GO:0003743

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Name translation initiation factor activity
Categary Function
Go Slim No
Go Link GO:0003743
Unique Molecular Interactions 96
Total Molecular Interactions 146
Total Single Events 605
Pain Genes Associated 23

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for translation initiation factor activity. They are ordered first by their pain relevance and then by number of times they were reported for translation initiation factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
2 INT341218 Binding of Eif4e and Eif4ebp1 1 0.19 2.65 1.23
3 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
4 INT51433 Gria1 Positive_regulation of Eif3g 1 0.03 0 0.7
5 INT224853 Binding of Bdnf and Eif4e 1 0.10 0 0.5
6 INT316065 Eif1 Positive_regulation of IL8 1 0.01 1.34 0.41
7 INT90593 Binding of Eif3h and Man2a2 1 0.01 0.32 0.38
8 INT38549 Binding of VIP and EIF1 1 0.06 0 0.36
9 INT75643 NCOR2 Positive_regulation of Positive_regulation of EIF2B3 1 0.00 0 0.33
10 INT75641 AR Positive_regulation of Positive_regulation of EIF2B3 1 0.02 0 0.33
11 INT341215 Binding of Eif4e and Eif4g3 1 0.10 0.41 0.33
12 INT130714 CA2 Positive_regulation of Eif2s1 1 0.16 0.59 0.24
13 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
14 INT316054 Eif1 Positive_regulation of Il6 1 0.00 0.78 0.21
15 INT58445 Binding of EIF3K and Klf6 1 0.00 0 0.2
16 INT44903 Binding of EIF2S1 and Sergef 1 0.02 0.32 0.17
17 INT76196 Binding of HTR1A and EIF2B3 1 0.06 0 0.17
18 INT273901 Mtor Positive_regulation of Eif4e 1 0.50 0.54 0.14
19 INT341239 Binding of EIF4E and Eif4e 1 0.08 0.23 0.12
20 INT341238 Binding of EIF4E and Eif4g3 1 0.03 0.23 0.12
21 INT308225 Alb Positive_regulation of Binding of EIF4G2 1 0.02 0.33 0.09
22 INT244452 CS Positive_regulation of Phosphorylation of EIF2S2 1 0.21 2.07 0.09
23 INT215884 Eif2ak3 Positive_regulation of Gene_expression of Musd1 1 0.01 0.96 0.09
24 INT130959 Binding of Gtf3a and Eif4h 1 0.05 0.29 0.08
25 INT130958 Binding of Eif4h and Ash1l 1 0.07 0.29 0.08
26 INT107722 ASIP Negative_regulation of EIF4E1B 1 0.02 0.43 0.07
27 INT203419 Binding of EIF4A1 and Gtf3a 1 0.00 0.5 0.07
28 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07
29 INT215883 Eif2ak3 Regulation of Musd1 1 0.00 0.8 0.06
30 INT341220 Eif4e Positive_regulation of Eif4ebp1 1 0.20 0.42 0.06
31 INT215878 Eif2ak3 Positive_regulation of Localization of Ins1 1 0.04 0.96 0.06
32 INT215877 Atf4 Regulation of Eif2ak3 1 0.44 0.21 0.06
33 INT257879 Negative_regulation of Eif4e Positive_regulation of Cdkn1b 1 0.28 0.54 0.06
34 INT257867 Negative_regulation of Eif4e Positive_regulation of Rb1 1 0.05 0.54 0.06
35 INT215873 Ddit3 Regulation of Eif2ak3 1 0.39 0.2 0.06
36 INT341219 Binding of Eif4ebp1 and Eif4g3 1 0.05 0 0.06
37 INT355439 Pdia3 Regulation of Gene_expression of Eif2ak3 1 0.01 0.83 0.05
38 INT244464 EIF2AK3 Positive_regulation of Positive_regulation of EIF2S2 1 0.17 0.37 0.04
39 INT244463 EIF2AK3 Regulation of Phosphorylation of EIF2S2 1 0.09 0.37 0.04
40 INT348885 Atpif1 Positive_regulation of EIF5B 1 0.01 0.08 0.04
41 INT341225 Negative_regulation of Binding of Eif4e and Eif4ebp1 1 0.17 0.14 0.03
42 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 0.10 0.78 0.03
43 INT222259 EIF4E Regulation of Negative_regulation of NOD2 1 0.13 0.1 0
44 INT211779 Binding of EIF4G1 and NTSR1 1 0.02 0 0
45 INT341232 Binding of EIF4A2 and Eif4e 1 0.06 0 0
46 INT186905 EIF1 Regulation of Gene_expression of IL8 1 0.07 0 0
47 INT186904 EIF1 Positive_regulation of Localization of IL8 1 0.06 0 0
48 INT272513 Binding of Mef2a and Eif2s2 1 0.03 0 0
49 INT244475 Binding of CS and Positive_regulation of EIF2S2 1 0.11 0.07 0
50 INT311389 Positive_regulation of Binding of Celf1 and Eif2s2 1 0.17 0.59 0
51 INT44886 Binding of EIF2S1 and MET 1 0.25 0.15 0
52 INT341240 Binding of EIF4E and Eif4ebp1 1 0.04 0.5 0
53 INT203853 Eif2ak3 Positive_regulation of Eif2ak1 1 0.05 0.63 0
54 INT341221 Eif4e Regulation of Binding of Eif4ebp1 1 0.18 0 0
55 INT217777 EIF4E Regulation of Gene_expression of MAP3K3 1 0.05 0.19 0
56 INT341234 Eif4g3 Positive_regulation of Binding of EIF4E 1 0.04 0 0
57 INT341216 Regulation of Binding of Eif4e and Eif4ebp1 1 0.11 0 0
58 INT244460 Binding of CS and Positive_regulation of Positive_regulation of EIF2S2 1 0.13 0.06 0
59 INT217790 EIF4E Regulation of Gene_expression of RASGRP1 1 0.01 0.19 0
60 INT186906 EIF1 Positive_regulation of Localization of LDHA 1 0.03 0 0
61 INT293811 Negative_regulation of EIF4E Negative_regulation of Gene_expression of CCND3 1 0.02 0.32 0
62 INT311394 Binding of Celf1 and Eif2s2 1 0.12 1.67 0
63 INT186902 EIF1 Positive_regulation of Gene_expression of IL8 1 0.08 0 0
64 INT341230 Eif4g3 Positive_regulation of EIF4E 1 0.04 0 0
65 INT244468 CS Positive_regulation of EIF2S2 1 0.16 0.43 0
66 INT186907 EIF1 Regulation of DEFB1 1 0.00 0 0
67 INT244467 Negative_regulation of CS Positive_regulation of EIF2S2 1 0.11 0.14 0
68 INT341233 Positive_regulation of Binding of EIF4E and Eif4ebp1 1 0.06 0.5 0
69 INT341224 Eif4g3 Positive_regulation of Eif4e 1 0.14 0 0
70 INT292149 Binding of GTF2B and SP1 1 0.03 0.4 0
71 INT220624 Eif1 Regulation of App 1 0.00 0.1 0
72 INT186908 EIF1 Positive_regulation of Transcription of IL8 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for translation initiation factor activity. They are ordered first by their pain relevance and then by number of times they were reported in translation initiation factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
2 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
3 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
4 INT75645 Binding of EIF2B3 10 0.07 0.21 4.9
5 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
6 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
7 INT150675 Regulation of Gene_expression of Eif2ak3 3 0.40 1.11 1.93
8 INT44888 Phosphorylation of EIF2S1 12 0.80 5.7 1.7
9 INT136788 Regulation of Eif4e 3 0.61 0 1.61
10 INT51426 Positive_regulation of Eif3g 3 0.07 0.24 1.59
11 INT109033 Positive_regulation of Positive_regulation of Eif2ak3 2 0.45 2.36 1.59
12 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46
13 INT113514 Positive_regulation of Eif2s1 2 0.49 0.85 1.46
14 INT75647 Positive_regulation of Binding of EIF2B3 3 0.07 0.11 1.42
15 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36
16 INT111132 Negative_regulation of Eif3g 2 0.10 1.8 1.27
17 INT136783 Regulation of Regulation of Eif4e 1 0.45 0 1.16
18 INT136785 Phosphorylation of Eif4e 2 0.82 0 1.1
19 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07
20 INT32474 Gene_expression of EIF3K 8 0.12 1.64 1
21 INT186924 Gene_expression of EIF1 25 0.08 2.64 0.97
22 INT341195 Binding of Eif4e 1 0.38 3.87 0.92
23 INT240368 Positive_regulation of Localization of Eif2ak3 1 0.34 0.66 0.87
24 INT109032 Negative_regulation of Positive_regulation of Eif2ak3 1 0.38 0.94 0.85
25 INT154053 Negative_regulation of Gene_expression of Eif2ak3 2 0.43 1.28 0.79
26 INT51430 Phosphorylation of Eif3g 1 0.06 0 0.72
27 INT55885 Positive_regulation of EIF1 3 0.43 1.17 0.71
28 INT75646 Positive_regulation of EIF2B3 2 0.06 0.11 0.68
29 INT136780 Positive_regulation of Eif4e 1 0.50 0 0.55
30 INT44899 Positive_regulation of EIF2S1 3 0.45 1.67 0.51
31 INT74153 Transcription of Eif3h 1 0.12 0.57 0.5
32 INT157023 Positive_regulation of Phosphorylation of EIF2S1 1 0.67 3.91 0.48
33 INT130695 Positive_regulation of Phosphorylation of Eif2s1 1 0.49 0.8 0.47
34 INT130692 Positive_regulation of Gene_expression of Eif2s1 1 0.49 0.81 0.47
35 INT130693 Phosphorylation of Eif2s1 1 0.80 0.8 0.47
36 INT130694 Gene_expression of Eif2s1 1 0.65 0.77 0.44
37 INT186912 Protein_catabolism of EIF1 1 0.10 1.88 0.39
38 INT90592 Binding of Eif3h 1 0.12 0 0.38
39 INT32476 Regulation of Gene_expression of EIF3K 2 0.03 1.05 0.31
40 INT44902 Localization of EIF2S1 1 0.28 0.61 0.31
41 INT86395 Negative_regulation of Binding of EIF2B3 1 0.05 0.06 0.3
42 INT51428 Positive_regulation of Phosphorylation of Eif3g 1 0.05 0 0.29
43 INT316035 Negative_regulation of Eif1 1 0.01 2.24 0.27
44 INT341173 Binding of Eif4g3 1 0.11 0.9 0.27
45 INT341182 Regulation of Eif4e 1 0.35 0.75 0.25
46 INT244524 Phosphorylation of EIF2S2 1 0.49 11.33 0.2
47 INT32475 Positive_regulation of Gene_expression of EIF3K 1 0.05 0.07 0.2
48 INT341163 Positive_regulation of Eif4e 1 0.54 0.56 0.19
49 INT211839 Binding of EIF4E 8 0.36 0.79 0.18
50 INT164567 Negative_regulation of EIF1 2 0.01 0.19 0.18
51 INT157022 Negative_regulation of Phosphorylation of EIF2S1 1 0.41 1.34 0.17
52 INT341175 Regulation of Eif4g3 1 0.04 0.19 0.17
53 INT186911 Regulation of EIF1 1 0.03 0 0.16
54 INT257859 Negative_regulation of Eif4e 1 0.23 1.07 0.16
55 INT20628 Positive_regulation of EIF3K 2 0.07 0.23 0.15
56 INT353246 Gene_expression of EIF4G1 1 0.06 1.23 0.14
57 INT341183 Positive_regulation of Eif4g3 1 0.15 0.29 0.14
58 INT260700 Regulation of Gene_expression of EIF1 1 0.01 0 0.14
59 INT44889 Binding of EIF2S1 2 0.23 0.35 0.13
60 INT215861 Positive_regulation of Negative_regulation of Eif2ak3 1 0.50 1.04 0.13
61 INT244563 Positive_regulation of EIF2S2 1 0.41 7.67 0.13
62 INT186917 Localization of EIF1 1 0.08 0.41 0.12
63 INT244559 Negative_regulation of Phosphorylation of EIF2S2 1 0.35 1.56 0.12
64 INT324246 Regulation of GTF2B 1 0.02 0.2 0.1
65 INT341192 Phosphorylation of Eif4e 1 0.49 0.36 0.1
66 INT44901 Gene_expression of EIF2S1 3 0.40 0.55 0.09
67 INT142966 Regulation of EIF3K 2 0.06 0.76 0.09
68 INT244566 Positive_regulation of Phosphorylation of EIF2S2 1 0.41 2.69 0.09
69 INT341169 Negative_regulation of Binding of Eif4g3 1 0.13 0.71 0.09
70 INT44900 Positive_regulation of Gene_expression of EIF2S1 1 0.18 0.16 0.09
71 INT142967 Regulation of Regulation of EIF3K 1 0.00 0.76 0.09
72 INT308214 Binding of EIF4G2 1 0.35 0.32 0.08
73 INT244544 Positive_regulation of Positive_regulation of EIF2S2 1 0.28 0.67 0.07
74 INT348864 Gene_expression of EIF5B 1 0.07 0.27 0.07
75 INT20635 Positive_regulation of Positive_regulation of EIF3K 1 0.07 0.14 0.06
76 INT176591 Positive_regulation of EIF5B 1 0.05 0.31 0.05
77 INT311304 Phosphorylation of Eif2s2 1 0.22 0.06 0.03
78 INT341167 Negative_regulation of Binding of Eif4e 1 0.33 0.23 0.03
79 INT311305 Positive_regulation of Eif2s2 1 0.19 0.57 0.03
80 INT244535 Negative_regulation of Positive_regulation of EIF2S2 1 0.35 0.54 0.03
81 INT244556 Regulation of Positive_regulation of EIF2S2 1 0.27 0.59 0.03
82 INT341200 Negative_regulation of Eif4e 1 0.46 0.14 0.03
83 INT268681 Binding of GTF2B 1 0.21 1.16 0.03
84 INT341189 Positive_regulation of Positive_regulation of Eif4e 1 0.36 0.13 0.03
85 INT227664 Phosphorylation of EIF4E 6 0.46 0.74 0
86 INT217806 Gene_expression of EIF4E 2 0.27 0.68 0
87 INT293778 Positive_regulation of EIF4E 2 0.45 0.42 0
88 INT272470 Binding of Eif2s2 2 0.10 0.95 0
89 INT186929 Positive_regulation of Gene_expression of EIF1 1 0.05 0.21 0
90 INT303322 Positive_regulation of Phosphorylation of EIF4A2 1 0.08 0.16 0
91 INT211840 Protein_catabolism of EIF4G1 1 0.35 0.13 0
92 INT211836 Binding of EIF4G1 1 0.12 0.07 0
93 INT244568 Positive_regulation of Gene_expression of EIF2S2 1 0.41 12.82 0
94 INT177549 Binding of Eif2s1 1 0.04 0.73 0
95 INT186927 Transcription of EIF1 1 0.07 0 0
96 INT304390 Transcription of EIF3K 1 0.08 0.11 0
97 INT293768 Regulation of Binding of EIF4E 1 0.18 0.13 0
98 INT244541 Negative_regulation of EIF2S2 1 0.25 0 0
99 INT245805 Regulation of Eif3g 1 0.00 0.21 0
100 INT341184 Positive_regulation of Localization of Eif4e 1 0.39 0 0
101 INT340310 Gene_expression of Eif2s2 1 0.01 0.18 0
102 INT227668 Positive_regulation of Phosphorylation of EIF4E 1 0.20 0.15 0
103 INT244509 Regulation of Gene_expression of EIF2S2 1 0.27 1.14 0
104 INT244562 Gene_expression of EIF2S2 1 0.46 23.74 0
105 INT244511 Regulation of EIF2S2 1 0.37 4.46 0
106 INT276879 Regulation of Phosphorylation of EIF4E 1 0.25 0.21 0
107 INT311341 Regulation of Binding of Eif2s2 1 0.11 0.39 0
108 INT293780 Positive_regulation of Binding of EIF4E 1 0.20 0.13 0
109 INT341191 Localization of Eif4e 1 0.63 0 0
110 INT303318 Phosphorylation of EIF4A2 1 0.11 0.16 0
111 INT341209 Binding of EIF4A2 1 0.06 0 0
112 INT341208 Negative_regulation of Binding of EIF4E 1 0.14 0 0
113 INT341188 Positive_regulation of Binding of Eif4e 1 0.34 0.18 0
114 INT244499 Binding of EIF2S2 1 0.22 0.33 0
115 INT293775 Regulation of EIF4E 1 0.24 0.64 0
116 INT293761 Negative_regulation of EIF4E 1 0.17 0.85 0
117 INT271085 Positive_regulation of Regulation of Eif2ak3 1 0.03 0.66 0
118 INT311319 Positive_regulation of Binding of Eif2s2 1 0.14 0.51 0
119 INT244503 Regulation of Regulation of EIF2S2 1 0.27 0.16 0
120 INT351112 Positive_regulation of Positive_regulation of EIF4E 1 0.45 0.22 0
121 INT186928 Binding of EIF1 1 0.04 0.22 0
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