GO:0004114

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Name 3',5'-cyclic-nucleotide phosphodiesterase activity
Categary Function
Go Slim No
Go Link GO:0004114
Unique Molecular Interactions 130
Total Molecular Interactions 161
Total Single Events 1553
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 3',5'-cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported for 3',5'-cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
2 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
3 INT128776 Cntn1 Positive_regulation of Gene_expression of Pde6b 1 0.02 0.55 1.26
4 INT152428 Ghrh Positive_regulation of Pde6b 1 0.07 0.5 1.18
5 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
6 INT55564 Binding of Oprk1 and Pde6b 1 0.01 0 0.92
7 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
8 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
9 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85
10 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83
11 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75
12 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7
13 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6
14 INT94089 Binding of Pnoc and Pde6b 1 0.02 0.09 0.57
15 INT273350 Pde7a Positive_regulation of Localization of Pde4d 1 0.33 1.35 0.49
16 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48
17 INT222923 Negative_regulation of Pde4a Negative_regulation of Positive_regulation of Mpo 1 0.04 0.59 0.45
18 INT222924 Negative_regulation of Pde4a Negative_regulation of Gene_expression of Il12a 1 0.01 0.59 0.45
19 INT222922 Negative_regulation of Pde4a Negative_regulation of Gene_expression of Il1 1 0.01 0.56 0.44
20 INT94092 Pnoc Positive_regulation of Pde6b 1 0.02 0.1 0.44
21 INT152430 Regulation of Ghrh Positive_regulation of Pde6b 1 0.04 0.16 0.43
22 INT275100 Pde4a Negative_regulation of RTP3 1 0.00 0.51 0.42
23 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
24 INT275089 Pde4a Negative_regulation of stm 1 0.02 0.51 0.42
25 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
26 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
27 INT275099 Pde9a Negative_regulation of RTP3 1 0.00 0.51 0.39
28 INT275093 Pde9a Negative_regulation of stm 1 0.00 0.51 0.39
29 INT152426 Ghrh Positive_regulation of Positive_regulation of Pde6b 1 0.07 0.14 0.38
30 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
31 INT275096 Pde9a Regulation of Ltp 1 0.00 0.11 0.35
32 INT275098 Pde9a Regulation of RTP3 1 0.00 0.11 0.35
33 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35
34 INT274172 Negative_regulation of Pde4a Negative_regulation of Positive_regulation of TNF 1 0.02 0.72 0.28
35 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
36 INT280181 Pde5a Positive_regulation of Regulation of Cpox 1 0.00 0.16 0.26
37 INT273352 Pde7a Positive_regulation of Localization of Pde4b 1 0.43 0.68 0.24
38 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
39 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 0.03 0.09 0.2
40 INT163055 Negative_regulation of Pde10a Positive_regulation of Gene_expression of Qrfp 1 0.03 0 0.2
41 INT30071 Gm8212 Regulation of Pde3a 1 0.00 0 0.2
42 INT32162 POMC Negative_regulation of PDE11A 1 0.23 0 0.19
43 INT196822 Negative_regulation of Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
44 INT196815 Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
45 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
46 INT274169 Mapk1 Regulation of Pde4a 1 0.05 0.62 0.17
47 INT276065 Camk2a Negative_regulation of Pde1b 1 0.56 0 0.17
48 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
49 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
50 INT263180 Binding of PDE5A and COPD 1 0.01 1 0.15
51 INT219597 Prkaca Positive_regulation of Pde4d 1 0.29 0 0.15
52 INT276060 Pde1b Regulation of Car2 1 0.30 0 0.15
53 INT263175 PDE5A Regulation of COPD 1 0.00 1 0.15
54 INT273017 Binding of PDE1B and PDE11A 1 0.08 0.35 0.14
55 INT196811 Binding of Pde1a and Adcy5 1 0.01 0 0.14
56 INT196837 Binding of CALM1 and Pde1a 1 0.00 0 0.14
57 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
58 INT276079 Pde1b Negative_regulation of Camk2a 1 0.41 0 0.12
59 INT219599 Pde4d Regulation of Prkaca 1 0.28 0 0.12
