GO:0004112

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Name cyclic-nucleotide phosphodiesterase activity
Categary Function
Go Slim No
Go Link GO:0004112
Unique Molecular Interactions 100
Total Molecular Interactions 129
Total Single Events 770
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported for cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
2 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
3 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
4 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
5 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
6 INT149925 Negative_regulation of Cpox Negative_regulation of Gene_expression of Pde4d 1 0.01 0.39 0.84
7 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83
8 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75
9 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7
10 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6
11 INT273350 Pde7a Positive_regulation of Localization of Pde4d 1 0.33 1.35 0.49
12 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48
13 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
14 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
15 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
16 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
17 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35
18 INT79383 Pde1b Regulation of Oprd1 1 0.02 0 0.34
19 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
20 INT280181 Pde5a Positive_regulation of Regulation of Cpox 1 0.00 0.16 0.26
21 INT273352 Pde7a Positive_regulation of Localization of Pde4b 1 0.43 0.68 0.24
22 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
23 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 0.03 0.09 0.2
24 INT163055 Negative_regulation of Pde10a Positive_regulation of Gene_expression of Qrfp 1 0.03 0 0.2
25 INT32162 POMC Negative_regulation of PDE11A 1 0.23 0 0.19
26 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
27 INT276065 Camk2a Negative_regulation of Pde1b 1 0.56 0 0.17
28 INT219597 Prkaca Positive_regulation of Pde4d 1 0.29 0 0.15
29 INT276060 Pde1b Regulation of Car2 1 0.30 0 0.15
30 INT273017 Binding of PDE1B and PDE11A 1 0.08 0.35 0.14
31 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
32 INT276079 Pde1b Negative_regulation of Camk2a 1 0.41 0 0.12
33 INT219599 Pde4d Regulation of Prkaca 1 0.28 0 0.12
34 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
35 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
36 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
37 INT219600 Pde4d Regulation of Binding of Prkaca 1 0.28 0 0.09
38 INT219602 Binding of Prkaca and Pde4d 1 0.23 0 0.09
39 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
40 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
41 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
42 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
43 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
44 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
45 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07
46 INT276067 Binding of Car2 and Pde1b 1 0.32 0 0.06
47 INT276050 Binding of Calm3 and Pde1b 1 0.15 0 0.06
48 INT276049 Pde1b Regulation of Positive_regulation of Rpa1 1 0.04 0 0.06
49 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
50 INT337608 Pde5a Regulation of Cnga1 1 0.00 0 0.04
51 INT263197 Binding of PDE3A and Pde5a 1 0.03 0.18 0.04
52 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
53 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
54 INT263198 Pde5a Negative_regulation of PDE4A 1 0.09 0.16 0.03
55 INT276036 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Prkaca 1 0.27 0 0.03
56 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
57 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03
58 INT276055 Negative_regulation of Pde1b Positive_regulation of Prkaca 1 0.27 0 0.03
59 INT276070 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Ppp1r1b 1 0.24 0 0.03
60 INT219596 Binding of Pde4a and Pde4d 1 0.28 0.31 0
61 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
62 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
63 INT276044 Binding of Pde1b and Ppp1cc 1 0.12 0 0
64 INT222556 Pde5a Regulation of Localization of LH 1 0.00 0.06 0
65 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0
66 INT276048 Binding of Pde1b and Myoz1 1 0.04 0 0
67 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
68 INT276078 Binding of Camk2a and Pde1b 1 0.36 0 0
69 INT263182 Ca2 Positive_regulation of Phosphorylation of Pde1b 1 0.01 0 0
70 INT276052 Negative_regulation of Pde1b Negative_regulation of Camk2a 1 0.41 0 0
71 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
72 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
73 INT263181 Binding of Pde1a and Pde5a 1 0.03 0 0
74 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
75 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
76 INT276058 Camk2a Regulation of Pde1b 1 0.26 0 0
