GO:0004003

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Name ATP-dependent DNA helicase activity
Categary Function
Go Slim No
Go Link GO:0004003
Unique Molecular Interactions 41
Total Molecular Interactions 79
Total Single Events 252
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ATP-dependent DNA helicase activity. They are ordered first by their pain relevance and then by number of times they were reported for ATP-dependent DNA helicase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
2 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
3 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
4 INT56250 Binding of NBN and NCOR2 1 0.00 0 0.3
5 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21
6 INT132054 NBN Positive_regulation of NOS1 1 0.00 0.08 0.2
7 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
8 INT309511 Binding of Xrcc6 and Xrcc5 1 0.18 1.18 0.08
9 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08
10 INT267152 Binding of LEP and DDX12P 1 0.00 0.69 0.05
11 INT273519 NBN Negative_regulation of YOD1 1 0.03 0.56 0.03
12 INT306511 Binding of XRCC6 and Ung 1 0.00 0.78 0
13 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0
14 INT284919 XRCC6 Negative_regulation of BAX 1 0.01 0.64 0
15 INT309515 Xrcc6 Regulation of Gene_expression of Htt 1 0.32 0.08 0
16 INT290022 Binding of PPARG and DDX12P 1 0.00 1.77 0
17 INT306509 Binding of XRCC6 and Clu 1 0.37 0.27 0
18 INT225642 Binding of XRCC5 and Acsl1 1 0.01 0 0
19 INT309517 Binding of Bax and Xrcc6 1 0.15 0.5 0
20 INT309519 Xrcc5 Regulation of Gene_expression of Htt 1 0.18 0.08 0
21 INT273518 Binding of ALB and NBN 1 0.06 0.47 0
22 INT253014 Binding of XRCC5 and Zic2 1 0.00 0.14 0
23 INT309512 Negative_regulation of Xrcc6 Positive_regulation of Phosphorylation of Gopc 1 0.20 0.17 0
24 INT149429 ERCC2 Negative_regulation of Localization of IL8 1 0.05 0.38 0
25 INT225614 Binding of XRCC5 and Parp1 1 0.09 0 0
26 INT252904 Binding of PRKDC and XRCC5 1 0.00 0.14 0
27 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
28 INT149431 ERCC2 Negative_regulation of Localization of Il6 1 0.14 0.2 0
29 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0
30 INT309518 Negative_regulation of Binding of Bax and Xrcc6 1 0.16 0.25 0
31 INT309516 Htt Positive_regulation of Gene_expression of Xrcc6 1 0.49 0.06 0
32 INT309509 Negative_regulation of Binding of Xrcc6 and Htt 1 0.31 0.41 0
33 INT309510 Htt Regulation of Gene_expression of Xrcc6 1 0.19 0.15 0
34 INT309508 Htt Negative_regulation of Binding of Xrcc6 1 0.31 0.48 0
35 INT149432 ERCC2 Regulation of Localization of Il6 1 0.15 1.06 0
36 INT286186 Binding of Blm and Fig4 1 0.09 0.34 0
37 INT149428 ERCC2 Regulation of Localization of IL8 1 0.05 0.53 0
38 INT199736 PRB1 Regulation of DHX9 1 0.00 0 0
39 INT309514 Positive_regulation of Binding of Xrcc6 and Htt 1 0.33 0 0
40 INT315814 Tst Positive_regulation of Localization of RTEL1 1 0.02 2.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ATP-dependent DNA helicase activity. They are ordered first by their pain relevance and then by number of times they were reported in ATP-dependent DNA helicase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
2 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
3 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
4 INT199741 Gene_expression of DHX9 6 0.17 0.28 0.83
5 INT117083 Localization of RTEL1 5 0.60 9.1 0.8
6 INT56251 Binding of NBN 4 0.38 3.16 0.62
7 INT134070 Binding of ERCC2 3 0.27 0.76 0.51
8 INT186882 Gene_expression of RTEL1 13 0.27 13.45 0.49
9 INT309465 Gene_expression of Xrcc6 24 0.59 5.49 0.43
10 INT148087 Positive_regulation of RTEL1 9 0.17 5.13 0.41
11 INT226818 Negative_regulation of RTEL1 1 0.06 1.17 0.41
