 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
4 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
5 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
6 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
7 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
8 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
9 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
10 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
11 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
12 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
13 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
14 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
15 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
16 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
17 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
18 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
19 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
20 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
21 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
22 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
23 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
24 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
25 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
26 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
27 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
28 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
29 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
30 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
31 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
32 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
33 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
34 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
35 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
36 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
37 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
38 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
39 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
40 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
41 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
42 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
43 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
44 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
45 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
46 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
47 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
48 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
49 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
50 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
51 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
52 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
53 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
54 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
55 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
56 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
57 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
58 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
59 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
60 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
61 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
62 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05
63 INT278208 Ciita Negative_regulation of Gene_expression of Hand2 1 0.34 0.7 0.05
64 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04
65 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
66 INT244856 Lbx1 Regulation of Isl1 1 0.60 0 0
67 INT305845 Polk Positive_regulation of Regulation of Hand2 1 0.08 0.34 0
68 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
69 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
70 INT264735 Binding of Hes1 and Mir199b 1 0.08 0.93 0
71 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
72 INT264738 Mir199b Regulation of Gene_expression of Hes1 1 0.08 0.89 0
73 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
74 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
75 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0
76 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0
77 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
78 INT197316 Hes1 Regulation of Atoh1 1 0.01 0.14 0
79 INT323254 Binding of Ptprv and Isl1 1 0.00 0.6 0
80 INT244860 Lbx1 Negative_regulation of Isl1 1 0.16 0 0
81 INT197304 Ahr Regulation of Hes1 1 0.06 0.17 0
82 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
83 INT264731 Gene_expression of Hes1 Negative_regulation of Positive_regulation of Musd1 1 0.00 0.18 0
84 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
85 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
86 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0
87 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
88 INT264729 Mir199b Regulation of Hes1 1 0.05 0.25 0
89 INT305847 Polk Positive_regulation of Hand2 1 0.09 0.34 0
90 INT197310 Hes1 Regulation of Ascl1 1 0.01 0.14 0
91 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
92 INT264734 Mir199b Negative_regulation of Negative_regulation of Hes1 1 0.07 0.1 0
93 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
94 INT264739 Mir199b Negative_regulation of Gene_expression of Hes1 1 0.07 0.82 0
95 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
96 INT264733 Hes1 Regulation of Mir199b 1 0.05 0.43 0
97 INT323252 Binding of H2-Ab1 and Isl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of secondary heart field cardioblast proliferation. They are ordered first by their pain relevance and then by number of times they were reported in regulation of secondary heart field cardioblast proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
3 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
4 INT173505 Localization of Hand2 63 0.57 45.32 13.66
5 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
6 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
7 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
8 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
9 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
10 INT156131 Binding of Hand2 14 0.25 10.35 3.99
11 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
12 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
13 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
14 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
15 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
16 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
17 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
18 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
19 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
20 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
21 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
22 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
23 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
24 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
25 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
26 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
27 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
28 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
29 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
30 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
31 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
32 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
33 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
34 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
35 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
36 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
37 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
38 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
39 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
40 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
41 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
42 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
43 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
44 INT172806 Localization of ISL1 4 0.26 2.64 0.29
45 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
46 INT78132 Binding of Isl1 1 0.16 0 0.27
47 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
48 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
49 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
50 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
51 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
52 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
53 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
54 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
55 INT243778 Binding of Isl1 1 0.26 0 0.19
56 INT264701 Negative_regulation of Gene_expression of Hes1 1 0.42 0.73 0.18
57 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
58 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
59 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
60 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
61 INT98772 Localization of Isl1 2 0.65 0 0.16
62 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
63 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
64 INT98774 Regulation of Localization of Isl1 1 0.08 0 0.13
65 INT207829 Positive_regulation of Localization of ISL1 1 0.02 0.1 0.1
66 INT173473 Positive_regulation of Positive_regulation of Isl1 1 0.02 0.06 0.09
67 INT173470 Positive_regulation of Phosphorylation of Isl1 1 0.02 0 0.09
68 INT173471 Phosphorylation of Isl1 1 0.04 0 0.09
69 INT298237 Regulation of Isl1 1 0.03 0.24 0.06
70 INT264717 Negative_regulation of Hes1 7 0.42 0.77 0.03
71 INT264704 Regulation of Hes1 4 0.44 1.03 0.03
72 INT192401 Positive_regulation of Binding of Hand2 1 0.08 0 0.03
73 INT352541 Transcription of ISL1 1 0.36 0.2 0.03
74 INT264702 Positive_regulation of Gene_expression of Hes1 1 0.68 1.39 0.03
75 INT264719 Regulation of Gene_expression of Hes1 2 0.28 0.12 0
76 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
77 INT180121 Phosphorylation of Isl1 1 0.27 0 0
78 INT264708 Transcription of Hes1 1 0.67 0.83 0
79 INT180097 Positive_regulation of Phosphorylation of Isl1 1 0.17 0 0
80 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
81 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
82 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
83 INT227625 Regulation of ISL1 1 0.05 0.35 0
84 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
85 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
86 INT264705 Binding of Hes1 1 0.35 0.07 0
87 INT264706 Positive_regulation of Hes1 1 0.40 0.14 0
88 INT243780 Positive_regulation of Gene_expression of Isl1 1 0.35 0 0
89 INT183071 Negative_regulation of Gene_expression of ISL1 1 0.20 0.34 0
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