GO:0003678

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Name DNA helicase activity
Categary Function
Go Slim No
Go Link GO:0003678
Unique Molecular Interactions 44
Total Molecular Interactions 64
Total Single Events 230
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA helicase activity. They are ordered first by their pain relevance and then by number of times they were reported for DNA helicase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65185 Binding of ATRX and Ssr1 1 0.03 1.68 0.49
2 INT314076 Peo1 Negative_regulation of Il6 1 0.35 0.62 0.21
3 INT314078 Peo1 Negative_regulation of Stat1 1 0.31 1.23 0.17
4 INT314075 Peo1 Regulation of Positive_regulation of Stat1 1 0.37 0.43 0.08
5 INT227836 Binding of ERCC6 and GPER 1 0.21 0.27 0.08
6 INT314072 Peo1 Negative_regulation of Cxcl10 1 0.24 0.39 0.07
7 INT333849 Binding of Mcm4 and Mir17 1 0.03 0.52 0.05
8 INT314073 Peo1 Negative_regulation of Nos2 1 0.11 0.32 0.04
9 INT314074 Peo1 Regulation of Cxcl10 1 0.25 0.21 0.03
10 INT314065 Peo1 Regulation of Nos2 1 0.18 0.2 0.03
11 INT314077 Peo1 Negative_regulation of Positive_regulation of Stat1 1 0.31 0.33 0.03
12 INT189375 Rpa1 Regulation of ERCC6 1 0.04 0.05 0
13 INT227830 CSH1 Regulation of ERCC6 1 0.11 0 0
14 INT227837 Positive_regulation of Binding of CSH1 and ERCC6 1 0.20 0.15 0
15 INT189373 Rpa1 Negative_regulation of ERCC6 1 0.03 0 0
16 INT227829 CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0
17 INT191183 Binding of GRB2 and RECQL5 1 0.37 0.17 0
18 INT227838 Binding of ERCC6 and PGBD3 1 0.40 0.23 0
19 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0
20 INT189330 PPA1 Positive_regulation of ERCC6 1 0.10 0 0
21 INT227832 Binding of CSH1 and ERCC6 1 0.15 0.15 0
22 INT227841 PGBD1 Positive_regulation of ERCC6 1 0.44 0.29 0
23 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0
24 INT189333 CSNK2A1 Positive_regulation of Phosphorylation of ERCC6 1 0.10 0 0
25 INT227833 Positive_regulation of CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0
26 INT230272 RAD54L Regulation of RAD54B 1 0.01 0 0
27 INT268317 Cdk1 Positive_regulation of Mcm7 1 0.33 0.25 0
28 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
29 INT191186 Binding of EGFR and RECQL5 1 0.35 0.34 0
30 INT268324 Cdc20 Positive_regulation of Mcm7 1 0.09 0.25 0
31 INT264678 Binding of SETX and KRT20 1 0.00 2.17 0
32 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0
33 INT227843 Binding of ERCC6 and MLL 1 0.00 0.34 0
34 INT189331 PPA1 Negative_regulation of Phosphorylation of ERCC6 1 0.06 0 0
35 INT319026 Binding of Npc1 and Ruvbl1 1 0.00 0.08 0
36 INT264682 Binding of VAPB and SETX 1 0.28 1.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA helicase activity. They are ordered first by their pain relevance and then by number of times they were reported in DNA helicase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT958 Negative_regulation of ATRX 6 0.58 2.92 1.25
2 INT959 Regulation of ATRX 5 0.47 5.04 0.89
3 INT86957 Gene_expression of Peo1 3 0.55 2.61 0.78
4 INT130385 Gene_expression of ERCC6 7 0.77 8.36 0.63
5 INT137223 Binding of Peo1 4 0.31 0.47 0.58
6 INT314059 Negative_regulation of Peo1 1 0.31 2.22 0.44
7 INT961 Positive_regulation of ATRX 3 0.53 1.99 0.36
8 INT314063 Regulation of Peo1 1 0.22 0.64 0.32
9 INT345260 Transcription of ATRX 1 0.31 0.28 0.28
10 INT962 Gene_expression of ATRX 2 0.59 1.72 0.27
11 INT189346 Positive_regulation of ERCC6 6 0.60 3.37 0.23
12 INT86958 Positive_regulation of Peo1 1 0.36 0.33 0.18
13 INT227876 Transcription of ERCC6 1 0.68 1.87 0.17
14 INT226416 Negative_regulation of Mcm4 1 0.13 1.29 0.17
15 INT189355 Phosphorylation of ERCC6 1 0.79 1.11 0.16
16 INT960 Negative_regulation of Positive_regulation of ATRX 1 0.45 0 0.15
17 INT182408 Localization of ERCC6 4 0.72 2.31 0.14
18 INT151702 Binding of ERCC6 6 0.37 1.47 0.09
19 INT74442 Binding of ATRX 2 0.41 3.2 0.09
20 INT227880 Positive_regulation of Transcription of ERCC6 1 0.50 0.52 0.09
21 INT309245 Binding of SETX 1 0.08 1.98 0.06
22 INT333790 Localization of Mcm4 1 0.34 0.52 0.05
23 INT319018 Binding of Ruvbl1 1 0.00 0.15 0.04
24 INT314062 Phosphorylation of Peo1 1 0.45 0.3 0.04
25 INT141562 Negative_regulation of ERCC6 11 0.50 3.04 0
26 INT141563 Regulation of ERCC6 6 0.59 2.54 0
27 INT227856 Regulation of Transcription of ERCC6 1 0.45 0 0
28 INT189352 Negative_regulation of Gene_expression of ERCC6 1 0.36 0 0
29 INT230326 Gene_expression of RAD54B 1 0.38 0 0
30 INT189345 Negative_regulation of Localization of ERCC6 1 0.41 0.06 0
31 INT268314 Gene_expression of Mcm7 1 0.38 0.26 0
32 INT265972 Positive_regulation of Gene_expression of ATRX 1 0.38 1.72 0
33 INT189344 Positive_regulation of Phosphorylation of ERCC6 1 0.58 0 0
34 INT189354 Negative_regulation of Phosphorylation of ERCC6 1 0.49 0 0
35 INT189358 Negative_regulation of Regulation of ERCC6 1 0.36 0 0
36 INT272128 Positive_regulation of Localization of ATRX 1 0.14 0.46 0
37 INT319020 Regulation of Ruvbl1 1 0.00 0 0
38 INT262399 Negative_regulation of Localization of Peo1 1 0.19 0.77 0
39 INT230306 Transcription of RAD54B 1 0.36 0 0
40 INT227866 Positive_regulation of Regulation of ERCC6 1 0.50 0.58 0
41 INT262398 Localization of Peo1 1 0.34 0.77 0
42 INT189357 Positive_regulation of Binding of ERCC6 1 0.42 0.15 0
43 INT256909 Positive_regulation of Mcm7 1 0.41 1.08 0
44 INT227883 Positive_regulation of Gene_expression of ERCC6 1 0.60 0.4 0
45 INT150198 Gene_expression of ERCC8 1 0.09 0.12 0
46 INT227879 Regulation of Protein_catabolism of ERCC6 1 0.27 0.38 0
47 INT191212 Gene_expression of RECQL5 1 0.63 0.17 0
48 INT189356 Regulation of Regulation of ERCC6 1 0.59 0 0
49 INT319017 Positive_regulation of Ruvbl1 1 0.00 0 0
50 INT272120 Localization of ATRX 1 0.27 1.36 0
51 INT230312 Regulation of RAD54B 1 0.12 0.13 0
52 INT150197 Regulation of ERCC8 1 0.03 0.13 0
53 INT189361 Regulation of Phosphorylation of ERCC6 1 0.38 0.07 0
54 INT227875 Protein_catabolism of ERCC6 1 0.65 0.81 0
55 INT319019 Protein_catabolism of Ruvbl1 1 0.01 0 0
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