GO:0004032

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Name alditol:NADP+ 1-oxidoreductase activity
Categary Function
Go Slim No
Go Link GO:0004032
Unique Molecular Interactions 25
Total Molecular Interactions 25
Total Single Events 218
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for alditol:NADP+ 1-oxidoreductase activity. They are ordered first by their pain relevance and then by number of times they were reported for alditol:NADP+ 1-oxidoreductase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT262367 Tcas1 Positive_regulation of Localization of Adh4 1 0.01 1.91 1.01
2 INT117604 AKR1C1 Negative_regulation of Positive_regulation of Mpo 1 0.00 1.45 0.78
3 INT34823 Regulation of Binding of Ldha and Akr7a3 1 0.43 0.28 0.72
4 INT34824 Binding of Ldha and Akr7a3 1 0.36 0.28 0.71
5 INT116926 Cpox Regulation of AKR1C3 1 0.01 0.28 0.45
6 INT17726 Positive_regulation of Binding of AKR1A1 and Aldh2 1 0.11 0.35 0.41
7 INT17725 Binding of AKR1A1 and Aldh2 1 0.08 0.35 0.4
8 INT122169 AKR1C3 Regulation of PPARG 1 0.45 0.26 0.33
9 INT122168 AKR1C1 Regulation of PPARG 1 0.12 0.25 0.31
10 INT156087 Binding of AKR1C3 and Akr1c1 1 0.05 0.31 0.3
11 INT139044 AKR1B1 Regulation of Gene_expression of PTGS2 1 0.09 0.37 0.3
12 INT156083 Binding of AKR1C2 and AKR1C3 1 0.05 0.31 0.3
13 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
14 INT156082 Binding of PTGS1 and AKR1C3 1 0.01 0.31 0.3
15 INT90772 Binding of AKR1C4 and AKR1C1 1 0.39 0.08 0.2
16 INT305335 Olfr927-ps1 Negative_regulation of Akr1b3 1 0.02 1.6 0.17
17 INT156056 AKR1C1 Negative_regulation of UMOD 1 0.03 0.41 0.1
18 INT321401 Gene_expression of ROS1 Negative_regulation of Positive_regulation of AKR1B1 1 0.01 0.8 0.05
19 INT170418 Ccrn4l Positive_regulation of Transcription of Adh4 1 0.11 0 0.05
20 INT281902 Binding of AGT and AKR1A1 1 0.01 0.08 0
21 INT281910 Binding of REN and AKR1A1 1 0.01 0.08 0
22 INT255384 Binding of AKR1C2 and DSG1 1 0.01 1.54 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for alditol:NADP+ 1-oxidoreductase activity. They are ordered first by their pain relevance and then by number of times they were reported in alditol:NADP+ 1-oxidoreductase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17352 Binding of Akr7a3 4 0.35 0.9 4.21
2 INT108086 Negative_regulation of AKR1C3 17 0.58 7.7 3.99
3 INT78146 Gene_expression of AKR1C3 24 0.77 5.71 2.77
4 INT300260 Localization of AKR1A1 3 0.10 3.1 2.18
5 INT17354 Regulation of Binding of Akr7a3 2 0.23 0.19 1.24
6 INT122171 Negative_regulation of AKR1C1 5 0.59 1.92 1.22
7 INT23834 Negative_regulation of AKR1B1 8 0.55 3.79 1.15
8 INT135289 Negative_regulation of Akr1b3 4 0.58 5.35 1.15
9 INT140244 Positive_regulation of Akr1b3 3 0.69 2.8 1.12
10 INT166482 Negative_regulation of AKR1A1 5 0.15 2.51 1.07
11 INT17353 Negative_regulation of Akr7a3 1 0.43 0 1.05
12 INT262366 Localization of Adh4 1 0.78 1.88 1
13 INT108085 Positive_regulation of Gene_expression of AKR1C3 2 0.53 0.58 0.75
14 INT260501 Positive_regulation of AKR1B1 5 0.67 4.31 0.71
15 INT109964 Binding of AKR1B1 4 0.31 3.95 0.7
16 INT156085 Negative_regulation of AKR1C2 3 0.54 0.79 0.66
17 INT115276 Gene_expression of AKR1C1 11 0.77 4.65 0.63
18 INT287529 Negative_regulation of Positive_regulation of AKR1B1 2 0.41 2.1 0.63
19 INT42098 Regulation of Akr1c1 1 0.37 0 0.6
20 INT78999 Binding of AKR1C1 3 0.36 1.75 0.58
21 INT156077 Negative_regulation of Akr1c1 1 0.09 0.74 0.57
22 INT116925 Binding of AKR1C3 2 0.36 0.75 0.56
23 INT97664 Binding of AKR1C2 1 0.48 0 0.51
24 INT97663 Localization of AKR1C2 2 0.71 0.43 0.5
25 INT97070 Positive_regulation of Binding of Akr7a3 1 0.18 0.17 0.49
26 INT130391 Positive_regulation of AKR1C3 4 0.50 1.7 0.47
27 INT44490 Positive_regulation of Akr7a3 2 0.30 0.2 0.46
28 INT105408 Negative_regulation of Gene_expression of AKR1C3 1 0.23 0.56 0.45
29 INT122170 Regulation of AKR1C1 1 0.12 0.22 0.42
30 INT156100 Gene_expression of AKR1B1 4 0.65 3.64 0.41
31 INT53210 Gene_expression of AKR1A1 2 0.45 0.36 0.4
32 INT42099 Regulation of AKR1B1 2 0.45 0.46 0.39
33 INT17355 Negative_regulation of Binding of Akr7a3 1 0.43 0 0.39
34 INT336270 Localization of AKR1C1 1 0.06 1.56 0.29
35 INT168052 Gene_expression of Akr1c1 1 0.40 0 0.28
36 INT154494 Transcription of AKR1C1 4 0.72 0.99 0.27
37 INT156076 Negative_regulation of Localization of Akr1c1 1 0.09 0.43 0.27
38 INT156086 Negative_regulation of Localization of AKR1C2 1 0.10 0.43 0.27
39 INT156078 Localization of Akr1c1 1 0.15 0.43 0.27
40 INT39221 Gene_expression of Akr7a3 2 0.57 0.38 0.23
41 INT267901 Regulation of Negative_regulation of AKR1A1 1 0.07 1.45 0.17
42 INT123396 Gene_expression of Akr1b3 1 0.50 1.2 0.17
43 INT123395 Positive_regulation of Gene_expression of Akr1b3 1 0.37 1.2 0.17
44 INT1275 Gene_expression of AKR1C2 1 0.75 2.92 0.16
45 INT153084 Positive_regulation of Gene_expression of AKR1C1 4 0.50 1.56 0.14
46 INT78144 Transcription of AKR1C3 4 0.72 1.21 0.13
47 INT44486 Positive_regulation of Gene_expression of Akr7a3 1 0.15 0 0.08
48 INT143828 Regulation of AKR1C3 1 0.06 1.32 0.07
49 INT177877 Positive_regulation of AKR1C1 3 0.50 1.13 0.06
50 INT170384 Positive_regulation of Transcription of Adh4 1 0.10 0 0.05
51 INT170379 Transcription of Adh4 1 0.15 0 0.05
52 INT250290 Positive_regulation of Adh4 1 0.29 0.16 0.05
53 INT250292 Gene_expression of Adh4 1 0.34 0.17 0.05
54 INT178538 Transcription of AKR1C2 3 0.67 1.17 0.03
55 INT305321 Regulation of Negative_regulation of Akr1b3 1 0.14 1.18 0
56 INT305319 Regulation of Akr1b3 1 0.14 1.17 0
57 INT281920 Negative_regulation of Negative_regulation of AKR1A1 1 0.04 0.08 0
58 INT178540 Regulation of Gene_expression of AKR1C3 1 0.59 0.32 0
59 INT207723 Positive_regulation of Transcription of AKR1C1 1 0.33 0.68 0
60 INT178543 Regulation of Gene_expression of AKR1C1 1 0.43 0.32 0
61 INT156099 Transcription of AKR1B1 1 0.52 0 0
62 INT207758 Positive_regulation of AKR1C2 1 0.52 0.67 0
63 INT178546 Negative_regulation of Gene_expression of AKR1C2 1 0.42 0.41 0
64 INT281927 Binding of AKR1A1 1 0.03 0.08 0
65 INT260500 Positive_regulation of Positive_regulation of AKR1B1 1 0.19 0.47 0
66 INT178533 Negative_regulation of Gene_expression of AKR1C1 1 0.41 0.61 0
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