GO:0004118

From wiki-pain
Jump to: navigation, search
Name cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Categary Function
Go Slim No
Go Link GO:0004118
Unique Molecular Interactions 40
Total Molecular Interactions 44
Total Single Events 259
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported for cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
2 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
3 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
4 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
5 INT163055 Negative_regulation of Pde10a Positive_regulation of Gene_expression of Qrfp 1 0.03 0 0.2
6 INT32162 POMC Negative_regulation of PDE11A 1 0.23 0 0.19
7 INT273017 Binding of PDE1B and PDE11A 1 0.08 0.35 0.14
8 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
9 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
10 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
11 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
12 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
13 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
14 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
15 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
16 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
17 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
18 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
19 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
20 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
21 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
22 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
23 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
24 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
25 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported in cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT160168 Gene_expression of Pde10a 10 0.74 8.66 7.94
2 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
3 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
4 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
5 INT24909 Negative_regulation of Pde10a 4 0.43 0.87 1.87
6 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
7 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
8 INT64529 Localization of Pde2a 1 0.59 0 1.63
9 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
10 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
11 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
12 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
13 INT160171 Localization of Pde10a 2 0.77 1.26 0.95
14 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
15 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
16 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
17 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
18 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
19 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
20 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
21 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
22 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
23 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
24 INT273021 Binding of PDE11A 1 0.35 0.78 0.26
25 INT32164 Positive_regulation of PDE11A 1 0.26 0 0.19
26 INT163053 Regulation of Negative_regulation of Pde10a 1 0.45 0 0.18
27 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
28 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
29 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
30 INT273022 Negative_regulation of PDE11A 1 0.40 0.24 0.11
31 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
32 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
33 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
34 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
35 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
36 INT183437 Regulation of Pde10a 1 0.05 0.4 0.04
37 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
38 INT183438 Regulation of Localization of Pde10a 1 0.08 0.4 0.04
39 INT162918 Transcription of PDE2A 1 0.65 0 0
40 INT162909 Gene_expression of PDE11A 1 0.17 0 0
41 INT162914 Regulation of Localization of PDE2A 1 0.37 0 0
42 INT162916 Negative_regulation of Transcription of PDE2A 1 0.40 0 0
43 INT183430 Binding of Pde2a 1 0.07 0 0
44 INT325558 Negative_regulation of Gene_expression of Pde2a 1 0.11 0.38 0
45 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox