GO:0003785

From wiki-pain
Jump to: navigation, search
Name actin monomer binding
Categary Function
Go Slim No
Go Link GO:0003785
Unique Molecular Interactions 111
Total Molecular Interactions 150
Total Single Events 1560
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for actin monomer binding. They are ordered first by their pain relevance and then by number of times they were reported for actin monomer binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
2 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
3 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
4 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
5 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
6 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
7 INT109842 Prkce Positive_regulation of Localization of Trpv1 1 0.13 1.31 0.91
8 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
9 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
10 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
11 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
12 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73
13 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
14 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
15 INT112513 Binding of Prkaca and Prkce 1 0.04 0.4 0.64
16 INT112516 Binding of Prkce and Trib3 1 0.01 0.4 0.64
17 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59
18 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 0.42 0.48 0.55
19 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
20 INT144128 Binding of Gja1 and Prkce 1 0.40 0.5 0.52
21 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 0.08 0.29 0.51
22 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
23 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46
24 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
25 INT95276 Obfc2a Negative_regulation of Nos3 1 0.02 1.02 0.46
26 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46
27 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
28 INT333158 asa Positive_regulation of Nos3 1 0.11 0.18 0.32
29 INT333166 Tlx2 Positive_regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
30 INT333155 Tlx2 Regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
31 INT333152 Tlx2 Positive_regulation of Nos3 1 0.08 0.18 0.32
32 INT333169 asa Positive_regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
33 INT333164 asa Regulation of Nos3 1 0.11 0.18 0.32
34 INT333149 asa Regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
35 INT333167 Tlx2 Regulation of Nos3 1 0.08 0.18 0.32
36 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
37 INT109098 Binding of ABL2 and PON1 1 0.36 1.32 0.28
38 INT141871 Binding of Nos3 and Slc2a4 1 0.25 0.51 0.28
39 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22
40 INT122576 Pik3cd Positive_regulation of Phosphorylation of Nos3 1 0.28 0.45 0.21
41 INT274578 Binding of ABL1 and PSTPIP1 1 0.07 1.55 0.21
42 INT239227 Prkca Regulation of Nos3 1 0.02 0.97 0.2
43 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19
44 INT137417 MAPK7 Regulation of Gene_expression of NOS3 1 0.00 0.5 0.19
45 INT269333 Binding of BDKRB2 and NOS3 1 0.02 0 0.17
46 INT82802 Binding of ABL2 and POMC 1 0.00 0 0.14
47 INT269332 Binding of NOS3 and TMPO 1 0.01 0 0.12
48 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12
49 INT213042 Apoa1 Positive_regulation of Nos3 1 0.10 2.17 0.11
50 INT288616 EPO Positive_regulation of Nos3 1 0.08 0.69 0.11
51 INT274583 Binding of ABL1 and PSTPIP2 1 0.06 0.79 0.11
52 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
53 INT302511 Binding of OPA1 and Nos3 1 0.02 1.57 0.1
54 INT172816 Crp Positive_regulation of Transcription of Nos3 1 0.06 0.91 0.1
55 INT172817 Crp Positive_regulation of Regulation of Nos3 1 0.09 0.84 0.1
56 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1
57 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
