GO:0003417

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Name growth plate cartilage development
Categary Process
Go Slim No
Go Link GO:0003417
Unique Molecular Interactions 121
Total Molecular Interactions 174
Total Single Events 1352
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for growth plate cartilage development. They are ordered first by their pain relevance and then by number of times they were reported for growth plate cartilage development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
2 INT150784 ZNF398 Positive_regulation of Localization of THBS3 1 0.07 1.02 1.07
3 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
4 INT150800 THBS3 Negative_regulation of SPARC 1 0.23 0.51 0.53
5 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
6 INT150797 ZNF398 Positive_regulation of THBS3 1 0.07 0.5 0.52
7 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52
8 INT150798 THBS3 Negative_regulation of TIMP2 1 0.18 0.49 0.52
9 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
10 INT150792 THBS3 Negative_regulation of MMP2 1 0.11 0.49 0.51
11 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
12 INT200469 Binding of COL7A1 and COMP 1 0.04 0.91 0.38
13 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
14 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
15 INT44985 KNG1 Positive_regulation of Rara 1 0.00 0.15 0.32
16 INT211997 CORD1 Positive_regulation of Rara 1 0.01 0.68 0.29
17 INT203733 Thbs1 Positive_regulation of Negative_regulation of Ppara 1 0.36 1.55 0.26
18 INT252356 Binding of THBS1 and Cd47 1 0.00 0.44 0.24
19 INT108842 RARA Positive_regulation of Gene_expression of GDF15 1 0.52 0.68 0.23
20 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21
21 INT137569 Comp Negative_regulation of Positive_regulation of Prl 1 0.23 0 0.2
22 INT279107 Binding of COMP and MATN3 1 0.41 1.43 0.2
23 INT137568 Comp Negative_regulation of Regulation of Prl 1 0.17 0 0.2
24 INT137570 Comp Negative_regulation of Prl 1 0.17 0 0.2
25 INT337260 ELL Positive_regulation of Gene_expression of THBS1 1 0.11 0.82 0.18
26 INT337263 ELL Regulation of Gene_expression of THBS1 1 0.10 0.82 0.18
27 INT180560 Binding of COMP and CYP27A1 1 0.12 0.47 0.18
28 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17
29 INT231677 Binding of CD47 and THBS1 1 0.18 0 0.16
30 INT252352 Binding of THBS1 and Sirpa 1 0.00 0.26 0.15
31 INT180566 Binding of COMP and DMD 1 0.02 0.72 0.15
32 INT192106 Regulation of Binding of Rara and Retsat 1 0.00 0.83 0.13
33 INT192105 Binding of Rara and Retsat 1 0.00 0.83 0.13
34 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12
35 INT289790 Binding of Col7a1 and Comp 1 0.14 1.2 0.12
36 INT289794 Binding of Comp and Fn1 1 0.07 2.59 0.12
37 INT192104 Binding of Rara and Rxrg 1 0.00 0.82 0.1
38 INT294439 KLK4 Negative_regulation of THBS1 1 0.01 0 0.1
39 INT260099 Binding of COMP and IL4 1 0.00 0.18 0.09
40 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
41 INT201380 RARA Positive_regulation of Regulation of CPOX 1 0.07 0.21 0.08
42 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07
43 INT197727 Binding of RARA and Positive_regulation of PPARA 1 0.02 0.96 0.05
44 INT203732 Thbs1 Regulation of Gene_expression of Ppara 1 0.33 0.94 0.05
45 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
46 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03
47 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
48 INT289789 Comp Positive_regulation of Gene_expression of Rer1 1 0.55 0.8 0.03
49 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
