GO:0003950

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Name NAD+ ADP-ribosyltransferase activity
Categary Function
Go Slim No
Go Link GO:0003950
Unique Molecular Interactions 60
Total Molecular Interactions 85
Total Single Events 994
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for NAD+ ADP-ribosyltransferase activity. They are ordered first by their pain relevance and then by number of times they were reported for NAD+ ADP-ribosyltransferase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
2 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
3 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
4 INT149684 Negative_regulation of Parp1 Positive_regulation of Oprm1 1 0.51 0 0.65
5 INT149681 Parp1 Regulation of Transcription of Oprm1 1 0.67 0 0.63
6 INT149682 Parp1 Negative_regulation of Oprm1 1 0.47 0 0.6
7 INT149683 Parp1 Negative_regulation of Transcription of Oprm1 1 0.47 0 0.58
8 INT155921 PARP1 Positive_regulation of Gene_expression of IL6 1 0.49 0.44 0.48
9 INT227495 Regulation of Binding of TCEA1 and SIRT2 1 0.01 0.45 0.45
10 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
11 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
12 INT341378 Positive_regulation of Ros1 Positive_regulation of Parp1 1 0.01 1.08 0.22
13 INT81159 Binding of PARP1 and IgG-2a 1 0.00 1.02 0.21
14 INT287693 Parp1 Positive_regulation of Positive_regulation of Nfkb1 1 0.07 0.54 0.2
15 INT336503 Parp1 Positive_regulation of Tubgcp2 1 0.11 0.52 0.13
16 INT336504 Parp1 Positive_regulation of Mcpt3 1 0.11 0.52 0.13
17 INT336506 Parp1 Positive_regulation of Cxcl2 1 0.16 0.52 0.13
18 INT336505 Parp1 Positive_regulation of Mcpt1 1 0.14 0.52 0.13
19 INT64188 ART3 Negative_regulation of HSD17B2 1 0.00 0 0.09
20 INT344254 Binding of PARP1 and CASP3 1 0.06 0.94 0.06
21 INT253193 Ros1 Regulation of Parp1 1 0.01 0.57 0.05
22 INT322358 Binding of Parp1 and Casp3 1 0.05 1.08 0.04
23 INT261962 Binding of Parp1 and El4 1 0.19 1.33 0.03
24 INT250796 Tlr4 Positive_regulation of Parp1 1 0.14 1 0.03
25 INT225479 Binding of Parp1 and Acsl1 1 0.00 0 0
26 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
27 INT66344 ANTXR1 Positive_regulation of ART1 1 0.00 0.69 0
28 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
29 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
30 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
31 INT155920 PARP1 Regulation of Gene_expression of IL6 1 0.19 0.08 0
32 INT308927 Gtf2i Positive_regulation of Gene_expression of Parp1 1 0.24 0 0
33 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
34 INT155926 PARP1 Regulation of Binding of NFKB1 1 0.24 0.16 0
35 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
36 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0
37 INT155916 PARP1 Positive_regulation of Gene_expression of TNF 1 0.42 0 0
38 INT155923 Negative_regulation of PARP1 Negative_regulation of Gene_expression of TNF 1 0.36 0.07 0
39 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
40 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
41 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
42 INT225614 Binding of XRCC5 and Parp1 1 0.09 0 0
43 INT341377 Gene_expression of Ros1 Positive_regulation of Parp1 1 0.01 1.03 0
44 INT233020 SFTPA1 Negative_regulation of Parp1 1 0.00 0.58 0
45 INT155919 Gene_expression of PARP1 Positive_regulation of Gene_expression of IL6 1 0.33 0 0
46 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
47 INT322363 TNF Positive_regulation of Positive_regulation of Parp1 1 0.02 1.54 0
48 INT155922 PARP1 Positive_regulation of Binding of NFKB1 1 0.42 0.06 0
49 INT155924 Binding of PARP1 and NFKB1 1 0.34 0.23 0
50 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
51 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
52 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
53 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
54 INT233117 Binding of SIRT2 and PAMR1 1 0.00 0 0
55 INT155925 PARP1 Positive_regulation of NFKB1 1 0.42 0.06 0
56 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
57 INT233118 Binding of SIRT2 and AICDA 1 0.00 0.21 0
58 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for NAD+ ADP-ribosyltransferase activity. They are ordered first by their pain relevance and then by number of times they were reported in NAD+ ADP-ribosyltransferase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84
2 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77
3 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56
4 INT126583 Positive_regulation of PARP1 50 0.68 41.44 7.78
5 INT10992 Gene_expression of PARP1 32 0.76 22.22 3.74
6 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36
7 INT155091 Localization of PARP1 15 0.63 13.34 3.15
8 INT123815 Gene_expression of Parp1 42 0.67 27.82 3.02
9 INT107677 Positive_regulation of Parp1 7 0.45 9.77 3
10 INT107674 Negative_regulation of Parp1 7 0.27 8.91 2.88
11 INT163833 Positive_regulation of Localization of PARP1 7 0.28 7.54 2.14
12 INT155928 Positive_regulation of Gene_expression of PARP1 13 0.68 6.54 2.1
13 INT153800 Positive_regulation of Protein_catabolism of PARP1 18 0.49 16.16 1.89
