GO:0004016

From wiki-pain
Jump to: navigation, search
Name adenylate cyclase activity
Categary Function
Go Slim No
Go Link GO:0004016
Unique Molecular Interactions 126
Total Molecular Interactions 136
Total Single Events 1195
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for adenylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported for adenylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
2 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
3 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
4 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
5 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
6 INT62381 ADCY10 Positive_regulation of Localization of IGHG3 1 0.04 0.36 1.11
7 INT62380 ADCY10 Positive_regulation of IGHG3 1 0.03 0.36 1.11
8 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
9 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
10 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
11 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
12 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
13 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
14 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
15 INT305034 Adcy8 Regulation of Localization of Adcy1 1 0.35 1.51 0.77
16 INT305033 Adcy1 Regulation of Localization of Adcy8 1 0.35 1.51 0.77
17 INT190788 Adcy8 Positive_regulation of Adcy1 1 0.23 0.77 0.77
18 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
19 INT130356 Adcy10 Negative_regulation of Positive_regulation of Crp 1 0.13 0.23 0.71
20 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
21 INT209593 Negative_regulation of Adcy1 Negative_regulation of Positive_regulation of Ltp 1 0.10 0 0.69
22 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
23 INT130357 Adcy10 Regulation of Fgg 1 0.03 0.2 0.66
24 INT130354 Adcy10 Regulation of Serpine1 1 0.17 0.2 0.66
25 INT281081 Prkaca Positive_regulation of Gene_expression of Adcy1 1 0.12 0 0.63
26 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
27 INT281078 Prkacb Positive_regulation of Gene_expression of Adcy1 1 0.03 0 0.63
28 INT281076 Adcy1 Positive_regulation of Mdk 1 0.07 0 0.62
29 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
30 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
31 INT64744 OR5D2P Negative_regulation of ADCY1 1 0.00 0 0.54
32 INT333309 Binding of Htr1b and Adcy1 1 0.01 0 0.53
33 INT93265 Binding of ADCY1 and OPRL1 1 0.13 0.17 0.51
34 INT89647 OPRM1 Regulation of ADCY1 1 0.09 0.09 0.47
35 INT258584 ADORA3 Negative_regulation of ADCY1 1 0.02 0 0.44
36 INT111275 BRI3P1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0 0.44
37 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
38 INT111274 C2 Positive_regulation of Negative_regulation of ADCY1 1 0.14 0 0.44
39 INT73832 Pld1 Positive_regulation of ADCY1 1 0.00 0.16 0.44
40 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
41 INT140140 Adcy1 Regulation of Regulation of Atf6b 1 0.14 0.34 0.41
42 INT68527 Binding of ADCY1 and OPRD1 1 0.06 0.07 0.41
43 INT105170 OPRD1 Positive_regulation of Phosphorylation of ADCY1 1 0.08 0 0.41
44 INT11425 OR2A12 Positive_regulation of Negative_regulation of ADCY1 1 0.01 0 0.4
45 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
46 INT124799 PRKCA Positive_regulation of Localization of ADCY6 1 0.19 0 0.4
47 INT151546 Adcy1 Positive_regulation of Atf2 1 0.36 0.37 0.37
48 INT151545 Adcy1 Positive_regulation of Regulation of Fmr1 1 0.48 0.37 0.37
49 INT151549 Regulation of Adcy1 Positive_regulation of Atf2 1 0.33 0.37 0.37
