GO:0004051

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Name arachidonate 5-lipoxygenase activity
Categary Function
Go Slim No
Go Link GO:0004051
Unique Molecular Interactions 153
Total Molecular Interactions 213
Total Single Events 1948
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for arachidonate 5-lipoxygenase activity. They are ordered first by their pain relevance and then by number of times they were reported for arachidonate 5-lipoxygenase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18
2 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14
3 INT68160 Alox5 Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.13
4 INT110671 Binding of Cnr1 and Alox5 1 0.07 0.2 1.13
5 INT68164 Mthfs Positive_regulation of Positive_regulation of Alox5 1 0.00 0.64 1.13
6 INT68167 Alox5 Positive_regulation of Positive_regulation of Mthfs 1 0.00 0.64 1.13
7 INT110669 Binding of Alox5 and Trpv1 1 0.07 0.2 1.13
8 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
9 INT68156 Pla2g1b Positive_regulation of Positive_regulation of Alox5 1 0.03 0.64 1.13
10 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
11 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
12 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 1.47 0.94
13 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9
14 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
15 INT352201 Negative_regulation of ALOX5 Negative_regulation of Cpox 1 0.02 0.89 0.81
16 INT203164 PTGER2 Regulation of ALOX5 1 0.00 0.9 0.78
17 INT203171 PTGER2 Negative_regulation of ALOX5 1 0.01 0.89 0.77
18 INT312101 ELANE Regulation of ALOX5AP 1 0.21 1.11 0.73
19 INT159569 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Fos 1 0.37 0.4 0.7
20 INT164286 Alox5ap Positive_regulation of Cysltr2 1 0.19 1.11 0.61
21 INT164284 Ltb4r Positive_regulation of Alox5ap 1 0.34 1.1 0.6
22 INT270100 Negative_regulation of Binding of ALOX5 and PLA2G2A 1 0.01 0.51 0.59
23 INT35398 Fnd3c2 Negative_regulation of Binding of Alox5 1 0.00 0 0.58
24 INT270102 ALOX5 Negative_regulation of PLA2G2A 1 0.01 0.49 0.57
25 INT251163 Gene_expression of Alox5 Positive_regulation of Trpv1 1 0.02 0.11 0.48
26 INT312112 ELANE Regulation of Transcription of ALOX5 1 0.09 0.82 0.47
27 INT158267 Olr1745 Negative_regulation of Alox5 1 0.05 0.94 0.43
28 INT203163 LTB4R Regulation of Gene_expression of ALOX5 1 0.00 0.98 0.41
29 INT159571 Trpv1 Positive_regulation of Gene_expression of Alox5 1 0.37 0.58 0.4
30 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4
31 INT203167 Gene_expression of PTGER2 Positive_regulation of Gene_expression of ALOX5AP 1 0.03 0.67 0.38
32 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
33 INT312102 Binding of ALOX5 and ALOX5AP 1 0.10 0.65 0.36
34 INT39208 ALOX5 Regulation of Gene_expression of IL2 1 0.04 0.06 0.34
35 INT312085 ELANE Regulation of Regulation of ALOX5 1 0.09 0.64 0.32
36 INT59189 Negative_regulation of GBE1 Negative_regulation of ALOX5 1 0.00 0.33 0.31
37 INT159572 Alox5 Regulation of Gene_expression of Fos 1 0.20 0.32 0.31
38 INT159570 Negative_regulation of Alox5 Regulation of Gene_expression of Fos 1 0.34 0.27 0.31
39 INT26737 Alox5 Regulation of Localization of Ins1 1 0.06 0.09 0.3
40 INT203170 Negative_regulation of CPOX Positive_regulation of ALOX5 1 0.01 0.53 0.29
41 INT194977 Binding of Alox5 and Syt1 1 0.04 0.65 0.27
42 INT55901 Negative_regulation of Alox5 Negative_regulation of Localization of Ptafr 1 0.01 0.35 0.24
43 INT110061 Binding of Alox5 and Cpox 1 0.28 0.37 0.23
44 INT313498 Binding of ALOX5 and SNRNP70 1 0.05 2.7 0.21
45 INT312091 ALOX5AP Regulation of Transcription of ALOX5 1 0.13 0.37 0.18
46 INT313554 Binding of ALOX5 and Cor 1 0.02 2.47 0.17