58 INT252790 Binding of NOS1 and NOS3 1 0.03 0.37 0.1
59 INT249848 Fgf2 Positive_regulation of Gene_expression of Nos3 1 0.33 0.44 0.1
60 INT172819 Crp Positive_regulation of Gene_expression of Nos3 1 0.06 0.91 0.1
61 INT249851 VEGFA Positive_regulation of Gene_expression of Nos3 1 0.05 0.44 0.1
62 INT172821 Crp Positive_regulation of Negative_regulation of Nos3 1 0.06 0.84 0.1
63 INT213023 Hdl1 Regulation of Nos3 2 0.09 4.06 0.09
64 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
65 INT252803 Binding of NOS3 and ISYNA1 1 0.02 0.32 0.09
66 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
67 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
68 INT309390 Gene_expression of Sod2 Negative_regulation of Nos3 1 0.31 0.2 0.08
69 INT88054 ABL2 Regulation of Gh 1 0.02 0.57 0.08
70 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
71 INT58151 Binding of MYL3 and DMRT3 1 0.00 0.35 0.06
72 INT250015 Binding of FLNA and Nos3 1 0.05 1.09 0.06
73 INT246691 Ide Positive_regulation of Gene_expression of Nos3 1 0.03 0.26 0.05
74 INT249954 Cpa1 Positive_regulation of Nos3 1 0.04 0.36 0.05
75 INT213047 Hdl1 Positive_regulation of Gene_expression of Nos3 1 0.14 0.94 0.04
76 INT213031 Positive_regulation of Pik3r1 Positive_regulation of Gene_expression of Nos3 1 0.10 0.8 0.04
77 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03
78 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03
79 INT281908 VEGFA Positive_regulation of NOS3 1 0.14 0.14 0
80 INT249953 Cpa1 Regulation of Nos3 1 0.03 0.08 0
81 INT183248 LPA Positive_regulation of NOS3 1 0.02 0 0
82 INT292680 Negative_regulation of TXK Negative_regulation of ABL1 1 0.00 0.26 0
83 INT98710 Pdyn Negative_regulation of Nos3 1 0.02 0 0
84 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0
85 INT249935 Nos3 Regulation of Nos2 1 0.25 0.19 0
86 INT133825 TNF Negative_regulation of NOS3 1 0.28 0.06 0
87 INT305265 Obsty1 Negative_regulation of Phosphorylation of Nos3 1 0.05 0.78 0
88 INT258202 ROCK1 Positive_regulation of MYL2 1 0.14 0.2 0
89 INT249937 Nos1 Regulation of Nos3 1 0.23 0.19 0
90 INT321772 Binding of Myo7a and Twf2 1 0.00 0 0
91 INT268013 Binding of Nos3 and Acot1 1 0.02 1.48 0
92 INT340178 Car2 Positive_regulation of Positive_regulation of Nos3 1 0.01 0.26 0
93 INT305254 Obsty1 Regulation of Gene_expression of Nos3 1 0.03 0.97 0
94 INT98711 Regulation of Pdyn Negative_regulation of Nos3 1 0.02 0 0
95 INT351165 Binding of CAV1 and Nos3 1 0.09 1.46 0
96 INT260134 CGA Positive_regulation of Gene_expression of Nos3 1 0.16 0.13 0
97 INT334102 Nos3 Positive_regulation of Gene_expression of ISYNA1 1 0.01 0.59 0
98 INT133824 IL1B Negative_regulation of NOS3 1 0.48 0.06 0
99 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0
100 INT333560 NOS3 Regulation of HCK 1 0.01 0.2 0
101 INT285582 Binding of ABL1 and S100A8 1 0.02 0.2 0
102 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
103 INT227796 Binding of Acsl1 and Nos3 1 0.16 1.16 0
104 INT343716 Nos3 Positive_regulation of Pde6b 1 0.20 0 0
105 INT260564 Binding of Nos3 and T2dm2 1 0.05 3.96 0
106 INT305262 Obsty1 Positive_regulation of Phosphorylation of Nos3 1 0.05 0.96 0
107 INT260563 Hdl1 Positive_regulation of Positive_regulation of Nos3 1 0.05 1.55 0
108 INT292726 ABL1 Positive_regulation of Mapk1 1 0.01 0.15 0
109 INT343718 Nos3 Regulation of Pde6b 1 0.10 0 0
110 INT160602 Binding of ABL2 and ADH1B 1 0.40 0.36 0
111 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for actin monomer binding. They are ordered first by their pain relevance and then by number of times they were reported in actin monomer binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
2 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
3 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
4 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
5 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
6 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