12 INT103901 Regulation of ERCC2 1 0.23 0.51 0.4
13 INT309493 Binding of Xrcc6 1 0.37 3 0.2
14 INT267166 Binding of DDX12P 1 0.01 3.34 0.18
15 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16
16 INT142384 Gene_expression of XRCC6 3 0.58 1.98 0.16
17 INT309492 Positive_regulation of Gene_expression of Xrcc6 1 0.38 1.29 0.13
18 INT231413 Negative_regulation of NBN 3 0.46 4.6 0.11
19 INT286183 Regulation of Blm 1 0.36 1.3 0.09
20 INT286184 Gene_expression of Blm 1 0.39 2.16 0.09
21 INT309460 Binding of Xrcc5 1 0.16 0.09 0.08
22 INT231412 Positive_regulation of NBN 3 0.55 3.13 0.07
23 INT309478 Regulation of Gene_expression of Xrcc6 1 0.21 0.36 0.07
24 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07
25 INT273525 Regulation of NBN 1 0.49 1.28 0.05
26 INT315806 Phosphorylation of RTEL1 1 0.04 0.68 0.03
27 INT291906 Positive_regulation of Negative_regulation of ERCC2 1 0.40 0 0.03
28 INT186878 Binding of RTEL1 7 0.12 4.75 0
29 INT284963 Binding of XRCC6 2 0.36 1.57 0
30 INT315808 Positive_regulation of Protein_catabolism of RTEL1 1 0.03 0.98 0
31 INT309463 Regulation of Negative_regulation of Xrcc6 1 0.18 0.15 0
32 INT315810 Positive_regulation of Gene_expression of RTEL1 1 0.03 1.77 0
33 INT186880 Regulation of RTEL1 1 0.11 0.54 0
34 INT315811 Negative_regulation of Binding of RTEL1 1 0.02 0.86 0
35 INT309499 Localization of Xrcc6 1 0.57 0.13 0
36 INT309491 Negative_regulation of Gene_expression of Xrcc6 1 0.32 0.56 0
37 INT350511 Negative_regulation of XRCC6 1 0.08 0.58 0
38 INT309475 Positive_regulation of Binding of Xrcc6 1 0.53 0 0
39 INT309464 Negative_regulation of Negative_regulation of Xrcc6 1 0.45 0.09 0
40 INT309472 Protein_catabolism of Xrcc6 1 0.67 0.43 0
41 INT309468 Transcription of Xrcc6 1 0.52 0.24 0
42 INT350522 Positive_regulation of Gene_expression of XRCC6 1 0.11 0.53 0
43 INT260848 Transcription of NBN 1 0.57 0.54 0
44 INT199745 Binding of DHX9 1 0.07 0 0
45 INT320730 Positive_regulation of Gene_expression of NBN 1 0.60 1.84 0
46 INT348467 Positive_regulation of XRCC5 1 0.25 0.43 0
47 INT260850 Regulation of Gene_expression of NBN 1 0.38 0.57 0
48 INT315970 Regulation of Gene_expression of RTEL1 1 0.03 1.35 0
49 INT309467 Gene_expression of Xrcc5 1 0.26 0.1 0
50 INT309483 Positive_regulation of Xrcc5 1 0.20 0.1 0
51 INT309461 Negative_regulation of Xrcc6 1 0.45 0.92 0
52 INT309476 Positive_regulation of Protein_catabolism of Xrcc6 1 0.38 0.43 0
53 INT169276 Localization of NBN 1 0.08 0.08 0
54 INT186879 Positive_regulation of Positive_regulation of RTEL1 1 0.12 0.29 0
55 INT199740 Regulation of DHX9 1 0.02 0 0
56 INT309502 Positive_regulation of Xrcc6 1 0.38 1.58 0
57 INT234190 Gene_expression of BRIP1 1 0.55 0.6 0
58 INT149430 Localization of ERCC2 1 0.43 0.76 0
59 INT315807 Protein_catabolism of RTEL1 1 0.05 0.84 0
60 INT286182 Positive_regulation of Gene_expression of Blm 1 0.29 0.53 0
61 INT309479 Negative_regulation of Binding of Xrcc6 1 0.28 0.25 0
62 INT309488 Negative_regulation of Localization of Xrcc6 1 0.32 0.13 0
63 INT273522 Negative_regulation of Gene_expression of NBN 1 0.34 0.91 0
64 INT199739 Negative_regulation of DHX9 1 0.08 0 0
65 INT315809 Regulation of Protein_catabolism of RTEL1 1 0.03 0.97 0
66 INT309503 Phosphorylation of Xrcc6 1 0.54 0.55 0
67 INT315971 Transcription of RTEL1 1 0.04 1.28 0
68 INT225463 Binding of XRCC5 1 0.36 0 0
69 INT290039 Gene_expression of DDX12P 1 0.00 1.41 0
70 INT352864 Regulation of BRIP1 1 0.51 0.13 0
71 INT314546 Positive_regulation of DHX9 1 0.03 0 0
72 INT309480 Positive_regulation of Negative_regulation of Xrcc6 1 0.38 0.12 0
73 INT186881 Positive_regulation of Binding of RTEL1 1 0.12 0.5 0
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