47 INT312089 LTB4R Positive_regulation of ALOX5AP 1 0.01 0.32 0.16
48 INT312095 LTB4R Positive_regulation of ALOX5 1 0.01 0.32 0.16
49 INT312126 ELANE Positive_regulation of ALOX5AP 1 0.20 0.25 0.15
50 INT116382 Lox Positive_regulation of Binding of Alox5 1 0.12 0.25 0.14
51 INT194975 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Nos2 1 0.13 0.69 0.13
52 INT312096 ELANE Positive_regulation of Transcription of ALOX5 1 0.06 0.27 0.13
53 INT194976 Alox5 Regulation of Gene_expression of Nos2 1 0.07 0.56 0.12
54 INT312116 Negative_regulation of PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 0.2 0.1
55 INT312121 Negative_regulation of PTGER2 Regulation of Gene_expression of ALOX5 1 0.02 0.2 0.1
56 INT273354 Binding of ALOX5 and LTC4S 1 0.04 0.19 0.09
57 INT312103 ELANE Regulation of Gene_expression of ALOX5 1 0.06 0.15 0.08
58 INT313503 Binding of ALOX5AP and CXADRP1 1 0.01 1.51 0.08
59 INT312093 ELANE Regulation of Gene_expression of ALOX5AP 1 0.13 0.15 0.08
60 INT313509 Binding of ALOX5 and SP1 1 0.07 1.51 0.08
61 INT325488 Negative_regulation of Ephx2 Positive_regulation of Alox5 1 0.13 0.24 0.08
62 INT184889 Binding of ALOX5 and MCRS1 1 0.06 1.34 0.07
63 INT312087 PTGER2 Regulation of Gene_expression of ALOX5 1 0.01 0.13 0.07
64 INT312113 ELANE Positive_regulation of Gene_expression of ALOX5AP 1 0.23 0.14 0.07
65 INT313504 Binding of ALOX5AP and SNRNP70 1 0.04 0.5 0.05
66 INT312110 ELANE Positive_regulation of Gene_expression of ALOX5 1 0.09 0.07 0.04
67 INT312104 Binding of ALOX5 and PTGES 1 0.13 0.14 0.04
68 INT312117 Negative_regulation of ELANE Positive_regulation of ALOX5AP 1 0.17 0.08 0.04
69 INT313551 Binding of ALOX5AP and Cor 1 0.02 1.01 0.03
70 INT184887 MCRS1 Positive_regulation of ALOX5 1 0.11 0.64 0
71 INT313499 Binding of ALOX5AP and CRP 1 0.07 0.45 0
72 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0
73 INT313507 Binding of ALOX5 and CXADRP1 1 0.01 0 0
74 INT298871 ALOX5AP Positive_regulation of RAB7A 1 0.09 0.35 0
75 INT343160 ACSL4 Regulation of Positive_regulation of ALOX5 1 0.02 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for arachidonate 5-lipoxygenase activity. They are ordered first by their pain relevance and then by number of times they were reported in arachidonate 5-lipoxygenase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17
2 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94
3 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29
4 INT195414 Gene_expression of ALOX5AP 65 0.72 31.22 15.25
5 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82
6 INT17421 Negative_regulation of Alox5 41 0.57 15.23 10.05
7 INT9889 Gene_expression of Alox5 34 0.63 20.83 8.85
8 INT28164 Regulation of ALOX5 25 0.60 12.76 5.47
9 INT28165 Positive_regulation of ALOX5 38 0.47 10.8 5.37
10 INT6577 Regulation of Alox5 18 0.47 9.19 5.06
11 INT30355 Positive_regulation of Gene_expression of Alox5 10 0.67 14.61 4.69
12 INT15995 Positive_regulation of Alox5 18 0.49 3.94 4.63
13 INT74365 Positive_regulation of Alox5 19 0.47 11.03 4.04
14 INT44254 Regulation of Gene_expression of ALOX5 12 0.43 7.06 3.65
15 INT10476 Binding of ALOX5 26 0.36 7.69 3.2
16 INT195415 Regulation of Gene_expression of ALOX5AP 10 0.45 6.43 3.13
17 INT35448 Negative_regulation of Gene_expression of ALOX5 11 0.57 5.28 3.03
18 INT76342 Positive_regulation of Gene_expression of Alox5 9 0.56 5.29 2.87
19 INT195421 Positive_regulation of Gene_expression of ALOX5AP 12 0.49 5.17 2.82
20 INT34905 Positive_regulation of Gene_expression of ALOX5 18 0.50 7.46 2.46
21 INT26736 Localization of Alox5 7 0.49 3.72 2.09
22 INT20251 Binding of Alox5 7 0.32 5.33 1.93
23 INT200779 Negative_regulation of Gene_expression of ALOX5AP 7 0.41 3.75 1.79
24 INT34552 Regulation of Gene_expression of Alox5 3 0.50 5.06 1.75
25 INT39229 Regulation of Alox5 6 0.57 3.2 1.72
26 INT164275 Gene_expression of Alox5ap 3 0.55 3.79 1.72
27 INT200778 Positive_regulation of ALOX5AP 3 0.49 2.54 1.7
28 INT27608 Localization of Alox5 7 0.61 2.66 1.69
29 INT9885 Negative_regulation of Gene_expression of Alox5 3 0.14 2.28 1.59
30 INT122204 Positive_regulation of Alox5ap 1 0.26 0.23 1.53
31 INT73926 Localization of ALOX5 8 0.44 3.14 1.52
32 INT170987 Transcription of ALOX5 4 0.69 2.71 1.41
33 INT29109 Negative_regulation of Gene_expression of Alox5 6 0.42 2.9 1.07
34 INT34553 Binding of Alox5 3 0.10 0.65 1.03
35 INT165009 Regulation of Negative_regulation of Alox5 1 0.05 1 1.01
36 INT184896 Negative_regulation of Positive_regulation of ALOX5 2 0.42 0.92 0.96
37 INT291677 Transcription of Alox5 1 0.58 3.91 0.91
38 INT68926 Binding of ALOX5AP 8 0.36 4.02 0.84
39 INT29056 Regulation of Gene_expression of Alox5 4 0.60 1.47 0.72
40 INT164276 Localization of Alox5ap 1 0.61 1.1 0.6
41 INT205494 Negative_regulation of Negative_regulation of ALOX5 2 0.32 1.2 0.54
42 INT39227 Regulation of Regulation of Alox5 2 0.36 0.38 0.45
43 INT122205 Negative_regulation of Alox5ap 1 0.24 0 0.45
44 INT44371 Positive_regulation of Positive_regulation of ALOX5 3 0.31 0.7 0.44
45 INT170989 Regulation of Transcription of ALOX5 2 0.26 0.58 0.39
46 INT6581 Regulation of Negative_regulation of Alox5 1 0.06 0 0.39
47 INT195416 Regulation of ALOX5AP 2 0.53 0.8 0.38
48 INT34551 Regulation of Binding of Alox5 1 0.08 0.19 0.38
49 INT195413 Negative_regulation of ALOX5AP 5 0.37 1.39 0.37
50 INT44274 Negative_regulation of Regulation of ALOX5 2 0.33 0.28 0.31
51 INT162441 Positive_regulation of Localization of Alox5 1 0.34 0.27 0.3
52 INT162442 Positive_regulation of Positive_regulation of Alox5 1 0.34 0.26 0.29
53 INT291679 Regulation of Transcription of Alox5 1 0.25 0.94 0.28
54 INT291672 Phosphorylation of Alox5 1 0.66 0.63 0.28
55 INT291667 Regulation of Phosphorylation of Alox5 1 0.22 0.63 0.28
56 INT59192 Regulation of Positive_regulation of ALOX5 1 0.15 0.29 0.24
57 INT96930 Positive_regulation of Positive_regulation of Alox5 2 0.43 0.15 0.23
58 INT96929 Phosphorylation of Alox5 1 0.04 0.22 0.22
59 INT203173 Localization of ALOX5AP 3 0.48 0.78 0.21
60 INT259884 Negative_regulation of Binding of ALOX5AP 1 0.10 0.46 0.21
61 INT291680 Positive_regulation of Transcription of Alox5 1 0.41 0.37 0.19
62 INT312127 Positive_regulation of Positive_regulation of ALOX5AP 1 0.35 0.37 0.19
63 INT312137 Transcription of ALOX5AP 1 0.50 0.37 0.18
64 INT194974 Regulation of Binding of Alox5 1 0.15 0.53 0.17
65 INT259885 Regulation of Binding of ALOX5 1 0.07 0.51 0.16
66 INT116380 Protein_catabolism of Alox5 1 0.31 0.25 0.14
67 INT312135 Negative_regulation of Regulation of ALOX5AP 1 0.30 0.19 0.13
68 INT194971 Negative_regulation of Negative_regulation of Alox5 1 0.14 0.81 0.13
69 INT96931 Negative_regulation of Binding of Alox5 2 0.14 0.46 0.12
70 INT26732 Negative_regulation of Localization of Alox5 2 0.28 0.06 0.11
71 INT116377 Transcription of Alox5 1 0.16 0.25 0.11
72 INT166890 Regulation of Binding of ALOX5AP 1 0.44 0.1 0.1
73 INT96928 Positive_regulation of Binding of Alox5 1 0.03 0.09 0.09
74 INT172862 Regulation of Localization of Alox5 1 0.04 0.67 0.06
75 INT312131 Positive_regulation of Transcription of ALOX5 1 0.16 0.12 0.06
76 INT312129 Positive_regulation of Transcription of ALOX5AP 1 0.35 0.1 0.05
77 INT184891 Positive_regulation of Localization of ALOX5 2 0.16 0.72 0.03
78 INT291671 Negative_regulation of Transcription of Alox5 1 0.35 0.4 0.03
79 INT312132 Regulation of Regulation of ALOX5AP 1 0.28 0.06 0.03
80 INT312136 Regulation of Regulation of ALOX5 1 0.14 0.06 0.03
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