GO:0003323

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Name type B pancreatic cell development
Categary Process
Go Slim No
Go Link GO:0003323
Unique Molecular Interactions 63
Total Molecular Interactions 70
Total Single Events 397
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for type B pancreatic cell development. They are ordered first by their pain relevance and then by number of times they were reported for type B pancreatic cell development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
2 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
3 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
4 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
5 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
6 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
7 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
8 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
9 INT69084 Binding of Adrb1 and Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.08 0.83
10 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
11 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
12 INT5631 Ubqln1 Positive_regulation of Pdpk1 1 0.05 0 0.53
13 INT259180 Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
14 INT259181 Phosphorylation of Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
15 INT95469 P2ry6 Positive_regulation of Positive_regulation of Pdpk1 1 0.15 0 0.46
16 INT15024 Prkcg Regulation of Pdpk1 1 0.09 0 0.43
17 INT151184 Pdpk1 Positive_regulation of Trpv1 1 0.08 0 0.42
18 INT151183 Pdpk1 Positive_regulation of Phosphorylation of Trpv1 1 0.08 0 0.42
19 INT236111 Binding of Pdpk1 and Ppara 1 0.26 1.21 0.39
20 INT112617 Pdpk1 Regulation of Il1b 1 0.03 1.11 0.36
21 INT112618 Pdpk1 Regulation of Tnf 1 0.03 1.11 0.36
22 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
23 INT222721 Binding of HTR1A and Pdpk1 1 0.00 0.35 0.33
24 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
25 INT18994 Negative_regulation of Pdpk1 Negative_regulation of Regulation of Cck 1 0.10 0 0.26
26 INT70661 Binding of Hrasls and Nkx2-2 1 0.02 0 0.24
27 INT58006 DYT10 Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.14 0.18
28 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
29 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
30 INT179849 Il11 Regulation of Positive_regulation of Pdpk1 1 0.05 0.07 0.17
31 INT349559 Mtor Regulation of Pdpk1 1 0.03 0.42 0.14
32 INT1233 Gcg Positive_regulation of Pdpk1 1 0.27 0 0.14
33 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
34 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
35 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
36 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
37 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
38 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
39 INT352941 Pik3cb Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.21 0.06
40 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
41 INT276211 Pdpk1 Regulation of Akt1 1 0.07 0.72 0.04
42 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
43 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0
44 INT78615 Pdpk1 Regulation of Gene_expression of Penk 1 0.03 0 0
45 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
46 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
47 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
48 INT215706 Binding of Cdk6 and Lamtor1 1 0.04 0 0
49 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
50 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
51 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0
52 INT215690 Binding of Cdk6 and Cdkn1c 1 0.03 0 0
53 INT185280 Binding of CDK4 and CDK6 1 0.20 0.87 0
54 INT215682 Binding of Cdkn1b and Cdk6 1 0.03 0 0
55 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
56 INT215701 Slc3a1 Regulation of Cdk6 1 0.01 0.05 0
57 INT240011 Ass1 Positive_regulation of Gene_expression of Nkx2-2 1 0.00 0 0
58 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
59 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
60 INT353435 Binding of Pdpk1 and Rock1 1 0.09 0.27 0
61 INT215703 Binding of Kras and Cdk6 1 0.01 0 0
62 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for type B pancreatic cell development. They are ordered first by their pain relevance and then by number of times they were reported in type B pancreatic cell development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