50 INT182918 Binding of DR1 and RARA 2 0.08 0 0
51 INT182949 Binding of RARA and VDR 1 0.20 0 0
52 INT312289 Binding of Col9a1 and Comp 1 0.09 1.38 0
53 INT279110 COMP Regulation of Localization of MATN3 1 0.59 0.45 0
54 INT325284 Binding of COMP and MCL1 1 0.01 1.69 0
55 INT337270 E2F1 Positive_regulation of Transcription of THBS1 1 0.67 0.19 0
56 INT337268 E2F1 Regulation of Transcription of THBS1 1 0.44 0 0
57 INT337274 E2F1 Regulation of THBS1 1 0.44 0 0
58 INT99770 Thbs1 Regulation of PGR 1 0.01 0 0
59 INT337269 Binding of E2F1 and Positive_regulation of Gene_expression of THBS1 1 0.45 0.21 0
60 INT337262 PRB1 Negative_regulation of THBS1 1 0.18 0.61 0
61 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0
62 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0
63 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0
64 INT99769 Thbs1 Regulation of THBS1 1 0.00 0 0
65 INT277490 Binding of F2 and Thbs1 1 0.09 0 0
66 INT337264 Binding of E2F1 and THBS1 1 0.47 0.78 0
67 INT279106 MATN3 Regulation of COMP 1 0.44 0.67 0
68 INT268524 MYC Regulation of THBS1 1 0.02 1.85 0
69 INT182919 TGFBI Regulation of RARA 1 0.29 0.08 0
70 INT337273 E2F1 Regulation of Gene_expression of THBS1 1 0.60 0 0
71 INT279108 MATN3 Regulation of Localization of COMP 1 0.44 0.67 0
72 INT342366 Binding of Rara and OSBPL1A 1 0.16 0 0
73 INT182961 Binding of RARA and KCNIP3 1 0.21 0.76 0
74 INT337266 E2F1 Positive_regulation of Gene_expression of THBS1 1 0.67 0.21 0
75 INT99772 Pgr Regulation of THBS1 1 0.00 0 0
76 INT291682 Positive_regulation of Binding of RARA and TNFRSF10B 1 0.03 0 0
77 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0
78 INT245734 Binding of COL9A1 and COL9A2 1 0.26 0.52 0
79 INT307307 COMP Positive_regulation of EREG 1 0.01 0.46 0
80 INT277489 Binding of Thbs1 and Gopc 1 0.14 0 0
81 INT291683 Binding of RARA and TNFRSF10B 1 0.03 0 0
82 INT337265 Negative_regulation of E2F1 Positive_regulation of THBS1 1 0.42 0 0
83 INT337272 E2F1 Positive_regulation of THBS1 1 0.49 1.27 0
84 INT337267 THBS1 Positive_regulation of E2F1 1 0.49 0.05 0
85 INT325285 COMP Positive_regulation of UBR5 1 0.00 2.9 0
86 INT312290 Binding of Col9a1 and Matn3 1 0.02 0.65 0
87 INT99771 Oxtr Regulation of THBS1 1 0.01 0 0
88 INT234440 Binding of PROC and RARA 1 0.00 0.73 0
89 INT289791 Comp Regulation of Gene_expression of Col7a1 1 0.20 0.21 0
90 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
91 INT225504 Binding of gr and Rara 1 0.02 0 0
92 INT289795 Binding of COMP and Comp 1 0.02 0.99 0
93 INT307310 Binding of CALR and COMP 1 0.28 0.82 0
94 INT182948 KCNIP3 Regulation of Transcription of RARA 1 0.23 0.55 0
95 INT245729 Binding of COL9A1 and COL9A3 1 0.29 0.52 0
96 INT289788 Binding of Comp and Scn8a 1 0.16 1.37 0
97 INT291681 Positive_regulation of Binding of DR1 and RARA 1 0.06 0 0
98 INT312291 Binding of Comp and Matn3 1 0.06 1.37 0
99 INT307308 Binding of COMP and EREG 1 0.01 0.41 0
100 INT268511 MIR19B1 Regulation of THBS1 1 0.20 0.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for growth plate cartilage development. They are ordered first by their pain relevance and then by number of times they were reported in growth plate cartilage development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
2 INT82829 Gene_expression of COMP 104 0.78 57 9.81
3 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98
4 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51
5 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2
6 INT13170 Gene_expression of Comp 25 0.74 8.68 5.62
7 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28
8 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2
9 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55
10 INT118095 Regulation of COMP 7 0.43 9.69 3.33
11 INT279122 Regulation of Gene_expression of COMP 3 0.39 8.82 3.19
12 INT200470 Positive_regulation of Gene_expression of COMP 13 0.69 13.73 2.93
13 INT73836 Regulation of Comp 4 0.19 4.2 2.79
14 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45
15 INT71273 Positive_regulation of Comp 8 0.42 3.8 2.32
16 INT8052 Negative_regulation of COMP 46 0.58 13.73 2.22
17 INT184305 Gene_expression of Comp 53 0.77 31.66 2.2
18 INT289775 Negative_regulation of Comp 4 0.41 5.69 2.2
19 INT27437 Negative_regulation of Comp 5 0.24 2.8 2.15
20 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97
21 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83
22 INT192092 Positive_regulation of Gene_expression of Rara 8 0.32 4.41 1.68
23 INT116022 Positive_regulation of Positive_regulation of RARA 3 0.11 0.94 1.68
24 INT67457 Binding of Rara 12 0.24 8.28 1.45
25 INT118097 Localization of COMP 18 0.70 9.99 1.42
26 INT81400 Binding of RARA 25 0.36 12.93 1.27
27 INT288546 Regulation of Positive_regulation of THBS1 1 0.36 2.65 1.27
28 INT184313 Positive_regulation of Comp 4 0.55 4.23 1.24
29 INT150805 Localization of THBS1 4 0.46 2.88 1.23
30 INT97909 Binding of COMP 13 0.37 5.98 1.22
31 INT333999 Protein_catabolism of Comp 1 0.72 1.77 1.19
32 INT182985 Transcription of RARA 9 0.60 3.52 1.12
33 INT203729 Binding of Thbs1 1 0.27 3.83 1.1
34 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08
35 INT150803 Localization of THBS3 1 0.50 1 1.05
36 INT99767 Regulation of THBS1 18 0.42 11.51 1.03
37 INT69758 Negative_regulation of Positive_regulation of Rara 2 0.32 0.24 0.97
38 INT118098 Protein_catabolism of COMP 5 0.66 2.76 0.9
39 INT192090 Localization of Rara 6 0.46 4.15 0.89
40 INT289785 Negative_regulation of Gene_expression of Comp 4 0.37 3.14 0.88
41 INT48251 Regulation of Positive_regulation of Rara 2 0.33 0 0.88
42 INT120366 Negative_regulation of Rara 2 0.35 0.15 0.86
43 INT48250 Regulation of Rara 3 0.29 2.47 0.83
44 INT48249 Positive_regulation of Positive_regulation of Rara 2 0.26 0 0.83
45 INT212109 Localization of RARA 5 0.65 3.17 0.79
46 INT130363 Localization of Thbs1 9 0.75 4.99 0.76
47 INT279130 Negative_regulation of Localization of COMP 5 0.51 3.75 0.69
48 INT103484 Binding of Comp 1 0.19 0.36 0.68
49 INT91398 Regulation of RARA 7 0.59 5.84 0.67
50 INT27435 Negative_regulation of Gene_expression of Comp 1 0.15 0.27 0.63
51 INT27436 Regulation of Gene_expression of Comp 1 0.10 0.28 0.63
52 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59
53 INT184307 Positive_regulation of Gene_expression of Comp 6 0.50 2.48 0.59
54 INT234472 Positive_regulation of Transcription of RARA 2 0.44 0.13 0.58
55 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57
56 INT150808 Negative_regulation of Localization of THBS1 1 0.25 0.5 0.53
57 INT201392 Negative_regulation of RARA 8 0.30 2.99 0.5
58 INT268576 Positive_regulation of Gene_expression of THBS1 2 0.64 2.26 0.47
59 INT167318 Negative_regulation of Col9a1 1 0.43 0.66 0.45
60 INT182966 Regulation of Gene_expression of RARA 2 0.39 0.12 0.42
61 INT203728 Regulation of Binding of Thbs1 1 0.33 2.76 0.42
62 INT211982 Negative_regulation of Binding of Rara 1 0.28 0.24 0.42
63 INT184310 Regulation of Comp 2 0.49 1.81 0.41
64 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41
65 INT130927 Negative_regulation of Thbs1 19 0.59 3.72 0.36
66 INT197038 Negative_regulation of Positive_regulation of Comp 1 0.23 1.39 0.35
67 INT13168 Localization of Comp 2 0.34 0.31 0.34
68 INT101540 Positive_regulation of Positive_regulation of COMP 2 0.39 0.77 0.33
69 INT112142 Transcription of Comp 1 0.26 0.35 0.25
70 INT130368 Transcription of Thbs1 2 0.69 1.39 0.23
71 INT130360 Positive_regulation of Transcription of Thbs1 1 0.46 1.41 0.23
72 INT10375 Negative_regulation of Gene_expression of RARA 1 0.57 0.97 0.22
73 INT222635 Gene_expression of Thbs1 4 0.39 15.2 0.2
74 INT178504 Positive_regulation of Localization of THBS1 2 0.05 1.9 0.19
75 INT231474 Binding of THBS1 4 0.34 2.04 0.16
76 INT221002 Transcription of COMP 2 0.60 1.79 0.16
77 INT348150 Binding of Thbs1 1 0.24 2.06 0.15
78 INT118096 Regulation of Negative_regulation of COMP 1 0.23 0.29 0.14
79 INT192091 Regulation of Localization of Rara 1 0.04 0.67 0.13
80 INT184306 Localization of Comp 2 0.69 5.1 0.12
81 INT348149 Regulation of Gene_expression of Thbs1 1 0.31 1.94 0.1
82 INT348145 Localization of Thbs1 1 0.41 6.72 0.1
83 INT214071 Negative_regulation of Transcription of RARA 3 0.37 1.77 0.07
84 INT222588 Negative_regulation of Gene_expression of Thbs1 2 0.30 7.93 0.07
85 INT182975 Phosphorylation of RARA 2 0.58 0.23 0.07
86 INT13169 Positive_regulation of Gene_expression of Comp 2 0.48 0.24 0.06
87 INT222624 Negative_regulation of Thbs1 2 0.30 8.42 0.04
88 INT99763 Regulation of Thbs1 2 0.23 2.08 0.04
89 INT348152 Positive_regulation of Localization of Thbs1 1 0.24 0.85 0.04
90 INT348157 Regulation of Transcription of Thbs1 1 0.14 0.96 0.04
91 INT348147 Transcription of Thbs1 1 0.27 0.96 0.04
92 INT294469 Transcription of THBS1 2 0.66 0.46 0.03
93 INT231690 Negative_regulation of Binding of THBS1 1 0.16 0.37 0.03
94 INT182990 Positive_regulation of Gene_expression of RARA 5 0.40 3.45 0
95 INT312287 Gene_expression of Col9a1 1 0.21 2.94 0
96 INT337281 Regulation of Gene_expression of THBS1 1 0.57 0.48 0
97 INT182965 Positive_regulation of Phosphorylation of RARA 1 0.29 0 0
98 INT277482 Negative_regulation of Transcription of Thbs1 1 0.43 0 0
99 INT252974 Positive_regulation of Negative_regulation of THBS1 1 0.03 0.09 0
100 INT312286 Binding of Col9a1 1 0.10 1.37 0
101 INT335229 Regulation of Transcription of RARA 1 0.15 0.95 0
102 INT348156 Positive_regulation of Gene_expression of Thbs1 1 0.24 0.9 0
103 INT183002 Positive_regulation of Binding of RARA 1 0.29 1.08 0
104 INT228789 Positive_regulation of Negative_regulation of Thbs1 1 0.26 0.07 0
105 INT335226 Negative_regulation of Negative_regulation of RARA 1 0.24 0.71 0
106 INT348146 Positive_regulation of Thbs1 1 0.25 2.41 0
107 INT277481 Negative_regulation of Negative_regulation of Thbs1 1 0.59 0 0
108 INT252970 Negative_regulation of Positive_regulation of THBS1 1 0.04 0.2 0
109 INT348158 Negative_regulation of Positive_regulation of Thbs1 1 0.22 0.65 0
110 INT245739 Gene_expression of COL9A1 1 0.54 0.53 0
111 INT289779 Regulation of Localization of Comp 1 0.39 1.29 0
112 INT207312 Phosphorylation of THBS1 1 0.43 0.28 0
113 INT277486 Negative_regulation of Positive_regulation of Thbs1 1 0.43 0 0
114 INT337279 Positive_regulation of Binding of THBS1 1 0.46 0 0
115 INT289781 Regulation of Gene_expression of Comp 1 0.39 0.39 0
116 INT307329 Negative_regulation of Positive_regulation of COMP 1 0.38 0.12 0
117 INT289777 Transcription of Comp 1 0.53 0 0
118 INT320827 Negative_regulation of Gene_expression of THBS1 1 0.03 1.52 0
119 INT312284 Binding of Comp 1 0.30 3.08 0
120 INT337283 Positive_regulation of Regulation of THBS1 1 0.46 0 0
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