GO:0004117

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Name calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
Categary Function
Go Slim No
Go Link GO:0004117
Unique Molecular Interactions 27
Total Molecular Interactions 44
Total Single Events 109
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported for calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86972 PDE1B Positive_regulation of Localization of Gh 1 0.00 0 0.42
2 INT196822 Negative_regulation of Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
3 INT196815 Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
4 INT276065 Camk2a Negative_regulation of Pde1b 1 0.56 0 0.17
5 INT276060 Pde1b Regulation of Car2 1 0.30 0 0.15
6 INT273017 Binding of PDE1B and PDE11A 1 0.08 0.35 0.14
7 INT196811 Binding of Pde1a and Adcy5 1 0.01 0 0.14
8 INT196837 Binding of CALM1 and Pde1a 1 0.00 0 0.14
9 INT276079 Pde1b Negative_regulation of Camk2a 1 0.41 0 0.12
10 INT273019 Binding of PDE1A and MDD1 1 0.30 0.69 0.12
11 INT273018 Binding of FGF9 and PDE1A 1 0.18 0.3 0.11
12 INT276067 Binding of Car2 and Pde1b 1 0.32 0 0.06
13 INT276050 Binding of Calm3 and Pde1b 1 0.15 0 0.06
14 INT276049 Pde1b Regulation of Positive_regulation of Rpa1 1 0.04 0 0.06
15 INT276038 Camk2a Negative_regulation of Pde1a 1 0.14 0 0.03
16 INT276036 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Prkaca 1 0.27 0 0.03
17 INT276055 Negative_regulation of Pde1b Positive_regulation of Prkaca 1 0.27 0 0.03
18 INT276070 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Ppp1r1b 1 0.24 0 0.03
19 INT276044 Binding of Pde1b and Ppp1cc 1 0.12 0 0
20 INT276048 Binding of Pde1b and Myoz1 1 0.04 0 0
21 INT276078 Binding of Camk2a and Pde1b 1 0.36 0 0
22 INT276052 Negative_regulation of Pde1b Negative_regulation of Camk2a 1 0.41 0 0
23 INT276058 Camk2a Regulation of Pde1b 1 0.26 0 0
24 INT276042 Negative_regulation of Binding of Calm3 and Pde1b 1 0.17 0 0
25 INT276047 Camk2a Regulation of Negative_regulation of Pde1b 1 0.43 0 0
26 INT276051 Pde1b Regulation of Regulation of Car2 1 0.30 0 0
27 INT276071 Pde1b Regulation of Positive_regulation of Camk2a 1 0.43 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported in calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19235 Negative_regulation of PDE1B 11 0.14 2.38 2.81
2 INT64562 Positive_regulation of Pde1a 2 0.06 0.28 1.28
3 INT67852 Negative_regulation of Pde1a 1 0.25 0.18 1.2
4 INT110400 Negative_regulation of Pde1b 21 0.50 0.58 1.14
5 INT86971 Localization of PDE1B 4 0.15 0.08 0.6
6 INT86970 Positive_regulation of Localization of PDE1B 1 0.00 0 0.42
7 INT242948 Gene_expression of PDE1B 1 0.02 0.91 0.34
8 INT276012 Gene_expression of Pde1b 8 0.66 0.58 0.32
9 INT276027 Positive_regulation of Pde1b 7 0.59 0.71 0.32
10 INT100251 Regulation of PDE1B 4 0.26 1.21 0.22
11 INT242946 Positive_regulation of Phosphorylation of PDE1B 1 0.01 0.22 0.17
12 INT275085 Transcription of PDE1B 1 0.04 0.27 0.16
13 INT179449 Binding of PDE1B 5 0.07 0.3 0.11
14 INT196773 Negative_regulation of Positive_regulation of Pde1a 1 0.01 0 0.11
15 INT242947 Phosphorylation of PDE1B 1 0.02 0.11 0.08
16 INT100247 Positive_regulation of PDE1B 2 0.40 0.65 0.07
17 INT276000 Negative_regulation of Positive_regulation of Pde1b 2 0.36 0.54 0.06
18 INT275994 Positive_regulation of Negative_regulation of Pde1b 1 0.43 0 0.06
19 INT273023 Regulation of PDE1A 1 0.33 0.08 0.05
20 INT19234 Positive_regulation of Negative_regulation of PDE1B 1 0.01 0.05 0.04
21 INT275993 Negative_regulation of Gene_expression of Pde1b 2 0.36 0.53 0.03
22 INT276029 Regulation of Negative_regulation of Pde1b 1 0.38 0 0.03
23 INT276013 Phosphorylation of Pde1a 1 0.18 0 0.03
24 INT275998 Positive_regulation of Gene_expression of Pde1b 1 0.43 0 0.03
25 INT100252 Regulation of Regulation of PDE1B 1 0.26 0.55 0
26 INT276008 Negative_regulation of Localization of Pde1b 1 0.36 0 0
27 INT276007 Negative_regulation of Phosphorylation of Pde1b 1 0.36 0 0
28 INT276001 Positive_regulation of Phosphorylation of Pde1b 1 0.40 0 0
29 INT162902 Positive_regulation of Protein_catabolism of PDE1B 1 0.11 0 0
30 INT276006 Phosphorylation of Pde1b 1 0.70 0 0
31 INT275991 Regulation of Phosphorylation of Pde1b 1 0.38 0 0
32 INT162908 Protein_catabolism of PDE1B 1 0.19 0 0
33 INT276011 Localization of Pde1b 1 0.64 0 0
34 INT100249 Negative_regulation of PDE1A 1 0.22 0.47 0
35 INT276023 Positive_regulation of Positive_regulation of Pde1b 1 0.43 0 0
36 INT275999 Binding of Pde1b 1 0.32 0 0
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