GO:0004000

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Name adenosine deaminase activity
Categary Function
Go Slim No
Go Link GO:0004000
Unique Molecular Interactions 109
Total Molecular Interactions 153
Total Single Events 1555
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for adenosine deaminase activity. They are ordered first by their pain relevance and then by number of times they were reported for adenosine deaminase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9546 Binding of Adarb1 and Penk 5 0.03 0 5.1
2 INT107331 Binding of PPBP and Adarb1 1 0.01 0 3.67
3 INT128513 Pnoc Regulation of Adarb1 1 0.01 0.92 3.14
4 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
5 INT164665 Adarb1 Positive_regulation of Negative_regulation of Tens1 1 0.03 0.42 1.97
6 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
7 INT30146 Binding of Adarb1 and Pdyn 1 0.01 0.17 1.91
8 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
9 INT67966 Cck Positive_regulation of Adarb1 2 0.03 0 1.63
10 INT94033 Binding of Adarb1 and SLAMF6 1 0.01 0 1.61
11 INT128512 Regulation of Pnoc Regulation of Adarb1 1 0.01 0.46 1.58
12 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 3 0.10 0.1 1.44
13 INT298458 Binding of Calcrl and Adarb1 1 0.00 0.23 1.41
14 INT73377 Npy Regulation of Adarb1 2 0.03 0.15 1.38
15 INT29599 Binding of Cyp21a1 and Adarb1 1 0.01 0 1.38
16 INT94630 Positive_regulation of Adarb1 Positive_regulation of Gene_expression of Fos 2 0.03 0.1 1.32
17 INT112097 Sstr1 Positive_regulation of Adarb1 1 0.02 0.15 1.29
18 INT298454 Prkcg Positive_regulation of Phosphorylation of Adarb1 1 0.00 0.41 1.19
19 INT109380 Binding of Adarb1 and Fos 1 0.02 0.38 1.19
20 INT351715 Pax3 Negative_regulation of Adarb1 1 0.00 0 1.19
21 INT73075 Adarb1 Regulation of Fos 1 0.01 0.07 1.18
22 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
23 INT21331 Binding of Adarb1 and Gm5195 1 0.00 0.26 1.08
24 INT33338 Adarb1 Positive_regulation of Localization of Gh1 1 0.04 0 1.08
25 INT33336 Adarb1 Positive_regulation of Negative_regulation of Gh1 1 0.03 0 1.08
26 INT33337 Adarb1 Positive_regulation of Gh1 1 0.03 0 1.08
27 INT121089 Binding of Oprd1 and Adarb1 2 0.06 0 1.07
28 INT132701 Adarb1 Negative_regulation of Gene_expression of Fos 1 0.01 0.73 1.07
29 INT57509 Trh Negative_regulation of Adarb1 1 0.02 0.22 1.05
30 INT57508 Pomc Negative_regulation of Adarb1 1 0.01 0.22 1.05
31 INT71000 Positive_regulation of Adarb1 Positive_regulation of Odc1 1 0.01 0 1
32 INT162299 Negative_regulation of Adarb1 Negative_regulation of Gene_expression of Calca 1 0.01 0.93 1
33 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
34 INT86350 Negative_regulation of Adarb1 Negative_regulation of Positive_regulation of Fos 1 0.04 0.8 0.92
35 INT113542 Binding of Calca and Adarb1 2 0.00 0.44 0.85
36 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
37 INT41108 Adarb1 Positive_regulation of Localization of Ins1 1 0.03 0 0.81
38 INT70422 Binding of Htr1a and Adarb1 1 0.01 0.37 0.81
39 INT61052 Binding of Adarb1 and Negative_regulation of Gene_expression of Odc1 1 0.02 0 0.81
40 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
41 INT111129 Adarb1 Regulation of Gene_expression of Fos 1 0.09 0 0.79
42 INT96307 Binding of Pnoc and Adarb1 1 0.12 0.37 0.77
43 INT73087 Adarb1 Positive_regulation of Fos 1 0.02 0 0.76
44 INT13344 Binding of Npy and Adarb1 2 0.02 0.41 0.73
45 INT72318 Adarb1 Positive_regulation of Positive_regulation of Cck 1 0.04 0 0.72
46 INT83714 Adarb1 Positive_regulation of Localization of Sst 1 0.00 0.9 0.72
47 INT107330 Binding of Adarb1 and Trh 1 0.01 0 0.65
48 INT124904 Binding of Tacr1 and Adarb1 2 0.01 0.5 0.63
49 INT52478 Binding of Adarb1 and Ift172 1 0.00 0 0.62
50 INT53312 Adarb1 Regulation of Regulation of Cfp 1 0.02 0.2 0.6
51 INT133500 Calca Negative_regulation of Adarb1 1 0.02 0.26 0.59
52 INT59635 Binding of Adarb1 and Gnaz 1 0.01 0 0.55
53 INT69178 Binding of SLC3A2 and Adarb1 1 0.00 0.16 0.53
54 INT69179 Binding of UBA7 and Adarb1 1 0.00 0.16 0.53
55 INT93616 Binding of Adarb1 and Ngf 1 0.08 0.6 0.51
56 INT73056 Binding of Hrh1 and Adarb1 1 0.00 0.25 0.49
57 INT110300 Cartpt Regulation of Adarb1 1 0.14 0 0.49
58 INT151890 Binding of PRLR and Adarb1 1 0.00 0 0.45
59 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
60 INT142171 Positive_regulation of Adarb1 Positive_regulation of Apcs 1 0.01 0.19 0.43
61 INT309199 Abat Positive_regulation of Adarb1 1 0.00 0 0.42
62 INT73453 Negative_regulation of Adarb1 Negative_regulation of Gene_expression of Fos 1 0.02 0 0.42
63 INT36783 Binding of Cck and Adarb1 1 0.27 0 0.41
64 INT272363 Binding of Adar and Adarb1 3 0.26 0.76 0.36
65 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35
66 INT4638 Binding of Agt and Adarb1 3 0.01 0 0.34
67 INT26071 Adarb1 Regulation of Localization of Crh 1 0.01 0.21 0.32
68 INT107944 Crh Regulation of Adarb1 1 0.06 0 0.32
69 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
70 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
71 INT107943 IgG-2a Positive_regulation of Adarb1 1 0.04 0 0.3
72 INT65523 Binding of Adarb1 and Oprl1 1 0.02 0 0.28
73 INT83540 Cck Regulation of Adarb1 1 0.01 0.06 0.26
74 INT51045 Adarb1 Regulation of Localization of Pgc 1 0.01 0 0.25
75 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
76 INT136492 Binding of Adarb1 and Sigmar1 1 0.03 0.1 0.21
77 INT272365 Gene_expression of Adarb1 Positive_regulation of Gene_expression of GRIA1 1 0.00 0.26 0.09
78 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08
79 INT351760 Adarb1 Regulation of Gria2 1 0.30 1.7 0.07
80 INT13343 Binding of Pomc and Adarb1 1 0.00 0.31 0.03
81 INT158907 Ogt Negative_regulation of Gene_expression of Ada 1 0.44 0 0
82 INT104529 Ada Negative_regulation of Positive_regulation of FSCN1 1 0.03 0 0
83 INT272364 Gene_expression of Adar Negative_regulation of Adarb1 1 0.31 0.17 0
84 INT104530 Ada Negative_regulation of FSCN1 1 0.03 0 0
85 INT210873 Binding of Ntrk2 and Adarb1 1 0.00 0 0
86 INT312950 Binding of ADA and HBN1 1 0.01 0.49 0
87 INT281718 Binding of Adar and Adarb2 1 0.11 0.21 0
88 INT351761 Adar Negative_regulation of Gene_expression of Adarb1 1 0.27 0.8 0
89 INT351762 Adarb1 Regulation of Car2 1 0.11 0.68 0
90 INT158906 Ogt Negative_regulation of Ada 1 0.33 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for adenosine deaminase activity. They are ordered first by their pain relevance and then by number of times they were reported in adenosine deaminase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92
2 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57
3 INT4637 Binding of Adarb1 132 0.41 14.48 67.76
4 INT6165 Gene_expression of Adarb1 85 0.58 18.39 51.03
5 INT12502 Regulation of Adarb1 50 0.53 7.58 30.01
6 INT21072 Localization of Adarb1 26 0.69 2.76 17.95
7 INT32802 Negative_regulation of Ada 21 0.57 4.03 14.87
8 INT18616 Positive_regulation of Positive_regulation of Adarb1 18 0.33 2.04 13.18
9 INT113765 Phosphorylation of Adarb1 10 0.05 4.91 10.51
10 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
11 INT4663 Positive_regulation of Ada 17 0.69 9.48 7.93
12 INT21435 Positive_regulation of Negative_regulation of Adarb1 7 0.39 3.13 6.5
13 INT29674 Gene_expression of Ada 16 0.78 4.59 5.69
14 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63
15 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18
16 INT14159 Negative_regulation of Positive_regulation of Adarb1 8 0.08 2.06 5.14
17 INT36256 Regulation of Ada 9 0.62 4.99 5.07
18 INT9767 Negative_regulation of Ada 5 0.55 0.06 5.06
19 INT25796 Regulation of Gene_expression of Adarb1 6 0.26 2.77 4.3
20 INT134590 Localization of ADA 7 0.65 8.43 3.96
21 INT80902 Negative_regulation of Gene_expression of Adarb1 4 0.25 1.82 3.56
22 INT72798 Binding of ADA 12 0.47 7.84 3.39
23 INT9578 Regulation of Binding of Adarb1 4 0.09 0.21 3.37
24 INT19392 Gene_expression of Ada 9 0.77 7.4 3.17
25 INT272358 Gene_expression of Adarb1 19 0.73 26.94 3.11
26 INT34604 Binding of Ada 11 0.31 4.15 3.1
27 INT9766 Positive_regulation of Ada 2 0.47 0.4 3.09
28 INT113768 Positive_regulation of Phosphorylation of Adarb1 3 0.04 1.37 3.02
29 INT131494 Regulation of ADA 8 0.52 7.37 2.97
30 INT16773 Negative_regulation of Binding of Adarb1 7 0.37 0 2.48
31 INT64543 Transcription of Adarb1 4 0.59 0 2.43
32 INT81312 Positive_regulation of Gene_expression of Ada 2 0.50 1.58 2.26
33 INT61806 Regulation of Negative_regulation of Ada 1 0.30 0.63 1.89
34 INT34287 Regulation of Positive_regulation of Adarb1 3 0.10 0.47 1.8
35 INT34605 Localization of Ada 7 0.80 0.13 1.61
36 INT137927 Positive_regulation of Positive_regulation of Ada 1 0.03 1.31 1.47
37 INT57866 Positive_regulation of Gene_expression of Adarb1 2 0.04 0.25 1.44
38 INT30277 Protein_catabolism of Ada 3 0.52 0.9 1.42
39 INT181873 Regulation of Localization of ADA 1 0.07 1.98 1.41
40 INT72321 Regulation of Negative_regulation of Adarb1 2 0.07 0.15 1.22
41 INT75893 Negative_regulation of Localization of Adarb1 1 0.33 0.51 1.2
42 INT272347 Positive_regulation of Gene_expression of Adarb1 9 0.65 4.43 1.15
43 INT192073 Positive_regulation of Gene_expression of ADA 8 0.47 10.35 1.12
44 INT238636 Regulation of Ada 2 0.15 1.12 1.06
45 INT154275 Regulation of Regulation of Adarb1 1 0.03 1.23 1.04
46 INT322390 Protein_catabolism of Adarb1 1 0.01 0 1.02
47 INT272351 Regulation of Adar 5 0.50 1.56 0.99
48 INT238637 Binding of Ada 2 0.26 1.01 0.94
49 INT65934 Negative_regulation of Negative_regulation of Adarb1 1 0.02 0 0.94
50 INT272350 Regulation of Adarb1 4 0.48 5.85 0.9
51 INT313713 Positive_regulation of Regulation of Adar 1 0.41 0 0.84
52 INT68200 Protein_catabolism of Ada 2 0.44 0.68 0.83
53 INT51623 Positive_regulation of Binding of Adarb1 2 0.03 0 0.81
54 INT279366 Positive_regulation of Localization of ADA 2 0.42 4.37 0.76
55 INT272331 Negative_regulation of Gene_expression of Adarb1 2 0.55 9.6 0.73
56 INT126402 Gene_expression of Adarb2 4 0.30 1.87 0.72
57 INT40605 Negative_regulation of Negative_regulation of Ada 1 0.32 0 0.7
58 INT272360 Gene_expression of Adar 13 0.61 4.33 0.69
59 INT55049 Regulation of Localization of Adarb1 1 0.02 0 0.67
60 INT210028 Protein_catabolism of ADA 1 0.07 0.13 0.62
61 INT47671 Positive_regulation of Localization of Adarb1 1 0.01 0 0.58
62 INT272342 Regulation of Gene_expression of Adarb1 5 0.58 5.72 0.5
63 INT272362 Binding of Adarb1 8 0.38 0.84 0.46
64 INT113767 Regulation of Phosphorylation of Adarb1 1 0.03 0 0.46
65 INT143682 Negative_regulation of Gene_expression of Ada 2 0.54 0.28 0.44
66 INT143683 Negative_regulation of Gene_expression of ADA 1 0.09 0.28 0.44
67 INT272338 Negative_regulation of Adarb1 4 0.46 8.88 0.43
68 INT56363 Regulation of Gene_expression of Ada 1 0.06 0.59 0.42
69 INT272348 Binding of Adar 8 0.38 1.01 0.36
70 INT272330 Positive_regulation of Adar 2 0.34 0.05 0.33
71 INT279365 Regulation of Regulation of ADA 1 0.23 0 0.33
72 INT272349 Positive_regulation of Adarb1 6 0.44 1.76 0.3
73 INT272357 Localization of Adarb1 7 0.63 0.35 0.24
74 INT272332 Positive_regulation of Localization of Adarb1 2 0.54 0.15 0.19
75 INT272343 Transcription of Adarb1 4 0.64 1.94 0.18
76 INT272329 Positive_regulation of Transcription of Adarb1 1 0.54 0.2 0.15
77 INT272352 Negative_regulation of Positive_regulation of Adarb1 1 0.29 0.2 0.15
78 INT272354 Regulation of Gene_expression of Adar 1 0.49 0.31 0.14
79 INT323226 Negative_regulation of Localization of ADA 1 0.35 3.05 0.1
80 INT110170 Positive_regulation of Positive_regulation of ADA 1 0.49 0.46 0.1
81 INT272344 Transcription of Adar 4 0.57 1.85 0.04
82 INT352834 Protein_catabolism of Adar 1 0.56 0.15 0.04
83 INT272346 Regulation of Transcription of Adar 2 0.36 0.96 0
84 INT272335 Positive_regulation of Transcription of Adar 1 0.40 0 0
85 INT272345 Binding of Adarb2 1 0.21 0.14 0
86 INT351755 Regulation of Transcription of Adarb1 1 0.42 0.86 0
87 INT272339 Positive_regulation of Adarb2 1 0.22 0.12 0
88 INT351754 Negative_regulation of Gene_expression of Adar 1 0.39 1.78 0
89 INT272334 Regulation of Binding of Adarb2 1 0.20 0.14 0
90 INT272359 Positive_regulation of Gene_expression of Adar 1 0.55 1.47 0
91 INT351756 Positive_regulation of Regulation of Adarb1 1 0.47 1.35 0
92 INT272353 Negative_regulation of Adarb2 1 0.26 2.8 0
93 INT351753 Negative_regulation of Transcription of Adar 1 0.28 0.91 0
94 INT272337 Positive_regulation of Binding of Adar 1 0.40 0 0
95 INT351752 Regulation of Regulation of Adarb1 1 0.42 0.76 0
96 INT272341 Positive_regulation of Binding of Adarb1 1 0.39 0 0
97 INT351757 Negative_regulation of Transcription of Adarb1 1 0.40 0.9 0
98 INT272336 Localization of Adar 1 0.63 0.12 0
99 INT351758 Regulation of Positive_regulation of Adarb1 1 0.25 1.23 0
100 INT272361 Negative_regulation of Adar 1 0.40 0.37 0
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