7 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
8 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
9 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
10 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
11 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
12 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86
13 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62
14 INT83712 Transcription of Nos3 19 0.69 13.09 6.31
15 INT91946 Regulation of Prkce 6 0.44 4.13 5.46
16 INT109838 Phosphorylation of Prkce 6 0.67 5.26 4.95
17 INT60758 Gene_expression of Prkce 8 0.20 4.12 4.59
18 INT83991 Regulation of Nos3 25 0.44 9.89 4.06
19 INT102515 Binding of Nos3 19 0.45 9.41 4.01
20 INT109840 Localization of Prkce 5 0.74 3.01 3.45
21 INT70958 Binding of NOS3 19 0.37 11.84 3.29
22 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
23 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
24 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73
25 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7
26 INT145101 Transcription of Nos3 8 0.70 6.04 2.47
27 INT73809 Regulation of Nos3 18 0.45 10.05 2.27
28 INT17617 Gene_expression of ABL2 8 0.75 2.73 2.25
29 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17
30 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
31 INT136941 Positive_regulation of Localization of Prkce 3 0.43 1.42 2.06
32 INT124052 Binding of Prkce 2 0.06 2.52 2.03
33 INT91594 Localization of NOS3 12 0.78 5.39 2.02
34 INT76532 Binding of Nos3 13 0.37 9.32 1.87
35 INT44723 Positive_regulation of ABL2 7 0.49 2.23 1.82
36 INT60999 Localization of Nos3 12 0.74 5.28 1.75
37 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
38 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
39 INT83713 Positive_regulation of Transcription of Nos3 3 0.67 2.92 1.38
40 INT89785 Regulation of Transcription of Nos3 1 0.32 0.85 1.36
41 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
42 INT91947 Negative_regulation of Negative_regulation of Prkce 1 0.42 0.69 1.3
43 INT136612 Positive_regulation of Positive_regulation of Nos3 5 0.43 4.22 1.26
44 INT91949 Regulation of Positive_regulation of Prkce 1 0.44 0.72 1.24
45 INT212983 Positive_regulation of Positive_regulation of Nos3 9 0.51 7.08 1.23
46 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17
47 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
48 INT98174 Positive_regulation of Gene_expression of ABL2 1 0.49 1.1 1.05
49 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
50 INT136944 Positive_regulation of Positive_regulation of Prkce 2 0.46 0.8 0.85
51 INT122572 Phosphorylation of Nos3 37 0.65 25.23 0.75
52 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
53 INT109839 Positive_regulation of Phosphorylation of Prkce 1 0.18 1.27 0.71
54 INT193486 Negative_regulation of Negative_regulation of Nos3 3 0.34 2.21 0.68
55 INT181576 Phosphorylation of Nos3 7 0.59 1.35 0.6
56 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
57 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56
58 INT152068 Regulation of Gene_expression of Prkce 1 0.05 0.74 0.56
59 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
60 INT136942 Negative_regulation of Positive_regulation of Prkce 1 0.39 0.66 0.48
61 INT145100 Regulation of Transcription of Nos3 4 0.44 2.05 0.46
62 INT144095 Localization of Nos3 8 0.57 4.5 0.43
63 INT77493 Regulation of ABL2 1 0.26 0.71 0.42
64 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
65 INT193491 Negative_regulation of Positive_regulation of Nos3 2 0.36 1.67 0.4
66 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39
67 INT65292 Binding of ABL2 2 0.36 0 0.39
68 INT82806 Negative_regulation of ABL2 3 0.41 0.58 0.37
69 INT95273 Regulation of Negative_regulation of Nos3 2 0.20 0.85 0.37
70 INT73854 Transcription of ABL1 4 0.52 2.26 0.34
71 INT212933 Regulation of Binding of Nos3 2 0.34 0.88 0.24