60 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
61 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
62 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
63 INT219600 Pde4d Regulation of Binding of Prkaca 1 0.28 0 0.09
64 INT219602 Binding of Prkaca and Pde4d 1 0.23 0 0.09
65 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
66 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
67 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
68 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
69 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
70 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
71 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07
72 INT276067 Binding of Car2 and Pde1b 1 0.32 0 0.06
73 INT276050 Binding of Calm3 and Pde1b 1 0.15 0 0.06
74 INT276049 Pde1b Regulation of Positive_regulation of Rpa1 1 0.04 0 0.06
75 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
76 INT337608 Pde5a Regulation of Cnga1 1 0.00 0 0.04
77 INT263197 Binding of PDE3A and Pde5a 1 0.03 0.18 0.04
78 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
79 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
80 INT276038 Camk2a Negative_regulation of Pde1a 1 0.14 0 0.03
81 INT263198 Pde5a Negative_regulation of PDE4A 1 0.09 0.16 0.03
82 INT276036 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Prkaca 1 0.27 0 0.03
83 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
84 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03
85 INT276055 Negative_regulation of Pde1b Positive_regulation of Prkaca 1 0.27 0 0.03
86 INT276070 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Ppp1r1b 1 0.24 0 0.03
87 INT219596 Binding of Pde4a and Pde4d 1 0.28 0.31 0
88 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
89 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
90 INT276044 Binding of Pde1b and Ppp1cc 1 0.12 0 0
91 INT222556 Pde5a Regulation of Localization of LH 1 0.00 0.06 0
92 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0
93 INT276048 Binding of Pde1b and Myoz1 1 0.04 0 0
94 INT121478 Binding of Pde3a and Positive_regulation of Localization of Ins1 1 0.24 0 0
95 INT209159 Binding of LHCGR and PDE5A 1 0.01 0 0
96 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
97 INT276078 Binding of Camk2a and Pde1b 1 0.36 0 0
98 INT276052 Negative_regulation of Pde1b Negative_regulation of Camk2a 1 0.41 0 0
99 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
100 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
101 INT191577 Binding of Pde6b and Tst 1 0.02 0.48 0
102 INT263181 Binding of Pde1a and Pde5a 1 0.03 0 0
103 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
104 INT242674 Binding of Pde6b and Ppp3cb 1 0.00 0.6 0
105 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
106 INT330056 Bcl2 Regulation of Localization of Cyct 1 0.27 0.97 0
107 INT276058 Camk2a Regulation of Pde1b 1 0.26 0 0
108 INT98236 LOC360919 Positive_regulation of Pde5a 1 0.00 0.33 0
109 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
110 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
111 INT268021 Pde5a Positive_regulation of Kcnj5 1 0.01 0 0
112 INT263183 Binding of Pde1b and Pde5a 1 0.03 0 0
113 INT276042 Negative_regulation of Binding of Calm3 and Pde1b 1 0.17 0 0
114 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
115 INT268052 Pde5a Positive_regulation of Positive_regulation of PRKG1 1 0.00 0 0
116 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0
117 INT268022 Pde5a Positive_regulation of Gene_expression of Kcnj5 1 0.01 0 0
118 INT343716 Nos3 Positive_regulation of Pde6b 1 0.20 0 0
119 INT276047 Camk2a Regulation of Negative_regulation of Pde1b 1 0.43 0 0
120 INT276051 Pde1b Regulation of Regulation of Car2 1 0.30 0 0
121 INT276071 Pde1b Regulation of Positive_regulation of Camk2a 1 0.43 0 0
122 INT222471 Gnrh1 Positive_regulation of Pde5a 1 0.00 0.07 0
123 INT308426 Binding of Pde4a and Aip 1 0.02 0.89 0
124 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0
125 INT343718 Nos3 Regulation of Pde6b 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 3',5'-cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported in 3',5'-cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23
2 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09
3 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
4 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
5 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
6 INT48009 Gene_expression of Pde6b 38 0.68 15.03 11.41
7 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
8 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
9 INT105777 Gene_expression of Pde4a 30 0.76 12.67 8.52
10 INT160168 Gene_expression of Pde10a 10 0.74 8.66 7.94
11 INT118492 Regulation of Pde4a 7 0.61 6.32 6.04
12 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
13 INT105775 Gene_expression of Pde4d 31 0.78 4.18 5.21
14 INT94862 Positive_regulation of Gene_expression of Pde5a 10 0.20 4.23 5.18
15 INT121471 Negative_regulation of Pde3a 24 0.34 13.79 4.73
16 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27
17 INT119498 Positive_regulation of Pde6b 11 0.43 18.75 4.22
18 INT48008 Negative_regulation of Pde6b 9 0.15 6.12 4.11
19 INT172852 Localization of Cyct 28 0.78 21.42 3.34
20 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31
21 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
22 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06
23 INT165915 Regulation of Negative_regulation of Pde4a 5 0.29 6.72 2.91
24 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
25 INT136675 Transcription of Pde5a 6 0.63 4.74 2.71
26 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7
27 INT172853 Positive_regulation of Localization of Cyct 14 0.67 10.48 2.65
28 INT94860 Negative_regulation of Gene_expression of Pde5a 2 0.33 3.2 2.64
29 INT257298 Regulation of Positive_regulation of Pde5a 1 0.19 2.03 2.54
30 INT128773 Regulation of Gene_expression of Pde6b 4 0.45 1.41 2.5
31 INT257299 Binding of Pde5a 14 0.27 4.31 2.45
32 INT137270 Positive_regulation of PDE4D 4 0.48 2.48 2.39
33 INT257301 Protein_catabolism of Pde5a 5 0.30 1.97 2.26
34 INT48007 Regulation of Pde6b 6 0.39 4.4 2.2
35 INT108422 Binding of Pde5a 11 0.36 3.07 2.07
36 INT105776 Negative_regulation of Gene_expression of Pde4d 5 0.59 2.2 2.01
37 INT165648 Negative_regulation of Transcription of Pde5a 1 0.41 3.6 1.93
38 INT24909 Negative_regulation of Pde10a 4 0.43 0.87 1.87
39 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
40 INT153606 Localization of Pde4a 2 0.69 1.23 1.79
41 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
42 INT135930 Regulation of Gene_expression of Pde4a 3 0.61 0.52 1.63
43 INT64529 Localization of Pde2a 1 0.59 0 1.63
44 INT135927 Positive_regulation of Pde4a 1 0.68 0 1.6
45 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
46 INT177525 Negative_regulation of Negative_regulation of Pde4a 5 0.28 5.22 1.58
47 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
48 INT291576 Positive_regulation of Protein_catabolism of Pde5a 1 0.12 1.15 1.43
49 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
50 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31
51 INT242945 Localization of PDE5A 9 0.75 4.57 1.28
52 INT135924 Positive_regulation of Gene_expression of Pde4d 2 0.59 0 1.28
53 INT64562 Positive_regulation of Pde1a 2 0.06 0.28 1.28
54 INT177527 Negative_regulation of Binding of Pde4a 4 0.28 3.5 1.23
55 INT67852 Negative_regulation of Pde1a 1 0.25 0.18 1.2
56 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17
57 INT238533 Negative_regulation of Localization of Cyct 7 0.57 5.75 1.15
58 INT110400 Negative_regulation of Pde1b 21 0.50 0.58 1.14
59 INT103043 Binding of PDE5A 16 0.37 7.79 1.12
60 INT219595 Positive_regulation of Gene_expression of Pde4a 3 0.39 2.81 1.11
61 INT105774 Negative_regulation of Gene_expression of Pde4a 3 0.42 0.4 1.03
62 INT219589 Binding of Pde4d 13 0.47 0.51 1.01
63 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
64 INT219568 Positive_regulation of Pde4d 9 0.49 1.74 1
65 INT160171 Localization of Pde10a 2 0.77 1.26 0.95
66 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
67 INT257200 Phosphorylation of Pde5a 1 0.25 0 0.94
68 INT177531 Binding of Pde4a 4 0.29 2.46 0.91
69 INT165644 Regulation of Transcription of Pde5a 1 0.44 1.65 0.91
70 INT164144 Phosphorylation of Pde5a 4 0.19 1.15 0.87
71 INT265568 Binding of PDE4D 1 0.05 0.81 0.85
72 INT226473 Negative_regulation of PDE4D 5 0.19 3.54 0.83