14 INT10993 Regulation of PARP1 4 0.26 2.04 1.89
15 INT180134 Gene_expression of SIRT2 70 0.11 6.95 1.84
16 INT131818 Binding of Parp1 14 0.46 8.74 1.76
17 INT63586 Regulation of Parp1 5 0.43 3.28 1.68
18 INT97053 Transcription of Parp1 3 0.66 2.04 1.43
19 INT175508 Protein_catabolism of Parp1 30 0.85 30 1.09
20 INT123816 Positive_regulation of Gene_expression of Parp1 9 0.50 6.64 1.04
21 INT153125 Negative_regulation of Protein_catabolism of PARP1 8 0.32 6.57 0.98
22 INT180136 Localization of SIRT2 15 0.12 1.42 0.88
23 INT147616 Negative_regulation of Positive_regulation of Parp1 3 0.43 2.53 0.84
24 INT157610 Gene_expression of Parp1 4 0.58 2.16 0.77
25 INT180139 Protein_catabolism of SIRT2 11 0.14 1.1 0.72
26 INT123814 Positive_regulation of Positive_regulation of Parp1 9 0.50 9.32 0.57
27 INT126585 Positive_regulation of Positive_regulation of PARP1 3 0.55 2.84 0.56
28 INT126586 Binding of PARP1 15 0.43 4.96 0.53
29 INT109867 Negative_regulation of Negative_regulation of Parp1 2 0.42 3.37 0.49
30 INT126584 Regulation of Positive_regulation of PARP1 1 0.24 0.78 0.49
31 INT107676 Positive_regulation of Protein_catabolism of Parp1 1 0.10 0.91 0.48
32 INT233013 Positive_regulation of Positive_regulation of Parp1 1 0.23 1.78 0.47
33 INT107675 Negative_regulation of Protein_catabolism of Parp1 1 0.08 0.91 0.47
34 INT107678 Protein_catabolism of Parp1 1 0.19 0.9 0.47
35 INT157609 Regulation of Parp1 2 0.26 1.4 0.43
36 INT180142 Negative_regulation of SIRT2 10 0.07 0.19 0.41
37 INT180138 Negative_regulation of Gene_expression of SIRT2 2 0.07 0.19 0.41
38 INT291905 Localization of ART1 1 0.01 0.27 0.38
39 INT10994 Regulation of Gene_expression of PARP1 1 0.01 0.2 0.38
40 INT186468 Positive_regulation of Protein_catabolism of Parp1 2 0.33 5.05 0.34
41 INT154804 Negative_regulation of Positive_regulation of PARP1 2 0.34 3.88 0.33
42 INT352918 Transcription of PARP1 1 0.25 0.85 0.33
43 INT287690 Negative_regulation of Positive_regulation of Parp1 1 0.20 0.65 0.33
44 INT36626 Negative_regulation of ART1 1 0.14 0.32 0.32
45 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
46 INT153126 Negative_regulation of Gene_expression of PARP1 3 0.19 2.09 0.29
47 INT180144 Binding of SIRT2 57 0.06 1.29 0.27
48 INT169195 Negative_regulation of Localization of PARP1 1 0.27 0.99 0.26
49 INT287683 Regulation of Gene_expression of Parp1 1 0.21 0.64 0.26
50 INT207809 Positive_regulation of Negative_regulation of Parp1 2 0.50 1.01 0.2
51 INT175663 Positive_regulation of SIRT2 56 0.14 3.58 0.17
52 INT175532 Localization of Parp1 9 0.74 5.73 0.17
53 INT250795 Negative_regulation of Gene_expression of Parp1 4 0.41 5.01 0.15
54 INT199856 Negative_regulation of Protein_catabolism of Parp1 2 0.41 1.46 0.15
55 INT325373 Negative_regulation of Binding of PARP1 1 0.31 0.98 0.15
56 INT233124 Positive_regulation of Gene_expression of SIRT2 17 0.04 0.16 0.14
57 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
58 INT253175 Regulation of Positive_regulation of Parp1 2 0.52 0.97 0.08
59 INT175513 Positive_regulation of Localization of Parp1 2 0.23 2.23 0.07
60 INT256156 Positive_regulation of ART1 1 0.01 0.21 0.07
61 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
62 INT253176 Regulation of Gene_expression of Parp1 2 0.23 0.61 0.05
63 INT257999 Phosphorylation of PARP1 1 0.12 0.28 0.05
64 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
65 INT155929 Positive_regulation of Negative_regulation of PARP1 2 0.49 1.02 0.04
66 INT236481 Negative_regulation of Negative_regulation of PARP1 1 0.15 0.95 0.04
67 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
68 INT204349 Regulation of SIRT1 8 0.61 1.99 0
69 INT233125 Positive_regulation of Positive_regulation of SIRT2 4 0.04 0 0
70 INT204353 Transcription of SIRT1 3 0.68 0.67 0
71 INT180140 Regulation of SIRT2 3 0.04 0 0
72 INT233126 Regulation of Gene_expression of SIRT2 2 0.03 0 0
73 INT180146 Positive_regulation of Binding of SIRT2 2 0.08 0 0
74 INT155927 Positive_regulation of Binding of PARP1 2 0.49 0.32 0
75 INT271494 Binding of ART1 1 0.01 0.66 0
76 INT233120 Regulation of Binding of SIRT2 1 0.03 0 0
77 INT175530 Regulation of Protein_catabolism of Parp1 1 0.09 1.36 0
78 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
79 INT330573 Gene_expression of ART1 1 0.01 0.5 0
80 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
81 INT301188 Regulation of Positive_regulation of SIRT2 1 0.03 1.05 0
82 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
83 INT207802 Regulation of Localization of Parp1 1 0.45 0.35 0
84 INT180143 Phosphorylation of SIRT2 1 0.13 0 0
85 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
86 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
87 INT276275 Positive_regulation of Localization of SIRT2 1 0.04 0 0
88 INT276271 Transcription of SIRT2 1 0.05 0 0
89 INT276273 Positive_regulation of Protein_catabolism of SIRT2 1 0.04 0.06 0
90 INT204331 Binding of SIRT1 1 0.47 0.39 0
91 INT233121 Negative_regulation of Positive_regulation of SIRT2 1 0.03 0.26 0
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