72 INT120047 Negative_regulation of Localization of ABL2 1 0.41 0 0.23
73 INT172796 Regulation of Negative_regulation of Nos3 1 0.16 1.4 0.23
74 INT120048 Localization of ABL2 2 0.73 0.19 0.22
75 INT316565 Negative_regulation of Regulation of Nos3 1 0.32 1.01 0.22
76 INT73810 Negative_regulation of Regulation of Nos3 2 0.36 1.01 0.21
77 INT118276 Regulation of Positive_regulation of Nos3 1 0.09 0 0.21
78 INT269409 Regulation of Phosphorylation of NOS3 1 0.18 0 0.2
79 INT163997 Positive_regulation of Negative_regulation of Nos3 1 0.49 1.15 0.2
80 INT92815 Positive_regulation of Negative_regulation of NOS3 1 0.12 1.03 0.2
81 INT239412 Binding of ABL1 8 0.28 5.39 0.18
82 INT141866 Regulation of Localization of Nos3 1 0.42 0.24 0.18
83 INT257201 Positive_regulation of Negative_regulation of Nos3 1 0.12 0 0.18
84 INT269403 Regulation of Positive_regulation of NOS3 1 0.18 0 0.17
85 INT163461 Regulation of ABL1 8 0.32 5.98 0.14
86 INT82805 Negative_regulation of Binding of ABL2 1 0.00 0 0.14
87 INT145102 Positive_regulation of Transcription of Nos3 1 0.45 0.46 0.14
88 INT290701 Protein_catabolism of Nos3 1 0.54 0.42 0.13
89 INT212996 Negative_regulation of Positive_regulation of Nos3 3 0.35 2.11 0.12
90 INT269395 Regulation of Binding of NOS3 2 0.39 1.84 0.12
91 INT323261 Positive_regulation of Binding of Nos3 1 0.18 0.25 0.12
92 INT186558 Negative_regulation of Positive_regulation of NOS3 2 0.37 0.26 0.1
93 INT172791 Negative_regulation of Transcription of Nos3 1 0.17 0.9 0.1
94 INT58152 Positive_regulation of MYL3 1 0.68 0.45 0.1
95 INT309385 Positive_regulation of Phosphorylation of Nos3 5 0.48 2.98 0.09
96 INT305235 Negative_regulation of Phosphorylation of Nos3 5 0.41 4.17 0.09
97 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09
98 INT58153 Gene_expression of MYL3 1 0.76 0.69 0.08
99 INT163462 Negative_regulation of Regulation of ABL1 1 0.11 1.17 0.06
100 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05
101 INT175698 Positive_regulation of Localization of Nos3 2 0.27 1.19 0.04
102 INT350897 Negative_regulation of Binding of ABL1 1 0.18 1.19 0.04
103 INT234417 Positive_regulation of Gene_expression of ABL1 4 0.37 3.65 0.03
104 INT343710 Positive_regulation of Localization of Nos3 1 0.38 0.22 0.03
105 INT269496 Regulation of Binding of Nos3 3 0.25 0.46 0
106 INT183067 Gene_expression of MYL2 2 0.25 1.19 0
107 INT292713 Phosphorylation of ABL1 2 0.44 1.04 0
108 INT355212 Positive_regulation of Phosphorylation of Nos3 1 0.23 0.18 0
109 INT336827 Regulation of Regulation of NOS3 1 0.23 0.51 0
110 INT309384 Regulation of Phosphorylation of Nos3 1 0.31 0.39 0
111 INT350510 Localization of ABL1 1 0.40 2.51 0
112 INT249944 Positive_regulation of Regulation of Nos3 1 0.35 0.07 0
113 INT292711 Regulation of Gene_expression of ABL1 1 0.06 1.02 0
114 INT350521 Negative_regulation of Negative_regulation of ABL1 1 0.23 0.55 0
115 INT321731 Positive_regulation of Gene_expression of Twf2 1 0.15 0 0
116 INT174535 Negative_regulation of Negative_regulation of NOS3 1 0.11 0.32 0
117 INT321750 Localization of Twf2 1 0.17 0 0
118 INT321740 Gene_expression of Twf2 1 0.17 0 0
119 INT156466 Regulation of Negative_regulation of ABL1 1 0.44 0.63 0
120 INT350517 Negative_regulation of Gene_expression of ABL1 1 0.23 0.53 0
121 INT165179 Regulation of Positive_regulation of ABL1 1 0.15 0.95 0
122 INT343712 Regulation of Positive_regulation of Nos3 1 0.50 0.93 0
123 INT287863 Binding of MYL2 1 0.05 0 0
124 INT321754 Binding of Twf2 1 0.08 0 0
125 INT350512 Positive_regulation of Phosphorylation of ABL1 1 0.27 0.75 0
126 INT351489 Regulation of Transcription of ABL1 1 0.28 0.08 0
127 INT140156 Positive_regulation of Transcription of NOS3 1 0.31 0 0
128 INT350508 Protein_catabolism of ABL1 1 0.54 0.5 0
129 INT159478 Negative_regulation of Phosphorylation of NOS3 1 0.51 0 0
130 INT321746 Regulation of Gene_expression of Twf2 1 0.10 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox