GO:0003684

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Name damaged DNA binding
Categary Function
Go Slim No
Go Link GO:0003684
Unique Molecular Interactions 415
Total Molecular Interactions 515
Total Single Events 3745
Pain Genes Associated 38

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for damaged DNA binding. They are ordered first by their pain relevance and then by number of times they were reported for damaged DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
3 INT113715 Msh3 Positive_regulation of tf 1 0.11 0 2.47
4 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
5 INT104709 Msh3 Positive_regulation of Rbm39 1 0.01 0.07 1.76
6 INT26893 OGG1 Negative_regulation of Gh1 1 0.12 0 1.37
7 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
8 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
9 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
10 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
11 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
12 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
13 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
14 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
15 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
16 INT251729 Binding of FEN1 and EXOSC1 1 0.19 1.13 0.74
17 INT145121 Msh3 Positive_regulation of Oprm1 1 0.06 0.15 0.72
18 INT145120 Msh3 Negative_regulation of Positive_regulation of Oprm1 1 0.05 0.15 0.72
19 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
20 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
21 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
22 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
23 INT145122 Oprm1 Negative_regulation of Msh3 1 0.06 0.15 0.63
24 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
25 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
26 INT131810 Nfkb1 Negative_regulation of Localization of Apex1 1 0.01 0.52 0.57
27 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
28 INT305851 Polk Positive_regulation of Gene_expression of Tslp 1 0.29 0.9 0.51
29 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
30 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
31 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
32 INT72203 GH1 Regulation of OGG1 1 0.10 0 0.46
33 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
34 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37
35 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
36 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
37 INT305856 Polk Regulation of Gene_expression of TH1L 1 0.43 0.93 0.35
38 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
39 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32
40 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
41 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
42 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
43 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
44 INT35963 Binding of ALB and MPG 1 0.40 0 0.3
45 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
46 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
47 INT56250 Binding of NBN and NCOR2 1 0.00 0 0.3
48 INT121186 Binding of Msh3 and Em 1 0.02 0.1 0.3
49 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
50 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
51 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
52 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
53 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
54 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
55 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
56 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
57 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
58 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
59 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
60 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
61 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
62 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26
63 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
64 INT305854 Polk Regulation of Gene_expression of Atp11c 1 0.05 0.73 0.26
65 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
66 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
67 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
68 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
69 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
70 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
71 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
72 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24
73 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
74 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
75 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23
76 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
77 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
78 INT305850 Polk Positive_regulation of Gene_expression of dp 1 0.07 0.64 0.21
79 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21
80 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
81 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
82 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2
83 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2
84 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2
85 INT132054 NBN Positive_regulation of NOS1 1 0.00 0.08 0.2
86 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
87 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
88 INT266404 Binding of HMGB1 and Thbd 1 0.06 0.3 0.2
89 INT39318 Binding of MPG and PTAFR 1 0.54 0.36 0.2
90 INT168828 Binding of DDB1 and UBR1 1 0.00 0.67 0.19
91 INT28432 ADRA1D Positive_regulation of MPG 1 0.54 0.2 0.19
92 INT305848 Polk Positive_regulation of dp 1 0.09 0 0.19
93 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
94 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
95 INT161144 MPG Regulation of Gene_expression of COMMD3 1 0.14 0 0.17
96 INT161143 MPG Regulation of ALB 1 0.16 0 0.17
97 INT305857 Polk Regulation of Gene_expression of IFN1@ 1 0.31 0.74 0.17
98 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
99 INT161146 MPG Regulation of OXA1L 1 0.27 0 0.17
100 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
101 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
102 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16
103 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
104 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
105 INT305846 Polk Positive_regulation of Gene_expression of Il4 1 0.13 0.24 0.15
106 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
107 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14
108 INT29207 Msh2 Regulation of POMC 1 0.02 0.1 0.14
109 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14
110 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14
111 INT89763 Positive_regulation of APEX1 Positive_regulation of Positive_regulation of NR4A1 1 0.10 0.87 0.14
112 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14
113 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
114 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
115 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
116 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
117 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
118 INT182607 Binding of MLH1 and MSH3 1 0.04 0.81 0.11
119 INT305855 Polk Regulation of Atp11c 1 0.02 0.73 0.11
120 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
121 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
122 INT168829 Binding of DDB1 and TRPC4AP 1 0.02 0.34 0.1
123 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
124 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
125 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09
126 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
127 INT74015 Binding of VHL and XRCC1 1 0.07 3.51 0.09
128 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
129 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
130 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
131 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
132 INT188007 NLRP3 Regulation of Binding of TP53BP1 1 0.28 0.62 0.08
133 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08
134 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08
135 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
136 INT94654 Trpc2 Positive_regulation of Positive_regulation of Tyr 1 0.40 0 0.08
137 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
138 INT278059 XRCC1 Positive_regulation of Gene_expression of IL2 1 0.01 1.06 0.07
139 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
140 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
141 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
142 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
143 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
144 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
145 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05
146 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
147 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05
148 INT313886 RPS6KB1 Positive_regulation of Gene_expression of XRCC1 1 0.01 0.8 0.05
149 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
150 INT313890 Akt1 Positive_regulation of Gene_expression of XRCC1 1 0.00 0.79 0.05
151 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
152 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
153 INT268677 IFNA2 Positive_regulation of XRCC1 1 0.05 0.75 0.05
154 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
155 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
156 INT214033 OGG1 Negative_regulation of BPIFA4P 1 0.08 0.71 0.05
157 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
158 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
159 INT201535 Binding of NPC1 and XRCC1 1 0.26 1.6 0.05
160 INT333841 Binding of Rad51 and Mir17 1 0.02 0.52 0.05
161 INT268674 IL2 Positive_regulation of XRCC1 1 0.08 0.75 0.05
162 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04
163 INT190046 Binding of Msh3 and Pms2 2 0.25 0.5 0.04
164 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
165 INT188006 NLRP3 Regulation of Gene_expression of TP53BP1 1 0.28 0.36 0.04
166 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
167 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
168 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
169 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04
170 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
171 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
172 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
173 INT188005 NLRP3 Regulation of TP53BP1 1 0.34 0.3 0.04
174 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
175 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
176 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
177 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
178 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
179 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
180 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
181 INT244132 DDB1 Regulation of Transcription of NOD1 1 0.01 0.09 0.03
182 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
183 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03
184 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
185 INT338900 MYC Positive_regulation of Gene_expression of TP73 1 0.05 0.27 0.03
186 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
187 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
188 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
189 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
190 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
191 INT287814 Apex1 Positive_regulation of Gene_expression of Rnf128 1 0.03 0.15 0.03
192 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
193 INT273519 NBN Negative_regulation of YOD1 1 0.03 0.56 0.03
194 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
195 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
196 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
197 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0
198 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
199 INT348532 TP63 Positive_regulation of CASP3 1 0.04 0.55 0
200 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for damaged DNA binding. They are ordered first by their pain relevance and then by number of times they were reported in damaged DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
3 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
4 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
5 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64
6 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
7 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
8 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
9 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
10 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
11 INT60585 Regulation of TP53 59 0.59 54.55 5.21
12 INT12412 Binding of MPG 21 0.47 3.92 4.94
13 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
14 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
15 INT131808 Localization of Apex1 2 0.16 13.46 4.61
16 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55
17 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
18 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
19 INT184288 Localization of HMGB1 20 0.61 14.5 3.84
20 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
21 INT26891 Gene_expression of OGG1 21 0.74 2.08 3.64
22 INT19538 Positive_regulation of MPG 8 0.67 3.21 3.57
23 INT104705 Regulation of Msh3 4 0.28 0.1 3.51
24 INT12844 Binding of TP63 15 0.47 10.57 3.38
25 INT104708 Gene_expression of Msh3 6 0.72 0.07 3.17
26 INT8103 Binding of TP53 46 0.44 40.2 2.96
27 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76
28 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
29 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
30 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
31 INT184272 Binding of HMGB1 14 0.37 8.78 2.49
32 INT55952 Transcription of TP53 16 0.61 12.14 2.36
33 INT97973 Positive_regulation of XRCC1 24 0.40 30.95 2.26
34 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
35 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
36 INT12413 Gene_expression of MPG 11 0.76 3.13 1.94
37 INT65855 Localization of TP53 18 0.76 17.08 1.89
38 INT50743 Positive_regulation of Trpc2 12 0.44 1.99 1.87
39 INT253756 Gene_expression of Apex1 1 0.14 7.47 1.84
40 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
41 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7
42 INT305832 Gene_expression of Polk 1 0.48 0.49 1.64
43 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62
44 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6
45 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58
46 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57
47 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
48 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53
49 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
50 INT120519 Localization of XRCC1 15 0.78 17.03 1.51
51 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
52 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
53 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
54 INT58109 Positive_regulation of Positive_regulation of MPG 2 0.49 0.37 1.42
55 INT112597 Positive_regulation of Msh3 2 0.25 0 1.42
56 INT172953 Binding of Trp53 33 0.37 20.76 1.41
57 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
58 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
59 INT145221 Binding of Tp53 10 0.37 8.59 1.37
60 INT121307 Gene_expression of Ercc1 4 0.73 12.69 1.37
61 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36
62 INT26890 Negative_regulation of Gene_expression of OGG1 2 0.34 0.13 1.26
63 INT74018 Binding of XRCC1 19 0.31 24.78 1.24
64 INT174156 Localization of Trp53 16 0.72 13.52 1.18
65 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16
66 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
67 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
68 INT278117 Negative_regulation of TP63 5 0.32 3.38 1.13
69 INT74879 Regulation of MPG 6 0.44 0.8 1.08
70 INT74020 Negative_regulation of XRCC1 16 0.35 17.18 1.06
71 INT113712 Positive_regulation of Gene_expression of Msh3 2 0.43 0 1.04
72 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
73 INT58107 Negative_regulation of MPG 2 0.41 0.92 0.98
74 INT86907 Negative_regulation of MSH6 8 0.33 6.76 0.93
75 INT74021 Regulation of XRCC1 15 0.44 16.91 0.88
76 INT50744 Negative_regulation of Positive_regulation of Trpc2 1 0.21 0.51 0.85
77 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
78 INT44293 Regulation of TP63 6 0.24 2.88 0.76
79 INT306520 Negative_regulation of Msh3 2 0.40 0.22 0.76
80 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
81 INT92142 Binding of MSH2 5 0.46 5.64 0.75
82 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
83 INT206929 Negative_regulation of Gene_expression of XRCC1 4 0.25 6.14 0.74
84 INT251735 Binding of FEN1 1 0.17 1.13 0.74
85 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
86 INT25176 Regulation of Msh2 3 0.37 0.48 0.68
87 INT128314 Gene_expression of Cry2 2 0.46 0.18 0.68
88 INT128326 Regulation of Gene_expression of Cry2 1 0.03 0.09 0.68
89 INT62421 Gene_expression of Trpc2 8 0.68 5.48 0.67
90 INT253750 Positive_regulation of Gene_expression of Apex1 1 0.10 1.43 0.64
91 INT56251 Binding of NBN 4 0.38 3.16 0.62
92 INT84755 Positive_regulation of Binding of MPG 1 0.49 0 0.62
93 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
94 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
95 INT182435 Localization of OGG1 36 0.76 1.66 0.58
96 INT184277 Regulation of Localization of HMGB1 1 0.37 1.15 0.58
97 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55
98 INT154151 Positive_regulation of TP73 5 0.67 5.71 0.52
99 INT25175 Gene_expression of Msh2 2 0.55 0.4 0.52
100 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51
