GO:0003300

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Name cardiac muscle hypertrophy
Categary Process
Go Slim No
Go Link GO:0003300
Unique Molecular Interactions 60
Total Molecular Interactions 88
Total Single Events 614
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cardiac muscle hypertrophy. They are ordered first by their pain relevance and then by number of times they were reported for cardiac muscle hypertrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
2 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
3 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
4 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
5 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
6 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
7 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
8 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
9 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
10 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
11 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
12 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
13 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
14 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
15 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
16 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
17 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
18 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
19 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19
20 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19
21 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
22 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11
23 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11
24 INT222472 Lep Positive_regulation of Localization of Cartpt 1 0.05 0 0.11
25 INT123864 Lep Positive_regulation of Positive_regulation of Cck 1 0.45 0.1 0.09
26 INT242324 Lep Regulation of Gene_expression of Ucp1 1 0.58 1.47 0.09
27 INT142418 Lep Positive_regulation of Gene_expression of Ghrl 1 0.48 1.66 0.09
28 INT222545 Lep Negative_regulation of Nmb 1 0.04 0.52 0.08
29 INT123866 Lep Negative_regulation of Olfr544 1 0.00 0.09 0.08
30 INT294743 Lep Positive_regulation of Transcription of Il6 1 0.18 0.42 0.07
31 INT294740 Lep Positive_regulation of Transcription of Ccl2 1 0.08 0.42 0.07
32 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06
33 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
34 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
35 INT253376 Lep Regulation of Mtor 1 0.17 0.08 0.04
36 INT332684 Binding of Edn1 and Lep 1 0.09 1.11 0.04
37 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04
38 INT222534 Gnrh1 Positive_regulation of Localization of Lep 1 0.07 0 0.04
39 INT253374 Lep Positive_regulation of Phosphorylation of Eif4ebp1 1 0.04 0.16 0.03
40 INT253375 Lep Positive_regulation of Phosphorylation of Rps6kb1 1 0.41 0.16 0.03
41 INT253414 Lep Negative_regulation of BCL2A1 1 0.16 0 0.03
42 INT253370 Lep Negative_regulation of Prkaa2 1 0.29 0.18 0.03
43 INT138526 Lep Positive_regulation of Localization of Gnrh1 1 0.39 0 0
44 INT233506 Tlr4 Positive_regulation of Htr2b 1 0.06 0.09 0
45 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0
46 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
47 INT289532 Lep Regulation of Arc 1 0.04 0.19 0
48 INT288214 Lep Negative_regulation of Gene_expression of Ins1 1 0.35 0.05 0
49 INT253364 Lep Positive_regulation of Rps6kb1 1 0.30 0.08 0
50 INT253379 Lep Positive_regulation of Prkaa2 1 0.39 0.19 0
51 INT253360 Lep Positive_regulation of Eif4ebp1 1 0.01 0.08 0
52 INT289520 Lep Regulation of Prkag1 1 0.00 0.08 0
53 INT218731 Lep Positive_regulation of Gene_expression of Trh 1 0.19 0.07 0
54 INT253410 ATIC Regulation of Lep 1 0.03 0.7 0
55 INT253367 Il6 Regulation of Gene_expression of Lep 1 0.31 1.66 0
56 INT138525 Lep Positive_regulation of Localization of LH 1 0.18 0 0
57 INT289527 Lep Regulation of Rps6kb1 1 0.10 0.07 0
58 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cardiac muscle hypertrophy. They are ordered first by their pain relevance and then by number of times they were reported in cardiac muscle hypertrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
2 INT73641 Regulation of Lep 45 0.62 26.2 12.59
3 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
4 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
5 INT82082 Localization of Lep 63 0.81 26.41 8.56
6 INT97391 Binding of Lep 18 0.48 8.97 4.47
7 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
8 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
9 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
10 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
11 INT83392 Transcription of Lep 6 0.54 5.07 2.04
12 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
13 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
14 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
15 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
16 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
17 INT30157 Gene_expression of Htr2b 2 0.48 0 0.94
18 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
19 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
20 INT57127 Binding of Htr2b 2 0.36 0.05 0.63
21 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
22 INT161218 Positive_regulation of Positive_regulation of Htr2b 1 0.67 0.69 0.43
23 INT76874 Negative_regulation of Htr2b 1 0.07 0 0.41
24 INT57126 Transcription of Htr2b 1 0.33 0 0.24
25 INT142417 Positive_regulation of Transcription of Lep 2 0.52 2.63 0.22
26 INT163816 Phosphorylation of Lep 2 0.63 2.2 0.17
27 INT163815 Negative_regulation of Negative_regulation of Lep 1 0.43 0.32 0.12
28 INT226984 Regulation of Transcription of Lep 1 0.27 0.3 0.11
29 INT253406 Negative_regulation of Positive_regulation of Lep 2 0.41 0.74 0
30 INT233451 Negative_regulation of Htr2b 1 0.33 0.09 0
31 INT309421 Positive_regulation of Regulation of Lep 1 0.41 0.61 0
32 INT347593 Negative_regulation of Gene_expression of Htr2b 1 0.01 0.16 0
33 INT288213 Positive_regulation of Negative_regulation of Lep 1 0.47 0.06 0
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