73 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
74 INT177532 Localization of Pde5a 2 0.56 0.96 0.81
75 INT135931 Regulation of Regulation of Pde4a 1 0.44 0 0.81
76 INT219578 Negative_regulation of Pde4d 3 0.46 2.95 0.8
77 INT135923 Regulation of Gene_expression of Pde4d 2 0.44 0 0.8
78 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
79 INT177533 Negative_regulation of Binding of Pde3a 1 0.21 2.46 0.76
80 INT165645 Positive_regulation of Negative_regulation of Pde5a 3 0.37 1.58 0.74
81 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
82 INT165647 Negative_regulation of Negative_regulation of Pde5a 1 0.31 1.22 0.67
83 INT235846 Transcription of Pde4a 2 0.30 0.88 0.66
84 INT257202 Protein_catabolism of Pde5a 2 0.38 0.36 0.66
85 INT165646 Positive_regulation of Transcription of Pde5a 1 0.33 1.21 0.66
86 INT208 Negative_regulation of Positive_regulation of Pde5a 3 0.17 2.02 0.65
87 INT219580 Localization of Pde4d 5 0.73 2.07 0.64
88 INT213617 Gene_expression of PDE4D 3 0.53 1.98 0.62
89 INT275071 Negative_regulation of Protein_catabolism of Pde5a 1 0.17 0.36 0.6
90 INT242944 Negative_regulation of Localization of PDE5A 3 0.35 3.18 0.59
91 INT275078 Negative_regulation of Pde9a 1 0.01 1.38 0.57
92 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
93 INT126754 Binding of Pde6b 5 0.34 1.34 0.55
94 INT94088 Transcription of Pde6b 2 0.55 0.39 0.53
95 INT219573 Positive_regulation of Localization of Pde4d 2 0.49 1.39 0.5
96 INT273179 Localization of PDE4D 1 0.34 2.01 0.5
97 INT257211 Negative_regulation of Localization of Pde5a 1 0.13 0.2 0.48
98 INT291577 Positive_regulation of Phosphorylation of Pde5a 1 0.12 0.35 0.48
99 INT273345 Gene_expression of Pde7a 1 0.65 1.45 0.47
100 INT222921 Protein_catabolism of Pde4a 1 0.07 1.78 0.47
101 INT152425 Positive_regulation of Positive_regulation of Pde6b 2 0.18 1.74 0.46
102 INT130371 Negative_regulation of Gene_expression of PDE5A 3 0.43 1.59 0.45
103 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
104 INT121469 Binding of Pde3a 2 0.23 1.42 0.44
105 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
106 INT119499 Regulation of Positive_regulation of Pde6b 2 0.11 0.8 0.43
107 INT273344 Negative_regulation of Pde7a 1 0.49 1.36 0.43
108 INT79597 Positive_regulation of Negative_regulation of PDE5A 5 0.50 3.39 0.41
109 INT275079 Positive_regulation of Pde9a 1 0.01 0 0.41
110 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4
111 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39
112 INT219565 Regulation of Pde4d 3 0.44 0.5 0.39
113 INT273347 Negative_regulation of Gene_expression of Pde7a 1 0.36 1.3 0.38
114 INT275368 Gene_expression of Cyct 5 0.65 3.21 0.37
115 INT275370 Positive_regulation of Gene_expression of Cyct 1 0.49 1.62 0.37
116 INT273330 Positive_regulation of Negative_regulation of Pde4d 1 0.39 1.25 0.35
117 INT275077 Protein_catabolism of Pde9a 1 0.01 0.05 0.35
118 INT275068 Negative_regulation of Protein_catabolism of Pde9a 1 0.01 0.05 0.35
119 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
120 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
121 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
122 INT235849 Regulation of Transcription of Pde4a 1 0.01 0.15 0.33
123 INT276012 Gene_expression of Pde1b 8 0.66 0.58 0.32
124 INT276027 Positive_regulation of Pde1b 7 0.59 0.71 0.32
125 INT219588 Negative_regulation of Gene_expression of Pde3a 1 0.25 0 0.32
126 INT219563 Gene_expression of Pde3a 1 0.39 0 0.32
127 INT275073 Positive_regulation of Negative_regulation of Pde5a 1 0.22 0.45 0.3
128 INT117995 Regulation of Negative_regulation of PDE5A 3 0.44 2.4 0.29
129 INT273021 Binding of PDE11A 1 0.35 0.78 0.26
130 INT183429 Localization of Pde5a 5 0.56 1.61 0.25
131 INT273341 Transcription of Pde4d 2 0.54 0.68 0.24
132 INT273329 Regulation of Negative_regulation of Pde7a 1 0.38 0.68 0.24
133 INT273336 Regulation of Negative_regulation of Pde4d 1 0.35 0.68 0.24
134 INT303483 Positive_regulation of PDE5A 2 0.39 1.5 0.23
135 INT249115 Localization of Pde6b 6 0.68 1.09 0.21
136 INT261276 Positive_regulation of Positive_regulation of Pde5a 1 0.26 0.07 0.21
137 INT273181 Negative_regulation of Localization of PDE4D 1 0.18 0.68 0.2
138 INT30069 Regulation of Pde3a 1 0.06 0 0.2