101 INT343799 Negative_regulation of Transcription of HMGB1 1 0.32 0.37 0.5
102 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
103 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49
104 INT220339 Transcription of HMGB1 2 0.53 2.03 0.49
105 INT278121 Negative_regulation of Negative_regulation of TP63 1 0.03 0 0.48
106 INT219178 Negative_regulation of Localization of HMGB1 1 0.22 1.26 0.45
107 INT305826 Regulation of Gene_expression of Polk 1 0.28 0 0.43
108 INT121310 Positive_regulation of Ercc1 2 0.45 1.78 0.42
109 INT244151 Localization of DDB1 1 0.02 0.05 0.4
110 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
111 INT19536 Positive_regulation of Gene_expression of MPG 2 0.49 0.7 0.39
112 INT219001 Gene_expression of ERCC1 12 0.54 3.77 0.38
113 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
114 INT188016 Gene_expression of TP53BP1 6 0.64 5.54 0.35
115 INT105934 Gene_expression of APTX 1 0.00 0 0.35
116 INT305817 Positive_regulation of Gene_expression of Polk 1 0.36 0.05 0.34
117 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34
118 INT182073 Binding of APEX1 4 0.12 1.72 0.32
119 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31
120 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
121 INT121185 Binding of Msh3 1 0.10 0.1 0.3
122 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
123 INT305837 Regulation of Polk 1 0.28 0 0.28
124 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27
125 INT199744 Regulation of REV1 2 0.16 0.91 0.27
126 INT127654 Positive_regulation of Gene_expression of XRCC1 11 0.38 13.7 0.26
127 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
128 INT158755 Localization of XPA 1 0.39 2.73 0.26
129 INT191460 Localization of REV1 4 0.19 1.46 0.25
130 INT188021 Positive_regulation of TP53BP1 3 0.48 1.33 0.25
131 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
132 INT154150 Regulation of TP73 3 0.15 2.81 0.24
133 INT69418 Positive_regulation of REV1 2 0.45 2.03 0.24
134 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
135 INT227426 Positive_regulation of Apex1 2 0.08 1.98 0.23
136 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
137 INT182413 Binding of OGG1 17 0.46 2.44 0.22
138 INT305841 Binding of Polk 1 0.23 0.43 0.22
139 INT121311 Positive_regulation of Gene_expression of Ercc1 3 0.62 1.23 0.21
140 INT220336 Negative_regulation of HMGB1 3 0.43 0.97 0.21
141 INT266367 Positive_regulation of Binding of HMGB1 1 0.26 0.31 0.21
142 INT158754 Gene_expression of XPA 3 0.57 4.24 0.2
143 INT253752 Negative_regulation of Localization of Apex1 1 0.08 1.26 0.2
144 INT154147 Gene_expression of TP73 7 0.34 3.97 0.19
145 INT89772 Positive_regulation of APEX1 4 0.21 2.29 0.19
146 INT266364 Protein_catabolism of HMGB1 1 0.34 0.29 0.19
147 INT221268 Localization of BRCA1 7 0.63 4.83 0.18
148 INT119061 Negative_regulation of Gene_expression of BRCA1 4 0.51 0.85 0.18
149 INT181920 Gene_expression of MSH3 2 0.50 2.54 0.18
150 INT89689 Binding of Brca1 2 0.37 2.55 0.18
151 INT188019 Negative_regulation of TP53BP1 1 0.48 1.42 0.18
152 INT182627 Regulation of MSH2 1 0.26 2.27 0.18
153 INT102527 Regulation of Positive_regulation of MPG 1 0.44 0.09 0.18
154 INT169875 Negative_regulation of Ercc1 3 0.43 3.07 0.17
155 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
156 INT266353 Negative_regulation of Binding of HMGB1 1 0.22 0.22 0.17
157 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
158 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16
159 INT305827 Negative_regulation of Gene_expression of Polk 1 0.26 0 0.16
160 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
161 INT139201 Localization of TP63 4 0.32 2.56 0.15
162 INT145147 Negative_regulation of Gene_expression of TP63 4 0.42 2.91 0.15
163 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
164 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
165 INT182442 Positive_regulation of Gene_expression of OGG1 1 0.58 0.07 0.15
166 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
167 INT154148 Negative_regulation of Gene_expression of TP73 3 0.21 1.89 0.14
168 INT85628 Positive_regulation of Positive_regulation of Trpc2 1 0.32 0.47 0.14
169 INT236392 Regulation of Rad51 1 0.00 0.3 0.14
170 INT256864 Gene_expression of Tp63 1 0.14 0.47 0.14
171 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
172 INT68177 Negative_regulation of APTX 1 0.20 0.33 0.13
173 INT326489 Negative_regulation of Gene_expression of MPG 1 0.12 0.21 0.13
174 INT182078 Gene_expression of APEX1 3 0.59 4.77 0.12
175 INT182623 Localization of MSH2 3 0.77 5.49 0.12
176 INT129774 Binding of Trpc2 2 0.18 0.73 0.12
177 INT246750 Gene_expression of Ogg1 1 0.69 10.04 0.12
178 INT182626 Localization of MSH3 1 0.22 0.77 0.12
179 INT182622 Regulation of MSH3 1 0.08 0.77 0.12
180 INT187590 Gene_expression of Brca1 12 0.65 4.94 0.11
181 INT181745 Positive_regulation of MSH2 4 0.48 5.73 0.11
182 INT231413 Negative_regulation of NBN 3 0.46 4.6 0.11
183 INT208914 Regulation of Brca1 1 0.10 0.79 0.11
184 INT146072 Binding of TP73 2 0.12 0.58 0.1
185 INT190501 Regulation of Apex1 1 0.12 0.32 0.1
186 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
187 INT121495 Transcription of XRCC1 7 0.49 6.11 0.09
188 INT111139 Localization of Tp53 4 0.45 2.4 0.09
189 INT273338 Protein_catabolism of Apex1 4 0.05 0.57 0.09
190 INT206737 Negative_regulation of Gene_expression of HMGB1 3 0.32 3.48 0.09
191 INT246741 Regulation of Gene_expression of Ogg1 1 0.55 1.92 0.09
192 INT188013 Phosphorylation of TP53BP1 1 0.78 1.81 0.09
193 INT15504 Positive_regulation of Msh2 1 0.33 0.15 0.09
194 INT244174 Positive_regulation of DDB1 1 0.01 0.41 0.09
195 INT285813 Negative_regulation of ERCC1 13 0.30 2.03 0.08
196 INT332857 Binding of Cry2 2 0.32 0 0.08
197 INT188017 Binding of TP53BP1 1 0.46 1.28 0.08
198 INT62423 Regulation of Gene_expression of Trpc2 1 0.45 0.33 0.08
199 INT332843 Negative_regulation of Binding of Cry2 1 0.33 0 0.08
200 INT256854 Regulation of Tp63 1 0.06 0.06 0.08
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