50 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32
51 INT339001 GSX1 Positive_regulation of ADCY1 1 0.01 0 0.29
52 INT141438 Gnai2 Positive_regulation of Localization of ADCY1 1 0.01 0.43 0.29
53 INT210828 POMC Positive_regulation of ADCY1 1 0.03 0.34 0.28
54 INT265831 BGN Positive_regulation of ADCY1 1 0.01 0.41 0.27
55 INT93952 CGA Positive_regulation of ADCY1 1 0.03 0 0.27
56 INT93953 Negative_regulation of CGA Positive_regulation of ADCY1 1 0.03 0 0.27
57 INT223042 AR Positive_regulation of ADCY1 1 0.01 0.41 0.25
58 INT223036 SLURP1 Regulation of Positive_regulation of ADCY1 1 0.00 0.42 0.25
59 INT34499 ADRB3 Positive_regulation of ADCY1 1 0.07 0.19 0.23
60 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22
61 INT224130 Positive_regulation of Adora2a Positive_regulation of ADCY1 1 0.01 0.11 0.22
62 INT196823 Adcy5 Positive_regulation of Prkaca 1 0.13 0 0.22
63 INT7332 CALM3 Positive_regulation of ADCY1 1 0.46 0.13 0.21
64 INT318357 Binding of Pmp2 and Adcy3 1 0.06 0.26 0.2
65 INT224133 Negative_regulation of Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
66 INT318356 Positive_regulation of Binding of Slc10a7 and Adcy3 1 0.17 0.26 0.2
67 INT318358 Positive_regulation of Binding of Pmp2 and Adcy3 1 0.08 0.26 0.2
68 INT224134 Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
69 INT318359 Binding of Slc10a7 and Adcy3 1 0.12 0.26 0.2
70 INT196822 Negative_regulation of Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
71 INT196815 Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
72 INT216841 TCIRG1 Negative_regulation of ADCY1 1 0.01 0.35 0.18
73 INT216842 ATP6V0A1 Negative_regulation of ADCY1 1 0.01 0.35 0.18
74 INT74600 Negative_regulation of YY1 Negative_regulation of ADCY1 1 0.36 0.25 0.17
75 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
76 INT261521 Binding of ADCY1 and GLUL 1 0.01 0.09 0.15
77 INT241772 AVP Positive_regulation of ADCY1 1 0.09 1.08 0.15
78 INT77122 WDTC1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0.39 0.15
79 INT196811 Binding of Pde1a and Adcy5 1 0.01 0 0.14
80 INT13014 Avp Positive_regulation of Adcy5 1 0.00 0.07 0.13
81 INT61998 GNPTAB Positive_regulation of ADCY1 1 0.03 0 0.13
82 INT52711 BSG Regulation of ADCY1 1 0.01 0.1 0.12
83 INT141426 ANTXRL Negative_regulation of ADCY1 1 0.00 0.41 0.11
84 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
85 INT72302 Regulation of ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
86 INT72304 ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
87 INT289764 Pgf Regulation of Adcy3 1 0.12 0 0.03
88 INT289761 Adcy1 Regulation of Adcy3 1 0.09 0 0.03
89 INT249538 Binding of BDNF and GNAS 1 0.08 0 0
90 INT179302 Gene_expression of GNAS Negative_regulation of CA2 1 0.01 0 0
91 INT344893 Binding of ADCY1 and Ptger4 1 0.00 0 0
92 INT344892 Binding of ADCY1 and Ptger2 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for adenylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported in adenylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
2 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
3 INT106720 Positive_regulation of Adcy1 30 0.50 22.05 22.68
4 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
5 INT130424 Negative_regulation of Adcy1 19 0.58 16.31 13.6
6 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
7 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
8 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
9 INT55038 Gene_expression of Adcy8 10 0.77 28.79 9.8
10 INT106719 Gene_expression of Adcy1 18 0.77 12.18 8.42