77 INT98236 LOC360919 Positive_regulation of Pde5a 1 0.00 0.33 0
78 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
79 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
80 INT268021 Pde5a Positive_regulation of Kcnj5 1 0.01 0 0
81 INT263183 Binding of Pde1b and Pde5a 1 0.03 0 0
82 INT276042 Negative_regulation of Binding of Calm3 and Pde1b 1 0.17 0 0
83 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
84 INT268052 Pde5a Positive_regulation of Positive_regulation of PRKG1 1 0.00 0 0
85 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0
86 INT268022 Pde5a Positive_regulation of Gene_expression of Kcnj5 1 0.01 0 0
87 INT276047 Camk2a Regulation of Negative_regulation of Pde1b 1 0.43 0 0
88 INT276051 Pde1b Regulation of Regulation of Car2 1 0.30 0 0
89 INT276071 Pde1b Regulation of Positive_regulation of Camk2a 1 0.43 0 0
90 INT222471 Gnrh1 Positive_regulation of Pde5a 1 0.00 0.07 0
91 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported in cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
2 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
3 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
4 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
5 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
6 INT160168 Gene_expression of Pde10a 10 0.74 8.66 7.94
7 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
8 INT105775 Gene_expression of Pde4d 31 0.78 4.18 5.21
9 INT94862 Positive_regulation of Gene_expression of Pde5a 10 0.20 4.23 5.18
10 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27
11 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31
12 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
13 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06
14 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
15 INT136675 Transcription of Pde5a 6 0.63 4.74 2.71
16 INT94860 Negative_regulation of Gene_expression of Pde5a 2 0.33 3.2 2.64
17 INT257298 Regulation of Positive_regulation of Pde5a 1 0.19 2.03 2.54
18 INT79399 Gene_expression of Pde4d 6 0.70 2.83 2.51
19 INT107489 Negative_regulation of Pde4d 3 0.42 0 2.47
20 INT257299 Binding of Pde5a 14 0.27 4.31 2.45
21 INT257301 Protein_catabolism of Pde5a 5 0.30 1.97 2.26
22 INT107490 Positive_regulation of Pde4d 3 0.69 0.07 2.13
23 INT108422 Binding of Pde5a 11 0.36 3.07 2.07
24 INT105776 Negative_regulation of Gene_expression of Pde4d 5 0.59 2.2 2.01
25 INT165648 Negative_regulation of Transcription of Pde5a 1 0.41 3.6 1.93
26 INT24909 Negative_regulation of Pde10a 4 0.43 0.87 1.87
27 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
28 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
29 INT64529 Localization of Pde2a 1 0.59 0 1.63
30 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
31 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
32 INT291576 Positive_regulation of Protein_catabolism of Pde5a 1 0.12 1.15 1.43
33 INT68451 Localization of Pde1b 4 0.22 0 1.35
34 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
35 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31
36 INT135924 Positive_regulation of Gene_expression of Pde4d 2 0.59 0 1.28
37 INT73011 Gene_expression of Pde1b 3 0.23 0.38 1.27
38 INT149924 Negative_regulation of Gene_expression of Pde4d 1 0.26 0.81 1.24
39 INT110400 Negative_regulation of Pde1b 21 0.50 0.58 1.14
40 INT219589 Binding of Pde4d 13 0.47 0.51 1.01
41 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
42 INT219568 Positive_regulation of Pde4d 9 0.49 1.74 1
43 INT69302 Positive_regulation of Pde1b 3 0.21 0.99 0.97
44 INT160171 Localization of Pde10a 2 0.77 1.26 0.95
45 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
46 INT257200 Phosphorylation of Pde5a 1 0.25 0 0.94
47 INT165644 Regulation of Transcription of Pde5a 1 0.44 1.65 0.91
48 INT164144 Phosphorylation of Pde5a 4 0.19 1.15 0.87
49 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
50 INT177532 Localization of Pde5a 2 0.56 0.96 0.81
51 INT219578 Negative_regulation of Pde4d 3 0.46 2.95 0.8
52 INT135923 Regulation of Gene_expression of Pde4d 2 0.44 0 0.8
53 INT118753 Regulation of Negative_regulation of Pde4d 1 0.02 0 0.8
54 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
55 INT165645 Positive_regulation of Negative_regulation of Pde5a 3 0.37 1.58 0.74
56 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
57 INT165647 Negative_regulation of Negative_regulation of Pde5a 1 0.31 1.22 0.67
58 INT257202 Protein_catabolism of Pde5a 2 0.38 0.36 0.66
59 INT165646 Positive_regulation of Transcription of Pde5a 1 0.33 1.21 0.66
60 INT208 Negative_regulation of Positive_regulation of Pde5a 3 0.17 2.02 0.65
61 INT219580 Localization of Pde4d 5 0.73 2.07 0.64
62 INT275071 Negative_regulation of Protein_catabolism of Pde5a 1 0.17 0.36 0.6
63 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
64 INT79397 Positive_regulation of Gene_expression of Pde4d 1 0.45 0.2 0.55
65 INT219573 Positive_regulation of Localization of Pde4d 2 0.49 1.39 0.5
66 INT257211 Negative_regulation of Localization of Pde5a 1 0.13 0.2 0.48
67 INT291577 Positive_regulation of Phosphorylation of Pde5a 1 0.12 0.35 0.48
68 INT273345 Gene_expression of Pde7a 1 0.65 1.45 0.47
69 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
70 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
71 INT273344 Negative_regulation of Pde7a 1 0.49 1.36 0.43
72 INT219565 Regulation of Pde4d 3 0.44 0.5 0.39
73 INT273347 Negative_regulation of Gene_expression of Pde7a 1 0.36 1.3 0.38
74 INT79379 Regulation of Pde1b 1 0.07 0 0.37
75 INT273330 Positive_regulation of Negative_regulation of Pde4d 1 0.39 1.25 0.35
76 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
77 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
78 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
79 INT276012 Gene_expression of Pde1b 8 0.66 0.58 0.32
80 INT276027 Positive_regulation of Pde1b 7 0.59 0.71 0.32
81 INT275073 Positive_regulation of Negative_regulation of Pde5a 1 0.22 0.45 0.3
82 INT273021 Binding of PDE11A 1 0.35 0.78 0.26
83 INT183429 Localization of Pde5a 5 0.56 1.61 0.25
84 INT273341 Transcription of Pde4d 2 0.54 0.68 0.24
85 INT273329 Regulation of Negative_regulation of Pde7a 1 0.38 0.68 0.24
86 INT273336 Regulation of Negative_regulation of Pde4d 1 0.35 0.68 0.24
87 INT261276 Positive_regulation of Positive_regulation of Pde5a 1 0.26 0.07 0.21
88 INT42375 Positive_regulation of Positive_regulation of Pde5a 2 0.14 0.1 0.19
89 INT32164 Positive_regulation of PDE11A 1 0.26 0 0.19
90 INT261275 Negative_regulation of Localization of Pde5a 2 0.31 1.11 0.18
91 INT42376 Regulation of Positive_regulation of Pde5a 1 0.03 0 0.18
92 INT163053 Regulation of Negative_regulation of Pde10a 1 0.45 0 0.18
93 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
94 INT177528 Negative_regulation of Binding of Pde5a 1 0.34 0.46 0.15
95 INT219593 Regulation of Binding of Pde4d 1 0.44 0 0.13
96 INT275069 Negative_regulation of Gene_expression of Pde5a 1 0.26 0.54 0.13
97 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
98 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
99 INT273022 Negative_regulation of PDE11A 1 0.40 0.24 0.11
100 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
101 INT219574 Phosphorylation of Pde4d 1 0.79 0.33 0.1
102 INT261274 Negative_regulation of Protein_catabolism of Pde5a 1 0.20 0.18 0.09
103 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
104 INT273349 Regulation of Gene_expression of Pde7a 1 0.38 0.32 0.08
105 INT257205 Transcription of Pde5a 1 0.21 0 0.08
106 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
107 INT276000 Negative_regulation of Positive_regulation of Pde1b 2 0.36 0.54 0.06
108 INT273340 Transcription of Pde7a 1 0.57 0.08 0.06
109 INT273327 Positive_regulation of Pde7a 1 0.39 0.08 0.06
110 INT219585 Positive_regulation of Positive_regulation of Pde4d 1 0.43 0 0.06
111 INT275994 Positive_regulation of Negative_regulation of Pde1b 1 0.43 0 0.06
112 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
113 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
114 INT183435 Regulation of Localization of Pde5a 1 0.34 0.35 0.04
115 INT183437 Regulation of Pde10a 1 0.05 0.4 0.04
116 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
117 INT323262 Negative_regulation of Negative_regulation of Pde5a 1 0.03 1.32 0.04
118 INT183438 Regulation of Localization of Pde10a 1 0.08 0.4 0.04
119 INT275993 Negative_regulation of Gene_expression of Pde1b 2 0.36 0.53 0.03
120 INT276029 Regulation of Negative_regulation of Pde1b 1 0.38 0 0.03
121 INT263185 Regulation of Gene_expression of Pde5a 1 0.12 0.19 0.03
122 INT275998 Positive_regulation of Gene_expression of Pde1b 1 0.43 0 0.03
123 INT248265 Regulation of Pde4d 1 0.21 0.87 0
124 INT268038 Regulation of Negative_regulation of Pde5a 1 0.03 0 0
125 INT162918 Transcription of PDE2A 1 0.65 0 0
126 INT276008 Negative_regulation of Localization of Pde1b 1 0.36 0 0
127 INT162909 Gene_expression of PDE11A 1 0.17 0 0
128 INT276007 Negative_regulation of Phosphorylation of Pde1b 1 0.36 0 0
129 INT276001 Positive_regulation of Phosphorylation of Pde1b 1 0.40 0 0
130 INT162914 Regulation of Localization of PDE2A 1 0.37 0 0
131 INT219570 Negative_regulation of Positive_regulation of Pde4d 1 0.42 0 0
132 INT276006 Phosphorylation of Pde1b 1 0.70 0 0
133 INT275991 Regulation of Phosphorylation of Pde1b 1 0.38 0 0
134 INT276011 Localization of Pde1b 1 0.64 0 0
135 INT219575 Positive_regulation of Binding of Pde4d 1 0.49 0 0
136 INT162916 Negative_regulation of Transcription of PDE2A 1 0.40 0 0
137 INT276023 Positive_regulation of Positive_regulation of Pde1b 1 0.43 0 0
138 INT183430 Binding of Pde2a 1 0.07 0 0
139 INT275999 Binding of Pde1b 1 0.32 0 0
140 INT325558 Negative_regulation of Gene_expression of Pde2a 1 0.11 0.38 0
141 INT263186 Phosphorylation of Pde1b 1 0.24 0 0
142 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0
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