2 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
3 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
4 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
5 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
6 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
7 INT71824 Phosphorylation of Pdpk1 14 0.38 4.9 6.86
8 INT55077 Positive_regulation of Positive_regulation of Pdpk1 6 0.26 1.77 5.78
9 INT68465 Positive_regulation of Gene_expression of Pdpk1 7 0.19 2.35 5.49
10 INT48840 Gene_expression of Nkx2-2 8 0.23 1.55 5.44
11 INT15257 Positive_regulation of Nkx2-2 10 0.21 1.75 4.2
12 INT51180 Regulation of Nkx2-2 5 0.26 2.16 4.14
13 INT1231 Negative_regulation of Positive_regulation of Pdpk1 6 0.35 1.88 4.13
14 INT8600 Binding of Nkx2-2 6 0.10 0.87 3.82
15 INT47846 Negative_regulation of Localization of Pdpk1 2 0.33 1.12 2.75
16 INT96763 Positive_regulation of Localization of Pdpk1 1 0.39 2.08 2.65
17 INT26735 Regulation of Gene_expression of Pdpk1 2 0.24 0.56 1.84
18 INT104014 Negative_regulation of Phosphorylation of Pdpk1 2 0.23 0.59 1.72
19 INT112845 Negative_regulation of Binding of Nkx2-2 2 0.12 0.14 1.47
20 INT132081 Regulation of Gene_expression of Nkx2-2 2 0.10 0.24 1.43
21 INT67464 Positive_regulation of Negative_regulation of Pdpk1 1 0.19 0.15 1.41
22 INT118927 Positive_regulation of Phosphorylation of Pdpk1 2 0.04 0.76 1.38
23 INT221206 Phosphorylation of Pdpk1 3 0.53 0.13 1.25
24 INT104011 Transcription of Pdpk1 1 0.28 0 1.2
25 INT104012 Regulation of Transcription of Pdpk1 1 0.14 0 1.2
26 INT26734 Binding of Pdpk1 4 0.29 1.01 1.19
27 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
28 INT250699 Binding of CDK6 3 0.33 2.54 0.97
29 INT68467 Regulation of Regulation of Pdpk1 1 0.05 0.09 0.96
30 INT270447 Binding of Smo 2 0.07 2.61 0.78
31 INT138396 Transcription of Nkx2-2 1 0.26 0.05 0.75
32 INT138395 Positive_regulation of Transcription of Nkx2-2 1 0.19 0.05 0.75
33 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
34 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
35 INT79249 Regulation of Negative_regulation of Pdpk1 1 0.03 0.09 0.57
36 INT98037 Negative_regulation of Negative_regulation of Pdpk1 1 0.05 0.26 0.52
37 INT48503 Positive_regulation of Positive_regulation of Nkx2-2 1 0.15 0 0.42
38 INT236107 Binding of Pdpk1 2 0.26 1.38 0.39
39 INT236105 Negative_regulation of Binding of Pdpk1 1 0.30 1.22 0.39
40 INT179816 Positive_regulation of Pdpk1 4 0.31 0.36 0.35
41 INT122619 Gene_expression of Nkx2-2 6 0.36 0.15 0.31
42 INT356400 Transcription of Smo 1 0.02 0.05 0.3
43 INT208497 Localization of Nkx2-2 1 0.01 0 0.26
44 INT226422 Negative_regulation of Cdk6 3 0.12 1.83 0.19
45 INT236109 Localization of Pdpk1 1 0.49 0.75 0.12
46 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
47 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
48 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
49 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
50 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
51 INT104656 Regulation of Phosphorylation of Pdpk1 1 0.05 1.74 0.07
52 INT120564 Gene_expression of Pdpk1 2 0.62 1.54 0.06
53 INT271084 Negative_regulation of Gene_expression of Cdk6 1 0.11 1.1 0.06
54 INT271086 Gene_expression of Cdk6 1 0.14 1.09 0.06
55 INT120565 Positive_regulation of Gene_expression of Pdpk1 1 0.40 1.26 0.06
56 INT122620 Negative_regulation of Gene_expression of Nkx2-2 1 0.20 0 0.04
57 INT236706 Regulation of Pdpk1 1 0.12 0.38 0.04
58 INT204060 Gene_expression of Cdk6 3 0.26 0.83 0
59 INT325167 Gene_expression of CDK6 2 0.43 0 0
60 INT252242 Gene_expression of Smo 1 0.01 0.23 0
61 INT331203 Positive_regulation of Binding of Pdpk1 1 0.15 0.17 0
62 INT335880 Regulation of Wnt5a 1 0.32 0.07 0
63 INT143655 Transcription of Nkx2-2 1 0.58 0 0
64 INT333821 Regulation of Cdk6 1 0.23 0 0
65 INT204061 Negative_regulation of Gene_expression of Cdk6 1 0.12 0.47 0
66 INT302260 Negative_regulation of CDK6 1 0.19 0.29 0
67 INT205956 Localization of Smo 1 0.06 0.71 0
68 INT215749 Regulation of Gene_expression of Cdk6 1 0.17 0 0
69 INT325171 Regulation of Gene_expression of CDK6 1 0.25 0 0
70 INT143654 Positive_regulation of Transcription of Nkx2-2 1 0.56 0 0
71 INT189989 Negative_regulation of Pdpk1 1 0.08 1.48 0
72 INT162572 Positive_regulation of Gene_expression of Wnt5a 1 0.02 0.3 0
73 INT236709 Phosphorylation of Cdk6 1 0.34 0.82 0
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