GO:0003756

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Name protein disulfide isomerase activity
Categary Function
Go Slim No
Go Link GO:0003756
Unique Molecular Interactions 48
Total Molecular Interactions 85
Total Single Events 380
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein disulfide isomerase activity. They are ordered first by their pain relevance and then by number of times they were reported for protein disulfide isomerase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
2 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
3 INT112032 Positive_regulation of Oprm1 Positive_regulation of Pdia3 1 0.44 0.13 0.62
4 INT5416 Negative_regulation of Penk Positive_regulation of Pdia4 1 0.03 0.09 0.58
5 INT148922 Pdia4 Negative_regulation of Tnf 1 0.09 1.01 0.56
6 INT5417 Penk Positive_regulation of Pdia4 1 0.03 0.09 0.52
7 INT12897 Penk Regulation of Pdia4 1 0.07 0 0.5
8 INT51480 Gtpc Positive_regulation of Pdia4 1 0.04 0 0.34
9 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26
10 INT261380 Nsdhl Negative_regulation of P4hb 1 0.02 1.36 0.11
11 INT261391 Binding of Nsdhl and P4hb 1 0.02 1.3 0.1
12 INT192865 Binding of Esr1 and Pdia3 1 0.07 0.67 0.08
13 INT355432 Gene_expression of Pdia3 Negative_regulation of Ddit3 1 0.04 1.29 0.06
14 INT355447 Gene_expression of Pdia3 Negative_regulation of Transcription of TNF 1 0.00 1.8 0.06
15 INT355444 Gene_expression of Pdia3 Negative_regulation of TNF 1 0.00 1.29 0.06
16 INT355431 Binding of Pdia3 and Positive_regulation of Gene_expression of Ddit3 1 0.04 1.14 0.06
17 INT355433 Gene_expression of Pdia3 Negative_regulation of Transcription of Ddit3 1 0.03 1.79 0.06
18 INT355440 Binding of Pdia3 and Positive_regulation of Transcription of VEGFA 1 0.01 1.15 0.06
19 INT355449 Binding of Pdia3 and Positive_regulation of Transcription of TNF 1 0.00 1.15 0.06
20 INT355443 Binding of Pdia3 and Positive_regulation of Gene_expression of TNF 1 0.00 1.15 0.06
21 INT355434 Binding of Pdia3 and Positive_regulation of Transcription of Ddit3 1 0.04 1.14 0.06
22 INT355446 Binding of Pdia3 and Positive_regulation of Gene_expression of VEGFA 1 0.01 1.15 0.06
23 INT336993 Binding of PDIA3 and CALCRL 1 0.00 0 0.06
24 INT355438 Gene_expression of Pdia3 Negative_regulation of Gene_expression of Ddit3 1 0.05 4.79 0.06
25 INT355439 Pdia3 Regulation of Gene_expression of Eif2ak3 1 0.01 0.83 0.05
26 INT355430 Pdia3 Regulation of Gene_expression of Ddit3 1 0.04 1 0.03
27 INT355437 Negative_regulation of Pdia3 Positive_regulation of Gene_expression of Ddit3 1 0.04 0.47 0
28 INT355442 Pdia3 Regulation of Gene_expression of TNF 1 0.00 0.44 0
29 INT233267 Hoxa10 Regulation of Itgb3 1 0.15 0.14 0
30 INT355450 Pdia3 Regulation of Transcription of TNF 1 0.00 0.59 0
31 INT333926 Binding of PDIA3 and ERLEC1 1 0.02 0.18 0
32 INT240215 Binding of SEC31A and PDIA2 1 0.00 0 0
33 INT321778 Binding of P4hb and Whrn 1 0.33 0.06 0
34 INT186392 Binding of TNF and P4hb 1 0.02 0.47 0
35 INT355448 Negative_regulation of Pdia3 Positive_regulation of Gene_expression of TNF 1 0.00 0.47 0
36 INT321771 Binding of P4hb and Gsn 1 0.31 0.38 0
37 INT355436 Pdia3 Regulation of Transcription of Ddit3 1 0.04 0.59 0
38 INT355445 Gene_expression of Pdia3 Negative_regulation of Gene_expression of TNF 1 0.00 1.31 0
39 INT333931 Binding of CALR and PDIA3 1 0.18 0.18 0
40 INT233270 Meis1 Regulation of Gene_expression of Itgb3 1 0.47 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein disulfide isomerase activity. They are ordered first by their pain relevance and then by number of times they were reported in protein disulfide isomerase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9818 Positive_regulation of Pdia4 12 0.34 0.67 6.65
2 INT45725 Binding of Pdia3 8 0.47 3.61 4.42
3 INT112 Gene_expression of Pdia3 11 0.74 0.18 3.74
4 INT91349 Negative_regulation of Binding of Pdia3 1 0.57 1.12 2.59
5 INT119680 Positive_regulation of Pdia3 4 0.31 2.36 1.97
6 INT5415 Negative_regulation of Pdia4 6 0.36 0.94 1.93
7 INT12895 Negative_regulation of Positive_regulation of Pdia4 2 0.14 0 1.91
8 INT20094 Binding of Pdia3 3 0.31 1.26 1.87
9 INT16686 Regulation of Pdia4 2 0.09 0.26 1.68
10 INT125800 Gene_expression of P4HB 5 0.47 5.4 1.47
11 INT93735 Gene_expression of P4hb 6 0.49 4.63 1.39
12 INT168675 Binding of P4HB 3 0.20 1.98 1.11
13 INT47213 Negative_regulation of Binding of Pdia3 1 0.38 0.15 1.03
14 INT119682 Positive_regulation of Positive_regulation of Pdia3 1 0.10 0.22 0.99
15 INT169472 Gene_expression of PDIA2 15 0.58 7.88 0.96
16 INT66673 Regulation of Pdia3 5 0.42 2.14 0.93
17 INT150117 Localization of P4HB 3 0.78 3.81 0.91
18 INT29762 Negative_regulation of P4hb 4 0.21 1.41 0.86
19 INT112533 Localization of P4hb 5 0.50 1.82 0.85
20 INT20097 Positive_regulation of Binding of Pdia3 1 0.10 0 0.8
21 INT55141 Gene_expression of P4hb 4 0.56 0.81 0.67
22 INT11179 Negative_regulation of Gene_expression of Pdia3 1 0.56 0 0.66
23 INT141726 Gene_expression of Pdia3 4 0.59 16.67 0.58
24 INT78238 Binding of PDIA3 2 0.36 0.87 0.54
25 INT111562 Negative_regulation of P4HB 1 0.37 0 0.53
26 INT22945 Regulation of Pdia3 4 0.26 0.56 0.5
27 INT9817 Positive_regulation of Positive_regulation of Pdia4 2 0.05 0 0.5
28 INT241869 Negative_regulation of Binding of P4HB 1 0.18 0.89 0.48
29 INT79311 Positive_regulation of Positive_regulation of PDIA3 1 0.49 0.34 0.47
30 INT169473 Positive_regulation of Localization of PDIA2 2 0.18 0.89 0.43
31 INT169476 Localization of PDIA2 3 0.27 1.09 0.42
32 INT2101 Binding of Pdia4 2 0.31 0.29 0.4
33 INT154408 Negative_regulation of Gene_expression of P4hb 1 0.30 0.31 0.3
34 INT228158 Positive_regulation of PDIA2 7 0.44 2.33 0.28
35 INT55142 Positive_regulation of P4hb 3 0.36 1.38 0.28
36 INT111563 Protein_catabolism of P4HB 1 0.56 0 0.26
37 INT125780 Negative_regulation of Itgb3 2 0.39 0.66 0.25
38 INT79313 Positive_regulation of PDIA3 2 0.49 0.27 0.23
39 INT160670 Negative_regulation of Pdia3 3 0.42 0.7 0.22
40 INT355427 Positive_regulation of Gene_expression of Pdia3 1 0.09 13.45 0.22
41 INT91278 Positive_regulation of Itgb3 4 0.31 1.73 0.19
42 INT150118 Negative_regulation of Localization of P4HB 1 0.42 1.26 0.19
43 INT233246 Localization of Itgb3 3 0.54 0.25 0.17
44 INT239859 Protein_catabolism of Itgb3 1 0.64 0.25 0.17
45 INT131584 Gene_expression of PDIA3 2 0.33 0.7 0.15
46 INT228155 Binding of PDIA2 4 0.32 0.62 0.14
47 INT118011 Localization of Pdia4 1 0.02 0 0.13
48 INT233217 Gene_expression of Itgb3 16 0.75 0.98 0.11
49 INT261366 Binding of P4hb 1 0.04 1.3 0.1
50 INT223879 Negative_regulation of PDIA2 3 0.37 0.46 0.09
51 INT28505 Positive_regulation of P4hb 1 0.41 0.18 0.09
52 INT233253 Regulation of Gene_expression of Itgb3 1 0.41 0.34 0.09
53 INT51479 Gene_expression of Pdia4 2 0.57 0.15 0.08
54 INT192852 Transcription of Pdia3 1 0.24 0.99 0.08
55 INT165418 Binding of P4hb 13 0.30 4.9 0.07
56 INT168672 Positive_regulation of Binding of P4HB 1 0.20 0.35 0.07
57 INT355421 Regulation of Gene_expression of Pdia3 1 0.06 0.91 0.05
58 INT219663 Binding of Itgb3 1 0.08 1.18 0.03
59 INT355423 Negative_regulation of Gene_expression of Pdia3 1 0.05 1.07 0.03
60 INT233234 Negative_regulation of Gene_expression of Itgb3 3 0.29 0.65 0
61 INT223878 Positive_regulation of Gene_expression of PDIA2 2 0.42 0 0
62 INT286064 Positive_regulation of Pdia3 2 0.06 0.95 0
63 INT355425 Negative_regulation of Pdia3 1 0.05 2.06 0
64 INT321730 Regulation of P4hb 1 0.28 0.06 0
65 INT321737 Negative_regulation of P4hb 1 0.27 0.07 0
66 INT340877 Localization of Pdia3 1 0.39 0.09 0
67 INT321738 Negative_regulation of Localization of P4hb 1 0.37 0.26 0
68 INT233231 Regulation of Transcription of Itgb3 1 0.30 0.12 0
69 INT336754 Regulation of Gene_expression of Pdia3 1 0.44 0 0
70 INT233238 Negative_regulation of Localization of Itgb3 1 0.29 0 0
71 INT174715 Positive_regulation of Transcription of P4hb 1 0.22 0.09 0
72 INT174707 Transcription of P4hb 1 0.23 0.7 0
73 INT177632 Regulation of P4hb 1 0.01 0.14 0
74 INT355420 Positive_regulation of Transcription of Pdia3 1 0.09 0.29 0
75 INT286063 Positive_regulation of Positive_regulation of Pdia3 1 0.06 0.4 0
76 INT233251 Regulation of Localization of Itgb3 1 0.30 0 0
77 INT355419 Negative_regulation of Transcription of Pdia3 1 0.07 0.29 0
78 INT337006 Positive_regulation of Binding of PDIA3 1 0.21 0 0
79 INT355428 Transcription of Pdia3 1 0.09 0.57 0
80 INT259389 Regulation of PDIA2 1 0.24 0 0
81 INT321751 Regulation of Localization of P4hb 1 0.28 0.25 0
82 INT233240 Negative_regulation of Transcription of Itgb3 1 0.29 0 0
83 INT233257 Transcription of Itgb3 1 0.48 0.11 0
84 INT233227 Positive_regulation of Transcription of Itgb3 1 0.47 0.12 0
85 INT233228 Regulation of Itgb3 1 0.30 0 0
86 INT351020 Positive_regulation of P4HB 1 0.09 0.69 0
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