139 INT42375 Positive_regulation of Positive_regulation of Pde5a 2 0.14 0.1 0.19
140 INT32164 Positive_regulation of PDE11A 1 0.26 0 0.19
141 INT275543 Negative_regulation of Gene_expression of PDE4D 1 0.11 0.87 0.19
142 INT261275 Negative_regulation of Localization of Pde5a 2 0.31 1.11 0.18
143 INT42376 Regulation of Positive_regulation of Pde5a 1 0.03 0 0.18
144 INT163053 Regulation of Negative_regulation of Pde10a 1 0.45 0 0.18
145 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
146 INT343714 Negative_regulation of Positive_regulation of Pde6b 1 0.15 1.87 0.17
147 INT219576 Positive_regulation of Gene_expression of Pde3a 1 0.29 0 0.17
148 INT275082 Regulation of Pde9a 1 0.00 0.28 0.16
149 INT213222 Negative_regulation of Protein_catabolism of PDE5A 1 0.24 0.65 0.16
150 INT177528 Negative_regulation of Binding of Pde5a 1 0.34 0.46 0.15
151 INT263121 Negative_regulation of Negative_regulation of PDE5A 2 0.43 1.33 0.14
152 INT242949 Phosphorylation of PDE5A 2 0.68 0.05 0.13
153 INT274166 Phosphorylation of Pde4a 1 0.30 1.1 0.13
154 INT219593 Regulation of Binding of Pde4d 1 0.44 0 0.13
155 INT275069 Negative_regulation of Gene_expression of Pde5a 1 0.26 0.54 0.13
156 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
157 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
158 INT196773 Negative_regulation of Positive_regulation of Pde1a 1 0.01 0 0.11
159 INT273022 Negative_regulation of PDE11A 1 0.40 0.24 0.11
160 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
161 INT219574 Phosphorylation of Pde4d 1 0.79 0.33 0.1
162 INT303482 Positive_regulation of Protein_catabolism of PDE5A 1 0.20 1.27 0.1
163 INT261274 Negative_regulation of Protein_catabolism of Pde5a 1 0.20 0.18 0.09
164 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
165 INT273349 Regulation of Gene_expression of Pde7a 1 0.38 0.32 0.08
166 INT257205 Transcription of Pde5a 1 0.21 0 0.08
167 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
168 INT276000 Negative_regulation of Positive_regulation of Pde1b 2 0.36 0.54 0.06
169 INT273340 Transcription of Pde7a 1 0.57 0.08 0.06
170 INT273327 Positive_regulation of Pde7a 1 0.39 0.08 0.06
171 INT219585 Positive_regulation of Positive_regulation of Pde4d 1 0.43 0 0.06
172 INT275994 Positive_regulation of Negative_regulation of Pde1b 1 0.43 0 0.06
173 INT343709 Positive_regulation of Negative_regulation of Pde6b 1 0.16 0.87 0.06
174 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
175 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
176 INT213216 Positive_regulation of Gene_expression of PDE5A 2 0.37 2.08 0.04
177 INT274162 Negative_regulation of Phosphorylation of Pde4a 1 0.16 0.8 0.04
178 INT266216 Negative_regulation of Localization of Pde6b 1 0.39 0 0.04
179 INT183435 Regulation of Localization of Pde5a 1 0.34 0.35 0.04
180 INT183437 Regulation of Pde10a 1 0.05 0.4 0.04
181 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
182 INT323262 Negative_regulation of Negative_regulation of Pde5a 1 0.03 1.32 0.04
183 INT183438 Regulation of Localization of Pde10a 1 0.08 0.4 0.04
184 INT315158 Positive_regulation of Cyct 3 0.67 3.03 0.03
185 INT275993 Negative_regulation of Gene_expression of Pde1b 2 0.36 0.53 0.03
186 INT276029 Regulation of Negative_regulation of Pde1b 1 0.38 0 0.03
187 INT276013 Phosphorylation of Pde1a 1 0.18 0 0.03
188 INT263185 Regulation of Gene_expression of Pde5a 1 0.12 0.19 0.03
189 INT275998 Positive_regulation of Gene_expression of Pde1b 1 0.43 0 0.03
190 INT275492 Positive_regulation of Gene_expression of Pde6b 3 0.50 0.12 0
191 INT269744 Negative_regulation of Binding of PDE5A 2 0.43 0.74 0
192 INT162907 Regulation of Gene_expression of PDE5A 2 0.51 0 0
193 INT269741 Positive_regulation of Localization of PDE5A 1 0.04 0.65 0
194 INT268038 Regulation of Negative_regulation of Pde5a 1 0.03 0 0
195 INT162918 Transcription of PDE2A 1 0.65 0 0
196 INT295905 Negative_regulation of Cyct 1 0.41 0.94 0
197 INT330034 Binding of Cyct 1 0.35 0.95 0
198 INT276008 Negative_regulation of Localization of Pde1b 1 0.36 0 0
199 INT245698 Positive_regulation of Transcription of Pde6b 1 0.40 0.3 0
200 INT162909 Gene_expression of PDE11A 1 0.17 0 0
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