11 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
12 INT55037 Positive_regulation of Adcy8 7 0.61 5.92 5.36
13 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
14 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
15 INT106721 Regulation of Adcy1 6 0.45 2.32 4.17
16 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
17 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
18 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
19 INT128138 Positive_regulation of Positive_regulation of Adcy1 5 0.45 2.67 3.25
20 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
21 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
22 INT69641 Positive_regulation of ADCY2 5 0.32 0.18 2.87
23 INT30815 Binding of ADCY1 7 0.36 0.21 2.79
24 INT80884 Positive_regulation of Phosphorylation of ADCY1 4 0.43 0.24 2.64
25 INT11426 Positive_regulation of Gene_expression of ADCY1 5 0.29 0.68 2.63
26 INT305030 Localization of Adcy8 2 0.75 8.18 2.63
27 INT55036 Regulation of Adcy8 3 0.44 0.85 2.56
28 INT55039 Positive_regulation of Gene_expression of Adcy8 3 0.69 6.64 2.39
29 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
30 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
31 INT190783 Binding of Adcy1 3 0.35 1.35 2.03
32 INT190782 Negative_regulation of Adcy8 3 0.58 4.37 1.84
33 INT62972 Gene_expression of Adcy5 3 0.67 0.23 1.72
34 INT87289 Positive_regulation of Localization of ADCY1 3 0.43 0.36 1.65
35 INT289739 Positive_regulation of Adcy3 3 0.28 0.64 1.63
36 INT305029 Localization of Adcy1 2 0.70 5.94 1.63
37 INT80890 Negative_regulation of Phosphorylation of ADCY1 2 0.36 0.24 1.57
38 INT72310 Regulation of Regulation of ADCY1 6 0.24 1.24 1.55
39 INT13013 Positive_regulation of Adcy5 4 0.67 0.3 1.49
40 INT121347 Binding of GNAS 8 0.13 3.99 1.47
41 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
42 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
43 INT61429 Gene_expression of Adcy5 6 0.60 1.49 1.27
44 INT80887 Negative_regulation of Regulation of ADCY1 3 0.35 0.1 1.26
45 INT75891 Regulation of ADCY2 3 0.06 0.06 1.17
46 INT295165 Negative_regulation of Adcy1 1 0.09 1.3 1.13
47 INT114326 Phosphorylation of ADCY6 2 0.70 0.05 1.11
48 INT124810 Gene_expression of ADCY6 6 0.65 0 1.06
49 INT72868 Transcription of ADCY1 4 0.57 0.69 1.04
50 INT196743 Binding of Adcy5 1 0.25 0 1.04
51 INT190776 Negative_regulation of Gene_expression of Adcy1 3 0.43 0.96 0.93
52 INT80871 Negative_regulation of Binding of ADCY1 1 0.03 0.1 0.91
53 INT305028 Positive_regulation of Positive_regulation of Adcy8 1 0.44 1.56 0.82
54 INT196762 Negative_regulation of Adcy5 5 0.39 1.49 0.8
55 INT124814 Localization of ADCY6 1 0.65 0 0.78
56 INT61427 Gene_expression of Adcy3 6 0.55 0.53 0.77
57 INT196734 Positive_regulation of Adcy5 1 0.35 0 0.75
58 INT62973 Positive_regulation of Gene_expression of Adcy5 1 0.05 0.16 0.74
59 INT124813 Negative_regulation of ADCY6 1 0.37 0 0.73
60 INT124811 Positive_regulation of Negative_regulation of ADCY6 1 0.40 0 0.73
61 INT130425 Negative_regulation of Negative_regulation of Adcy1 2 0.43 0.57 0.65
62 INT36313 Localization of ADCY10 3 0.73 1.74 0.62
63 INT249551 Negative_regulation of Transcription of GNAS 1 0.06 0.16 0.6
64 INT127930 Gene_expression of ADCY2 6 0.11 0.1 0.59
65 INT94190 Positive_regulation of ADCY10 5 0.49 3.17 0.58
66 INT165848 Protein_catabolism of ADCY1 1 0.25 0.28 0.57
67 INT190778 Positive_regulation of Gene_expression of Adcy1 2 0.50 1.49 0.55
68 INT62384 Negative_regulation of ADCY10 2 0.42 0.18 0.55
69 INT165845 Positive_regulation of Transcription of ADCY1 1 0.26 0.36 0.55
70 INT333289 Positive_regulation of Binding of Adcy1 1 0.28 0 0.52
71 INT235847 Transcription of Adcy1 2 0.25 0.42 0.5
72 INT110905 Regulation of Negative_regulation of ADCY1 1 0.59 0 0.48
73 INT235845 Positive_regulation of Transcription of Adcy1 1 0.13 0.43 0.44
74 INT336707 Negative_regulation of Gene_expression of Adcy8 1 0.58 3.17 0.43
75 INT164178 Gene_expression of ADCY10 9 0.65 2.72 0.39
76 INT124808 Positive_regulation of Localization of ADCY6 1 0.43 0 0.38
77 INT138362 Regulation of Negative_regulation of ADCY2 1 0.01 0 0.34
78 INT336709 Negative_regulation of Localization of Adcy1 1 0.35 0.88 0.34
79 INT164337 Localization of Adcy5 1 0.38 0 0.33
80 INT124812 Positive_regulation of ADCY6 1 0.43 0 0.33
81 INT164338 Regulation of Adcy5 1 0.14 0 0.33
82 INT138363 Positive_regulation of Gene_expression of ADCY2 1 0.01 0 0.3
83 INT200894 Positive_regulation of Adcy1 1 0.06 0.23 0.26
84 INT289743 Regulation of Positive_regulation of Adcy3 1 0.25 0 0.25
85 INT196792 Binding of Adcy5 1 0.35 0 0.25
86 INT289745 Positive_regulation of Positive_regulation of Adcy3 1 0.28 0 0.25
87 INT108902 Localization of GNAS 5 0.13 1.31 0.23
88 INT51109 Gene_expression of Adcy1 2 0.09 0.15 0.23
89 INT130423 Regulation of Positive_regulation of Adcy1 1 0.05 0.1 0.21
90 INT127931 Positive_regulation of Gene_expression of ADCY6 2 0.49 0 0.17
91 INT285210 Regulation of Adcy3 1 0.28 0.07 0.14
92 INT127934 Regulation of ADCY6 1 0.09 0 0.13
93 INT127929 Regulation of Gene_expression of ADCY6 1 0.21 0 0.13
94 INT127928 Regulation of Gene_expression of ADCY2 1 0.08 0 0.13
95 INT340828 Regulation of ADCY10 1 0.06 5.17 0.11
96 INT196776 Negative_regulation of Negative_regulation of Adcy5 1 0.22 0 0.11
97 INT289728 Positive_regulation of Gene_expression of Adcy3 1 0.28 0 0.1
98 INT285212 Negative_regulation of Gene_expression of Adcy3 1 0.30 0.17 0.1
99 INT252444 Positive_regulation of Binding of ADCY1 1 0.03 0 0.09
100 INT127926 Negative_regulation of Gene_expression of ADCY2 1 0.06 0 0.08
101 INT127924 Transcription of ADCY6 1 0.18 0 0.07
102 INT127932 Regulation of Transcription of ADCY6 1 0.09 0 0.07
103 INT179307 Regulation of GNAS 7 0.01 1.93 0.05
104 INT289737 Transcription of Adcy3 1 0.38 0 0.05
105 INT289730 Negative_regulation of Transcription of Adcy1 1 0.15 0 0.05
106 INT289732 Negative_regulation of Transcription of Adcy3 1 0.24 0 0.05
107 INT196788 Positive_regulation of Binding of Adcy5 1 0.22 0 0.05
108 INT177312 Negative_regulation of Gene_expression of GNAS 2 0.05 0.46 0
109 INT255830 Positive_regulation of Localization of GNAS 1 0.01 0.28 0
110 INT279689 Regulation of Gene_expression of Adcy10 1 0.02 0.16 0
111 INT84292 Negative_regulation of Positive_regulation of ADCY2 1 0.03 0 0
112 INT289726 Negative_regulation of Adcy3 1 0.24 0 0
113 INT179318 Regulation of Transcription of GNAS 1 0.01 0 0
114 INT179310 Positive_regulation of Gene_expression of GNAS 1 0.01 0 0
115 INT351494 Positive_regulation of Protein_catabolism of GNAS 1 0.00 0.94 0
116 INT351518 Protein_catabolism of GNAS 1 0.01 1.29 0
117 INT255817 Positive_regulation of Positive_regulation of GNAS 1 0.01 0.85 0
118 INT279686 Gene_expression of Adcy10 1 0.03 0.37 0
119 INT249548 Negative_regulation of Positive_regulation of GNAS 1 0.06 0 0
120 INT336705 Regulation of Gene_expression of Adcy8 1 0.45 0.37 0
121 INT246343 Positive_regulation of Gene_expression of ADCY10 1 0.19 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox